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The map label for this gene is thd [H]

Identifier: 18310147

GI number: 18310147

Start: 1363219

End: 1364427

Strand: Direct

Name: thd [H]

Synonym: CPE1165

Alternate gene names: 18310147

Gene position: 1363219-1364427 (Clockwise)

Preceding gene: 18310144

Following gene: 18310149

Centisome position: 44.97

GC content: 30.36

Gene sequence:

>1209_bases
GTGATTATTTTGTATTTAGAAAAAATTATTAAAGCAAAAAAAAATATAGAAGATGTAGTTATAAAAACACCTTTAATATA
TAGCGAGGTCTTTTCAAGGAAATCTGGAAACCAAGTGTATATGAAATGTGAAAATTTACAATTAACAGGTGCTTACAAAA
TAAGAGGTGCTTTAAATAAAATAAGATCTTTATCAGATGAAGAAAAATCAAAAGGTGTTGTTTGTTCTTCTGCCGGAAAT
CATGCTCAAGGCGTAGCTTTTGCAGCATCACAAGCTAATGTTAAATCAACTATAGTAATGCCAAAGACTACTCCTCTACT
AAAAATCCAATCAACAAAGGATTTAGGAGGGAATGTTGTTTTATCAGGTTATGTTTATGATGATGCTTTTAATGAGGCTA
AAAGAATTGAACAAGAACAAGGAGCCTTATTTATACATCCATTTAATGATATTGATGTAATTTGTGGACAAGGTACAGTA
GCCTTAGAAATATTTGAAGATTTAAATGATGTAGATATTATTCTCTGCCCTATAGGTGGCGGTGGCTTAATAAGTGGAGT
TACCCTAGCTGCTAAGGCTTTAAACCCTAATGTTAAAGTAATTGGAGTACAGGCTGAAGGTGCAAATGCAATGGTTAAAA
GTTTTAAGGCAGGAGAAATAATTGCTTTAGACGCTGTTGATACTATTGCTGATGGAATTGCAGTAAAAAGACCTGGTGAT
TTAACATTTAAATTTATAAAAGAATATGTTGATGATATAATAACTGTATCAGATCATGAAATTGTTGAAGCATTCTTTAC
ATTAAGTGAAAAACATAAACTTTTAGCAGAAGCTTCAGGAGCAGTCTCATTAGCAGCTTCTGCTAAATTAAATTGTAAAG
ATAAAAATATAGTATCAGTAATAAGTGGTGGTAATATAGATATGGTTACTATAACTTCATTAATAAACAGCGCATTAGTA
GCTAAAGGAAGACTTTTTGGATTTAGTTTAGAAGTTCCTCATAAACCAGGACAAATATTGAAGATTGCTAAAGTTCTTGC
TGATACTAATGCTAATATAGTAAAACTTGAACATGATCATTTTAAAGCAAGGGATGCTCTTAAAAATATGGTTATAGAAG
TAACTTTAGAGACAAATGGACACTCTCACATAGAGGAAATAAAAAAAGCTTTAACAGATCAAAATTATGTAATAAAACAA
ATTTATTAA

Upstream 100 bases:

>100_bases
CTATTATTTTGCATACTTTTTTAAAAAATATTCCCTGTAAAAAACCATTTTTATTTGTTATAATTAAATTATAAAAGGTT
TACATAATGAGAAATGAGGG

Downstream 100 bases:

>100_bases
TTTTAAAATAAAAAAGAGGTGAAAAAACCACCTCTTTTTTTAGTAAGAAAATACTTCATCTTCTATACTCTCATCAGTAT
CTATATGCTCTACACTTAAG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MIILYLEKIIKAKKNIEDVVIKTPLIYSEVFSRKSGNQVYMKCENLQLTGAYKIRGALNKIRSLSDEEKSKGVVCSSAGN
HAQGVAFAASQANVKSTIVMPKTTPLLKIQSTKDLGGNVVLSGYVYDDAFNEAKRIEQEQGALFIHPFNDIDVICGQGTV
ALEIFEDLNDVDIILCPIGGGGLISGVTLAAKALNPNVKVIGVQAEGANAMVKSFKAGEIIALDAVDTIADGIAVKRPGD
LTFKFIKEYVDDIITVSDHEIVEAFFTLSEKHKLLAEASGAVSLAASAKLNCKDKNIVSVISGGNIDMVTITSLINSALV
AKGRLFGFSLEVPHKPGQILKIAKVLADTNANIVKLEHDHFKARDALKNMVIEVTLETNGHSHIEEIKKALTDQNYVIKQ
IY

Sequences:

>Translated_402_residues
MIILYLEKIIKAKKNIEDVVIKTPLIYSEVFSRKSGNQVYMKCENLQLTGAYKIRGALNKIRSLSDEEKSKGVVCSSAGN
HAQGVAFAASQANVKSTIVMPKTTPLLKIQSTKDLGGNVVLSGYVYDDAFNEAKRIEQEQGALFIHPFNDIDVICGQGTV
ALEIFEDLNDVDIILCPIGGGGLISGVTLAAKALNPNVKVIGVQAEGANAMVKSFKAGEIIALDAVDTIADGIAVKRPGD
LTFKFIKEYVDDIITVSDHEIVEAFFTLSEKHKLLAEASGAVSLAASAKLNCKDKNIVSVISGGNIDMVTITSLINSALV
AKGRLFGFSLEVPHKPGQILKIAKVLADTNANIVKLEHDHFKARDALKNMVIEVTLETNGHSHIEEIKKALTDQNYVIKQ
IY
>Mature_402_residues
MIILYLEKIIKAKKNIEDVVIKTPLIYSEVFSRKSGNQVYMKCENLQLTGAYKIRGALNKIRSLSDEEKSKGVVCSSAGN
HAQGVAFAASQANVKSTIVMPKTTPLLKIQSTKDLGGNVVLSGYVYDDAFNEAKRIEQEQGALFIHPFNDIDVICGQGTV
ALEIFEDLNDVDIILCPIGGGGLISGVTLAAKALNPNVKVIGVQAEGANAMVKSFKAGEIIALDAVDTIADGIAVKRPGD
LTFKFIKEYVDDIITVSDHEIVEAFFTLSEKHKLLAEASGAVSLAASAKLNCKDKNIVSVISGGNIDMVTITSLINSALV
AKGRLFGFSLEVPHKPGQILKIAKVLADTNANIVKLEHDHFKARDALKNMVIEVTLETNGHSHIEEIKKALTDQNYVIKQ
IY

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=317, Percent_Identity=36.2776025236593, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI33469958, Length=322, Percent_Identity=27.9503105590062, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI19923959, Length=305, Percent_Identity=28.1967213114754, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1789505, Length=313, Percent_Identity=42.8115015974441, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1790207, Length=399, Percent_Identity=34.0852130325814, Blast_Score=204, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI71991565, Length=391, Percent_Identity=36.3171355498721, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17537387, Length=394, Percent_Identity=33.502538071066, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17508781, Length=310, Percent_Identity=32.9032258064516, Blast_Score=149, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322631, Length=318, Percent_Identity=38.9937106918239, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6320930, Length=345, Percent_Identity=33.6231884057971, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6319788, Length=283, Percent_Identity=26.5017667844523, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6322024, Length=159, Percent_Identity=25.7861635220126, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355833, Length=359, Percent_Identity=32.8690807799443, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24645328, Length=295, Percent_Identity=31.1864406779661, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43422; Mature: 43422

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILYLEKIIKAKKNIEDVVIKTPLIYSEVFSRKSGNQVYMKCENLQLTGAYKIRGALNK
CEEEEHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCCEEEEEEECEEEEEEEEHHHHHHH
IRSLSDEEKSKGVVCSSAGNHAQGVAFAASQANVKSTIVMPKTTPLLKIQSTKDLGGNVV
HHCCCCCHHHCCEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCEEEEECCCCCCCCEE
LSGYVYDDAFNEAKRIEQEQGALFIHPFNDIDVICGQGTVALEIFEDLNDVDIILCPIGG
EEEEEECHHHHHHHHHHHHCCEEEEEECCCCEEEECCCEEEEEEECCCCCCEEEEEECCC
GGLISGVTLAAKALNPNVKVIGVQAEGANAMVKSFKAGEIIALDAVDTIADGIAVKRPGD
CHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHCCCCCCEEEEECHHHHHCCEEEECCCC
LTFKFIKEYVDDIITVSDHEIVEAFFTLSEKHKLLAEASGAVSLAASAKLNCKDKNIVSV
HHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEECCCCCCEEEE
ISGGNIDMVTITSLINSALVAKGRLFGFSLEVPHKPGQILKIAKVLADTNANIVKLEHDH
EECCCEEEEEHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECHH
FKARDALKNMVIEVTLETNGHSHIEEIKKALTDQNYVIKQIY
HHHHHHHCCEEEEEEEECCCCHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MIILYLEKIIKAKKNIEDVVIKTPLIYSEVFSRKSGNQVYMKCENLQLTGAYKIRGALNK
CEEEEHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCCEEEEEEECEEEEEEEEHHHHHHH
IRSLSDEEKSKGVVCSSAGNHAQGVAFAASQANVKSTIVMPKTTPLLKIQSTKDLGGNVV
HHCCCCCHHHCCEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCEEEEECCCCCCCCEE
LSGYVYDDAFNEAKRIEQEQGALFIHPFNDIDVICGQGTVALEIFEDLNDVDIILCPIGG
EEEEEECHHHHHHHHHHHHCCEEEEEECCCCEEEECCCEEEEEEECCCCCCEEEEEECCC
GGLISGVTLAAKALNPNVKVIGVQAEGANAMVKSFKAGEIIALDAVDTIADGIAVKRPGD
CHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHCCCCCCEEEEECHHHHHCCEEEECCCC
LTFKFIKEYVDDIITVSDHEIVEAFFTLSEKHKLLAEASGAVSLAASAKLNCKDKNIVSV
HHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEECCCCCCEEEE
ISGGNIDMVTITSLINSALVAKGRLFGFSLEVPHKPGQILKIAKVLADTNANIVKLEHDH
EECCCEEEEEHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECHH
FKARDALKNMVIEVTLETNGHSHIEEIKKALTDQNYVIKQIY
HHHHHHHCCEEEEEEEECCCCHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]