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The map label for this gene is mutL [H]

Identifier: 18310138

GI number: 18310138

Start: 1353763

End: 1355787

Strand: Direct

Name: mutL [H]

Synonym: CPE1156

Alternate gene names: 18310138

Gene position: 1353763-1355787 (Clockwise)

Preceding gene: 18310137

Following gene: 18310139

Centisome position: 44.66

GC content: 28.94

Gene sequence:

>2025_bases
TTGAATAGAATAAATATTTTAAATGCAGATACAGCAAATAAAATAGCTGCAGGAGAGGTTGTTGAAAGACCCTCTTCTGT
GGTTAAAGAACTTGTAGAAAATTCATTAGATGCAGGGGCTAAAAATATAACTATAGAGATTCAAAATGGTGGAGAATCTC
TTATAAAAATAATAGATGATGGCTCAGGGGTTCATCCAGAGGATGTTGAAAAAGCTTTTAATCCTCATGCTACAAGTAAA
ATAAAAGATACTTATGATATATTCAGCATAAACACTCTTGGATTTAGAGGAGAAGCTTTGCCTAGTATAGCTTCTATAGC
AAGGGTTGATTTTAAAAGTAAAACAGAAGACTTTGACATGGGTAAGGAGCTAATAATTAGTGGTGGAGAAAAAGAATCTT
TAACAGATTGTTCTATGAATAGAGGAACTCAAATAGAAGTTAGGGATTTATTCTTTAATGTACCTGCTAGAAAGAAGTTT
TTAAAGACAACGGCTAGAGAAAGTGCCTTAATAAATGACTTAGTAAACAGAATTTCACTAGCTAACCCAGATGTATCATT
TAAATTATTTAATAACAATAAAAAAATTTTAAATACTTATGGCAATGGAAAACTAATAGATGTTATAAGAACTATTTATG
GTAAATCCACTGCTGAAAATTTAATATATTTTGAAGAGCATAAGGATACAGCTTCTGTTTATGGATTTATAGGAAATGAT
ACCTTAGCAAGAGCCTCTAGAAATAATCAAAGTCTTTTTGTAAATAAAAGATATGTAAAAAATAGAAGCTTAACTGTAGC
TGTGGAAAATGCATTTAGGTCCTTTAATGTTACAGGTAAGTTTCCATTCTTCGTATTATTTATAGATACTTATCCAGAGC
TTATAGATGTTAACATACATCCAACAAAATCTGAAATTAAATTTAAAGATGAACGTTTTATATTCAAGGTTGTTTTTGAT
GCTGTTCATTCAGCTATGAGGGAATATGTAAAAGATACCTTTACTCTTCCAGAAGAAGAGGAGAAAAAATTTGAAGCTTT
AAAAGAAGAAGTTATTCAGGAAAGCTTAGATAAGGAAATAAGTACCTTAGAAAAGTTAAAAGAAAATATAAATTATAAGG
TAAGCGAGGATAAAAAAAAAGAAGAGATTTATTCTTATAATCCCTCTAAGGATTATGAAGCTAAAACAGAGGTTAATATT
CCAGTAGATTTCTTGTCTAAAGAAAATCAGGATGAATCTTTTAGTATTAATAACTCTTTAGAAAATAATGAGTTTAAAGA
GGTTTCAGCTAAAAGAGAGATTTCATATGATCCTATACTTATAAAAAATGAACTTAAAGATAAAGTAAGTGAAAGTACTT
CTGAATCACTTGAAAGAAGTGACTATAAATGTAATAAGAATGAATATGGAAATTCCATAGAGGAAATAATTTATAGAGAA
GCAAAATTCCCTAAGCTAAGAGTTATTGGTCAATTTAATAAAACCTATATATTAGCTGAGTATGATTCTACTTTATATTT
AATAGACCAACATGCAGCTCATGAGAAGATTTTATTTGAGAAGTATTCTTCAGATATAGCTAAAAAGAAGGTTGAAATTC
AGCCTCTAATGATTCCACTAGTAGTAACTTTGCCTACAGAGGATTATCTTTATTACGATGAAAATAAAGAGATTTTTGAA
AAGGCAGGATTTAAAATAAGTGATTTTGGTGATAATTCTATAAGAATTGAAGAAGTACCATACTTTTTAGATAAATTAAA
TCCAACAGAGCTAATAACATCTATGATAAATAACTTAAAGAAAATGGGTACTGGAGAAACTGTAGAGGTTAAATATAATA
AAATAGCATCTATGTCCTGTAGGGCGGCAGTTAAGGCTAATGATGTTTTAAGCATATTAGAAATGGAAAACTTAATAGAG
GATTTAAGATACATAAATGATCCTTTCCACTGTCCACATGGACGTCCAACTATAATTAAATTTACCAGTTATGAATTAGA
TAAGAAGTTTAAAAGAATAACTTAA

Upstream 100 bases:

>100_bases
TTTTATCTTTAAATCCTATGGAGGCTATGAATAGATTATATGCTCTAGTTAAAGAAGCTAAAAATTTAATTTAGCTTATG
GGAAGGAGCTGTTATAAATT

Downstream 100 bases:

>100_bases
GGAGAGATACAGTTTAAATGAATAATAATTTACTTATTATTGCTGGGCCAACAGCCGTAGGAAAAAGTGACCTTTCAGTA
GATCTAGCAAAGAAGCTAAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 674; Mature: 674

Protein sequence:

>674_residues
MNRINILNADTANKIAAGEVVERPSSVVKELVENSLDAGAKNITIEIQNGGESLIKIIDDGSGVHPEDVEKAFNPHATSK
IKDTYDIFSINTLGFRGEALPSIASIARVDFKSKTEDFDMGKELIISGGEKESLTDCSMNRGTQIEVRDLFFNVPARKKF
LKTTARESALINDLVNRISLANPDVSFKLFNNNKKILNTYGNGKLIDVIRTIYGKSTAENLIYFEEHKDTASVYGFIGND
TLARASRNNQSLFVNKRYVKNRSLTVAVENAFRSFNVTGKFPFFVLFIDTYPELIDVNIHPTKSEIKFKDERFIFKVVFD
AVHSAMREYVKDTFTLPEEEEKKFEALKEEVIQESLDKEISTLEKLKENINYKVSEDKKKEEIYSYNPSKDYEAKTEVNI
PVDFLSKENQDESFSINNSLENNEFKEVSAKREISYDPILIKNELKDKVSESTSESLERSDYKCNKNEYGNSIEEIIYRE
AKFPKLRVIGQFNKTYILAEYDSTLYLIDQHAAHEKILFEKYSSDIAKKKVEIQPLMIPLVVTLPTEDYLYYDENKEIFE
KAGFKISDFGDNSIRIEEVPYFLDKLNPTELITSMINNLKKMGTGETVEVKYNKIASMSCRAAVKANDVLSILEMENLIE
DLRYINDPFHCPHGRPTIIKFTSYELDKKFKRIT

Sequences:

>Translated_674_residues
MNRINILNADTANKIAAGEVVERPSSVVKELVENSLDAGAKNITIEIQNGGESLIKIIDDGSGVHPEDVEKAFNPHATSK
IKDTYDIFSINTLGFRGEALPSIASIARVDFKSKTEDFDMGKELIISGGEKESLTDCSMNRGTQIEVRDLFFNVPARKKF
LKTTARESALINDLVNRISLANPDVSFKLFNNNKKILNTYGNGKLIDVIRTIYGKSTAENLIYFEEHKDTASVYGFIGND
TLARASRNNQSLFVNKRYVKNRSLTVAVENAFRSFNVTGKFPFFVLFIDTYPELIDVNIHPTKSEIKFKDERFIFKVVFD
AVHSAMREYVKDTFTLPEEEEKKFEALKEEVIQESLDKEISTLEKLKENINYKVSEDKKKEEIYSYNPSKDYEAKTEVNI
PVDFLSKENQDESFSINNSLENNEFKEVSAKREISYDPILIKNELKDKVSESTSESLERSDYKCNKNEYGNSIEEIIYRE
AKFPKLRVIGQFNKTYILAEYDSTLYLIDQHAAHEKILFEKYSSDIAKKKVEIQPLMIPLVVTLPTEDYLYYDENKEIFE
KAGFKISDFGDNSIRIEEVPYFLDKLNPTELITSMINNLKKMGTGETVEVKYNKIASMSCRAAVKANDVLSILEMENLIE
DLRYINDPFHCPHGRPTIIKFTSYELDKKFKRIT
>Mature_674_residues
MNRINILNADTANKIAAGEVVERPSSVVKELVENSLDAGAKNITIEIQNGGESLIKIIDDGSGVHPEDVEKAFNPHATSK
IKDTYDIFSINTLGFRGEALPSIASIARVDFKSKTEDFDMGKELIISGGEKESLTDCSMNRGTQIEVRDLFFNVPARKKF
LKTTARESALINDLVNRISLANPDVSFKLFNNNKKILNTYGNGKLIDVIRTIYGKSTAENLIYFEEHKDTASVYGFIGND
TLARASRNNQSLFVNKRYVKNRSLTVAVENAFRSFNVTGKFPFFVLFIDTYPELIDVNIHPTKSEIKFKDERFIFKVVFD
AVHSAMREYVKDTFTLPEEEEKKFEALKEEVIQESLDKEISTLEKLKENINYKVSEDKKKEEIYSYNPSKDYEAKTEVNI
PVDFLSKENQDESFSINNSLENNEFKEVSAKREISYDPILIKNELKDKVSESTSESLERSDYKCNKNEYGNSIEEIIYRE
AKFPKLRVIGQFNKTYILAEYDSTLYLIDQHAAHEKILFEKYSSDIAKKKVEIQPLMIPLVVTLPTEDYLYYDENKEIFE
KAGFKISDFGDNSIRIEEVPYFLDKLNPTELITSMINNLKKMGTGETVEVKYNKIASMSCRAAVKANDVLSILEMENLIE
DLRYINDPFHCPHGRPTIIKFTSYELDKKFKRIT

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=328, Percent_Identity=35.0609756097561, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI310128478, Length=342, Percent_Identity=28.3625730994152, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=28.3625730994152, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4505911, Length=326, Percent_Identity=27.9141104294479, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI189458898, Length=326, Percent_Identity=27.9141104294479, Blast_Score=126, Evalue=9e-29,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=32.0512820512821, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI189458896, Length=316, Percent_Identity=27.5316455696203, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=25.7627118644068, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI91992162, Length=384, Percent_Identity=25.2604166666667, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992160, Length=384, Percent_Identity=25.2604166666667, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1790612, Length=662, Percent_Identity=27.0392749244713, Blast_Score=219, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=34.472049689441, Blast_Score=179, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=376, Percent_Identity=26.8617021276596, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323819, Length=576, Percent_Identity=28.4722222222222, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324247, Length=413, Percent_Identity=28.8135593220339, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323063, Length=371, Percent_Identity=25.6064690026954, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325093, Length=577, Percent_Identity=21.6637781629116, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17136968, Length=312, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17136970, Length=359, Percent_Identity=26.1838440111421, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 77206; Mature: 77206

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1 ; PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRINILNADTANKIAAGEVVERPSSVVKELVENSLDAGAKNITIEIQNGGESLIKIIDD
CCCEEEECCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GSGVHPEDVEKAFNPHATSKIKDTYDIFSINTLGFRGEALPSIASIARVDFKSKTEDFDM
CCCCCHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCC
GKELIISGGEKESLTDCSMNRGTQIEVRDLFFNVPARKKFLKTTARESALINDLVNRISL
CCCEEEECCCCCCCCCCCCCCCCEEEEEHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
ANPDVSFKLFNNNKKILNTYGNGKLIDVIRTIYGKSTAENLIYFEEHKDTASVYGFIGND
CCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEEECCC
TLARASRNNQSLFVNKRYVKNRSLTVAVENAFRSFNVTGKFPFFVLFIDTYPELIDVNIH
HHHHCCCCCCEEEEEEHHHCCCCEEEEEECHHHHCCCCCCCCEEEEEEECCCCEEEEEEC
PTKSEIKFKDERFIFKVVFDAVHSAMREYVKDTFTLPEEEEKKFEALKEEVIQESLDKEI
CCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
STLEKLKENINYKVSEDKKKEEIYSYNPSKDYEAKTEVNIPVDFLSKENQDESFSINNSL
HHHHHHHHCCCEEECCCCCHHHHHCCCCCCCCCCCEEECCCHHHHCCCCCCCCEEECCCC
ENNEFKEVSAKREISYDPILIKNELKDKVSESTSESLERSDYKCNKNEYGNSIEEIIYRE
CCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHH
AKFPKLRVIGQFNKTYILAEYDSTLYLIDQHAAHEKILFEKYSSDIAKKKVEIQPLMIPL
CCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEECEEEEEE
VVTLPTEDYLYYDENKEIFEKAGFKISDFGDNSIRIEEVPYFLDKLNPTELITSMINNLK
EEEECCCCCEEECCCHHHHHHCCCEEEECCCCCEEEEECCHHHHCCCHHHHHHHHHHHHH
KMGTGETVEVKYNKIASMSCRAAVKANDVLSILEMENLIEDLRYINDPFHCPHGRPTIIK
HCCCCCEEEEEECHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
FTSYELDKKFKRIT
EECCHHHHHHHCCC
>Mature Secondary Structure
MNRINILNADTANKIAAGEVVERPSSVVKELVENSLDAGAKNITIEIQNGGESLIKIIDD
CCCEEEECCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GSGVHPEDVEKAFNPHATSKIKDTYDIFSINTLGFRGEALPSIASIARVDFKSKTEDFDM
CCCCCHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCC
GKELIISGGEKESLTDCSMNRGTQIEVRDLFFNVPARKKFLKTTARESALINDLVNRISL
CCCEEEECCCCCCCCCCCCCCCCEEEEEHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
ANPDVSFKLFNNNKKILNTYGNGKLIDVIRTIYGKSTAENLIYFEEHKDTASVYGFIGND
CCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEEECCC
TLARASRNNQSLFVNKRYVKNRSLTVAVENAFRSFNVTGKFPFFVLFIDTYPELIDVNIH
HHHHCCCCCCEEEEEEHHHCCCCEEEEEECHHHHCCCCCCCCEEEEEEECCCCEEEEEEC
PTKSEIKFKDERFIFKVVFDAVHSAMREYVKDTFTLPEEEEKKFEALKEEVIQESLDKEI
CCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
STLEKLKENINYKVSEDKKKEEIYSYNPSKDYEAKTEVNIPVDFLSKENQDESFSINNSL
HHHHHHHHCCCEEECCCCCHHHHHCCCCCCCCCCCEEECCCHHHHCCCCCCCCEEECCCC
ENNEFKEVSAKREISYDPILIKNELKDKVSESTSESLERSDYKCNKNEYGNSIEEIIYRE
CCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHH
AKFPKLRVIGQFNKTYILAEYDSTLYLIDQHAAHEKILFEKYSSDIAKKKVEIQPLMIPL
CCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEECEEEEEE
VVTLPTEDYLYYDENKEIFEKAGFKISDFGDNSIRIEEVPYFLDKLNPTELITSMINNLK
EEEECCCCCEEECCCHHHHHHCCCEEEECCCCCEEEEECCHHHHCCCHHHHHHHHHHHHH
KMGTGETVEVKYNKIASMSCRAAVKANDVLSILEMENLIEDLRYINDPFHCPHGRPTIIK
HCCCCCEEEEEECHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
FTSYELDKKFKRIT
EECCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA