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The map label for this gene is fabF [H]

Identifier: 18310053

GI number: 18310053

Start: 1277132

End: 1278373

Strand: Direct

Name: fabF [H]

Synonym: CPE1071

Alternate gene names: 18310053

Gene position: 1277132-1278373 (Clockwise)

Preceding gene: 18310052

Following gene: 18310054

Centisome position: 42.13

GC content: 33.01

Gene sequence:

>1242_bases
ATGGAAAACAGAGTTGTTATAACGGGATTGGGAGCAATTACACCAATTGGAAACAATGTAAATGAATTTTGGACCAATGC
TAAAAAAGGTGTTTGTGGAATTGATGAAATAACTTTATTTGATGCTAGTGATTATAAAGTTAAAATTGCAGGAGAAGTTA
AAAACTTTAAAGCAGAGGATTTTATAGATAAAAAGGAAGCTAAGCGTTTAGATAGATTTACTCATTTTGCTCTTGCAGCT
ACAGAAGAGGCAATGAAGGATGCTAAATTAGACTTAAAGGATGAAAATGTAGATCAAAATAGAGTAGGTGTTATAGTTGG
TTCAGGAATAGGTGGATATGGTACCTTAGAAGCACAATTTGATGTTTTATTAACTAAAGGACCAAATAGAGTTTCACCTT
TTGCAATTCCATCAGGAATAATAAACTTAGTTGCTGGAAATATTGCTATTAAGTATGGGGCAAAAGGAGTATGTGAATCA
CTAGTTACTGCCTGCGCTACAGGGGTAAGCTCTATAGGGGCAGCTTATAGAAGTATAAAACATGGATATTCAGATATAGT
TATATCAGGTGGATCAGAAGCTTCTATAACTAGAGCTGCCATTGCAGGATTTACTAATCTTAAGGCATTAAATACTAATA
ATGATCCTAAAAGAGCTTCAATACCTTTCGATAAAGAAAGATCTGGATTCGTTATGGGAGAAGGCGCTGGAATATTAATA
TTAGAAAGTTTAGAGAGTGCTCAAAAAAGAGGTGCTAGAATCTATGGAGAAATTATAGGATATGGTGCAACTTGTGATGC
ATATCATATAACTTCACCTGATCCAGAAGGTGATGGAGCTAAGAGAGCTATAGAAGCAGCTATAGAAGAAGGAAAAATAA
ATAAGGATGAAATTTCATATATAAATGCACATGGAACAAGTACTCCTTTAAACGATAAATTTGAAACTTTAGCTATTAAA
GGATGTTTTGGTGAAAAAGCTTATGATATACCAGTTTCATCAACAAAATCAATGACTGGTCATTTATTAGGTGCAGCTGG
AGCTATAGAATCAGTAATATGTGTTAAAGCTTTAGAAGAAGGATTTATTCCACCAACAATAGGATATAAAGTTCCTGATG
AAGATTGTGATTTAGATTATGTTGTAAATGAAGGTAGAGAATTAGAATTAAATTATGTAATCAATAACGCATTAGGTTTT
GGTGGTCATAACGCATCATTATTATTTAAAAAGTGGGATTAG

Upstream 100 bases:

>100_bases
CTAACTTAGTAGGATTCTTAGCATCAGATGCAGCAAATTATATAACAGGTCAAGTCATAAATGTAGATGGCGGAATGGTA
ATGTAGGAGGAGTAATTATT

Downstream 100 bases:

>100_bases
GAGTTGAAATTATGAATCTTAATGAGATTAAAGAGCTTATAGATAAAATCGATTCTTCTAATATTGCTTATTTTGAGGTT
AAAGTAGATAATTCATATAT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MENRVVITGLGAITPIGNNVNEFWTNAKKGVCGIDEITLFDASDYKVKIAGEVKNFKAEDFIDKKEAKRLDRFTHFALAA
TEEAMKDAKLDLKDENVDQNRVGVIVGSGIGGYGTLEAQFDVLLTKGPNRVSPFAIPSGIINLVAGNIAIKYGAKGVCES
LVTACATGVSSIGAAYRSIKHGYSDIVISGGSEASITRAAIAGFTNLKALNTNNDPKRASIPFDKERSGFVMGEGAGILI
LESLESAQKRGARIYGEIIGYGATCDAYHITSPDPEGDGAKRAIEAAIEEGKINKDEISYINAHGTSTPLNDKFETLAIK
GCFGEKAYDIPVSSTKSMTGHLLGAAGAIESVICVKALEEGFIPPTIGYKVPDEDCDLDYVVNEGRELELNYVINNALGF
GGHNASLLFKKWD

Sequences:

>Translated_413_residues
MENRVVITGLGAITPIGNNVNEFWTNAKKGVCGIDEITLFDASDYKVKIAGEVKNFKAEDFIDKKEAKRLDRFTHFALAA
TEEAMKDAKLDLKDENVDQNRVGVIVGSGIGGYGTLEAQFDVLLTKGPNRVSPFAIPSGIINLVAGNIAIKYGAKGVCES
LVTACATGVSSIGAAYRSIKHGYSDIVISGGSEASITRAAIAGFTNLKALNTNNDPKRASIPFDKERSGFVMGEGAGILI
LESLESAQKRGARIYGEIIGYGATCDAYHITSPDPEGDGAKRAIEAAIEEGKINKDEISYINAHGTSTPLNDKFETLAIK
GCFGEKAYDIPVSSTKSMTGHLLGAAGAIESVICVKALEEGFIPPTIGYKVPDEDCDLDYVVNEGRELELNYVINNALGF
GGHNASLLFKKWD
>Mature_413_residues
MENRVVITGLGAITPIGNNVNEFWTNAKKGVCGIDEITLFDASDYKVKIAGEVKNFKAEDFIDKKEAKRLDRFTHFALAA
TEEAMKDAKLDLKDENVDQNRVGVIVGSGIGGYGTLEAQFDVLLTKGPNRVSPFAIPSGIINLVAGNIAIKYGAKGVCES
LVTACATGVSSIGAAYRSIKHGYSDIVISGGSEASITRAAIAGFTNLKALNTNNDPKRASIPFDKERSGFVMGEGAGILI
LESLESAQKRGARIYGEIIGYGATCDAYHITSPDPEGDGAKRAIEAAIEEGKINKDEISYINAHGTSTPLNDKFETLAIK
GCFGEKAYDIPVSSTKSMTGHLLGAAGAIESVICVKALEEGFIPPTIGYKVPDEDCDLDYVVNEGRELELNYVINNALGF
GGHNASLLFKKWD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=41.1057692307692, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI223972627, Length=169, Percent_Identity=44.3786982248521, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI41872631, Length=423, Percent_Identity=24.5862884160757, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=48.3009708737864, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=37.2881355932203, Blast_Score=229, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=37.410071942446, Blast_Score=264, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=39.9239543726236, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI212642053, Length=428, Percent_Identity=25.4672897196262, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=276, Percent_Identity=28.6231884057971, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=455, Percent_Identity=37.1428571428571, Blast_Score=283, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=39.3364928909953, Blast_Score=289, Evalue=3e-78,
Organism=Drosophila melanogaster, GI19920632, Length=430, Percent_Identity=25.3488372093023, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI221330659, Length=430, Percent_Identity=25.3488372093023, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24581345, Length=424, Percent_Identity=24.0566037735849, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44003; Mature: 44003

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENRVVITGLGAITPIGNNVNEFWTNAKKGVCGIDEITLFDASDYKVKIAGEVKNFKAED
CCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHHH
FIDKKEAKRLDRFTHFALAATEEAMKDAKLDLKDENVDQNRVGVIVGSGIGGYGTLEAQF
HHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEE
DVLLTKGPNRVSPFAIPSGIINLVAGNIAIKYGAKGVCESLVTACATGVSSIGAAYRSIK
EEEEECCCCCCCCCCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
HGYSDIVISGGSEASITRAAIAGFTNLKALNTNNDPKRASIPFDKERSGFVMGEGAGILI
CCCCEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LESLESAQKRGARIYGEIIGYGATCDAYHITSPDPEGDGAKRAIEAAIEEGKINKDEISY
EHHHHHHHHCCCEEEEHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHEEE
INAHGTSTPLNDKFETLAIKGCFGEKAYDIPVSSTKSMTGHLLGAAGAIESVICVKALEE
EECCCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GFIPPTIGYKVPDEDCDLDYVVNEGRELELNYVINNALGFGGHNASLLFKKWD
CCCCCCCCCCCCCCCCCCHHEECCCCEEEEEEEEECCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MENRVVITGLGAITPIGNNVNEFWTNAKKGVCGIDEITLFDASDYKVKIAGEVKNFKAED
CCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHHH
FIDKKEAKRLDRFTHFALAATEEAMKDAKLDLKDENVDQNRVGVIVGSGIGGYGTLEAQF
HHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEE
DVLLTKGPNRVSPFAIPSGIINLVAGNIAIKYGAKGVCESLVTACATGVSSIGAAYRSIK
EEEEECCCCCCCCCCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
HGYSDIVISGGSEASITRAAIAGFTNLKALNTNNDPKRASIPFDKERSGFVMGEGAGILI
CCCCEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LESLESAQKRGARIYGEIIGYGATCDAYHITSPDPEGDGAKRAIEAAIEEGKINKDEISY
EHHHHHHHHCCCEEEEHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHEEE
INAHGTSTPLNDKFETLAIKGCFGEKAYDIPVSSTKSMTGHLLGAAGAIESVICVKALEE
EECCCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GFIPPTIGYKVPDEDCDLDYVVNEGRELELNYVINNALGFGGHNASLLFKKWD
CCCCCCCCCCCCCCCCCCHHEECCCCEEEEEEEEECCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]