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The map label for this gene is licA [H]

Identifier: 18310015

GI number: 18310015

Start: 1235303

End: 1236103

Strand: Reverse

Name: licA [H]

Synonym: CPE1033

Alternate gene names: 18310015

Gene position: 1236103-1235303 (Counterclockwise)

Preceding gene: 18310033

Following gene: 18310011

Centisome position: 40.78

GC content: 23.1

Gene sequence:

>801_bases
ATGACTAACAAAATGAAAAATCATAAGATAACCAAACTAGGCGGTCTTAATAACTCAAATTATTTATTAGAGTGTGAAAA
TAATAAATATGTTTTAAGAATACCTAGTAAAGATAATAAAAATAATTTTTCAGAGGAAAATTTTGTTTTAATATTTGCTA
ATTTGAACAAGCTATCCCCCCCTATTATATATCATAATAAGGATAATGGAATACTAATAAGCAAATTTTTAGAAGATTCA
AAGGTAAATATGAGTACATTTACATCTTTAGAATTCCTTGAAAAACTCTCAATTAATTTAAAAAAACTACATATTCTTAA
GTGTGAACATATTTTTAACCCTTTTGAACATATAAGAAAAAATTTTCATATTTTAAAATCTAAAAACTTTAATTTTCATG
AAGGCATTGATTTAGTCTTAAATAAATTAAATATTCTTGAAGAAAAATTAAGCAAAAATATGACTCTTGGCCTTTGTCAT
AATGATTTAAATTCTTCAAATGTACTATATCATAATAAAAATGTTCTTTTTATTGACTTTGAATTTTCTGCTATGTGTGA
TATATTTTTTGATTTAGCTACTGTATCTTGGATGCTAGATGAAAAAAAGAGATATTTTTTAATAAAAAGTTATTTTGGCT
ACTACTCTTATGAATTAATGGAAAAATTAGAAAATTACCTTTTTGTAGTTAAGCTTTGGAATGCTTCTTGGAGCTTCTTG
AAGTCTTTAAATACTAATTCTACATATGATTATAAATTAGGTGGAAATATGATCATAGATGATTTATTATCCACTCTATA
A

Upstream 100 bases:

>100_bases
TAAACCTTCTATTCCTTTTAACACCTCATTTAACATTATCCTTTTCCATCCCTTCTTATTTTTTGATATAATATTTTCAT
TAGAATATAAGGAGATTAAG

Downstream 100 bases:

>100_bases
AAGGGCTGTATCAAAATATAACAATAAAACTTACAAACATATTCCAAGAATCACTAAATATTCTCTTCATACTGTTTGTA
AGTTTTATAAAAAGTTATTT

Product: choline/ethanolamine kinase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MTNKMKNHKITKLGGLNNSNYLLECENNKYVLRIPSKDNKNNFSEENFVLIFANLNKLSPPIIYHNKDNGILISKFLEDS
KVNMSTFTSLEFLEKLSINLKKLHILKCEHIFNPFEHIRKNFHILKSKNFNFHEGIDLVLNKLNILEEKLSKNMTLGLCH
NDLNSSNVLYHNKNVLFIDFEFSAMCDIFFDLATVSWMLDEKKRYFLIKSYFGYYSYELMEKLENYLFVVKLWNASWSFL
KSLNTNSTYDYKLGGNMIIDDLLSTL

Sequences:

>Translated_266_residues
MTNKMKNHKITKLGGLNNSNYLLECENNKYVLRIPSKDNKNNFSEENFVLIFANLNKLSPPIIYHNKDNGILISKFLEDS
KVNMSTFTSLEFLEKLSINLKKLHILKCEHIFNPFEHIRKNFHILKSKNFNFHEGIDLVLNKLNILEEKLSKNMTLGLCH
NDLNSSNVLYHNKNVLFIDFEFSAMCDIFFDLATVSWMLDEKKRYFLIKSYFGYYSYELMEKLENYLFVVKLWNASWSFL
KSLNTNSTYDYKLGGNMIIDDLLSTL
>Mature_265_residues
TNKMKNHKITKLGGLNNSNYLLECENNKYVLRIPSKDNKNNFSEENFVLIFANLNKLSPPIIYHNKDNGILISKFLEDSK
VNMSTFTSLEFLEKLSINLKKLHILKCEHIFNPFEHIRKNFHILKSKNFNFHEGIDLVLNKLNILEEKLSKNMTLGLCHN
DLNSSNVLYHNKNVLFIDFEFSAMCDIFFDLATVSWMLDEKKRYFLIKSYFGYYSYELMEKLENYLFVVKLWNASWSFLK
SLNTNSTYDYKLGGNMIIDDLLSTL

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 31340; Mature: 31208

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKMKNHKITKLGGLNNSNYLLECENNKYVLRIPSKDNKNNFSEENFVLIFANLNKLSP
CCCCCCCCEEEEECCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCC
PIIYHNKDNGILISKFLEDSKVNMSTFTSLEFLEKLSINLKKLHILKCEHIFNPFEHIRK
CEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEHHHHCCHHHHHHC
NFHILKSKNFNFHEGIDLVLNKLNILEEKLSKNMTLGLCHNDLNSSNVLYHNKNVLFIDF
CEEEEECCCCCHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCEEEEEE
EFSAMCDIFFDLATVSWMLDEKKRYFLIKSYFGYYSYELMEKLENYLFVVKLWNASWSFL
CHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCEEEEEEEECCCHHHH
KSLNTNSTYDYKLGGNMIIDDLLSTL
HHCCCCCEEEEEECCCHHHHHHHHHC
>Mature Secondary Structure 
TNKMKNHKITKLGGLNNSNYLLECENNKYVLRIPSKDNKNNFSEENFVLIFANLNKLSP
CCCCCCCEEEEECCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCC
PIIYHNKDNGILISKFLEDSKVNMSTFTSLEFLEKLSINLKKLHILKCEHIFNPFEHIRK
CEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEHHHHCCHHHHHHC
NFHILKSKNFNFHEGIDLVLNKLNILEEKLSKNMTLGLCHNDLNSSNVLYHNKNVLFIDF
CEEEEECCCCCHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCEEEEEE
EFSAMCDIFFDLATVSWMLDEKKRYFLIKSYFGYYSYELMEKLENYLFVVKLWNASWSFL
CHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCEEEEEEEECCCHHHH
KSLNTNSTYDYKLGGNMIIDDLLSTL
HHCCCCCEEEEEECCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]