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The map label for this gene is folE [H]

Identifier: 18310001

GI number: 18310001

Start: 1222555

End: 1223112

Strand: Direct

Name: folE [H]

Synonym: CPE1019

Alternate gene names: 18310001

Gene position: 1222555-1223112 (Clockwise)

Preceding gene: 18310000

Following gene: 18310002

Centisome position: 40.33

GC content: 32.26

Gene sequence:

>558_bases
ATGATCGATAAAGAGAAGATAAAAGAAGGAATGAAACTAATACTTGAAGCAATAGGAGAAGATGTTAATAGAGAGGGCTT
AATAGAAACTCCAGATAGAATTGCAAGAATGTATGAAGAAATATTTTCAGGCATAGGAATGAATGCAAAGGAGCATTTAA
GTAAAACTTTTGAAGTTCATAGCAATGATCTTGTTTTAGAGAAGGATATAACTTTCTATTCTATGTGTGAGCATCATTTA
GTTCCTTTCTATGGGAAAGTTCATATAGCATATATACCAAATGGAAGGGTTGTAGGTTTATCTAAACTTGCTAGATGTGT
TGAGGTTTATTCAAAAAAACCACAACTTCAAGAAAGGCTTACAAAGGAAATAGCTGATTCTATAATGGAATACTTAGATG
CACAAGGTGTAATGGTAGTTGTAGAAGGTGAACATATGTGTATGACCATGAGAGGTGTTAGAAAACCAGGTGCAAAAACA
GTAACAACAACTTATAGAGGAAAGTTCTTAGAAGATGAAAGCTTAAAAAATGATGTTTTTAGAATGATTTCTATGTAG

Upstream 100 bases:

>100_bases
GTCAATTTGAAGAAGAATTTTTTGGGGAAAAAGATTTAATAGAAGAAATAAAAAGTAAATATGAAAGTTCTATTATACGC
TTTTAAATATGGAGGGCAAA

Downstream 100 bases:

>100_bases
ATATTATTCTTTGAGGTGTTTATTATGGAGAGAATAAATAAGATACTTAATAATAGTAAGTATAAAGATTATTTAAATAG
GAATTCTTTTTGTGAAAAGG

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MIDKEKIKEGMKLILEAIGEDVNREGLIETPDRIARMYEEIFSGIGMNAKEHLSKTFEVHSNDLVLEKDITFYSMCEHHL
VPFYGKVHIAYIPNGRVVGLSKLARCVEVYSKKPQLQERLTKEIADSIMEYLDAQGVMVVVEGEHMCMTMRGVRKPGAKT
VTTTYRGKFLEDESLKNDVFRMISM

Sequences:

>Translated_185_residues
MIDKEKIKEGMKLILEAIGEDVNREGLIETPDRIARMYEEIFSGIGMNAKEHLSKTFEVHSNDLVLEKDITFYSMCEHHL
VPFYGKVHIAYIPNGRVVGLSKLARCVEVYSKKPQLQERLTKEIADSIMEYLDAQGVMVVVEGEHMCMTMRGVRKPGAKT
VTTTYRGKFLEDESLKNDVFRMISM
>Mature_185_residues
MIDKEKIKEGMKLILEAIGEDVNREGLIETPDRIARMYEEIFSGIGMNAKEHLSKTFEVHSNDLVLEKDITFYSMCEHHL
VPFYGKVHIAYIPNGRVVGLSKLARCVEVYSKKPQLQERLTKEIADSIMEYLDAQGVMVVVEGEHMCMTMRGVRKPGAKT
VTTTYRGKFLEDESLKNDVFRMISM

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=177, Percent_Identity=49.1525423728814, Blast_Score=166, Evalue=1e-41,
Organism=Homo sapiens, GI4503949, Length=177, Percent_Identity=49.1525423728814, Blast_Score=166, Evalue=1e-41,
Organism=Homo sapiens, GI66932972, Length=137, Percent_Identity=49.6350364963504, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI66932970, Length=137, Percent_Identity=49.6350364963504, Blast_Score=128, Evalue=2e-30,
Organism=Escherichia coli, GI1788476, Length=182, Percent_Identity=35.7142857142857, Blast_Score=114, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17560486, Length=172, Percent_Identity=45.9302325581395, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6321706, Length=167, Percent_Identity=49.1017964071856, Blast_Score=167, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24656782, Length=174, Percent_Identity=45.4022988505747, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24656791, Length=174, Percent_Identity=45.4022988505747, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24656796, Length=174, Percent_Identity=45.4022988505747, Blast_Score=148, Evalue=2e-36,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 21180; Mature: 21180

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
6.5 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKEKIKEGMKLILEAIGEDVNREGLIETPDRIARMYEEIFSGIGMNAKEHLSKTFEVH
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
SNDLVLEKDITFYSMCEHHLVPFYGKVHIAYIPNGRVVGLSKLARCVEVYSKKPQLQERL
CCCEEEECCCHHHHHHHHCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHCCCCHHHHHH
TKEIADSIMEYLDAQGVMVVVEGEHMCMTMRGVRKPGAKTVTTTYRGKFLEDESLKNDVF
HHHHHHHHHHHHCCCCEEEEEECCCEEHHHHHCCCCCCCEEEEHHCCCCCCCHHHHHHHH
RMISM
HHHCC
>Mature Secondary Structure
MIDKEKIKEGMKLILEAIGEDVNREGLIETPDRIARMYEEIFSGIGMNAKEHLSKTFEVH
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
SNDLVLEKDITFYSMCEHHLVPFYGKVHIAYIPNGRVVGLSKLARCVEVYSKKPQLQERL
CCCEEEECCCHHHHHHHHCCCCCCCCEEEEECCCCCEECHHHHHHHHHHHCCCCHHHHHH
TKEIADSIMEYLDAQGVMVVVEGEHMCMTMRGVRKPGAKTVTTTYRGKFLEDESLKNDVF
HHHHHHHHHHHHCCCCEEEEEECCCEEHHHHHCCCCCCCEEEEHHCCCCCCCHHHHHHHH
RMISM
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA