Click here to switch to the map view.

The map label for this gene is (tetP [H]

Identifier: 18309957

GI number: 18309957

Start: 1174529

End: 1176469

Strand: Direct

Name: (tetP [H]

Synonym: CPE0975

Alternate gene names: 18309957

Gene position: 1174529-1176469 (Clockwise)

Preceding gene: 18309954

Following gene: 18309958

Centisome position: 38.75

GC content: 30.6

Gene sequence:

>1941_bases
ATGAAAAAGACTATTGGTATATTAGCTCATGTTGATGGAGGAAAAACCACTTTTTCTGAGCAACTTTTATATCATACAAA
GAGTATAAGAAATAGGGGAAGAGTTGATCATAAGAATTCTTATTTAGATAATAATGAAATAGAGAAAGATAGAGGCATAA
CTATATATTCTGAGGTAGGTAAATTTTCTATAGAAAATCAAGAATATTATCTTATAGATACTCCAGGGCATATAGATTTT
TCACCAGAAATGGAAAGAGCTATTAGTGTTTTAGATTATGCTATTTTGATTATAAGTGCAGTAGAAGGGGTTCAGGGACA
TAGTGAAACAATATGGGAATTATTAAATAAGTATAAGGTTCCTACTTTTATTTTCATAAATAAGATTGATAGAGAAGGAG
CAGAAGTAAATAAGGTTATAAATGAAATGAAAGACAAACTTAGTGAAGATATTATTTTCTTTTCAAGTGAATTAGAAGAT
GAGACTATAGAAGAAGTAGTTGAAAGAGATGAGGACTTATTAAACTTATATTTAGAAGGGAATTTAAGTGAAGAAGAATT
ATTAAATAAAATACAGAGCATGATAAAGGAACTTAAAATTTTTCCTTGTTTATGTGGTTCTGCTTTACTAGATGAGGGCG
TAGAAGATTTTATAAGGTGGTTTCATAACTTATCATTTACTAACTATGAGGAATCGAAAGATTCTTTTAGAGGAAGAGTT
TTTAAAGTAAGACATGATGAAAAGGGAAATAGATTAACCTTTATAAAAGCTCTAAGTGGAACTTTAAGAACTAAGGAAGA
ATTGACATACTTAAAAGAAGGAAAAGAGTCTTTAGAGAAAGTAAATGAAATTAGAATATATAATGGAAGTAAATATGAAC
TTGTAAATGAAGTCAGGTCAGGAGATATATTTGCAGTGGTAGGAGTTAAAGGACTAGAATCTGGTGATGGGATTGGTATA
GAAAATATTGATTCATATGATATGGTTCCCACTTTGAAGTCTAAGGTGGTTTATAGAGAAGGGTTAAATCCAAAGGAAGT
ACTTTCATGGTTTAAAATCTTAGAAAGTGAAGAGAGTACTTTAAGTGTATCTTGGGATGAAAGGTTAAAAGAAATTCACG
TTAATATTATGGGAAAAGTTCAATTGGAAGTTCTTAAAGAAGTTATGAAAAATAGATTTAATGAAGAAATAGAATTTGGA
ACTCCAGAGATATTATATAAGGAAACATTAAATGAAGAAGTAATAGGATATGGCCATTTTGAGCCCTTAGGACATTATAG
TGAGGTTCACTTAAAAATTGAGCCTTTGGAAAGAAATTCAGGAATAGTATTTGAAAATAAGTGCCATGCAGATGATCTTA
CAGTTGGAAATCAAAATTTAATAAGGACTCATATATTTGAATGTGAGCATAAGGGAATATTAACAGGTTCGCCTATTACG
GATCTTAAAATAACCTTATTAACAGGAAGAGCTCATAATAAACATACAAGTGGTGGAGATTTTAGAGAAGCTACAAAGAG
AGCTTTAAGACAGGGATTAGAAAGTGGAGAAAATAAACTTTTGGAGCCCTATTATAAGTTTAAAATAGATGTGGATCTTA
ACCTAATAGGAAGAGTAATGAATGATATACAAAAGATGCATGGGGAGTTTAAGGATCCAATTATAGATGGAGAGAGAGCA
ACCATAGAAGGAAAGGGACCTGTTTCTACATTTATAAATTATGGTATGGAGTTTCAGTCATTTACTAAGGGAAAGGGAGG
ACTTTCTCTTAAGTTTCATGGGTATGATTTATGTCACAATGAAGAGGATATTATTGAAAAGGTGGCATATGATAGAAATG
CAGACATTGATTATACTTCTACTTCTATATTTTGTTCAAAGGGTCAAGCTTATTTAGTTAAAGGAGGAGAGGCAAAAGAA
CATATGCATTGTTTAGTTTAG

Upstream 100 bases:

>100_bases
ATATTATTTGTTATACCATATAAAACAAAAATAGTAAAGAATATAAAATAAAAAACATATATAATTTTTAATGTTTAGAT
TTTTTTAATGGAGGACAAAG

Downstream 100 bases:

>100_bases
ATAAATTTTTGTTTTTTATATCCCTTTGTATAACCTTTAAAGAAATATATGAAATTAAAATTTAGCTAAATTATATTCAT
TAGACAAAAATATGTAGCTT

Product: tetracycline resistant protein

Products: NA

Alternate protein names: TetB(P) [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MKKTIGILAHVDGGKTTFSEQLLYHTKSIRNRGRVDHKNSYLDNNEIEKDRGITIYSEVGKFSIENQEYYLIDTPGHIDF
SPEMERAISVLDYAILIISAVEGVQGHSETIWELLNKYKVPTFIFINKIDREGAEVNKVINEMKDKLSEDIIFFSSELED
ETIEEVVERDEDLLNLYLEGNLSEEELLNKIQSMIKELKIFPCLCGSALLDEGVEDFIRWFHNLSFTNYEESKDSFRGRV
FKVRHDEKGNRLTFIKALSGTLRTKEELTYLKEGKESLEKVNEIRIYNGSKYELVNEVRSGDIFAVVGVKGLESGDGIGI
ENIDSYDMVPTLKSKVVYREGLNPKEVLSWFKILESEESTLSVSWDERLKEIHVNIMGKVQLEVLKEVMKNRFNEEIEFG
TPEILYKETLNEEVIGYGHFEPLGHYSEVHLKIEPLERNSGIVFENKCHADDLTVGNQNLIRTHIFECEHKGILTGSPIT
DLKITLLTGRAHNKHTSGGDFREATKRALRQGLESGENKLLEPYYKFKIDVDLNLIGRVMNDIQKMHGEFKDPIIDGERA
TIEGKGPVSTFINYGMEFQSFTKGKGGLSLKFHGYDLCHNEEDIIEKVAYDRNADIDYTSTSIFCSKGQAYLVKGGEAKE
HMHCLV

Sequences:

>Translated_646_residues
MKKTIGILAHVDGGKTTFSEQLLYHTKSIRNRGRVDHKNSYLDNNEIEKDRGITIYSEVGKFSIENQEYYLIDTPGHIDF
SPEMERAISVLDYAILIISAVEGVQGHSETIWELLNKYKVPTFIFINKIDREGAEVNKVINEMKDKLSEDIIFFSSELED
ETIEEVVERDEDLLNLYLEGNLSEEELLNKIQSMIKELKIFPCLCGSALLDEGVEDFIRWFHNLSFTNYEESKDSFRGRV
FKVRHDEKGNRLTFIKALSGTLRTKEELTYLKEGKESLEKVNEIRIYNGSKYELVNEVRSGDIFAVVGVKGLESGDGIGI
ENIDSYDMVPTLKSKVVYREGLNPKEVLSWFKILESEESTLSVSWDERLKEIHVNIMGKVQLEVLKEVMKNRFNEEIEFG
TPEILYKETLNEEVIGYGHFEPLGHYSEVHLKIEPLERNSGIVFENKCHADDLTVGNQNLIRTHIFECEHKGILTGSPIT
DLKITLLTGRAHNKHTSGGDFREATKRALRQGLESGENKLLEPYYKFKIDVDLNLIGRVMNDIQKMHGEFKDPIIDGERA
TIEGKGPVSTFINYGMEFQSFTKGKGGLSLKFHGYDLCHNEEDIIEKVAYDRNADIDYTSTSIFCSKGQAYLVKGGEAKE
HMHCLV
>Mature_646_residues
MKKTIGILAHVDGGKTTFSEQLLYHTKSIRNRGRVDHKNSYLDNNEIEKDRGITIYSEVGKFSIENQEYYLIDTPGHIDF
SPEMERAISVLDYAILIISAVEGVQGHSETIWELLNKYKVPTFIFINKIDREGAEVNKVINEMKDKLSEDIIFFSSELED
ETIEEVVERDEDLLNLYLEGNLSEEELLNKIQSMIKELKIFPCLCGSALLDEGVEDFIRWFHNLSFTNYEESKDSFRGRV
FKVRHDEKGNRLTFIKALSGTLRTKEELTYLKEGKESLEKVNEIRIYNGSKYELVNEVRSGDIFAVVGVKGLESGDGIGI
ENIDSYDMVPTLKSKVVYREGLNPKEVLSWFKILESEESTLSVSWDERLKEIHVNIMGKVQLEVLKEVMKNRFNEEIEFG
TPEILYKETLNEEVIGYGHFEPLGHYSEVHLKIEPLERNSGIVFENKCHADDLTVGNQNLIRTHIFECEHKGILTGSPIT
DLKITLLTGRAHNKHTSGGDFREATKRALRQGLESGENKLLEPYYKFKIDVDLNLIGRVMNDIQKMHGEFKDPIIDGERA
TIEGKGPVSTFINYGMEFQSFTKGKGGLSLKFHGYDLCHNEEDIIEKVAYDRNADIDYTSTSIFCSKGQAYLVKGGEAKE
HMHCLV

Specific function: Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes [H]

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TetM/tetO subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=699, Percent_Identity=25.6080114449213, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI19923640, Length=706, Percent_Identity=23.5127478753541, Blast_Score=189, Evalue=8e-48,
Organism=Homo sapiens, GI25306287, Length=699, Percent_Identity=22.3175965665236, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI25306283, Length=379, Percent_Identity=27.1767810026385, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI157426893, Length=177, Percent_Identity=31.0734463276836, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=37.593984962406, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI310132016, Length=106, Percent_Identity=39.622641509434, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI310110807, Length=106, Percent_Identity=39.622641509434, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI310123363, Length=106, Percent_Identity=39.622641509434, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1789738, Length=686, Percent_Identity=27.6967930029155, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI1790835, Length=457, Percent_Identity=23.6323851203501, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI48994988, Length=433, Percent_Identity=22.4018475750577, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788922, Length=153, Percent_Identity=28.7581699346405, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789737, Length=127, Percent_Identity=31.496062992126, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790412, Length=127, Percent_Identity=31.496062992126, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17533571, Length=688, Percent_Identity=25.1453488372093, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17556745, Length=145, Percent_Identity=40.6896551724138, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17557151, Length=173, Percent_Identity=30.0578034682081, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71988811, Length=149, Percent_Identity=33.5570469798658, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71988819, Length=149, Percent_Identity=33.5570469798658, Blast_Score=84, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323098, Length=678, Percent_Identity=26.9911504424779, Blast_Score=210, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6322359, Length=519, Percent_Identity=26.2042389210019, Blast_Score=150, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6323320, Length=180, Percent_Identity=31.6666666666667, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324707, Length=145, Percent_Identity=30.3448275862069, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320593, Length=145, Percent_Identity=30.3448275862069, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24582462, Length=694, Percent_Identity=27.0893371757925, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI221458488, Length=710, Percent_Identity=24.2253521126761, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI78706572, Length=197, Percent_Identity=31.4720812182741, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI28574573, Length=138, Percent_Identity=35.5072463768116, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24585711, Length=149, Percent_Identity=28.8590604026846, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24585713, Length=149, Percent_Identity=28.8590604026846, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24585709, Length=149, Percent_Identity=28.8590604026846, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR002127
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 73869; Mature: 73869

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTIGILAHVDGGKTTFSEQLLYHTKSIRNRGRVDHKNSYLDNNEIEKDRGITIYSEVG
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCC
KFSIENQEYYLIDTPGHIDFSPEMERAISVLDYAILIISAVEGVQGHSETIWELLNKYKV
CEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
PTFIFINKIDREGAEVNKVINEMKDKLSEDIIFFSSELEDETIEEVVERDEDLLNLYLEG
CEEEEEECCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHCCHHEEEEEEEC
NLSEEELLNKIQSMIKELKIFPCLCGSALLDEGVEDFIRWFHNLSFTNYEESKDSFRGRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEE
FKVRHDEKGNRLTFIKALSGTLRTKEELTYLKEGKESLEKVNEIRIYNGSKYELVNEVRS
EEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHCC
GDIFAVVGVKGLESGDGIGIENIDSYDMVPTLKSKVVYREGLNPKEVLSWFKILESEEST
CCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCE
LSVSWDERLKEIHVNIMGKVQLEVLKEVMKNRFNEEIEFGTPEILYKETLNEEVIGYGHF
EEECHHHHHHHHHHHHEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCC
EPLGHYSEVHLKIEPLERNSGIVFENKCHADDLTVGNQNLIRTHIFECEHKGILTGSPIT
CCCCCCEEEEEEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
DLKITLLTGRAHNKHTSGGDFREATKRALRQGLESGENKLLEPYYKFKIDVDLNLIGRVM
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECHHHHHHHH
NDIQKMHGEFKDPIIDGERATIEGKGPVSTFINYGMEFQSFTKGKGGLSLKFHGYDLCHN
HHHHHHHCHHCCCCCCCCCEEECCCCCHHHHHHCCCCHHHHCCCCCCEEEEECCCCCCCC
EEDIIEKVAYDRNADIDYTSTSIFCSKGQAYLVKGGEAKEHMHCLV
HHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEECCCHHHHHHCCC
>Mature Secondary Structure
MKKTIGILAHVDGGKTTFSEQLLYHTKSIRNRGRVDHKNSYLDNNEIEKDRGITIYSEVG
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCC
KFSIENQEYYLIDTPGHIDFSPEMERAISVLDYAILIISAVEGVQGHSETIWELLNKYKV
CEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
PTFIFINKIDREGAEVNKVINEMKDKLSEDIIFFSSELEDETIEEVVERDEDLLNLYLEG
CEEEEEECCCCCCHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHCCHHEEEEEEEC
NLSEEELLNKIQSMIKELKIFPCLCGSALLDEGVEDFIRWFHNLSFTNYEESKDSFRGRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEE
FKVRHDEKGNRLTFIKALSGTLRTKEELTYLKEGKESLEKVNEIRIYNGSKYELVNEVRS
EEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHCC
GDIFAVVGVKGLESGDGIGIENIDSYDMVPTLKSKVVYREGLNPKEVLSWFKILESEEST
CCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCE
LSVSWDERLKEIHVNIMGKVQLEVLKEVMKNRFNEEIEFGTPEILYKETLNEEVIGYGHF
EEECHHHHHHHHHHHHEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCC
EPLGHYSEVHLKIEPLERNSGIVFENKCHADDLTVGNQNLIRTHIFECEHKGILTGSPIT
CCCCCCEEEEEEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
DLKITLLTGRAHNKHTSGGDFREATKRALRQGLESGENKLLEPYYKFKIDVDLNLIGRVM
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECHHHHHHHH
NDIQKMHGEFKDPIIDGERATIEGKGPVSTFINYGMEFQSFTKGKGGLSLKFHGYDLCHN
HHHHHHHCHHCCCCCCCCCEEECCCCCHHHHHHCCCCHHHHCCCCCCEEEEECCCCCCCC
EEDIIEKVAYDRNADIDYTSTSIFCSKGQAYLVKGGEAKEHMHCLV
HHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEECCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8170402 [H]