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The map label for this gene is mutL

Identifier: 182682515

GI number: 182682515

Start: 2239612

End: 2241471

Strand: Reverse

Name: mutL

Synonym: XfasM23_2002

Alternate gene names: 182682515

Gene position: 2241471-2239612 (Counterclockwise)

Preceding gene: 182682516

Following gene: 182682514

Centisome position: 88.4

GC content: 57.85

Gene sequence:

>1860_bases
ATGCCAATCCGTCAGCTACCCGAGATTTTGATTAACCAGATTGCCGCCGGGGAGGTGGTTGAGCGTCCCGCCTCGGTGGT
TAAAGAGTTGGTTGAGAATGCAATTGATGCCGGTGCGACGCGTGTGGACATTGAGTTGGAAGCAGCAGGGGTGCGCTTGA
TTCGCATCCGTGACAACGGCCACGGTATGGCTGCTCAGGAATTGCCGCTGGCAGTCTTGCGGCACGCTACCAGCAAGATT
GCCTCATTGGATGATTTGGAAGCGGTCGCCACCCTGGGTTTCCGTGGTGAGGCACTGCCTTCGATTGCTTCGGTGAGTCG
GTTTACCTTGATGTCGCGTCGTGCCACGGATGAACACGGTGCGGTATTGCAGATTGAGGGAGGTACGCTGGGCGAGGTGA
TCCCCCATGCGCATGCACCGGGGACCACCGTTGAGGTGCGTGAGTTGTTCTATAACGTGCCAGCGCGGCGTAAGTTCCTC
CGTGCTGAGCGTACCGAGCTGGGGCATATTGAGGAATGGGCACGTTCTCTGGCGCTGGCGCATCCAGATTTAGAATTGCG
TCTTTCACATAATGGCAAACTTTCGCGTCGCTATAAGCCGGGTGACTGGTATTCAGATGTGCGCTTGATCGAGATTTTGG
GAGAAGATTTTGCGCATCAGGCATTGCGTGTAGATCACAGTGGCGCGGGGTTACGTCTGCATGGGTGCATTGTGCAGCCG
CATTACTCGCGTTTGAATGCGGATCAGCAATATTTGTACGTCAATGGACGTCCAGTCCGTGATCGTAGTGTTGCTCACGC
CGTCAAACAGGCTTACAGCGATGTGCTCTATCAGGGGCGACATCCGGCGTATGTGCTGTTTCTGGAGCTGGACCCGGCAC
GTGTGGACGTGAACGTACACCCGGCCAAACATGAGGTGCGTTTCCGTGATGCACGGCTCATCCATGATTTTGTCTACCGT
ACTGTTCAGGGCACGTTGGCACAGACGCGTGCGGGTACGCCGCCGTTGGCGGTGGGTGTGGGTGATGTGGAGGGGGAGGG
TGCAAGGCCTCCTGGCCGTCATGCGGTGTCGTTTTCAGGGCGGCGTGGTGGTGCCTCGCATGTGCTGGGGAGCTACTCTG
CCAGCACGGCTCCTCTGATGCAGGGTGTGCCAAGCGTGTCTGTGGCTGACGCGCCCGCAGCGTATGCAGCCCTGTATGCT
GCGCCACCGACGCAGGTAATGGATGCAGTGCCACAGATGCAGACGGGGCTACCGCTGGCTGCTGGGGCGGGCGACGTACC
GCTACTTGGCTATGCCATCGCACAGCTGCATGGCATTTATATCTTGGCTGAGTGTGCCGATGGGCTGATTGTGGTGGATA
TGCATGCGGCTCACGAGCGTATTGGTTACGAGCGCCTGAAGCGCGCCCATGATGGTATTGGGTTACGTACCCAGCCACTG
TTGGTGCCGATGACGTTGATGGTTGCCGAGCGTGAGGCTGATGTTGCTGAGTGTGAAGCTGAGACGTTGGCCAATCTTGG
CTTTGAAGTGACCCGCAGTGGTCCGGGTTCGTTACAGGTGCGTAGCATCCCGGCGTTGCTTTCCCAAGCGGAGCCAGAAA
TGTTACTGCGCGATGTGCTCAGCGATCTGAGTGAACATGGCCACACCCGGCGTGTGGCTGAGGCGCGTGATACGTTGCTT
GCGACGATGGCTTGTCATGGTGCTGTGCGTGCTCACCGGCGCTTGAGCATTTCCGAGATGAACGCGTTGTTGCGTGATAT
GGAGGCTACGGAGCGCTCAGGTCAATGTAATCACGGACGTCCTACCTGGGCGCGTTTTAGTTTGGCTGAGATCGATCGTT
GGTTTCTTAGGGGGCGGTGA

Upstream 100 bases:

>100_bases
ATGTCCGGGTGTCGTTGCTGCGTGTTTCCCGTGTGTCTGAGTGTTTGATCGTTTTAGATCTGATGGCTGTTGCCTGTCCG
TTATCCTTGGAGAAGTGCTG

Downstream 100 bases:

>100_bases
TGCGGCGTGAATACCAATACGGGGCAGTATTGATATTGTTGGCTGTGGTCGCAGTGCTTTTCACGTTTTTCGCGTGGTGG
CAGCGTGATCGCGATGTTGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MPIRQLPEILINQIAAGEVVERPASVVKELVENAIDAGATRVDIELEAAGVRLIRIRDNGHGMAAQELPLAVLRHATSKI
ASLDDLEAVATLGFRGEALPSIASVSRFTLMSRRATDEHGAVLQIEGGTLGEVIPHAHAPGTTVEVRELFYNVPARRKFL
RAERTELGHIEEWARSLALAHPDLELRLSHNGKLSRRYKPGDWYSDVRLIEILGEDFAHQALRVDHSGAGLRLHGCIVQP
HYSRLNADQQYLYVNGRPVRDRSVAHAVKQAYSDVLYQGRHPAYVLFLELDPARVDVNVHPAKHEVRFRDARLIHDFVYR
TVQGTLAQTRAGTPPLAVGVGDVEGEGARPPGRHAVSFSGRRGGASHVLGSYSASTAPLMQGVPSVSVADAPAAYAALYA
APPTQVMDAVPQMQTGLPLAAGAGDVPLLGYAIAQLHGIYILAECADGLIVVDMHAAHERIGYERLKRAHDGIGLRTQPL
LVPMTLMVAEREADVAECEAETLANLGFEVTRSGPGSLQVRSIPALLSQAEPEMLLRDVLSDLSEHGHTRRVAEARDTLL
ATMACHGAVRAHRRLSISEMNALLRDMEATERSGQCNHGRPTWARFSLAEIDRWFLRGR

Sequences:

>Translated_619_residues
MPIRQLPEILINQIAAGEVVERPASVVKELVENAIDAGATRVDIELEAAGVRLIRIRDNGHGMAAQELPLAVLRHATSKI
ASLDDLEAVATLGFRGEALPSIASVSRFTLMSRRATDEHGAVLQIEGGTLGEVIPHAHAPGTTVEVRELFYNVPARRKFL
RAERTELGHIEEWARSLALAHPDLELRLSHNGKLSRRYKPGDWYSDVRLIEILGEDFAHQALRVDHSGAGLRLHGCIVQP
HYSRLNADQQYLYVNGRPVRDRSVAHAVKQAYSDVLYQGRHPAYVLFLELDPARVDVNVHPAKHEVRFRDARLIHDFVYR
TVQGTLAQTRAGTPPLAVGVGDVEGEGARPPGRHAVSFSGRRGGASHVLGSYSASTAPLMQGVPSVSVADAPAAYAALYA
APPTQVMDAVPQMQTGLPLAAGAGDVPLLGYAIAQLHGIYILAECADGLIVVDMHAAHERIGYERLKRAHDGIGLRTQPL
LVPMTLMVAEREADVAECEAETLANLGFEVTRSGPGSLQVRSIPALLSQAEPEMLLRDVLSDLSEHGHTRRVAEARDTLL
ATMACHGAVRAHRRLSISEMNALLRDMEATERSGQCNHGRPTWARFSLAEIDRWFLRGR
>Mature_618_residues
PIRQLPEILINQIAAGEVVERPASVVKELVENAIDAGATRVDIELEAAGVRLIRIRDNGHGMAAQELPLAVLRHATSKIA
SLDDLEAVATLGFRGEALPSIASVSRFTLMSRRATDEHGAVLQIEGGTLGEVIPHAHAPGTTVEVRELFYNVPARRKFLR
AERTELGHIEEWARSLALAHPDLELRLSHNGKLSRRYKPGDWYSDVRLIEILGEDFAHQALRVDHSGAGLRLHGCIVQPH
YSRLNADQQYLYVNGRPVRDRSVAHAVKQAYSDVLYQGRHPAYVLFLELDPARVDVNVHPAKHEVRFRDARLIHDFVYRT
VQGTLAQTRAGTPPLAVGVGDVEGEGARPPGRHAVSFSGRRGGASHVLGSYSASTAPLMQGVPSVSVADAPAAYAALYAA
PPTQVMDAVPQMQTGLPLAAGAGDVPLLGYAIAQLHGIYILAECADGLIVVDMHAAHERIGYERLKRAHDGIGLRTQPLL
VPMTLMVAEREADVAECEAETLANLGFEVTRSGPGSLQVRSIPALLSQAEPEMLLRDVLSDLSEHGHTRRVAEARDTLLA
TMACHGAVRAHRRLSISEMNALLRDMEATERSGQCNHGRPTWARFSLAEIDRWFLRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=338, Percent_Identity=33.1360946745562, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI189458898, Length=324, Percent_Identity=30.5555555555556, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI4505911, Length=324, Percent_Identity=30.5555555555556, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI189458896, Length=315, Percent_Identity=29.8412698412698, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4505913, Length=330, Percent_Identity=28.4848484848485, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI310128478, Length=330, Percent_Identity=28.4848484848485, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=25.7627118644068, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI91992162, Length=329, Percent_Identity=26.7477203647416, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI91992160, Length=349, Percent_Identity=26.0744985673352, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI263191589, Length=244, Percent_Identity=28.6885245901639, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790612, Length=606, Percent_Identity=40.9240924092409, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI71991825, Length=318, Percent_Identity=32.3899371069182, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=356, Percent_Identity=27.247191011236, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=313, Percent_Identity=33.5463258785943, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324247, Length=156, Percent_Identity=34.6153846153846, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325093, Length=735, Percent_Identity=20.952380952381, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=359, Percent_Identity=23.6768802228412, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136968, Length=335, Percent_Identity=33.4328358208955, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17136970, Length=379, Percent_Identity=26.9129287598945, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67530; Mature: 67399

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRQLPEILINQIAAGEVVERPASVVKELVENAIDAGATRVDIELEAAGVRLIRIRDNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEEEEEEECC
HGMAAQELPLAVLRHATSKIASLDDLEAVATLGFRGEALPSIASVSRFTLMSRRATDEHG
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
AVLQIEGGTLGEVIPHAHAPGTTVEVRELFYNVPARRKFLRAERTELGHIEEWARSLALA
CEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHC
HPDLELRLSHNGKLSRRYKPGDWYSDVRLIEILGEDFAHQALRVDHSGAGLRLHGCIVQP
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECC
HYSRLNADQQYLYVNGRPVRDRSVAHAVKQAYSDVLYQGRHPAYVLFLELDPARVDVNVH
CHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC
PAKHEVRFRDARLIHDFVYRTVQGTLAQTRAGTPPLAVGVGDVEGEGARPPGRHAVSFSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEECC
RRGGASHVLGSYSASTAPLMQGVPSVSVADAPAAYAALYAAPPTQVMDAVPQMQTGLPLA
CCCCHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEE
AGAGDVPLLGYAIAQLHGIYILAECADGLIVVDMHAAHERIGYERLKRAHDGIGLRTQPL
CCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
LVPMTLMVAEREADVAECEAETLANLGFEVTRSGPGSLQVRSIPALLSQAEPEMLLRDVL
HHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCCCEEEEHHHHHHHCCCHHHHHHHHH
SDLSEHGHTRRVAEARDTLLATMACHGAVRAHRRLSISEMNALLRDMEATERSGQCNHGR
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
PTWARFSLAEIDRWFLRGR
CCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PIRQLPEILINQIAAGEVVERPASVVKELVENAIDAGATRVDIELEAAGVRLIRIRDNG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEEEEEEECC
HGMAAQELPLAVLRHATSKIASLDDLEAVATLGFRGEALPSIASVSRFTLMSRRATDEHG
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
AVLQIEGGTLGEVIPHAHAPGTTVEVRELFYNVPARRKFLRAERTELGHIEEWARSLALA
CEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHC
HPDLELRLSHNGKLSRRYKPGDWYSDVRLIEILGEDFAHQALRVDHSGAGLRLHGCIVQP
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECC
HYSRLNADQQYLYVNGRPVRDRSVAHAVKQAYSDVLYQGRHPAYVLFLELDPARVDVNVH
CHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC
PAKHEVRFRDARLIHDFVYRTVQGTLAQTRAGTPPLAVGVGDVEGEGARPPGRHAVSFSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEECC
RRGGASHVLGSYSASTAPLMQGVPSVSVADAPAAYAALYAAPPTQVMDAVPQMQTGLPLA
CCCCHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEE
AGAGDVPLLGYAIAQLHGIYILAECADGLIVVDMHAAHERIGYERLKRAHDGIGLRTQPL
CCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
LVPMTLMVAEREADVAECEAETLANLGFEVTRSGPGSLQVRSIPALLSQAEPEMLLRDVL
HHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCCCEEEEHHHHHHHCCCHHHHHHHHH
SDLSEHGHTRRVAEARDTLLATMACHGAVRAHRRLSISEMNALLRDMEATERSGQCNHGR
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
PTWARFSLAEIDRWFLRGR
CCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA