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The map label for this gene is groEL

Identifier: 182682145

GI number: 182682145

Start: 1798709

End: 1800352

Strand: Direct

Name: groEL

Synonym: XfasM23_1623

Alternate gene names: 182682145

Gene position: 1798709-1800352 (Clockwise)

Preceding gene: 182682144

Following gene: 182682158

Centisome position: 70.94

GC content: 51.52

Gene sequence:

>1644_bases
ATGGCTGCCAAAGAAATTATTTTCAGTGAAAAAGCCCGTTCACGTATGGTGCACGGGGTGAACCTGCTTGCTAATGCAGT
GAAAGCCACCTTAGGTCCCAAAGGCCGCCACGTAGTGCTTGATAAGAGCTTCGGCTCCCCAATCATTACTAAAGACGGCG
TCTCTGTCGCCAAAGAGATTGAGTTGGCCGACAAGTTTGAAAACATGGGCGCACAAATGCTTAAAGAAGTTGCGTCCAAA
ACAAATGACCATGCAGGCGACGGCACCACCACTGCAACGGTACTAGCCCAGGCGTTGATCCGTGAAGGATGCAAAGCAGT
GGCCGCTGGTATGAATCCAATGGATCTTAAGCGTGGTATCGATAAAGCAGTCATTGCCGCGGTTACCGAACTGAAGAAGA
TCTCCAAGCCAACCAGCGACGATAAAGCCATTGCCCAAGTCGCAACCATCTCTGCTAACTCAGACGAGTCTATCGGCAAC
ATTATTGCCGAAGCAATGAAGAAGGTCGGTAAAGAAGGAGTGATTACCATTGAGGAAGGCACAACTCTAGAAAACGAATT
GGATGTCGTCGAAGGGATGCAGTTTGACCGTGGTTACTCTTCGCCATATTTCATCAACAACCAGCAGTCCCAAATTGTTG
AGCTGGATAATCCCTACATCCTCCTTCACGACAAGAAAATTTCCAGTGTGCGCGATTTACTCACCGTGCTTGACGCCGTC
GCCAAAGAAAGCAAGCCGTTGCTGATCGTCGCTGAGGAAGTCGAAGGCGAAGCTTTGGCAACTCTGGTCGTTAACAACAT
CCGCGGCATCATCAAAGTCTGCGCAGTCAAAGCACCTGGCTTCGGTGATCGTCGCAAAGCCATGCTGGAAGATATGGCTG
TGCTGACAGGCGGCACCGTCATCTCGGAAGAAGTAGGTCTGTCTCTGGAAAAGGCCACGACCAGCCATCTTGGCAAGGCC
AAGAAAGTACGCGTCTCTAAAGAAAACACCACCATTATTGATGGTATGGGTGACAACGATGCGATCAATGGTCGCGTCAA
GCAAATCAAGACCCAGATCGAGGAAACCACCTCGGACTACGACCGCGAAAAACTGCAGGAACGTGTAGCCAAGCTCGCCG
GTGGTGTAGCCGTCATCAAGGTCGGTGCTGCAACCGAAGTGGAAATGAAGGAAAAGAAAGCACGTGTTGATGATGCTTTA
CTTGCAACCCGTGCAGCCGTTGAAGAAGGAGTGATTCCAGGTGGCGGCGTGGCCCTGATACGTGCAATCACGGCAATCAG
CAATCTGAAGGGTGCCAATGAAGACCAGACACACGGCATTCAAATCGCATTGCGCGCTATGGAGGCACCATTACGCGAAA
TTGTTGCCAACGCCGGTGAAGAGCCATCGGTCATCTTAAATAAGGTGAAAGAAGGCAAGGACAATTTTGGCTACAACGCC
GCTACTGGCGAATTCGGCGATATGGTCAACCTTGGCATCCTGGACCCAACCAAGGTCACCCGTTCAGCACTCCAGAACGC
TGCTTCAATCGCTGGCCTGATGATCACCACAGAAGCAATGGTCGCCGAGGCTCCGAAGAAAGACGAGCCAACCCCACCTG
CTGCTGGTGGCGGCATGGGCGGTATGGGCGGTATGGATTTCTAA

Upstream 100 bases:

>100_bases
CCCGAAACTCGTGAATGCATCCGACATATCACGCCAACAGCGGACACATTGTTCCATACATCACTAATGTTCTCATCGCG
AATCTTGGAGTAAAAACATA

Downstream 100 bases:

>100_bases
GAAAATAAACTAACGGTTGTTGTATTTATCAAAAAAGCCCTGCTCACGCGGGGCTTTTTTTCTGCGGCGATCCTTCAGCG
TGCAATGGTGACACAGCAAC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKEIIFSEKARSRMVHGVNLLANAVKATLGPKGRHVVLDKSFGSPIITKDGVSVAKEIELADKFENMGAQMLKEVASK
TNDHAGDGTTTATVLAQALIREGCKAVAAGMNPMDLKRGIDKAVIAAVTELKKISKPTSDDKAIAQVATISANSDESIGN
IIAEAMKKVGKEGVITIEEGTTLENELDVVEGMQFDRGYSSPYFINNQQSQIVELDNPYILLHDKKISSVRDLLTVLDAV
AKESKPLLIVAEEVEGEALATLVVNNIRGIIKVCAVKAPGFGDRRKAMLEDMAVLTGGTVISEEVGLSLEKATTSHLGKA
KKVRVSKENTTIIDGMGDNDAINGRVKQIKTQIEETTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVDDAL
LATRAAVEEGVIPGGGVALIRAITAISNLKGANEDQTHGIQIALRAMEAPLREIVANAGEEPSVILNKVKEGKDNFGYNA
ATGEFGDMVNLGILDPTKVTRSALQNAASIAGLMITTEAMVAEAPKKDEPTPPAAGGGMGGMGGMDF

Sequences:

>Translated_547_residues
MAAKEIIFSEKARSRMVHGVNLLANAVKATLGPKGRHVVLDKSFGSPIITKDGVSVAKEIELADKFENMGAQMLKEVASK
TNDHAGDGTTTATVLAQALIREGCKAVAAGMNPMDLKRGIDKAVIAAVTELKKISKPTSDDKAIAQVATISANSDESIGN
IIAEAMKKVGKEGVITIEEGTTLENELDVVEGMQFDRGYSSPYFINNQQSQIVELDNPYILLHDKKISSVRDLLTVLDAV
AKESKPLLIVAEEVEGEALATLVVNNIRGIIKVCAVKAPGFGDRRKAMLEDMAVLTGGTVISEEVGLSLEKATTSHLGKA
KKVRVSKENTTIIDGMGDNDAINGRVKQIKTQIEETTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVDDAL
LATRAAVEEGVIPGGGVALIRAITAISNLKGANEDQTHGIQIALRAMEAPLREIVANAGEEPSVILNKVKEGKDNFGYNA
ATGEFGDMVNLGILDPTKVTRSALQNAASIAGLMITTEAMVAEAPKKDEPTPPAAGGGMGGMGGMDF
>Mature_546_residues
AAKEIIFSEKARSRMVHGVNLLANAVKATLGPKGRHVVLDKSFGSPIITKDGVSVAKEIELADKFENMGAQMLKEVASKT
NDHAGDGTTTATVLAQALIREGCKAVAAGMNPMDLKRGIDKAVIAAVTELKKISKPTSDDKAIAQVATISANSDESIGNI
IAEAMKKVGKEGVITIEEGTTLENELDVVEGMQFDRGYSSPYFINNQQSQIVELDNPYILLHDKKISSVRDLLTVLDAVA
KESKPLLIVAEEVEGEALATLVVNNIRGIIKVCAVKAPGFGDRRKAMLEDMAVLTGGTVISEEVGLSLEKATTSHLGKAK
KVRVSKENTTIIDGMGDNDAINGRVKQIKTQIEETTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVDDALL
ATRAAVEEGVIPGGGVALIRAITAISNLKGANEDQTHGIQIALRAMEAPLREIVANAGEEPSVILNKVKEGKDNFGYNAA
TGEFGDMVNLGILDPTKVTRSALQNAASIAGLMITTEAMVAEAPKKDEPTPPAAGGGMGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=51.7045454545455, Blast_Score=540, Evalue=1e-154,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=51.7045454545455, Blast_Score=540, Evalue=1e-154,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=75, Blast_Score=792, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.4177693761815, Blast_Score=543, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=53.0805687203791, Blast_Score=223, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=54.1984732824427, Blast_Score=545, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322524, Length=145, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=50.853889943074, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=50.853889943074, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=49.4274809160305, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=49.4274809160305, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=49.4274809160305, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17864606, Length=554, Percent_Identity=39.8916967509025, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24584129, Length=528, Percent_Identity=37.3106060606061, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI19921262, Length=528, Percent_Identity=37.3106060606061, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI28571140, Length=562, Percent_Identity=23.4875444839858, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18858175, Length=562, Percent_Identity=23.4875444839858, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_XYLF2 (B2I7D4)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830305.1
- ProteinModelPortal:   B2I7D4
- SMR:   B2I7D4
- GeneID:   6202745
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1623
- HOGENOM:   HBG625289
- OMA:   NSDTSIG
- ProtClustDB:   PRK00013
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57776; Mature: 57645

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEIIFSEKARSRMVHGVNLLANAVKATLGPKGRHVVLDKSFGSPIITKDGVSVAKEI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEECCCHHHHHHH
ELADKFENMGAQMLKEVASKTNDHAGDGTTTATVLAQALIREGCKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIAAVTELKKISKPTSDDKAIAQVATISANSDESIGNIIAEAMKKVGKEGVITIEEG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCEEEEECC
TTLENELDVVEGMQFDRGYSSPYFINNQQSQIVELDNPYILLHDKKISSVRDLLTVLDAV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKESKPLLIVAEEVEGEALATLVVNNIRGIIKVCAVKAPGFGDRRKAMLEDMAVLTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEE
ISEEVGLSLEKATTSHLGKAKKVRVSKENTTIIDGMGDNDAINGRVKQIKTQIEETTSDY
EHHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVDDALLATRAAVEEGVIPGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAITAISNLKGANEDQTHGIQIALRAMEAPLREIVANAGEEPSVILNKVKEGKDNFGYNA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
ATGEFGDMVNLGILDPTKVTRSALQNAASIAGLMITTEAMVAEAPKKDEPTPPAAGGGMG
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GMGGMDF
CCCCCCC
>Mature Secondary Structure 
AAKEIIFSEKARSRMVHGVNLLANAVKATLGPKGRHVVLDKSFGSPIITKDGVSVAKEI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEECCCHHHHHHH
ELADKFENMGAQMLKEVASKTNDHAGDGTTTATVLAQALIREGCKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIAAVTELKKISKPTSDDKAIAQVATISANSDESIGNIIAEAMKKVGKEGVITIEEG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCEEEEECC
TTLENELDVVEGMQFDRGYSSPYFINNQQSQIVELDNPYILLHDKKISSVRDLLTVLDAV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKESKPLLIVAEEVEGEALATLVVNNIRGIIKVCAVKAPGFGDRRKAMLEDMAVLTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEE
ISEEVGLSLEKATTSHLGKAKKVRVSKENTTIIDGMGDNDAINGRVKQIKTQIEETTSDY
EHHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVDDALLATRAAVEEGVIPGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAITAISNLKGANEDQTHGIQIALRAMEAPLREIVANAGEEPSVILNKVKEGKDNFGYNA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
ATGEFGDMVNLGILDPTKVTRSALQNAASIAGLMITTEAMVAEAPKKDEPTPPAAGGGMG
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GMGGMDF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA