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The map label for this gene is thrC [H]

Identifier: 182681888

GI number: 182681888

Start: 1494968

End: 1496269

Strand: Reverse

Name: thrC [H]

Synonym: XfasM23_1356

Alternate gene names: 182681888

Gene position: 1496269-1494968 (Counterclockwise)

Preceding gene: 182681889

Following gene: 182681887

Centisome position: 59.01

GC content: 60.37

Gene sequence:

>1302_bases
ATGATTCAAATGAACTTCCATTCCACCCGCACCACAGCTCCGGTGACCACCCTCAGCCAGGCAATCGCTGCAGGCTTAGC
ACCGGATGGCGGCTTATATGTCCCCGAGTGCTTGCCACCCCTTGGTGACTTGGACCACAGCGCAGATTTAATCAACACCG
CCACCGCACTACTGACCCCCTTCTTTGCGGGGGATCCGCTAGAAGTGCATGTGCCGTCGATCTGTGCCGAAGCGCTGGAT
CTCCCCGCACCACTGCTGCCCTTGGCTACCCCTGAAGATTATGTCCTTGAGTTATTTCACGGCCCCACTGCTGCCTTCAA
GGATTTTGGCGCACGTTTTCTAGCGGCCTGCCTGACTCGGCTACGACGTGATGCCGAACGTCCCTTGACGATTCTGGTGG
CTACCTCCGGTGATACGGGTGCTGCGGTGGCGGCGGCATTTCATCGGCAACCCGGATTGCGTGTCGTCGTTCTGTACCCG
GATGGCCGTGTATCGCCACGTCAGGCCCACCAATTGGGTTGTTTTGGCGACAACATACATACACTGCGTGTGGCTGGCGT
GTTCGATGACTGCCAAGCCATGGTCAAGCAGGCCCTGAACGATACCAGCCTCCAAACAGCCGTGCCGCTGAGTTCGGCCA
ACAGCATCAGCCTGGGCCGCTTGCTGCCGCAGATGAGCTACTACGCCCATGCAGCCTTGACCCACCGTGCCAGCACGGGC
CGCCCTCTGAACCTCATTGTGCCCACCGGCAACCTCGGCAATGCCTTGGCCGCGATTCTGGCGCGCGCCCTGGGAGTACC
CTTAGGACAGATTGTGTTGGCGACAAACGCCAACCACGTACTCCCTGATTACTTTTCCGGAGCACATTACCGCCCCCAGC
CCAGTGTGGCGACGTTGGCCAATGCAATGGACGTTGGAGCGCCCAGTAATTTTGAACGATTGCGCTGGTTGTATCGCGGC
GATGACGCCGCATTGCGTGCCGCCTTTACCGCCTATTCCGTCGACGACACCGCGATCCGCCAGACCATCACCGCACGGCA
TCGTCGCTACGACGAGATATTTTGTCCCCATACCGCTACGGCGGTGTTTGTGCTTGAGCACTTGCGTGCACAGGGCGTCG
CTGGGGATTGGGCCGTTGTGGCGACCGCGCATCCAGCCAAATTTGAGCAGGTGGTAGAACCGTTGATCGGTACCACCGTG
CCCGTGCCGGCGGCCCTGGATAGCCTCCTGCAACGTCCCGCGCGCGACGAACCGCTTGCCCCAGAGTACCCGGCATTGCG
GCACATGCTACTGGCCACCTAA

Upstream 100 bases:

>100_bases
GGTTTTGATAGCCAAGCCTGGGTGACACCACTCACCAGCCCAGGCGCGCGCCTGCTATGAGACCGTTGCCTCCTTCGATT
TTTTTCTCTTTCCACCATCT

Downstream 100 bases:

>100_bases
CGCAGCATGTGTGTGCCACTGCATGAGTGCGGATCTGAGCCGATCCCTGATCCTATTGAGTGGCTAGAGCGCTAACGCTG
CGCCTATTGCCGTGTGCCGT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MIQMNFHSTRTTAPVTTLSQAIAAGLAPDGGLYVPECLPPLGDLDHSADLINTATALLTPFFAGDPLEVHVPSICAEALD
LPAPLLPLATPEDYVLELFHGPTAAFKDFGARFLAACLTRLRRDAERPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYP
DGRVSPRQAHQLGCFGDNIHTLRVAGVFDDCQAMVKQALNDTSLQTAVPLSSANSISLGRLLPQMSYYAHAALTHRASTG
RPLNLIVPTGNLGNALAAILARALGVPLGQIVLATNANHVLPDYFSGAHYRPQPSVATLANAMDVGAPSNFERLRWLYRG
DDAALRAAFTAYSVDDTAIRQTITARHRRYDEIFCPHTATAVFVLEHLRAQGVAGDWAVVATAHPAKFEQVVEPLIGTTV
PVPAALDSLLQRPARDEPLAPEYPALRHMLLAT

Sequences:

>Translated_433_residues
MIQMNFHSTRTTAPVTTLSQAIAAGLAPDGGLYVPECLPPLGDLDHSADLINTATALLTPFFAGDPLEVHVPSICAEALD
LPAPLLPLATPEDYVLELFHGPTAAFKDFGARFLAACLTRLRRDAERPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYP
DGRVSPRQAHQLGCFGDNIHTLRVAGVFDDCQAMVKQALNDTSLQTAVPLSSANSISLGRLLPQMSYYAHAALTHRASTG
RPLNLIVPTGNLGNALAAILARALGVPLGQIVLATNANHVLPDYFSGAHYRPQPSVATLANAMDVGAPSNFERLRWLYRG
DDAALRAAFTAYSVDDTAIRQTITARHRRYDEIFCPHTATAVFVLEHLRAQGVAGDWAVVATAHPAKFEQVVEPLIGTTV
PVPAALDSLLQRPARDEPLAPEYPALRHMLLAT
>Mature_433_residues
MIQMNFHSTRTTAPVTTLSQAIAAGLAPDGGLYVPECLPPLGDLDHSADLINTATALLTPFFAGDPLEVHVPSICAEALD
LPAPLLPLATPEDYVLELFHGPTAAFKDFGARFLAACLTRLRRDAERPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYP
DGRVSPRQAHQLGCFGDNIHTLRVAGVFDDCQAMVKQALNDTSLQTAVPLSSANSISLGRLLPQMSYYAHAALTHRASTG
RPLNLIVPTGNLGNALAAILARALGVPLGQIVLATNANHVLPDYFSGAHYRPQPSVATLANAMDVGAPSNFERLRWLYRG
DDAALRAAFTAYSVDDTAIRQTITARHRRYDEIFCPHTATAVFVLEHLRAQGVAGDWAVVATAHPAKFEQVVEPLIGTTV
PVPAALDSLLQRPARDEPLAPEYPALRHMLLAT

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=489, Percent_Identity=29.4478527607362, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI149193323, Length=456, Percent_Identity=30.0438596491228, Blast_Score=152, Evalue=5e-37,
Organism=Escherichia coli, GI1786185, Length=433, Percent_Identity=36.7205542725173, Blast_Score=264, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6319901, Length=462, Percent_Identity=31.3852813852814, Blast_Score=198, Evalue=2e-51,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46258; Mature: 46258

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQMNFHSTRTTAPVTTLSQAIAAGLAPDGGLYVPECLPPLGDLDHSADLINTATALLTP
CEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEECHHHCCCCCCCCCHHHHHHHHHHHHHH
FFAGDPLEVHVPSICAEALDLPAPLLPLATPEDYVLELFHGPTAAFKDFGARFLAACLTR
HHCCCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LRRDAERPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRVSPRQAHQLGCFGDNIH
HHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCEE
TLRVAGVFDDCQAMVKQALNDTSLQTAVPLSSANSISLGRLLPQMSYYAHAALTHRASTG
EEEEECCHHHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
RPLNLIVPTGNLGNALAAILARALGVPLGQIVLATNANHVLPDYFSGAHYRPQPSVATLA
CCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHCCCCCCCCCCHHHHHH
NAMDVGAPSNFERLRWLYRGDDAALRAAFTAYSVDDTAIRQTITARHRRYDEIFCPHTAT
HHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
AVFVLEHLRAQGVAGDWAVVATAHPAKFEQVVEPLIGTTVPVPAALDSLLQRPARDEPLA
HHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
PEYPALRHMLLAT
CCCHHHHHHHHCC
>Mature Secondary Structure
MIQMNFHSTRTTAPVTTLSQAIAAGLAPDGGLYVPECLPPLGDLDHSADLINTATALLTP
CEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEECHHHCCCCCCCCCHHHHHHHHHHHHHH
FFAGDPLEVHVPSICAEALDLPAPLLPLATPEDYVLELFHGPTAAFKDFGARFLAACLTR
HHCCCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LRRDAERPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRVSPRQAHQLGCFGDNIH
HHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCEE
TLRVAGVFDDCQAMVKQALNDTSLQTAVPLSSANSISLGRLLPQMSYYAHAALTHRASTG
EEEEECCHHHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
RPLNLIVPTGNLGNALAAILARALGVPLGQIVLATNANHVLPDYFSGAHYRPQPSVATLA
CCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHCCCCCCCCCCHHHHHH
NAMDVGAPSNFERLRWLYRGDDAALRAAFTAYSVDDTAIRQTITARHRRYDEIFCPHTAT
HHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
AVFVLEHLRAQGVAGDWAVVATAHPAKFEQVVEPLIGTTVPVPAALDSLLQRPARDEPLA
HHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
PEYPALRHMLLAT
CCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]