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The map label for this gene is pepP [H]

Identifier: 182681399

GI number: 182681399

Start: 1000172

End: 1001500

Strand: Direct

Name: pepP [H]

Synonym: XfasM23_0848

Alternate gene names: 182681399

Gene position: 1000172-1001500 (Clockwise)

Preceding gene: 182681398

Following gene: 182681402

Centisome position: 39.44

GC content: 52.75

Gene sequence:

>1329_bases
GTGAAGAAACATACAGGCATTGCCCCTGCCGAATATGGGCGTCGTCGCCGTCAATTGATGAAGATGGTTGGTCCCCAGGG
CATCGTTGTGCTGCCTGCTGCGCCTGAGCGGGTACGTAGCCGTGATACTCATTATCCGTACCGTCAGGATTCGGATTTTT
GGTACCTATGCGGCTTTCCCGAGCCCGATGCGGTGTTGGTGCTGGTGCCAGGGCGTTGCCATGGTCAAGTCCTGCTGTTC
TGTCGCGAACGCGATCCTGAGCGCGAGGCATGGGATGGTCCACGTTCCGGGTACGATGGCGCAATCGAGCAGTACGGCAT
GGATGATGCGTATCCGATTGATGATTTGGACGAAATCTTACCCGGTCTGCTCGAAGGTAGGTCCCATGTCTATTATCATT
TCGGTCGTGATGTTGAATTTGATCTAAGGTTGATTGGTTGGGTCAATCGTGTGCGTGATCAGGTGCGCTACGCTGCGGAT
TCTCCACACGAGTTTATAGACCTGGGGCATCTGCTGCATGAGCAGCGTTTGTTCAAATCTTATGATGAAATTGTGTTGCT
TCAGTGTGCAGCTGATATCAGTGTCGAAGCGCATCTTGCCGCGTTGCGCTATGCGCATCCTGGCGTCTCTGAATATGTGT
TGCAGGCTGAGCTTGAGCGTGTGTTCCGAGCTGCTGACAGTTGTCCGGCGTATACAAGTATTGTTGCTGCTGGCGCTAAT
GCGTGCGTATTGCATTACTGTGCCAATGCGGAATGCAGTCGTGATGGGGATTTAGTGTTGATTGATGCCGGTGCAGAGTA
CCGCGGTTATGCTGCTGACATTACCCGTACTTTTCCTGTCAACGGTCGTTTCAGTCCTGCCCAGCGTGCGCTATACGATC
TGGTCGGTGCTGCTTATGATGTTGCATTAGCGCAGGCGCGGCCTGGGTTGCCATATGAGGCTGGTCATTTGTCTGCGGTG
CAGACATTGACTGAGGGGTTGCTGCGGCTTGGTCTGTTGCATGGCACGTTGGAGGATAATTTGGCTGATCAGAGTTACAA
GCGCTTTTATCGTCACAAGACTGGGCATTGGTTGGGTTTGGACGTGCATGATGTTGGTGACTATCGCATTGATGGTAAGT
CTCGATTACTTGAGCCTGGCATGGTATTTACGATTGAGCCAGGGTTATACGTTCTTCCGGACGATACGACTGTCCACCCG
AAGTGGCGCGGCATTGGTATACGTACCGAGGATGATGTATTGATTACGGAAGATGGGCATTGTGTGCTGACAGGAGTGTT
ACCACGCTCAGCTGATGAAATCGAGGCGGAGATGGCTGCGGTGCAGTGA

Upstream 100 bases:

>100_bases
TGGAAGAGATTGAAGAATTCGTGCGTGTGGCAGTGTTGTTGCTGCATGGGGACTGTTTGATTGGTCCGTGCGCTCCTCAG
CGTCTTAATTGAATCGAATC

Downstream 100 bases:

>100_bases
GAAGTGTTTGATGTGGCTGGGGCATTCGCAAAACTAAATGTTTGAGTATATGAGCAGTCTTTTCCCGTATGCGACTCGGG
TTATTGTTGCTTCTTGCGGT

Product: peptidase M24B X-Pro dipeptidase/aminopeptidase domain-containing protein

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MKKHTGIAPAEYGRRRRQLMKMVGPQGIVVLPAAPERVRSRDTHYPYRQDSDFWYLCGFPEPDAVLVLVPGRCHGQVLLF
CRERDPEREAWDGPRSGYDGAIEQYGMDDAYPIDDLDEILPGLLEGRSHVYYHFGRDVEFDLRLIGWVNRVRDQVRYAAD
SPHEFIDLGHLLHEQRLFKSYDEIVLLQCAADISVEAHLAALRYAHPGVSEYVLQAELERVFRAADSCPAYTSIVAAGAN
ACVLHYCANAECSRDGDLVLIDAGAEYRGYAADITRTFPVNGRFSPAQRALYDLVGAAYDVALAQARPGLPYEAGHLSAV
QTLTEGLLRLGLLHGTLEDNLADQSYKRFYRHKTGHWLGLDVHDVGDYRIDGKSRLLEPGMVFTIEPGLYVLPDDTTVHP
KWRGIGIRTEDDVLITEDGHCVLTGVLPRSADEIEAEMAAVQ

Sequences:

>Translated_442_residues
MKKHTGIAPAEYGRRRRQLMKMVGPQGIVVLPAAPERVRSRDTHYPYRQDSDFWYLCGFPEPDAVLVLVPGRCHGQVLLF
CRERDPEREAWDGPRSGYDGAIEQYGMDDAYPIDDLDEILPGLLEGRSHVYYHFGRDVEFDLRLIGWVNRVRDQVRYAAD
SPHEFIDLGHLLHEQRLFKSYDEIVLLQCAADISVEAHLAALRYAHPGVSEYVLQAELERVFRAADSCPAYTSIVAAGAN
ACVLHYCANAECSRDGDLVLIDAGAEYRGYAADITRTFPVNGRFSPAQRALYDLVGAAYDVALAQARPGLPYEAGHLSAV
QTLTEGLLRLGLLHGTLEDNLADQSYKRFYRHKTGHWLGLDVHDVGDYRIDGKSRLLEPGMVFTIEPGLYVLPDDTTVHP
KWRGIGIRTEDDVLITEDGHCVLTGVLPRSADEIEAEMAAVQ
>Mature_442_residues
MKKHTGIAPAEYGRRRRQLMKMVGPQGIVVLPAAPERVRSRDTHYPYRQDSDFWYLCGFPEPDAVLVLVPGRCHGQVLLF
CRERDPEREAWDGPRSGYDGAIEQYGMDDAYPIDDLDEILPGLLEGRSHVYYHFGRDVEFDLRLIGWVNRVRDQVRYAAD
SPHEFIDLGHLLHEQRLFKSYDEIVLLQCAADISVEAHLAALRYAHPGVSEYVLQAELERVFRAADSCPAYTSIVAAGAN
ACVLHYCANAECSRDGDLVLIDAGAEYRGYAADITRTFPVNGRFSPAQRALYDLVGAAYDVALAQARPGLPYEAGHLSAV
QTLTEGLLRLGLLHGTLEDNLADQSYKRFYRHKTGHWLGLDVHDVGDYRIDGKSRLLEPGMVFTIEPGLYVLPDDTTVHP
KWRGIGIRTEDDVLITEDGHCVLTGVLPRSADEIEAEMAAVQ

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=444, Percent_Identity=36.2612612612613, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI149589008, Length=457, Percent_Identity=31.5098468271335, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI260593665, Length=301, Percent_Identity=35.2159468438538, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI260593663, Length=446, Percent_Identity=29.1479820627803, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1789275, Length=438, Percent_Identity=44.5205479452055, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1790282, Length=280, Percent_Identity=30.3571428571429, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788728, Length=254, Percent_Identity=31.1023622047244, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508215, Length=462, Percent_Identity=30.952380952381, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI71989583, Length=372, Percent_Identity=27.1505376344086, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320922, Length=450, Percent_Identity=30, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321118, Length=428, Percent_Identity=29.2056074766355, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI19920384, Length=457, Percent_Identity=35.2297592997812, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI21357079, Length=442, Percent_Identity=30.316742081448, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49477; Mature: 49477

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHTGIAPAEYGRRRRQLMKMVGPQGIVVLPAAPERVRSRDTHYPYRQDSDFWYLCGFP
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHCCCCCCCCCCCCCEEEECCCC
EPDAVLVLVPGRCHGQVLLFCRERDPEREAWDGPRSGYDGAIEQYGMDDAYPIDDLDEIL
CCCEEEEEECCCCCCEEEEEEECCCCCCHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHH
PGLLEGRSHVYYHFGRDVEFDLRLIGWVNRVRDQVRYAADSPHEFIDLGHLLHEQRLFKS
HHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YDEIVLLQCAADISVEAHLAALRYAHPGVSEYVLQAELERVFRAADSCPAYTSIVAAGAN
HCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
ACVLHYCANAECSRDGDLVLIDAGAEYRGYAADITRTFPVNGRFSPAQRALYDLVGAAYD
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHHHHHH
VALAQARPGLPYEAGHLSAVQTLTEGLLRLGLLHGTLEDNLADQSYKRFYRHKTGHWLGL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEE
DVHDVGDYRIDGKSRLLEPGMVFTIEPGLYVLPDDTTVHPKWRGIGIRTEDDVLITEDGH
EEECCCCEEECCHHHCCCCCEEEEECCCEEECCCCCEECCCCCCCCCCCCCCEEEECCCC
CVLTGVLPRSADEIEAEMAAVQ
EEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKKHTGIAPAEYGRRRRQLMKMVGPQGIVVLPAAPERVRSRDTHYPYRQDSDFWYLCGFP
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHCCCCCCCCCCCCCEEEECCCC
EPDAVLVLVPGRCHGQVLLFCRERDPEREAWDGPRSGYDGAIEQYGMDDAYPIDDLDEIL
CCCEEEEEECCCCCCEEEEEEECCCCCCHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHH
PGLLEGRSHVYYHFGRDVEFDLRLIGWVNRVRDQVRYAADSPHEFIDLGHLLHEQRLFKS
HHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YDEIVLLQCAADISVEAHLAALRYAHPGVSEYVLQAELERVFRAADSCPAYTSIVAAGAN
HCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
ACVLHYCANAECSRDGDLVLIDAGAEYRGYAADITRTFPVNGRFSPAQRALYDLVGAAYD
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHHHHHH
VALAQARPGLPYEAGHLSAVQTLTEGLLRLGLLHGTLEDNLADQSYKRFYRHKTGHWLGL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEE
DVHDVGDYRIDGKSRLLEPGMVFTIEPGLYVLPDDTTVHPKWRGIGIRTEDDVLITEDGH
EEECCCCEEECCHHHCCCCCEEEEECCCEEECCCCCEECCCCCCCCCCCCCCEEEECCCC
CVLTGVLPRSADEIEAEMAAVQ
EEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]