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The map label for this gene is fumC

Identifier: 182681360

GI number: 182681360

Start: 954332

End: 955741

Strand: Direct

Name: fumC

Synonym: XfasM23_0807

Alternate gene names: 182681360

Gene position: 954332-955741 (Clockwise)

Preceding gene: 182681359

Following gene: 182681363

Centisome position: 37.64

GC content: 53.4

Gene sequence:

>1410_bases
ATGAGCAACAGTGATCGTTACAGAATTGAACACGACAGTATGGGTGATCTACGGGTGCCGATTGATGCGTTGTGGGGCGC
GCAGACGCAACGTGCTATCGAGAACTTTCCGATTTCCGGGCGGTCAATGCCTCAGGGATTTATCCACGCATTGGGGTTTA
TCAAGGCGGCTGCGGCGAAGGTTAACGCTGAGCTGGGGCTGTTACCAAAGTCAATGGCCAAGGAGATTGAGGCCGCTGCA
TTGGATGTCGCTGCGGGCCGTTATGATGCGGAATTTCCAGTCGATATTTACCAGACTGGCTCAGGAACCTCGTCGAATAT
GAACGCTAATGAGGTGATTGCGACGCTGGCCATGCGTGCCACCAAGGGGCCTATCCACCCCAACGACCATGTCAACCTTG
GCCAAAGTTCTAATGATGTGGTTCCAACAGCGATTCGGATTTCCGCAACGTTGGCGGTTCAGGGACGATTATTACCAGCG
CTCAAGCATTTACGCAAAATGATTAACAAGCGTGCCCGTGGTTTGGGCAGTGTGGTGAAGACCGGCCGTACCCACCTGAT
GGATGCGATGCCGCTGACGTTCGCTCAAGAATTCGGTGCCTGGTCGGCACAAATTGTCTCTGCAGAGGCGCGCTTGAATG
ACACCCTGAAACGGTTGCATCGGCTGCCATTGGGAGGGACAGCAATTGGTACCGGCATCAATACGGATCCACATTTCGGC
CGTAATGCGGTGAAGGTACTGTCAGCATTGACAGGGATTCACTTTGAGAGTGCGAACAATAAGTTCGAAGGATTGGCAGC
GCAAGATGATTTGGTTGAGTTATCCGGCCAGTTCAATACGTTAGCAGTGGCGTTGATGAAGATTGCTAATGATCTACGCT
GGATGAACGCTGGACCGCTTGCTGGCTTGGGAGAGATTGAGTTGCCCGCGTTGCAGCCGGGAAGTTCGATCATGCCAGGT
AAGGTAAACCCGGTGATTCCGGAAGCAGTGGTGATGGTCGCCTCGCAAGTGATTGGCCATCACACTGCAGTGACCGTGGC
TGGGCAGAGTGGCAATTTTCAGTTGAATGTGACGTTACCGCTGATTGCTTACAACCTATTGGAGTCTGCGACGTTGCTTG
GAAATGTGGTGATGCTGTTGGCTGATAAAGTCATCGTTGGCCTGAAGGTGCGTCAGGATCGAGTGCAGGAGGTGCTGGAG
CGGAATCCGATTTTGGTGACAGCGTTGAATCCGATCATTGGCTATGAGAAAGCTGCGGTGATTGCTAAGCGTGCTTATAA
GGAGCACCGGCCAGTGCTTGAGGTCGCCTGCGAGGAGAGCAACCTAAACCCTGTGGAGTTGGCGCGCTTACTTGATCCGG
CTGCGTTGACTGAGGGTGGGATTCATGTCGTCGGGGGAGGTGGTGGATAA

Upstream 100 bases:

>100_bases
ATTAAGGGAGTATCTTGCGGGTGTGCTGTCAATTCATGAGTGCAGTTTTTGTCGCTTTTCCGTTCCGTATCAAGCGGAAC
ACTGATCCGTGGAGATGCAG

Downstream 100 bases:

>100_bases
GACATGTTGCTGGAGGCTTTGTGTCATCACATTGGCGGATGCGGATGTTGCATCAATAATCGACCCAATTAATGCATGAA
TATCTAATATAATCAATGAA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSNSDRYRIEHDSMGDLRVPIDALWGAQTQRAIENFPISGRSMPQGFIHALGFIKAAAAKVNAELGLLPKSMAKEIEAAA
LDVAAGRYDAEFPVDIYQTGSGTSSNMNANEVIATLAMRATKGPIHPNDHVNLGQSSNDVVPTAIRISATLAVQGRLLPA
LKHLRKMINKRARGLGSVVKTGRTHLMDAMPLTFAQEFGAWSAQIVSAEARLNDTLKRLHRLPLGGTAIGTGINTDPHFG
RNAVKVLSALTGIHFESANNKFEGLAAQDDLVELSGQFNTLAVALMKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPG
KVNPVIPEAVVMVASQVIGHHTAVTVAGQSGNFQLNVTLPLIAYNLLESATLLGNVVMLLADKVIVGLKVRQDRVQEVLE
RNPILVTALNPIIGYEKAAVIAKRAYKEHRPVLEVACEESNLNPVELARLLDPAALTEGGIHVVGGGGG

Sequences:

>Translated_469_residues
MSNSDRYRIEHDSMGDLRVPIDALWGAQTQRAIENFPISGRSMPQGFIHALGFIKAAAAKVNAELGLLPKSMAKEIEAAA
LDVAAGRYDAEFPVDIYQTGSGTSSNMNANEVIATLAMRATKGPIHPNDHVNLGQSSNDVVPTAIRISATLAVQGRLLPA
LKHLRKMINKRARGLGSVVKTGRTHLMDAMPLTFAQEFGAWSAQIVSAEARLNDTLKRLHRLPLGGTAIGTGINTDPHFG
RNAVKVLSALTGIHFESANNKFEGLAAQDDLVELSGQFNTLAVALMKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPG
KVNPVIPEAVVMVASQVIGHHTAVTVAGQSGNFQLNVTLPLIAYNLLESATLLGNVVMLLADKVIVGLKVRQDRVQEVLE
RNPILVTALNPIIGYEKAAVIAKRAYKEHRPVLEVACEESNLNPVELARLLDPAALTEGGIHVVGGGGG
>Mature_468_residues
SNSDRYRIEHDSMGDLRVPIDALWGAQTQRAIENFPISGRSMPQGFIHALGFIKAAAAKVNAELGLLPKSMAKEIEAAAL
DVAAGRYDAEFPVDIYQTGSGTSSNMNANEVIATLAMRATKGPIHPNDHVNLGQSSNDVVPTAIRISATLAVQGRLLPAL
KHLRKMINKRARGLGSVVKTGRTHLMDAMPLTFAQEFGAWSAQIVSAEARLNDTLKRLHRLPLGGTAIGTGINTDPHFGR
NAVKVLSALTGIHFESANNKFEGLAAQDDLVELSGQFNTLAVALMKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPGK
VNPVIPEAVVMVASQVIGHHTAVTVAGQSGNFQLNVTLPLIAYNLLESATLLGNVVMLLADKVIVGLKVRQDRVQEVLER
NPILVTALNPIIGYEKAAVIAKRAYKEHRPVLEVACEESNLNPVELARLLDPAALTEGGIHVVGGGGG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=46.4208242950108, Blast_Score=406, Evalue=1e-113,
Organism=Escherichia coli, GI1787896, Length=427, Percent_Identity=48.711943793911, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI87082375, Length=453, Percent_Identity=40.8388520971302, Blast_Score=287, Evalue=9e-79,
Organism=Escherichia coli, GI1790398, Length=273, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17553882, Length=456, Percent_Identity=47.1491228070175, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI32565146, Length=321, Percent_Identity=46.417445482866, Blast_Score=293, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6324993, Length=454, Percent_Identity=44.7136563876652, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6321806, Length=338, Percent_Identity=26.3313609467456, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI78710009, Length=440, Percent_Identity=46.8181818181818, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24640179, Length=433, Percent_Identity=47.1131639722864, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24640177, Length=433, Percent_Identity=47.1131639722864, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24662684, Length=430, Percent_Identity=46.5116279069767, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=40.997830802603, Blast_Score=373, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49892; Mature: 49761

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSDRYRIEHDSMGDLRVPIDALWGAQTQRAIENFPISGRSMPQGFIHALGFIKAAAAK
CCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
VNAELGLLPKSMAKEIEAAALDVAAGRYDAEFPVDIYQTGSGTSSNMNANEVIATLAMRA
HCCHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
TKGPIHPNDHVNLGQSSNDVVPTAIRISATLAVQGRLLPALKHLRKMINKRARGLGSVVK
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
TGRTHLMDAMPLTFAQEFGAWSAQIVSAEARLNDTLKRLHRLPLGGTAIGTGINTDPHFG
CCHHHHHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCC
RNAVKVLSALTGIHFESANNKFEGLAAQDDLVELSGQFNTLAVALMKIANDLRWMNAGPL
HHHHHHHHHHHCCEEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
AGLGEIELPALQPGSSIMPGKVNPVIPEAVVMVASQVIGHHTAVTVAGQSGNFQLNVTLP
CCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEHH
LIAYNLLESATLLGNVVMLLADKVIVGLKVRQDRVQEVLERNPILVTALNPIIGYEKAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHCCCEEEEECCHHHCCHHHHH
IAKRAYKEHRPVLEVACEESNLNPVELARLLDPAALTEGGIHVVGGGGG
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCHHHHCCCCEEEEECCCC
>Mature Secondary Structure 
SNSDRYRIEHDSMGDLRVPIDALWGAQTQRAIENFPISGRSMPQGFIHALGFIKAAAAK
CCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
VNAELGLLPKSMAKEIEAAALDVAAGRYDAEFPVDIYQTGSGTSSNMNANEVIATLAMRA
HCCHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
TKGPIHPNDHVNLGQSSNDVVPTAIRISATLAVQGRLLPALKHLRKMINKRARGLGSVVK
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
TGRTHLMDAMPLTFAQEFGAWSAQIVSAEARLNDTLKRLHRLPLGGTAIGTGINTDPHFG
CCHHHHHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCC
RNAVKVLSALTGIHFESANNKFEGLAAQDDLVELSGQFNTLAVALMKIANDLRWMNAGPL
HHHHHHHHHHHCCEEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
AGLGEIELPALQPGSSIMPGKVNPVIPEAVVMVASQVIGHHTAVTVAGQSGNFQLNVTLP
CCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEHH
LIAYNLLESATLLGNVVMLLADKVIVGLKVRQDRVQEVLERNPILVTALNPIIGYEKAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHCCCEEEEECCHHHCCHHHHH
IAKRAYKEHRPVLEVACEESNLNPVELARLLDPAALTEGGIHVVGGGGG
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]