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The map label for this gene is czcD [H]

Identifier: 182680567

GI number: 182680567

Start: 4163989

End: 4164978

Strand: Reverse

Name: czcD [H]

Synonym: Bind_3672

Alternate gene names: 182680567

Gene position: 4164978-4163989 (Counterclockwise)

Preceding gene: 182680568

Following gene: 182680560

Centisome position: 99.88

GC content: 58.08

Gene sequence:

>990_bases
ATGTCTGATCGTCAAGGGCCGCCGCACGCGCATCACACGATTTCACAAGCGTCCTCCACCCCGCTTCATGACCATGATGC
CCATGATCATGGTCATGAACACCATATGCATGCAGTTACTGATTATGGCCGGCGTTTCATCATCGGCATCGGCCTCAATA
TTTTGATCGTGGTCCTGGAAGTCCTGTTCGGTTTCCTTGGCAATTCGGTCGCCCTCATCGCCGATGCCGGGCATAATCTG
TCCGATGTGTTGAGTCTCGTCATGGCCTATGCCGCCCATCGGCTCGCCAAGCGTCCACCCTCCGCGCGCTACACTTATGG
ACTGCATGGTTTCTCGATTCTCGCGGCTTTGTTCAATGCCGTGGCGCTGCTCCTCGTGAGCGGCGCCTTGAGCTGGGAAT
CGCTTCGGCGCCTGTTCACGCCGGAACCCGTCACGGCTTCCCTCATGATGGGCATGGCCCTGGCTGGCATGATCATCAAT
GCGTTGACAGCGGCGCTTTTCATTTCGGGTAGCAAAGAGGATTTGAATATCAGGGGCGCTTTCCTGCACATGGCCTCCGA
CGCGCTGATTTCGGCGGGCGTGCTCATTGGTGGATTGCTGATTGCCCTCACCGGCCTTCTCTGGCTCGATCCAGCCATCA
GCCTCCTCATCAATGCGGTGATTATTCTCGGCACATGGTCCCTGCTCCGCGAGAGCCTCGCCATGTCCTTGAATGCGGTT
CCCTCCGGCATCGAGACCGAGACGGTGCGCGCTTATCTGCTCTCCCTACCCGGCGTCCAAGGGCTACATGATCTGCATAT
CTGGCCGGTTTCAACCAGCGAGACCGCCTTAACCGCGCATGTCCTCATGCCCGGGGGACATCCTGGCGATGAATTTTTGA
TGCGGACCAGCGCCGAATTGCGCGATCATTATCGCATCGGCCACGTGACTTTGCAGATCGAGAGCGATGGGGCAACTCTG
TGTGCCCTCGCGCCCGATCATGTCGTTTGA

Upstream 100 bases:

>100_bases
ATTTCGTTGAATCAACCTCCCACTCGTCATAGAACCAGACTGTAAAACAGTTTTCGTCTGAGGGACGAGGAGAAGGCGAT
GCGGATGCGTGGGATGGGTG

Downstream 100 bases:

>100_bases
TGCATCAGATCAGCGGTGCGGCCCAGACGACGATCTGCTGCATCACCTGACTGAGCGCCTGATCGAGCGCCGCCGTAGCG
CTCGCGCCATCATCATGCAC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSDRQGPPHAHHTISQASSTPLHDHDAHDHGHEHHMHAVTDYGRRFIIGIGLNILIVVLEVLFGFLGNSVALIADAGHNL
SDVLSLVMAYAAHRLAKRPPSARYTYGLHGFSILAALFNAVALLLVSGALSWESLRRLFTPEPVTASLMMGMALAGMIIN
ALTAALFISGSKEDLNIRGAFLHMASDALISAGVLIGGLLIALTGLLWLDPAISLLINAVIILGTWSLLRESLAMSLNAV
PSGIETETVRAYLLSLPGVQGLHDLHIWPVSTSETALTAHVLMPGGHPGDEFLMRTSAELRDHYRIGHVTLQIESDGATL
CALAPDHVV

Sequences:

>Translated_329_residues
MSDRQGPPHAHHTISQASSTPLHDHDAHDHGHEHHMHAVTDYGRRFIIGIGLNILIVVLEVLFGFLGNSVALIADAGHNL
SDVLSLVMAYAAHRLAKRPPSARYTYGLHGFSILAALFNAVALLLVSGALSWESLRRLFTPEPVTASLMMGMALAGMIIN
ALTAALFISGSKEDLNIRGAFLHMASDALISAGVLIGGLLIALTGLLWLDPAISLLINAVIILGTWSLLRESLAMSLNAV
PSGIETETVRAYLLSLPGVQGLHDLHIWPVSTSETALTAHVLMPGGHPGDEFLMRTSAELRDHYRIGHVTLQIESDGATL
CALAPDHVV
>Mature_328_residues
SDRQGPPHAHHTISQASSTPLHDHDAHDHGHEHHMHAVTDYGRRFIIGIGLNILIVVLEVLFGFLGNSVALIADAGHNLS
DVLSLVMAYAAHRLAKRPPSARYTYGLHGFSILAALFNAVALLLVSGALSWESLRRLFTPEPVTASLMMGMALAGMIINA
LTAALFISGSKEDLNIRGAFLHMASDALISAGVLIGGLLIALTGLLWLDPAISLLINAVIILGTWSLLRESLAMSLNAVP
SGIETETVRAYLLSLPGVQGLHDLHIWPVSTSETALTAHVLMPGGHPGDEFLMRTSAELRDHYRIGHVTLQIESDGATLC
ALAPDHVV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=286, Percent_Identity=26.9230769230769, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI289803013, Length=288, Percent_Identity=26.0416666666667, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI289803009, Length=288, Percent_Identity=26.0416666666667, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI289803007, Length=288, Percent_Identity=26.0416666666667, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI289803003, Length=288, Percent_Identity=26.0416666666667, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI64762489, Length=288, Percent_Identity=26.0416666666667, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI21359890, Length=300, Percent_Identity=22.6666666666667, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI21361112, Length=298, Percent_Identity=28.1879194630872, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI14210520, Length=218, Percent_Identity=27.5229357798165, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI52351208, Length=157, Percent_Identity=29.2993630573248, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786966, Length=276, Percent_Identity=36.231884057971, Blast_Score=155, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI193210990, Length=339, Percent_Identity=26.8436578171091, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17555794, Length=307, Percent_Identity=26.3843648208469, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17555796, Length=283, Percent_Identity=27.208480565371, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32564488, Length=298, Percent_Identity=27.5167785234899, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323899, Length=131, Percent_Identity=37.4045801526718, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=125, Percent_Identity=37.6, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=167, Percent_Identity=30.5389221556886, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583858, Length=348, Percent_Identity=25.5747126436782, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24585900, Length=154, Percent_Identity=31.1688311688312, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585898, Length=154, Percent_Identity=31.1688311688312, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585896, Length=154, Percent_Identity=31.1688311688312, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921672, Length=154, Percent_Identity=31.1688311688312, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35156; Mature: 35025

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRQGPPHAHHTISQASSTPLHDHDAHDHGHEHHMHAVTDYGRRFIIGIGLNILIVVLE
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHH
VLFGFLGNSVALIADAGHNLSDVLSLVMAYAAHRLAKRPPSARYTYGLHGFSILAALFNA
HHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHH
VALLLVSGALSWESLRRLFTPEPVTASLMMGMALAGMIINALTAALFISGSKEDLNIRGA
HHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
FLHMASDALISAGVLIGGLLIALTGLLWLDPAISLLINAVIILGTWSLLRESLAMSLNAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PSGIETETVRAYLLSLPGVQGLHDLHIWPVSTSETALTAHVLMPGGHPGDEFLMRTSAEL
CCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
RDHYRIGHVTLQIESDGATLCALAPDHVV
HHCEEEEEEEEEEECCCCEEEECCCCCCC
>Mature Secondary Structure 
SDRQGPPHAHHTISQASSTPLHDHDAHDHGHEHHMHAVTDYGRRFIIGIGLNILIVVLE
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHH
VLFGFLGNSVALIADAGHNLSDVLSLVMAYAAHRLAKRPPSARYTYGLHGFSILAALFNA
HHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHH
VALLLVSGALSWESLRRLFTPEPVTASLMMGMALAGMIINALTAALFISGSKEDLNIRGA
HHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
FLHMASDALISAGVLIGGLLIALTGLLWLDPAISLLINAVIILGTWSLLRESLAMSLNAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PSGIETETVRAYLLSLPGVQGLHDLHIWPVSTSETALTAHVLMPGGHPGDEFLMRTSAEL
CCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
RDHYRIGHVTLQIESDGATLCALAPDHVV
HHCEEEEEEEEEEECCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]