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The map label for this gene is hisN [H]

Identifier: 182680537

GI number: 182680537

Start: 4131637

End: 4132440

Strand: Reverse

Name: hisN [H]

Synonym: Bind_3642

Alternate gene names: 182680537

Gene position: 4132440-4131637 (Counterclockwise)

Preceding gene: 182680538

Following gene: 182680530

Centisome position: 99.1

GC content: 61.94

Gene sequence:

>804_bases
ATGTCCGCCGTCGATTTTGCCGCCTTCGTCGAAAAGCTCGCCGACGCCGCCAGTGAGGCTGTGCTGCCTTTCTTTCGCAC
CTCTCTCGGCGCGATCGACAAGAATGCTGGCGGCCCCTTCGATCCGGTGACCGAGGCCGATCATGCCGCCGAAAGCGCGA
TGCGGCAGTTGATAGAGATGACTTTTCCGCGGCATGGCATCATCGGCGAGGAATTCGGCACCATCCGGGAAGATGCAGAA
TATGTCTGGGTCCTCGATCCGATCGATGGCACCAAAAGTTTCATCGCCGGCATGCCAATATGGGGGACGTTGATCGGGCT
CCTGCACCACGGCCAGCCGATCTATGGGATGATGGCCCAGCCCTTCATCCGCGAACGTTTTGCCGGCGATGGCCAACATG
CCGAGTGGCGCGGCCCCGGTATCGATCTCGCACTGATAAAACGCACCCTGCGCGCGCGCACCTGCGCTTCGCTTGCCGAT
GCAATCCTCATGACGACCTCTCCGCTGCTCTATGAACCCGCCAAGCTCGAAGCCTTCCGCCGGGTCGAGGCAGAGGTTCG
CCTCTCGCGCTATGGCTGCGATTGCTATGCCTTCGCCATGCTGGCGGCGGGTCACGTCGATTGCGTCATCGAATCCGGCC
TCAAGCCCTATGATATCGCACCCCTCGTTCCGATCATCCGTGGCGCGGGCGGCTGCGTCACGACCTGGGAGGGTGGCGAG
CCAGCGCAGGGCGGCGATATCGTGGCCTCCGGTTGTGCAGCCTTGCATGATCAGGTCCTGTCTCTTCTGCGTCAGAGATC
ATGA

Upstream 100 bases:

>100_bases
CTGAAAAGCCTTCGGGCATTTGCTATGGGTTTCGAGAGCTGCGCCGCTCGCGCTTTTTGTTCGCGCGCTCTCCGCAATGT
CCGCATGGAAAGGTTGTCTT

Downstream 100 bases:

>100_bases
GTGCGCCTGAAGAGGGACCATCCGCAAAATCAAACGGCTGTCTGGACGATGAGCGGCTCGTCCCGTGGTTTCAACACCTC
TTCTGGCGAACCGAGAATGA

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSAVDFAAFVEKLADAASEAVLPFFRTSLGAIDKNAGGPFDPVTEADHAAESAMRQLIEMTFPRHGIIGEEFGTIREDAE
YVWVLDPIDGTKSFIAGMPIWGTLIGLLHHGQPIYGMMAQPFIRERFAGDGQHAEWRGPGIDLALIKRTLRARTCASLAD
AILMTTSPLLYEPAKLEAFRRVEAEVRLSRYGCDCYAFAMLAAGHVDCVIESGLKPYDIAPLVPIIRGAGGCVTTWEGGE
PAQGGDIVASGCAALHDQVLSLLRQRS

Sequences:

>Translated_267_residues
MSAVDFAAFVEKLADAASEAVLPFFRTSLGAIDKNAGGPFDPVTEADHAAESAMRQLIEMTFPRHGIIGEEFGTIREDAE
YVWVLDPIDGTKSFIAGMPIWGTLIGLLHHGQPIYGMMAQPFIRERFAGDGQHAEWRGPGIDLALIKRTLRARTCASLAD
AILMTTSPLLYEPAKLEAFRRVEAEVRLSRYGCDCYAFAMLAAGHVDCVIESGLKPYDIAPLVPIIRGAGGCVTTWEGGE
PAQGGDIVASGCAALHDQVLSLLRQRS
>Mature_266_residues
SAVDFAAFVEKLADAASEAVLPFFRTSLGAIDKNAGGPFDPVTEADHAAESAMRQLIEMTFPRHGIIGEEFGTIREDAEY
VWVLDPIDGTKSFIAGMPIWGTLIGLLHHGQPIYGMMAQPFIRERFAGDGQHAEWRGPGIDLALIKRTLRARTCASLADA
ILMTTSPLLYEPAKLEAFRRVEAEVRLSRYGCDCYAFAMLAAGHVDCVIESGLKPYDIAPLVPIIRGAGGCVTTWEGGEP
AQGGDIVASGCAALHDQVLSLLRQRS

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788882, Length=226, Percent_Identity=32.3008849557522, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193202570, Length=235, Percent_Identity=27.2340425531915, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193202572, Length=241, Percent_Identity=25.7261410788382, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357957, Length=270, Percent_Identity=26.2962962962963, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664918, Length=270, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24664926, Length=232, Percent_Identity=25.8620689655172, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357329, Length=212, Percent_Identity=27.3584905660377, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28805; Mature: 28674

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVDFAAFVEKLADAASEAVLPFFRTSLGAIDKNAGGPFDPVTEADHAAESAMRQLIEM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TFPRHGIIGEEFGTIREDAEYVWVLDPIDGTKSFIAGMPIWGTLIGLLHHGQPIYGMMAQ
HCCCCCCCCHHHCCHHCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
PFIRERFAGDGQHAEWRGPGIDLALIKRTLRARTCASLADAILMTTSPLLYEPAKLEAFR
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHH
RVEAEVRLSRYGCDCYAFAMLAAGHVDCVIESGLKPYDIAPLVPIIRGAGGCVTTWEGGE
HHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEECCCCC
PAQGGDIVASGCAALHDQVLSLLRQRS
CCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAVDFAAFVEKLADAASEAVLPFFRTSLGAIDKNAGGPFDPVTEADHAAESAMRQLIEM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TFPRHGIIGEEFGTIREDAEYVWVLDPIDGTKSFIAGMPIWGTLIGLLHHGQPIYGMMAQ
HCCCCCCCCHHHCCHHCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
PFIRERFAGDGQHAEWRGPGIDLALIKRTLRARTCASLADAILMTTSPLLYEPAKLEAFR
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHH
RVEAEVRLSRYGCDCYAFAMLAAGHVDCVIESGLKPYDIAPLVPIIRGAGGCVTTWEGGE
HHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEECCCCC
PAQGGDIVASGCAALHDQVLSLLRQRS
CCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]