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The map label for this gene is hemH [H]

Identifier: 182680376

GI number: 182680376

Start: 3951741

End: 3952802

Strand: Reverse

Name: hemH [H]

Synonym: Bind_3476

Alternate gene names: 182680376

Gene position: 3952802-3951741 (Counterclockwise)

Preceding gene: 182680377

Following gene: 182680368

Centisome position: 94.79

GC content: 60.64

Gene sequence:

>1062_bases
ATGAAACCCCTTGCCGCTTCTACGACGAAAGCGCGTCTGACGGACCGAATCGGTGTTCTGCTTGTCAATCTCGGAACGCC
GGATGCGACCGATTACTGGTCCATGCGCCGTTATCTCCGCGAATTCCTGTCCGACCGCCGGGTGGTCGAACTGCCGCGCT
GGGTCTGGTGGCCAATCCTGCATGGGATTATCCTCACCACGCGCCCGCATCGGAGCGGACGCCGCTATGCCGGGATCTGG
GACAAGGAGCGTAACGAGAGCCCGCTCAAAACCATCACCCGCGCGCAAGGGGAACTCCTGGCTCGTTCGATTGGCGCCTC
ATCCGCGCCAGGGGACGGAAAAGCGCAAGATATCGTGATTGATTTCGCGATGCGATATGGCAATCCTTCGATCGCTTCGG
GTCTCGATCGCCTGTTGCAACAGAATTGCGGCCGCATTCTTGTCGTGCCGCTCTATCCGCAATATGCAGCGGCGACCACG
GCGAGCGTCGCGGATAAGGTTTTCGAGATTTTGCGGGCGCGGCGCTGGCAGCCGGCCTTGCGGATTGCACCCCCCTATTA
TGCCGAGCCCTTCTATATAGAAGCCTTGGCGCGTTCCGTGCGGCGCGGTCTCGCCGGGCTTGATTTCGAGCCGGACGCGA
TCCTTTTGTCTTTTCACGGCATTCCGAAATCCTCCGTCGACAAGGGCGATCCCTATTATGAGCATTGCCTGATCACGGCG
GATTTGTTGCGGCAAGCCCTGGGTCTCGACGAGGCGCATTGCGTGACGACTTTTCAATCCCGCTTCGGCCGCGCCGAATG
GATCGGACCCGCGACCGATGCGACGGTGAAAGCTTTGGCCGCGCGAGGTGTCAAAAAACTGGCTGTCGTCATGCCAGGTT
TTGCCGCCGATTGCCTGGAAACAATCGAGGAAGTGGGCGGGGAGATCCGCGCCTTATTCCTGGGCGCGGGGGGCGAGGAT
TATGCCGCGCTCCCCTGCCTCAACGCGAGCGAGGAGGGCATGGAGGTTATTGCCCGGCTGGTTCGGCGTGAATTGCAAGG
CTGGCTGACCTCAACAGATTAG

Upstream 100 bases:

>100_bases
ATGACCCGTCGCTCCACGCCCTTGGCCTCGACAACGGTCGAATGGCTGGCGTCCCTTCTGCCCCAATCGACGGCCTCATA
AGCGGGAATTGAGTGTGAGT

Downstream 100 bases:

>100_bases
TCACGTCCCGCGATTGCCAGCACGCTGGCGTCCCTCGCTCACCCAGGTCAGGATGAACGCGCTCAACAGCACGGCAAGCC
CGAGGAAGCCAATGGCCAAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKPLAASTTKARLTDRIGVLLVNLGTPDATDYWSMRRYLREFLSDRRVVELPRWVWWPILHGIILTTRPHRSGRRYAGIW
DKERNESPLKTITRAQGELLARSIGASSAPGDGKAQDIVIDFAMRYGNPSIASGLDRLLQQNCGRILVVPLYPQYAAATT
ASVADKVFEILRARRWQPALRIAPPYYAEPFYIEALARSVRRGLAGLDFEPDAILLSFHGIPKSSVDKGDPYYEHCLITA
DLLRQALGLDEAHCVTTFQSRFGRAEWIGPATDATVKALAARGVKKLAVVMPGFAADCLETIEEVGGEIRALFLGAGGED
YAALPCLNASEEGMEVIARLVRRELQGWLTSTD

Sequences:

>Translated_353_residues
MKPLAASTTKARLTDRIGVLLVNLGTPDATDYWSMRRYLREFLSDRRVVELPRWVWWPILHGIILTTRPHRSGRRYAGIW
DKERNESPLKTITRAQGELLARSIGASSAPGDGKAQDIVIDFAMRYGNPSIASGLDRLLQQNCGRILVVPLYPQYAAATT
ASVADKVFEILRARRWQPALRIAPPYYAEPFYIEALARSVRRGLAGLDFEPDAILLSFHGIPKSSVDKGDPYYEHCLITA
DLLRQALGLDEAHCVTTFQSRFGRAEWIGPATDATVKALAARGVKKLAVVMPGFAADCLETIEEVGGEIRALFLGAGGED
YAALPCLNASEEGMEVIARLVRRELQGWLTSTD
>Mature_353_residues
MKPLAASTTKARLTDRIGVLLVNLGTPDATDYWSMRRYLREFLSDRRVVELPRWVWWPILHGIILTTRPHRSGRRYAGIW
DKERNESPLKTITRAQGELLARSIGASSAPGDGKAQDIVIDFAMRYGNPSIASGLDRLLQQNCGRILVVPLYPQYAAATT
ASVADKVFEILRARRWQPALRIAPPYYAEPFYIEALARSVRRGLAGLDFEPDAILLSFHGIPKSSVDKGDPYYEHCLITA
DLLRQALGLDEAHCVTTFQSRFGRAEWIGPATDATVKALAARGVKKLAVVMPGFAADCLETIEEVGGEIRALFLGAGGED
YAALPCLNASEEGMEVIARLVRRELQGWLTSTD

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=294, Percent_Identity=25.5102040816327, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI60499021, Length=294, Percent_Identity=25.5102040816327, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786681, Length=326, Percent_Identity=43.2515337423313, Blast_Score=256, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17864156, Length=301, Percent_Identity=25.5813953488372, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24651774, Length=271, Percent_Identity=24.7232472324723, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39066; Mature: 39066

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLAASTTKARLTDRIGVLLVNLGTPDATDYWSMRRYLREFLSDRRVVELPRWVWWPIL
CCCCCCCCHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHH
HGIILTTRPHRSGRRYAGIWDKERNESPLKTITRAQGELLARSIGASSAPGDGKAQDIVI
HCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
DFAMRYGNPSIASGLDRLLQQNCGRILVVPLYPQYAAATTASVADKVFEILRARRWQPAL
HHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCE
RIAPPYYAEPFYIEALARSVRRGLAGLDFEPDAILLSFHGIPKSSVDKGDPYYEHCLITA
EECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHH
DLLRQALGLDEAHCVTTFQSRFGRAEWIGPATDATVKALAARGVKKLAVVMPGFAADCLE
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHHCCCHHHHHHH
TIEEVGGEIRALFLGAGGEDYAALPCLNASEEGMEVIARLVRRELQGWLTSTD
HHHHHCCCEEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKPLAASTTKARLTDRIGVLLVNLGTPDATDYWSMRRYLREFLSDRRVVELPRWVWWPIL
CCCCCCCCHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHH
HGIILTTRPHRSGRRYAGIWDKERNESPLKTITRAQGELLARSIGASSAPGDGKAQDIVI
HCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
DFAMRYGNPSIASGLDRLLQQNCGRILVVPLYPQYAAATTASVADKVFEILRARRWQPAL
HHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCE
RIAPPYYAEPFYIEALARSVRRGLAGLDFEPDAILLSFHGIPKSSVDKGDPYYEHCLITA
EECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHH
DLLRQALGLDEAHCVTTFQSRFGRAEWIGPATDATVKALAARGVKKLAVVMPGFAADCLE
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHHCCCHHHHHHH
TIEEVGGEIRALFLGAGGEDYAALPCLNASEEGMEVIARLVRRELQGWLTSTD
HHHHHCCCEEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA