Click here to switch to the map view.

The map label for this gene is groEL [H]

Identifier: 182680293

GI number: 182680293

Start: 3852790

End: 3854433

Strand: Reverse

Name: groEL [H]

Synonym: Bind_3393

Alternate gene names: 182680293

Gene position: 3854433-3852790 (Counterclockwise)

Preceding gene: 182680294

Following gene: 182680292

Centisome position: 92.43

GC content: 60.95

Gene sequence:

>1644_bases
ATGGTCAAGCTGATGTTGCATGGGGCTGAAGCACGCGCTGCTTTGGCGCAGGGCGTAGGTAAACTCACGGCCGCCGTGGG
CGGCACGCTGGGCCCGCGTGGCTTGAATGCGATCATTGATCGACCGGTCGGCGCGCCGATCATATCGCGCGACGGGGTCA
GCATCGCGGAGGAGATCGAGCTTCCGTGCCGCTTTGAAAATCTTGGCGCGCAGGTCGTCCGGCAAGTCTCGAAACAGACC
GAGACGGTCGCGGGTGATGGCACGACCACCGCGGTTGTTCTTGCCAATGCGCTGATCCAGGAGGGCGTCGGCCTTCTGGC
CTCGGGGGGAGCCGTGGCGGTTGATCTCATCCAGGGACTCGACGAAGCCGAGGAAGCGATGATCGAGGCACTGGTTGCGG
AGGCCAGGCCGCTTTCTGGCGGGCGCGAATTACGCTGCATCACCACCATTGCGGGCAATGATCGCATTGTTGGCGATTTG
TCGGCGAAGGCTCTGGAAGCGGTGGGCAGTGAGGGGCTCATCACTGTCGAGGATGGTCCTGATTGGCGTGATACACTTGA
GATCCTCGAAGGCTTTACCTTTGATCGCGGTTATGTCTCCCACCATATGATCACCGATGTTCCGACCATGCGGGCCGTGC
TCAACGACGCCTATATTTTCTTGACGGATCAGAAGATCAGACGGTTCGAGGAGATTGCTTCCCTCGTTGACACCCTTGTT
GCGAAGGATGCTTGCCTCCTTATTCTGGCCGAGGAAGTGGATGCGACGGTGCTCGTCGGTTTGCTTGCGACACAGACCAA
GGGACGCGGCCGTTTCGTCGTGGTCAATCCGCCGGATTTCGGTCATTGGCGCAAAGCGATGATGGAGGATATCGGCATTC
TGACCGGTGGCCGCGTGATCTCCGGTGATCTCGGCCATAGCCTGGCGCAAACGCGCCTCGAGGATCTTGGCCGTGCCGAA
AAGGTCATCGTCTCCCAATTCGAAACGATGATCCTCAAGGGGCACGGATCGCCTGAGGCCGTCGTGGCGCGCCGCGCGCA
GATCCAACAACAGCTGGATCAAGCGCCGCAAAATGTCGAACGCGACAAACTCGATGAGCGCATGTCGAAAATGACCTCTG
GCACGGTGCGGATTCTGGCTGGCGGCGCGACGCCCGCCGAACGTCGCCGCCGCGTCCAATTGTTTGATGATGCGCTCTGT
GCGGGGCGGGCTGCTCTGCGGGATGGCATTGTTTCAGGGGGCGGGACCACTTTGGTTCAGCTCGCCTCCCAGCTCGCGCC
GAAAGCCAATGGCAAGACCGAACCGTCCGTCTTGAAAGGGCTTGAATTGTTCCGCTCGGCCATGCGCCGCCCGTTGGCGC
AAATCGCGGAAAATGCTGGCCGTGATCCCATTTTGGTGGTGGAGACCGTCCGTCAAGCCCCCAAGGGCACGGGTTTTGAC
GCCCGCACCAATAAATTCGTCGATATGTTCGAGGCGGGTATCATCGACCCCGTGCGTGTCACGATCACCTCGGTGCGCAA
TGCAACCTCCTCGGCCAAGATGATCCTCGGCACCAATTCGCTGATCATCGACAAGCCGGAATTCGTCGATCCAACCGCGG
GCCCCGCGCGCGGTGGAGGAGGGGAATTGCTCGGCCGCGCCTGA

Upstream 100 bases:

>100_bases
CGAAATCAGCGTATTCGATTGTTCCAGATGACCTTTGCCATAACGACAACAATTAATAATGACAATGATCGAAAATTCGA
TCAAAAATTCGGGAGGGAAC

Downstream 100 bases:

>100_bases
GGCCGCTCCGAGAGGAAGGACGATCGAAGAGGATCGAAATCAAAGAAAGACGAGTATTTTCGCGGGAATAGGGTGGTCAG
GCCGCTCTCTCCCGCGCATG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 4; Protein Cpn60 4 [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MVKLMLHGAEARAALAQGVGKLTAAVGGTLGPRGLNAIIDRPVGAPIISRDGVSIAEEIELPCRFENLGAQVVRQVSKQT
ETVAGDGTTTAVVLANALIQEGVGLLASGGAVAVDLIQGLDEAEEAMIEALVAEARPLSGGRELRCITTIAGNDRIVGDL
SAKALEAVGSEGLITVEDGPDWRDTLEILEGFTFDRGYVSHHMITDVPTMRAVLNDAYIFLTDQKIRRFEEIASLVDTLV
AKDACLLILAEEVDATVLVGLLATQTKGRGRFVVVNPPDFGHWRKAMMEDIGILTGGRVISGDLGHSLAQTRLEDLGRAE
KVIVSQFETMILKGHGSPEAVVARRAQIQQQLDQAPQNVERDKLDERMSKMTSGTVRILAGGATPAERRRRVQLFDDALC
AGRAALRDGIVSGGGTTLVQLASQLAPKANGKTEPSVLKGLELFRSAMRRPLAQIAENAGRDPILVVETVRQAPKGTGFD
ARTNKFVDMFEAGIIDPVRVTITSVRNATSSAKMILGTNSLIIDKPEFVDPTAGPARGGGGELLGRA

Sequences:

>Translated_547_residues
MVKLMLHGAEARAALAQGVGKLTAAVGGTLGPRGLNAIIDRPVGAPIISRDGVSIAEEIELPCRFENLGAQVVRQVSKQT
ETVAGDGTTTAVVLANALIQEGVGLLASGGAVAVDLIQGLDEAEEAMIEALVAEARPLSGGRELRCITTIAGNDRIVGDL
SAKALEAVGSEGLITVEDGPDWRDTLEILEGFTFDRGYVSHHMITDVPTMRAVLNDAYIFLTDQKIRRFEEIASLVDTLV
AKDACLLILAEEVDATVLVGLLATQTKGRGRFVVVNPPDFGHWRKAMMEDIGILTGGRVISGDLGHSLAQTRLEDLGRAE
KVIVSQFETMILKGHGSPEAVVARRAQIQQQLDQAPQNVERDKLDERMSKMTSGTVRILAGGATPAERRRRVQLFDDALC
AGRAALRDGIVSGGGTTLVQLASQLAPKANGKTEPSVLKGLELFRSAMRRPLAQIAENAGRDPILVVETVRQAPKGTGFD
ARTNKFVDMFEAGIIDPVRVTITSVRNATSSAKMILGTNSLIIDKPEFVDPTAGPARGGGGELLGRA
>Mature_547_residues
MVKLMLHGAEARAALAQGVGKLTAAVGGTLGPRGLNAIIDRPVGAPIISRDGVSIAEEIELPCRFENLGAQVVRQVSKQT
ETVAGDGTTTAVVLANALIQEGVGLLASGGAVAVDLIQGLDEAEEAMIEALVAEARPLSGGRELRCITTIAGNDRIVGDL
SAKALEAVGSEGLITVEDGPDWRDTLEILEGFTFDRGYVSHHMITDVPTMRAVLNDAYIFLTDQKIRRFEEIASLVDTLV
AKDACLLILAEEVDATVLVGLLATQTKGRGRFVVVNPPDFGHWRKAMMEDIGILTGGRVISGDLGHSLAQTRLEDLGRAE
KVIVSQFETMILKGHGSPEAVVARRAQIQQQLDQAPQNVERDKLDERMSKMTSGTVRILAGGATPAERRRRVQLFDDALC
AGRAALRDGIVSGGGTTLVQLASQLAPKANGKTEPSVLKGLELFRSAMRRPLAQIAENAGRDPILVVETVRQAPKGTGFD
ARTNKFVDMFEAGIIDPVRVTITSVRNATSSAKMILGTNSLIIDKPEFVDPTAGPARGGGGELLGRA

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=35.4166666666667, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=35.4166666666667, Blast_Score=312, Evalue=4e-85,
Organism=Escherichia coli, GI1790586, Length=522, Percent_Identity=39.8467432950192, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17555558, Length=524, Percent_Identity=33.7786259541985, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=31.9047619047619, Blast_Score=129, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6323288, Length=527, Percent_Identity=35.8633776091082, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6322524, Length=158, Percent_Identity=31.6455696202532, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641193, Length=523, Percent_Identity=35.1816443594646, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24641191, Length=523, Percent_Identity=35.1816443594646, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI45550936, Length=523, Percent_Identity=34.7992351816444, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI45550132, Length=523, Percent_Identity=34.7992351816444, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI45550935, Length=523, Percent_Identity=34.7992351816444, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI17864606, Length=522, Percent_Identity=32.5670498084291, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24584129, Length=525, Percent_Identity=31.6190476190476, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI19921262, Length=525, Percent_Identity=31.6190476190476, Blast_Score=218, Evalue=1e-56,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58002; Mature: 58002

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLMLHGAEARAALAQGVGKLTAAVGGTLGPRGLNAIIDRPVGAPIISRDGVSIAEEIE
CEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEECCCCCCHHHHCC
LPCRFENLGAQVVRQVSKQTETVAGDGTTTAVVLANALIQEGVGLLASGGAVAVDLIQGL
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCC
DEAEEAMIEALVAEARPLSGGRELRCITTIAGNDRIVGDLSAKALEAVGSEGLITVEDGP
CHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEECHHHHHHHHCCCCCEEEECCCC
DWRDTLEILEGFTFDRGYVSHHMITDVPTMRAVLNDAYIFLTDQKIRRFEEIASLVDTLV
CHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHH
AKDACLLILAEEVDATVLVGLLATQTKGRGRFVVVNPPDFGHWRKAMMEDIGILTGGRVI
HCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCEEECCEEE
SGDLGHSLAQTRLEDLGRAEKVIVSQFETMILKGHGSPEAVVARRAQIQQQLDQAPQNVE
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCCCH
RDKLDERMSKMTSGTVRILAGGATPAERRRRVQLFDDALCAGRAALRDGIVSGGGTTLVQ
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LASQLAPKANGKTEPSVLKGLELFRSAMRRPLAQIAENAGRDPILVVETVRQAPKGTGFD
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCC
ARTNKFVDMFEAGIIDPVRVTITSVRNATSSAKMILGTNSLIIDKPEFVDPTAGPARGGG
CHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCCC
GELLGRA
CCCCCCC
>Mature Secondary Structure
MVKLMLHGAEARAALAQGVGKLTAAVGGTLGPRGLNAIIDRPVGAPIISRDGVSIAEEIE
CEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEECCCCCCHHHHCC
LPCRFENLGAQVVRQVSKQTETVAGDGTTTAVVLANALIQEGVGLLASGGAVAVDLIQGL
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCC
DEAEEAMIEALVAEARPLSGGRELRCITTIAGNDRIVGDLSAKALEAVGSEGLITVEDGP
CHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCEEEECHHHHHHHHCCCCCEEEECCCC
DWRDTLEILEGFTFDRGYVSHHMITDVPTMRAVLNDAYIFLTDQKIRRFEEIASLVDTLV
CHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHH
AKDACLLILAEEVDATVLVGLLATQTKGRGRFVVVNPPDFGHWRKAMMEDIGILTGGRVI
HCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCEEECCEEE
SGDLGHSLAQTRLEDLGRAEKVIVSQFETMILKGHGSPEAVVARRAQIQQQLDQAPQNVE
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCCCH
RDKLDERMSKMTSGTVRILAGGATPAERRRRVQLFDDALCAGRAALRDGIVSGGGTTLVQ
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LASQLAPKANGKTEPSVLKGLELFRSAMRRPLAQIAENAGRDPILVVETVRQAPKGTGFD
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCC
ARTNKFVDMFEAGIIDPVRVTITSVRNATSSAKMILGTNSLIIDKPEFVDPTAGPARGGG
CHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCCC
GELLGRA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]