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The map label for this gene is purL

Identifier: 182680023

GI number: 182680023

Start: 3563497

End: 3565707

Strand: Reverse

Name: purL

Synonym: Bind_3119

Alternate gene names: 182680023

Gene position: 3565707-3563497 (Counterclockwise)

Preceding gene: 182680024

Following gene: 182680022

Centisome position: 85.51

GC content: 61.01

Gene sequence:

>2211_bases
GTGAGCGCAGATCCCCCCATCACGCCCGAACTCGTCGCCGCCCATGGCCTAAAGCCCGACGAATATCAGCGCATTCTCAC
CCTTATCGGCCGGGAGCCGAGTTTCACCGAACTCGGCATTTTCTCGGCCATGTGGAACGAGCATTGTTCCTATAAATCCT
CGCGCATTCATCTCCGCAAATTGCCGACCAAGGCGCCCTGGGTCATCCAGGGGCCGGGGGAGAATGCCGGCGTCATCGAC
ATTGGCGATGGCGAGGCCTGCATCTTCAAGATGGAGAGCCATAATCATCCCTCTTACATCGAGCCGCACCAGGGCGCGGC
GACGGGCGTCGGAGGCATTTTGCGCGATGTCTTCACCATGGGCGCGCGTCCGGTCGCCAGTCTCGACCTGTTGCGCTTTG
GTGCGCCGGAGCATCCGCTGATGCGTCACCTCATTGCAGGTGTTGCGAGCGGCATTGGCTCCTATGGCAATAGTTTCGGC
GTGCCGACTGTTGGCGGCTCGACCAAGTTCGACCGACGCTACAATGGCAATATTCTCGTCAATGCCATGGCCGTCGGCAT
CGCCCGGCAGGACGAGATTTTCTATGCCAAGGCGACGGGTGTCGGCAATCCGATCGTCTATCTCGGCTCCAAGACCGGGC
GCGACGGCATTCACGGCGCGACCATGGCCTCGGCGGCCTTTGAGGCCGATGCGCAGGAAAAGCGTCCGACCGTCCAGGTT
GGCGATCCTTTCGCCGAGAAATTGCTGTTGGAGGCCTGTCTCGAACTGATGAAGACGGGGGCCGTCATCGCCATTCAGGA
TATGGGGGCTGCGGGCCTGACCTCCTCGGCGGTGGAAATGGGCGCCAAGGGTAATCTTGGCATCGAACTCGATCTTGATG
CCGTGCCTTGTCGCGAGCCCGGCATGAGCGCCTATGAAATGCTGCTGTCCGAAAGCCAGGAGCGTATGCTCATGGTGCTC
GCGCCCGAAAAAGCCGCTGAGGCCGAGGCGGTCTTCCGCAAATGGGGGCTCGATTTCGCGATCATCGGCAAGACCACGGA
CGATTTGCGCTTCGTCATCAAACATGAGGGTGAGATCAAGGCTGATCTGCCGATCAAGGAATTGGGTGACGAGGCGCCCG
TCTATGATCGGCCTTCGGTGCTGACGCCGCGCCCCGCCACGATCGCGGCGGACACCATTGTCCCGCCCATTTCCCATGGC
GAGGCTTTGCTGCGCCTTATTGGCAGCCCGGACCTTGCCTCAAAACTGTGGATTACCGAACAATATGATTCGCTGATCCT
CGGCAATACCATTCAGGGACCGGGGGGCGATGCCGCTTTGATCCGCCTCGGCGACGGGCCGAAAGGTTTGGCGCTGACCG
CCGATGTGACACAGCGCTATTGCGAGGCTGACCCTTATGAAGGCGGCAAGCAGGCCGTCACCATGGCCTGGCGCAATCTG
ACCGCTGTCGGCGCCCTGCCGCTCGCCGTCACCGATAATCTGAATTTCGGCAATCCCGAAAATCCGAAAATCATGGGCCA
GTTCATCGGCTGTCTCGAAGGCATTGGCGAGGCCTGCCGTGCCCTCGATTTCCCGATCGTTTCCGGCAATGTCTCGCTCT
ATAATGCGAGTGAAGGCCAGGATATTCCGCCGACCCCCGCGATCGGCGGCGTTGGTCTCCTGGAGGATGCGAGCCGAGGC
GCAACCCTCTCCATCAAGCGGCCGGGCGATGCGATTCTTTTGCTTGGCGAGACACAGGGCTGGCTCGGTGCCTCACTCTA
TCTGCGCGATATTTGCGGCCGCGAGGACGGCGCGCCACCCGTGGTCGATCTGGCGCTCGAAAAACGCATTGGCAATTTCT
TGCGCGGCCTGATCGCCAATCGAGCCTTGACGGCGGTCCATACGCTGACGGATGGAGGCTTGGCCGTGGGCCTTGCGAAA
ATGGCTTTGGCTGGCGGCATCGGTGCGCGGATCGATATTCCGGGACATTGTCCCGCTCATGCCTATCTCTTCGGCGAGGA
TCAGGCCCGTTATCTTGTGACCGCCGCCCCGGAAAAGGCGGAAGCGATCAGGATCGAGGCGGAACAGCTCGGCATTGCCT
GCCAATTGATCGGTCGGACGGGCGGCCCCACATTGGAACTCGGCCAAGAGGCCAGTGTGGCAATCGAGGATCTGCGCCGG
GCTTTCGAGGAATGGCTGCCAAACCATATGACAGGCATTGTGATCGAGTAG

Upstream 100 bases:

>100_bases
CTGATGCCGCATCCTGAAAATCTGATCGAGCCGATCATCGGCGGCACGGATGGGCTGCCCCTTTTTCTCAGCCTCGCGCA
ATTCAAGAAAGCCGCCTGAC

Downstream 100 bases:

>100_bases
GAAGAGTCTGTTTCCTGTTTCTAGCGCGGTTCTTGCTTAAGCGGTAGATTTGAACGATTGGACTGTCCGGCTCGTATCGA
GAATCACAGATTCTCGATAC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 736; Mature: 735

Protein sequence:

>736_residues
MSADPPITPELVAAHGLKPDEYQRILTLIGREPSFTELGIFSAMWNEHCSYKSSRIHLRKLPTKAPWVIQGPGENAGVID
IGDGEACIFKMESHNHPSYIEPHQGAATGVGGILRDVFTMGARPVASLDLLRFGAPEHPLMRHLIAGVASGIGSYGNSFG
VPTVGGSTKFDRRYNGNILVNAMAVGIARQDEIFYAKATGVGNPIVYLGSKTGRDGIHGATMASAAFEADAQEKRPTVQV
GDPFAEKLLLEACLELMKTGAVIAIQDMGAAGLTSSAVEMGAKGNLGIELDLDAVPCREPGMSAYEMLLSESQERMLMVL
APEKAAEAEAVFRKWGLDFAIIGKTTDDLRFVIKHEGEIKADLPIKELGDEAPVYDRPSVLTPRPATIAADTIVPPISHG
EALLRLIGSPDLASKLWITEQYDSLILGNTIQGPGGDAALIRLGDGPKGLALTADVTQRYCEADPYEGGKQAVTMAWRNL
TAVGALPLAVTDNLNFGNPENPKIMGQFIGCLEGIGEACRALDFPIVSGNVSLYNASEGQDIPPTPAIGGVGLLEDASRG
ATLSIKRPGDAILLLGETQGWLGASLYLRDICGREDGAPPVVDLALEKRIGNFLRGLIANRALTAVHTLTDGGLAVGLAK
MALAGGIGARIDIPGHCPAHAYLFGEDQARYLVTAAPEKAEAIRIEAEQLGIACQLIGRTGGPTLELGQEASVAIEDLRR
AFEEWLPNHMTGIVIE

Sequences:

>Translated_736_residues
MSADPPITPELVAAHGLKPDEYQRILTLIGREPSFTELGIFSAMWNEHCSYKSSRIHLRKLPTKAPWVIQGPGENAGVID
IGDGEACIFKMESHNHPSYIEPHQGAATGVGGILRDVFTMGARPVASLDLLRFGAPEHPLMRHLIAGVASGIGSYGNSFG
VPTVGGSTKFDRRYNGNILVNAMAVGIARQDEIFYAKATGVGNPIVYLGSKTGRDGIHGATMASAAFEADAQEKRPTVQV
GDPFAEKLLLEACLELMKTGAVIAIQDMGAAGLTSSAVEMGAKGNLGIELDLDAVPCREPGMSAYEMLLSESQERMLMVL
APEKAAEAEAVFRKWGLDFAIIGKTTDDLRFVIKHEGEIKADLPIKELGDEAPVYDRPSVLTPRPATIAADTIVPPISHG
EALLRLIGSPDLASKLWITEQYDSLILGNTIQGPGGDAALIRLGDGPKGLALTADVTQRYCEADPYEGGKQAVTMAWRNL
TAVGALPLAVTDNLNFGNPENPKIMGQFIGCLEGIGEACRALDFPIVSGNVSLYNASEGQDIPPTPAIGGVGLLEDASRG
ATLSIKRPGDAILLLGETQGWLGASLYLRDICGREDGAPPVVDLALEKRIGNFLRGLIANRALTAVHTLTDGGLAVGLAK
MALAGGIGARIDIPGHCPAHAYLFGEDQARYLVTAAPEKAEAIRIEAEQLGIACQLIGRTGGPTLELGQEASVAIEDLRR
AFEEWLPNHMTGIVIE
>Mature_735_residues
SADPPITPELVAAHGLKPDEYQRILTLIGREPSFTELGIFSAMWNEHCSYKSSRIHLRKLPTKAPWVIQGPGENAGVIDI
GDGEACIFKMESHNHPSYIEPHQGAATGVGGILRDVFTMGARPVASLDLLRFGAPEHPLMRHLIAGVASGIGSYGNSFGV
PTVGGSTKFDRRYNGNILVNAMAVGIARQDEIFYAKATGVGNPIVYLGSKTGRDGIHGATMASAAFEADAQEKRPTVQVG
DPFAEKLLLEACLELMKTGAVIAIQDMGAAGLTSSAVEMGAKGNLGIELDLDAVPCREPGMSAYEMLLSESQERMLMVLA
PEKAAEAEAVFRKWGLDFAIIGKTTDDLRFVIKHEGEIKADLPIKELGDEAPVYDRPSVLTPRPATIAADTIVPPISHGE
ALLRLIGSPDLASKLWITEQYDSLILGNTIQGPGGDAALIRLGDGPKGLALTADVTQRYCEADPYEGGKQAVTMAWRNLT
AVGALPLAVTDNLNFGNPENPKIMGQFIGCLEGIGEACRALDFPIVSGNVSLYNASEGQDIPPTPAIGGVGLLEDASRGA
TLSIKRPGDAILLLGETQGWLGASLYLRDICGREDGAPPVVDLALEKRIGNFLRGLIANRALTAVHTLTDGGLAVGLAKM
ALAGGIGARIDIPGHCPAHAYLFGEDQARYLVTAAPEKAEAIRIEAEQLGIACQLIGRTGGPTLELGQEASVAIEDLRRA
FEEWLPNHMTGIVIE

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=724, Percent_Identity=25.414364640884, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI48994899, Length=733, Percent_Identity=25.37517053206, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17553022, Length=739, Percent_Identity=23.5453315290934, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321498, Length=804, Percent_Identity=23.6318407960199, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24582111, Length=746, Percent_Identity=23.5924932975871, Blast_Score=93, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24582109, Length=746, Percent_Identity=23.5924932975871, Blast_Score=93, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17137292, Length=746, Percent_Identity=23.5924932975871, Blast_Score=93, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_BEII9 (B2IC83)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001834169.1
- GeneID:   6198377
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_3119
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 77969; Mature: 77838

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADPPITPELVAAHGLKPDEYQRILTLIGREPSFTELGIFSAMWNEHCSYKSSRIHLRK
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
LPTKAPWVIQGPGENAGVIDIGDGEACIFKMESHNHPSYIEPHQGAATGVGGILRDVFTM
CCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHC
GARPVASLDLLRFGAPEHPLMRHLIAGVASGIGSYGNSFGVPTVGGSTKFDRRYNGNILV
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCEEE
NAMAVGIARQDEIFYAKATGVGNPIVYLGSKTGRDGIHGATMASAAFEADAQEKRPTVQV
EEEEECEECCCCEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCHHHCCCEEEE
GDPFAEKLLLEACLELMKTGAVIAIQDMGAAGLTSSAVEMGAKGNLGIELDLDAVPCREP
CCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCC
GMSAYEMLLSESQERMLMVLAPEKAAEAEAVFRKWGLDFAIIGKTTDDLRFVIKHEGEIK
CHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCHHEEEEEEECCCEE
ADLPIKELGDEAPVYDRPSVLTPRPATIAADTIVPPISHGEALLRLIGSPDLASKLWITE
ECCCHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHEEEEC
QYDSLILGNTIQGPGGDAALIRLGDGPKGLALTADVTQRYCEADPYEGGKQAVTMAWRNL
CCCCEEECCCCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCCCCCCHHHHHHHHHH
TAVGALPLAVTDNLNFGNPENPKIMGQFIGCLEGIGEACRALDFPIVSGNVSLYNASEGQ
HHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCCCC
DIPPTPAIGGVGLLEDASRGATLSIKRPGDAILLLGETQGWLGASLYLRDICGREDGAPP
CCCCCCCCCCCCHHCCCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCC
VVDLALEKRIGNFLRGLIANRALTAVHTLTDGGLAVGLAKMALAGGIGARIDIPGHCPAH
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCCCCE
AYLFGEDQARYLVTAAPEKAEAIRIEAEQLGIACQLIGRTGGPTLELGQEASVAIEDLRR
EEEECCCCCCEEEEECCCCCCEEEEEHHHHCEEEEEECCCCCCCEECCCCHHHHHHHHHH
AFEEWLPNHMTGIVIE
HHHHHCCCCCCEEEEC
>Mature Secondary Structure 
SADPPITPELVAAHGLKPDEYQRILTLIGREPSFTELGIFSAMWNEHCSYKSSRIHLRK
CCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
LPTKAPWVIQGPGENAGVIDIGDGEACIFKMESHNHPSYIEPHQGAATGVGGILRDVFTM
CCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHC
GARPVASLDLLRFGAPEHPLMRHLIAGVASGIGSYGNSFGVPTVGGSTKFDRRYNGNILV
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCEEE
NAMAVGIARQDEIFYAKATGVGNPIVYLGSKTGRDGIHGATMASAAFEADAQEKRPTVQV
EEEEECEECCCCEEEEEECCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCHHHCCCEEEE
GDPFAEKLLLEACLELMKTGAVIAIQDMGAAGLTSSAVEMGAKGNLGIELDLDAVPCREP
CCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCC
GMSAYEMLLSESQERMLMVLAPEKAAEAEAVFRKWGLDFAIIGKTTDDLRFVIKHEGEIK
CHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCHHEEEEEEECCCEE
ADLPIKELGDEAPVYDRPSVLTPRPATIAADTIVPPISHGEALLRLIGSPDLASKLWITE
ECCCHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHEEEEC
QYDSLILGNTIQGPGGDAALIRLGDGPKGLALTADVTQRYCEADPYEGGKQAVTMAWRNL
CCCCEEECCCCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCCCCCCHHHHHHHHHH
TAVGALPLAVTDNLNFGNPENPKIMGQFIGCLEGIGEACRALDFPIVSGNVSLYNASEGQ
HHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCCCC
DIPPTPAIGGVGLLEDASRGATLSIKRPGDAILLLGETQGWLGASLYLRDICGREDGAPP
CCCCCCCCCCCCHHCCCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCC
VVDLALEKRIGNFLRGLIANRALTAVHTLTDGGLAVGLAKMALAGGIGARIDIPGHCPAH
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCCCCE
AYLFGEDQARYLVTAAPEKAEAIRIEAEQLGIACQLIGRTGGPTLELGQEASVAIEDLRR
EEEECCCCCCEEEEECCCCCCEEEEEHHHHCEEEEEECCCCCCCEECCCCHHHHHHHHHH
AFEEWLPNHMTGIVIE
HHHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA