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The map label for this gene is sdhA [H]

Identifier: 182679664

GI number: 182679664

Start: 3133547

End: 3135385

Strand: Reverse

Name: sdhA [H]

Synonym: Bind_2749

Alternate gene names: 182679664

Gene position: 3135385-3133547 (Counterclockwise)

Preceding gene: 182679665

Following gene: 182679663

Centisome position: 75.19

GC content: 58.95

Gene sequence:

>1839_bases
ATGGCCCTTAACGGATCATCGAACGGAACCGCGGCGCCGGCCTATAACGGGACCGCTTATCCGATCACCGATCATACGTT
CGATGTGGTTATCGTCGGTGCAGGCGGGGCTGGTCTTCGCGCGACCGTGGGATGTTCCCAGGCGGGGCTTCGCACGGCCT
GTATTTCCAAGGTTTTCCCGACCCGTTCGCATACGGTCGCGGCGCAGGGCGGTGTCGCCGCCTCGCTCGCCAATATGGGG
CCGGACAATTGGAAATGGCACATGTACGATACCGTCAAGGGATCGGACTGGCTGGGCGATCAGGATTCCATCGAATATCT
CTGCCGCAATGCGCCGGCAGCCGTGTTCGAGCTCGAACACTGGGGCGTGCCGTTTTCGCGCACGGAAGACGGCCGTATCT
ATCAGCGGCCCTTCGGCGGTATGACCACGGATTTCGGCAAGGGTCCGCCGGCACAGCGGACTTGCGCGGCTGCTGACCGC
ACAGGCCATGCCATTCTGCATACGCTTTATGGGCAGGCCCTGCGTAACCAAACCGAATTCTTCATCGAATATTTCGCCAT
CGATCTAATCATGGAAGATGGCCATTGCCGTGGTGTCGTCTGTCTCAAGCTCGATGATGGCACGATTCACCGTTTCCGTT
CCCAGCTCGTGATTCTCGCGACGGGTGGCTATGGCCGCGCTTATTTCTCGGCGACATCCGCCCATACCTGCACGGGCGAC
GGCAATGCCATGGTGCTGCGTGCTGGTCTGCCGCTGCAGGATATGGAATTCGTGCAATTCCATCCGACTGGCATCTATGG
CGCGGGTTGCCTGATCACCGAAGGCGCGCGCGGCGAAGGCGGTTATCTGACCAATTCGTCAGGTGAGCGTTTCATGGAAC
GCTATGCGCCGTCGGTGAAGGATCTGGCGCCCCGCGACATGGTTTCGCGCGCTATGACGATGGAGATCCGCGAAGGCCGT
GGCGTCGGTAAGGGCAAGGATCACATCTTTCTTCATCTCGACCATCTCGACCCGAAAATCCTGCATGAGCGGCTCCCCGG
CATTTCGGAAAGCGCCAGGATCTTCGCGGGCGTCGATGTCACGAAGGAGCCGATCCCGGTTCTGCCGACCGTCCATTATA
ACATGGGCGGCATCCCGACGAATTATCACGGCGAAGTCGTCATCAAGAAGGGTGATGATCCAGATGTCGTCGTGCCGGGC
TTGATGGCGCTTGGCGAGGCGGCTTGCGTGTCCGTACACGGCGCCAATCGTCTTGGCTCGAATTCGCTGATCGATCTGGT
GGTTTTCGGCCGCGCCGCGGGCCTCCGTGCCGCCGAGATCGTAACGGCCGGTGCGAAACAGCCGGAACTTCCGGCCGGTT
CTGCTGATCTTTCGCTCTCCCGCCTCGATCATTTCCGCAATGCCAAGGGCTCGTTGCCCACCGCTGAACTGCGGTTGCGG
ATGCAGAAGGTCATGCAAAATAATTGCGCGGTCTACCGGACCGGCGAGACCCTGGAAGAAGGCTCCAAGCTCATCCATGA
AGTCTGGAAGGCTAAGGATCAAATCGGTGTGACGGATCGCGGTTTGATCTGGAATACAGATCTGATCGAGACCTTGGAAT
TCGATAATCTGATCGTGCAGGCCGTCGTCACAATGGATGGCGCGGTCAACCGCACGGAATCACGTGGTGCCCATGCGCGT
GAGGATTATGCCGAGCGCGATGACAAGAACTGGATGAAACATACATTGGCCTCGATCGATGGCACGGCCCATACGGTGAG
CCTCGATTACCGGCCGGTGCATAATTACACCATGACCAACGAGATGCAGTATATTGAGCCCAAGGCGCGTGTTTATTGA

Upstream 100 bases:

>100_bases
CTGCATCGGCCTCGCCTGTATCTATGCCGTCTTGAAGCTGAGCTTCCTCTGACGAATACGGGACCGGACTGGTCGTTTAA
ATTGGCTGAAAGGCAGTATC

Downstream 100 bases:

>100_bases
TCAGTAGACTATCGGACGGCGTGAGCTTTCCGATACCTGGGCCGCATGAACAAAAAAGCCGTTTAAGGCGTTGTTTCAAA
TAGGCTCCCGGCAATCGAAT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MALNGSSNGTAAPAYNGTAYPITDHTFDVVIVGAGGAGLRATVGCSQAGLRTACISKVFPTRSHTVAAQGGVAASLANMG
PDNWKWHMYDTVKGSDWLGDQDSIEYLCRNAPAAVFELEHWGVPFSRTEDGRIYQRPFGGMTTDFGKGPPAQRTCAAADR
TGHAILHTLYGQALRNQTEFFIEYFAIDLIMEDGHCRGVVCLKLDDGTIHRFRSQLVILATGGYGRAYFSATSAHTCTGD
GNAMVLRAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLTNSSGERFMERYAPSVKDLAPRDMVSRAMTMEIREGR
GVGKGKDHIFLHLDHLDPKILHERLPGISESARIFAGVDVTKEPIPVLPTVHYNMGGIPTNYHGEVVIKKGDDPDVVVPG
LMALGEAACVSVHGANRLGSNSLIDLVVFGRAAGLRAAEIVTAGAKQPELPAGSADLSLSRLDHFRNAKGSLPTAELRLR
MQKVMQNNCAVYRTGETLEEGSKLIHEVWKAKDQIGVTDRGLIWNTDLIETLEFDNLIVQAVVTMDGAVNRTESRGAHAR
EDYAERDDKNWMKHTLASIDGTAHTVSLDYRPVHNYTMTNEMQYIEPKARVY

Sequences:

>Translated_612_residues
MALNGSSNGTAAPAYNGTAYPITDHTFDVVIVGAGGAGLRATVGCSQAGLRTACISKVFPTRSHTVAAQGGVAASLANMG
PDNWKWHMYDTVKGSDWLGDQDSIEYLCRNAPAAVFELEHWGVPFSRTEDGRIYQRPFGGMTTDFGKGPPAQRTCAAADR
TGHAILHTLYGQALRNQTEFFIEYFAIDLIMEDGHCRGVVCLKLDDGTIHRFRSQLVILATGGYGRAYFSATSAHTCTGD
GNAMVLRAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLTNSSGERFMERYAPSVKDLAPRDMVSRAMTMEIREGR
GVGKGKDHIFLHLDHLDPKILHERLPGISESARIFAGVDVTKEPIPVLPTVHYNMGGIPTNYHGEVVIKKGDDPDVVVPG
LMALGEAACVSVHGANRLGSNSLIDLVVFGRAAGLRAAEIVTAGAKQPELPAGSADLSLSRLDHFRNAKGSLPTAELRLR
MQKVMQNNCAVYRTGETLEEGSKLIHEVWKAKDQIGVTDRGLIWNTDLIETLEFDNLIVQAVVTMDGAVNRTESRGAHAR
EDYAERDDKNWMKHTLASIDGTAHTVSLDYRPVHNYTMTNEMQYIEPKARVY
>Mature_611_residues
ALNGSSNGTAAPAYNGTAYPITDHTFDVVIVGAGGAGLRATVGCSQAGLRTACISKVFPTRSHTVAAQGGVAASLANMGP
DNWKWHMYDTVKGSDWLGDQDSIEYLCRNAPAAVFELEHWGVPFSRTEDGRIYQRPFGGMTTDFGKGPPAQRTCAAADRT
GHAILHTLYGQALRNQTEFFIEYFAIDLIMEDGHCRGVVCLKLDDGTIHRFRSQLVILATGGYGRAYFSATSAHTCTGDG
NAMVLRAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLTNSSGERFMERYAPSVKDLAPRDMVSRAMTMEIREGRG
VGKGKDHIFLHLDHLDPKILHERLPGISESARIFAGVDVTKEPIPVLPTVHYNMGGIPTNYHGEVVIKKGDDPDVVVPGL
MALGEAACVSVHGANRLGSNSLIDLVVFGRAAGLRAAEIVTAGAKQPELPAGSADLSLSRLDHFRNAKGSLPTAELRLRM
QKVMQNNCAVYRTGETLEEGSKLIHEVWKAKDQIGVTDRGLIWNTDLIETLEFDNLIVQAVVTMDGAVNRTESRGAHARE
DYAERDDKNWMKHTLASIDGTAHTVSLDYRPVHNYTMTNEMQYIEPKARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=611, Percent_Identity=61.0474631751228, Blast_Score=742, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=586, Percent_Identity=52.3890784982935, Blast_Score=550, Evalue=1e-157,
Organism=Escherichia coli, GI1790597, Length=578, Percent_Identity=42.560553633218, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1788928, Length=559, Percent_Identity=30.2325581395349, Blast_Score=202, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17550100, Length=628, Percent_Identity=59.2356687898089, Blast_Score=745, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=614, Percent_Identity=58.3061889250814, Blast_Score=716, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=611, Percent_Identity=63.9934533551555, Blast_Score=792, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=595, Percent_Identity=64.7058823529412, Blast_Score=781, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=619, Percent_Identity=60.4200323101777, Blast_Score=761, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=619, Percent_Identity=60.4200323101777, Blast_Score=761, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=619, Percent_Identity=60.4200323101777, Blast_Score=761, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=612, Percent_Identity=54.5751633986928, Blast_Score=674, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66539; Mature: 66408

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNGSSNGTAAPAYNGTAYPITDHTFDVVIVGAGGAGLRATVGCSQAGLRTACISKVFP
CCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHCC
TRSHTVAAQGGVAASLANMGPDNWKWHMYDTVKGSDWLGDQDSIEYLCRNAPAAVFELEH
CCCCEEEECCCCHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEHH
WGVPFSRTEDGRIYQRPFGGMTTDFGKGPPAQRTCAAADRTGHAILHTLYGQALRNQTEF
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHH
FIEYFAIDLIMEDGHCRGVVCLKLDDGTIHRFRSQLVILATGGYGRAYFSATSAHTCTGD
HHHHEEEEEEEECCCCCEEEEEEECCCHHHHCCCCEEEEEECCCCEEEEECCCCEEECCC
GNAMVLRAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLTNSSGERFMERYAPSVK
CCEEEEECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHH
DLAPRDMVSRAMTMEIREGRGVGKGKDHIFLHLDHLDPKILHERLPGISESARIFAGVDV
HCCHHHHHHHHHHEEECCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCEEEEECCC
TKEPIPVLPTVHYNMGGIPTNYHGEVVIKKGDDPDVVVPGLMALGEAACVSVHGANRLGS
CCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCEECCHHHHCCCEEEEEEECCCCCCC
NSLIDLVVFGRAAGLRAAEIVTAGAKQPELPAGSADLSLSRLDHFRNAKGSLPTAELRLR
CCEEEEEEECCCCCCCHHHHEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHH
MQKVMQNNCAVYRTGETLEEGSKLIHEVWKAKDQIGVTDRGLIWNTDLIETLEFDNLIVQ
HHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHH
AVVTMDGAVNRTESRGAHAREDYAERDDKNWMKHTLASIDGTAHTVSLDYRPVHNYTMTN
HHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCEEEEEEECEECCCCEECC
EMQYIEPKARVY
CEEEECCHHCCC
>Mature Secondary Structure 
ALNGSSNGTAAPAYNGTAYPITDHTFDVVIVGAGGAGLRATVGCSQAGLRTACISKVFP
CCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHCC
TRSHTVAAQGGVAASLANMGPDNWKWHMYDTVKGSDWLGDQDSIEYLCRNAPAAVFELEH
CCCCEEEECCCCHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEHH
WGVPFSRTEDGRIYQRPFGGMTTDFGKGPPAQRTCAAADRTGHAILHTLYGQALRNQTEF
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHH
FIEYFAIDLIMEDGHCRGVVCLKLDDGTIHRFRSQLVILATGGYGRAYFSATSAHTCTGD
HHHHEEEEEEEECCCCCEEEEEEECCCHHHHCCCCEEEEEECCCCEEEEECCCCEEECCC
GNAMVLRAGLPLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLTNSSGERFMERYAPSVK
CCEEEEECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHH
DLAPRDMVSRAMTMEIREGRGVGKGKDHIFLHLDHLDPKILHERLPGISESARIFAGVDV
HCCHHHHHHHHHHEEECCCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCEEEEECCC
TKEPIPVLPTVHYNMGGIPTNYHGEVVIKKGDDPDVVVPGLMALGEAACVSVHGANRLGS
CCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCEECCHHHHCCCEEEEEEECCCCCCC
NSLIDLVVFGRAAGLRAAEIVTAGAKQPELPAGSADLSLSRLDHFRNAKGSLPTAELRLR
CCEEEEEEECCCCCCCHHHHEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHH
MQKVMQNNCAVYRTGETLEEGSKLIHEVWKAKDQIGVTDRGLIWNTDLIETLEFDNLIVQ
HHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHH
AVVTMDGAVNRTESRGAHAREDYAERDDKNWMKHTLASIDGTAHTVSLDYRPVHNYTMTN
HHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCEEEEEEECEECCCCEECC
EMQYIEPKARVY
CEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA