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The map label for this gene is ilvD

Identifier: 182679632

GI number: 182679632

Start: 3095350

End: 3097203

Strand: Reverse

Name: ilvD

Synonym: Bind_2717

Alternate gene names: 182679632

Gene position: 3097203-3095350 (Counterclockwise)

Preceding gene: 182679634

Following gene: 182679631

Centisome position: 74.27

GC content: 60.52

Gene sequence:

>1854_bases
ATGCCCGATTATCGTTCCCGCACCACCACTCATGGCCGCAATATGGCCGGCGCCCGTGGCCTCTGGCGCGCGACGGGCGT
CAAGGACGAGGATTTCGGCAAACCGATCATCGCCATCGCCAATTCCTTCACGCAATTCGTGCCGGGCCATGTTCATCTCA
AGGATCTCGGCCAGCTTGTCGCCGGCGAGATCGAAAAGGCGGGTGGCATTGCCAAGGAATTCAACACGATTGCCGTCGAT
GACGGCATTGCTATGGGGCATGATGGCATGCTCTACAGCTTGCCCTCGCGCGAACTCATCGCCGACAGCGTCGAATATAT
GGTCAACGCCCATTGCGCCGATGCTCTCGTTTGCATCTCGAATTGCGACAAGATCACGCCCGGCATGTTGATGGCCGCGC
TGCGCCTGAATATTCCGACCATTTTCGTGTCGGGTGGACCCATGGAGGCTGGCAAGGCGCAGGTCGGTGGCAAGACCTTG
GCGCTTGATCTGGTTGATGCCATGGTTGCGGCGGCTGATGACCGGGTCAGCGCCGAGGATGTGGCGGTGATCGAGCGTTC
GGCCTGCCCGACTTGCGGCTCCTGTTCGGGCATGTTCACTGCCAATTCCATGAATTGCCTGACCGAGGCCTTGGGGCTTT
CTCTGCCCGGCAATGGTTCCGTCCTCGCAACCCATGCCGATCGCCGGCGTCTCTTCGTGGAAGCCGGGCATTTGATCGTC
GATCTGGCGCGCCGCTATTATGAGCAAAATGATGGTTCCGTTCTGCCGCGCGCCATCGCTTCCTTCAAGGCCTTTGAAAA
TGCCATGACGCTCGATATCGCCATGGGCGGCTCGACCAATACGGTCTTGCACCTTCTGGCGGCGGCCCATGAGGCGGGCG
TGCCGTTCATGATGGCGGATATCGACCGCCTGTCCCGTGGCGTGCCGTGCCTCTGCAAGGTCGCGCCGGCGAAGAATGAC
GTCCATATGGAGGATGTGCACCGGGCTGGTGGCATTATGGCGATTTTGGGGGAACTCGATAGGGCAGGGCTTCTCCATGC
GGACTTGCCGACGGTCCATTCGAGCAGTCTGGGGGAAGCCTTGATGCGTTGGGATATCCGGCGCAGCAATAGCGAGATGG
TTCAGACTTTCTATAAAGCAGCGCCGGGCAACGTGCCGACGACGCAGGCCTTTAGCCAGGAAAAACGCTATGAGGCCCTG
GATCTCGATCGGGAAACCGGGGTGATCCGCGATCAGGCGCATGCCTTTTCGCAAGATGGCGGGCTTGCCGTCCTCTTCGG
CAATCTGGCTGAGGAAGGATCGATCGTGAAGACAGCCGGCGTTGATGAAAGCATTTTGACCTTTGCCGGGCCGGCCAGGG
TTTTCGAGAGCCAGGACAGCGCGGTCGAGGCGATTCTTGCTGGGCGGATTGTCGCCGGTGACGTGGTGGTGATCCGTTAC
GAAGGACCACGGGGTGGTCCTGGCATGCAGGAAATGCTTTATCCGACGAGCTATTTGAAATCGAAAGGGCTTGGCAAGGC
CTGCGCCTTGATCACCGATGGGCGCTTTTCTGGCGGCACCTCTGGCCTGTCCATCGGCCATGTCTCGCCGGAGGCGGCTG
AAGGCGGCATGATTGCTTTGGTCGAGGAGGGCGATCGGATCGAGATCGATATCAAGACCCGTTCTCTTATCCTGGCCGTG
CCCGAAGCGGAACTGGCGCGTCGGCGTGGAGTCATGGAGGCGAAAGGCGCGAATGCTTTCAAGCCGCGTGAGCGCCAGCG
CCAGGTCTCGACGGCCTTGCGCGCCTATGCCGCCTTTACGACCAGTGCTGCCCGCGGTGCGGTCCGTGATCTTGATCAGA
AGCCGCGCTTTTGA

Upstream 100 bases:

>100_bases
GTTTGGACCTTTAGGTCCTGATCGCAGCGTTTGATCGATGGGATCACGCGGCGTGCAATCCGCTTGAGCGAGATCCAGAG
ACGAGATTCAGAGGTTGAAC

Downstream 100 bases:

>100_bases
TCAATTTCTGCCAGATCCCACCCTGTTTCGCGTGGAAAATGCATAGGAGCTTGTCGAGTTGAGCGAACCTTGGCGGTTTG
CTGGCGCTTAATATGCTTGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MPDYRSRTTTHGRNMAGARGLWRATGVKDEDFGKPIIAIANSFTQFVPGHVHLKDLGQLVAGEIEKAGGIAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTIFVSGGPMEAGKAQVGGKTL
ALDLVDAMVAAADDRVSAEDVAVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADRRRLFVEAGHLIV
DLARRYYEQNDGSVLPRAIASFKAFENAMTLDIAMGGSTNTVLHLLAAAHEAGVPFMMADIDRLSRGVPCLCKVAPAKND
VHMEDVHRAGGIMAILGELDRAGLLHADLPTVHSSSLGEALMRWDIRRSNSEMVQTFYKAAPGNVPTTQAFSQEKRYEAL
DLDRETGVIRDQAHAFSQDGGLAVLFGNLAEEGSIVKTAGVDESILTFAGPARVFESQDSAVEAILAGRIVAGDVVVIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAAEGGMIALVEEGDRIEIDIKTRSLILAV
PEAELARRRGVMEAKGANAFKPRERQRQVSTALRAYAAFTTSAARGAVRDLDQKPRF

Sequences:

>Translated_617_residues
MPDYRSRTTTHGRNMAGARGLWRATGVKDEDFGKPIIAIANSFTQFVPGHVHLKDLGQLVAGEIEKAGGIAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTIFVSGGPMEAGKAQVGGKTL
ALDLVDAMVAAADDRVSAEDVAVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADRRRLFVEAGHLIV
DLARRYYEQNDGSVLPRAIASFKAFENAMTLDIAMGGSTNTVLHLLAAAHEAGVPFMMADIDRLSRGVPCLCKVAPAKND
VHMEDVHRAGGIMAILGELDRAGLLHADLPTVHSSSLGEALMRWDIRRSNSEMVQTFYKAAPGNVPTTQAFSQEKRYEAL
DLDRETGVIRDQAHAFSQDGGLAVLFGNLAEEGSIVKTAGVDESILTFAGPARVFESQDSAVEAILAGRIVAGDVVVIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAAEGGMIALVEEGDRIEIDIKTRSLILAV
PEAELARRRGVMEAKGANAFKPRERQRQVSTALRAYAAFTTSAARGAVRDLDQKPRF
>Mature_616_residues
PDYRSRTTTHGRNMAGARGLWRATGVKDEDFGKPIIAIANSFTQFVPGHVHLKDLGQLVAGEIEKAGGIAKEFNTIAVDD
GIAMGHDGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTIFVSGGPMEAGKAQVGGKTLA
LDLVDAMVAAADDRVSAEDVAVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADRRRLFVEAGHLIVD
LARRYYEQNDGSVLPRAIASFKAFENAMTLDIAMGGSTNTVLHLLAAAHEAGVPFMMADIDRLSRGVPCLCKVAPAKNDV
HMEDVHRAGGIMAILGELDRAGLLHADLPTVHSSSLGEALMRWDIRRSNSEMVQTFYKAAPGNVPTTQAFSQEKRYEALD
LDRETGVIRDQAHAFSQDGGLAVLFGNLAEEGSIVKTAGVDESILTFAGPARVFESQDSAVEAILAGRIVAGDVVVIRYE
GPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAAEGGMIALVEEGDRIEIDIKTRSLILAVP
EAELARRRGVMEAKGANAFKPRERQRQVSTALRAYAAFTTSAARGAVRDLDQKPRF

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=72.2950819672131, Blast_Score=914, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=527, Percent_Identity=32.4478178368121, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI1788157, Length=542, Percent_Identity=30.9963099630996, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI1786464, Length=557, Percent_Identity=32.6750448833034, Blast_Score=188, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6322476, Length=612, Percent_Identity=37.4183006535948, Blast_Score=349, Evalue=8e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_BEII9 (B2IJH6)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001833778.1
- GeneID:   6199305
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_2717
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65617; Mature: 65486

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYRSRTTTHGRNMAGARGLWRATGVKDEDFGKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AGEIEKAGGIAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPTIFVSGGPMEAGKAQVGGKTLALDLVDAMVAAADDRVSAED
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCHHH
VAVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADRRRLFVEAGHLIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCCEEEHHHHHHHH
DLARRYYEQNDGSVLPRAIASFKAFENAMTLDIAMGGSTNTVLHLLAAAHEAGVPFMMAD
HHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHH
IDRLSRGVPCLCKVAPAKNDVHMEDVHRAGGIMAILGELDRAGLLHADLPTVHSSSLGEA
HHHHHCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHCCCCEEECCCCCCCCHHHHHH
LMRWDIRRSNSEMVQTFYKAAPGNVPTTQAFSQEKRYEALDLDRETGVIRDQAHAFSQDG
HHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCC
GLAVLFGNLAEEGSIVKTAGVDESILTFAGPARVFESQDSAVEAILAGRIVAGDVVVIRY
CEEEEECCCCCCCCEEEECCCCHHHHHHCCHHHHHCCCHHHHHHHHHCCEEECCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAAEGGMIAL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VEEGDRIEIDIKTRSLILAVPEAELARRRGVMEAKGANAFKPRERQRQVSTALRAYAAFT
EECCCEEEEEEEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TSAARGAVRDLDQKPRF
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PDYRSRTTTHGRNMAGARGLWRATGVKDEDFGKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AGEIEKAGGIAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPTIFVSGGPMEAGKAQVGGKTLALDLVDAMVAAADDRVSAED
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCHHH
VAVIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADRRRLFVEAGHLIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCCEEEHHHHHHHH
DLARRYYEQNDGSVLPRAIASFKAFENAMTLDIAMGGSTNTVLHLLAAAHEAGVPFMMAD
HHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHH
IDRLSRGVPCLCKVAPAKNDVHMEDVHRAGGIMAILGELDRAGLLHADLPTVHSSSLGEA
HHHHHCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHCCCCEEECCCCCCCCHHHHHH
LMRWDIRRSNSEMVQTFYKAAPGNVPTTQAFSQEKRYEALDLDRETGVIRDQAHAFSQDG
HHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCC
GLAVLFGNLAEEGSIVKTAGVDESILTFAGPARVFESQDSAVEAILAGRIVAGDVVVIRY
CEEEEECCCCCCCCEEEECCCCHHHHHHCCHHHHHCCCHHHHHHHHHCCEEECCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAAEGGMIAL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VEEGDRIEIDIKTRSLILAVPEAELARRRGVMEAKGANAFKPRERQRQVSTALRAYAAFT
EECCCEEEEEEEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TSAARGAVRDLDQKPRF
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA