Click here to switch to the map view.

The map label for this gene is serS

Identifier: 182679617

GI number: 182679617

Start: 3080170

End: 3081480

Strand: Reverse

Name: serS

Synonym: Bind_2702

Alternate gene names: 182679617

Gene position: 3081480-3080170 (Counterclockwise)

Preceding gene: 182679618

Following gene: 182679616

Centisome position: 73.89

GC content: 60.03

Gene sequence:

>1311_bases
ATGTACGACATCAAATGGATACGCGACAATAGCGCCCTGTTTGACCAGGGCCGTGAAAGGCGGGGCCTGCCGAAGCTCTC
CGCCGAGCTTTTGGCGCTGGATGACGCGCGCCGCGCCGCTATCGCGGAGTCGCAGGCAGCGCAGGAACGCCGCAACGCCG
CCTCCAAGGAAATTGGCGCGGCGATGAAGGCCAAGGACAATGCTCGTGCCGAGGCTCTGAAAGCCGAAATGGCCGAACTC
AAAGCCGTGTCCCCGGCCCTTGAGGAGGCCGAGCGTCTGGCGATTGCCGCGCTCGACCGCGCGCTTGCGGAAATTCCCAA
TCTGCCGCTGGAGGACGTTCCCTTCGGCCGCGACGAAAATGACAATCCTGAATTGCGCGTGGTTGGCGAAAAGCCGGTCT
TCTCGTTCGTGCCGAAGGAGCATTTCGATATTGGTGAAGGCTTGGGCCTCATGGATTTCGAGGCCGCGGCCAAATTGTCG
GGCGCGCGTTTCGTCGTCAACAAGGGACCTCTTGCGCGTCTCGAACGCGCGCTCGGTCAATTCATGCTGGATCTGCATAC
GGGTGAGCATGGATATACCGAAGTCAATCCACCTATTCTCGCGCGTGATGATGCTCTGTTCGGTACGGCGCAATTGCCGA
AATTAGAAGAAGACATGTTTGCTGCTCACGCTGGACGCGTGCCGCAAGAGGCTGCGGGGGATCTCTATTGGCTGATTCCG
ACGTCTGAAGTTGTGCTCACCAATCTGGTGCGTGAAACGATCCTTGACGAAAAACAGCTTCCTTTGCGCTTTACTGCCTG
CACCCCTTGTTTCCGTGCCGAGGCGGGTTCGGCGGGGCGTGATACGCGCGGCATGATCCGCCAGCACCAATTCACCAAGA
CGGAACTTGTCTCCATCACCACGCCGGAAGAGGCGCTTGTGGAGCACGAGCGCATGCTCACTTGCGCCGAAGAAGTGCTG
AAGCGGCTCGGCCTTGCCTATCGTGTCGTCACCCTTTGCACGGGTGACATGGGTTTTGCCTCGCAAAAGACCTATGACAT
CGAGGTCTGGCTGCCGGGGCAGGGGCGCTATCGCGAGATTTCTTCCTGCTCCGTCTGCGGCGATTTCCAGGCAAGGCGGA
TGAATGCACGCTATCGCCCCGAGGGCGGTAAGACGACACGGTTCGTGCATACATTGAACGGGTCCGGTGTCGCCGTGGGG
CGTGCCTTGGTGGCCGTGCTCGAGAATTACCAGCGGGAAGATGGCGGTGTGAATGTGCCGAGGGCACTGCTGCCTTACAT
GGGCGGCATCACCACGATCACCCGTGGATAG

Upstream 100 bases:

>100_bases
TGGCGAGGAAGCGACAGCCAAATTTTGACGATTTGTTTCAAGGCCAAAGTCGTCGTCTTGTCGAGAGACGATGATAGGGC
GCTGATGTCTGGATAGCGGC

Downstream 100 bases:

>100_bases
GCCGGAGAGAGGCAGGGAACAGGCGCGATGCGGATTCTGATCACCAATGATGATGGCATCAATGCGCCGGGCCTTGCCGT
GCTGGAACGGATCGCCAGCG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MYDIKWIRDNSALFDQGRERRGLPKLSAELLALDDARRAAIAESQAAQERRNAASKEIGAAMKAKDNARAEALKAEMAEL
KAVSPALEEAERLAIAALDRALAEIPNLPLEDVPFGRDENDNPELRVVGEKPVFSFVPKEHFDIGEGLGLMDFEAAAKLS
GARFVVNKGPLARLERALGQFMLDLHTGEHGYTEVNPPILARDDALFGTAQLPKLEEDMFAAHAGRVPQEAAGDLYWLIP
TSEVVLTNLVRETILDEKQLPLRFTACTPCFRAEAGSAGRDTRGMIRQHQFTKTELVSITTPEEALVEHERMLTCAEEVL
KRLGLAYRVVTLCTGDMGFASQKTYDIEVWLPGQGRYREISSCSVCGDFQARRMNARYRPEGGKTTRFVHTLNGSGVAVG
RALVAVLENYQREDGGVNVPRALLPYMGGITTITRG

Sequences:

>Translated_436_residues
MYDIKWIRDNSALFDQGRERRGLPKLSAELLALDDARRAAIAESQAAQERRNAASKEIGAAMKAKDNARAEALKAEMAEL
KAVSPALEEAERLAIAALDRALAEIPNLPLEDVPFGRDENDNPELRVVGEKPVFSFVPKEHFDIGEGLGLMDFEAAAKLS
GARFVVNKGPLARLERALGQFMLDLHTGEHGYTEVNPPILARDDALFGTAQLPKLEEDMFAAHAGRVPQEAAGDLYWLIP
TSEVVLTNLVRETILDEKQLPLRFTACTPCFRAEAGSAGRDTRGMIRQHQFTKTELVSITTPEEALVEHERMLTCAEEVL
KRLGLAYRVVTLCTGDMGFASQKTYDIEVWLPGQGRYREISSCSVCGDFQARRMNARYRPEGGKTTRFVHTLNGSGVAVG
RALVAVLENYQREDGGVNVPRALLPYMGGITTITRG
>Mature_436_residues
MYDIKWIRDNSALFDQGRERRGLPKLSAELLALDDARRAAIAESQAAQERRNAASKEIGAAMKAKDNARAEALKAEMAEL
KAVSPALEEAERLAIAALDRALAEIPNLPLEDVPFGRDENDNPELRVVGEKPVFSFVPKEHFDIGEGLGLMDFEAAAKLS
GARFVVNKGPLARLERALGQFMLDLHTGEHGYTEVNPPILARDDALFGTAQLPKLEEDMFAAHAGRVPQEAAGDLYWLIP
TSEVVLTNLVRETILDEKQLPLRFTACTPCFRAEAGSAGRDTRGMIRQHQFTKTELVSITTPEEALVEHERMLTCAEEVL
KRLGLAYRVVTLCTGDMGFASQKTYDIEVWLPGQGRYREISSCSVCGDFQARRMNARYRPEGGKTTRFVHTLNGSGVAVG
RALVAVLENYQREDGGVNVPRALLPYMGGITTITRG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=455, Percent_Identity=32.967032967033, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI8923421, Length=406, Percent_Identity=32.512315270936, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI225579074, Length=328, Percent_Identity=35.3658536585366, Blast_Score=189, Evalue=6e-48,
Organism=Escherichia coli, GI1787120, Length=436, Percent_Identity=50.2293577981651, Blast_Score=403, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17539260, Length=453, Percent_Identity=31.1258278145695, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17542084, Length=258, Percent_Identity=28.6821705426357, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320226, Length=399, Percent_Identity=33.0827067669173, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6321799, Length=294, Percent_Identity=32.9931972789116, Blast_Score=169, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24581334, Length=441, Percent_Identity=31.2925170068027, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17737985, Length=340, Percent_Identity=33.2352941176471, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_BEII9 (B2IJG1)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001833763.1
- GeneID:   6198532
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_2702
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48009; Mature: 48009

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 295-295 BINDING 395-395

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDIKWIRDNSALFDQGRERRGLPKLSAELLALDDARRAAIAESQAAQERRNAASKEIGA
CCCEEEEECCCHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKAKDNARAEALKAEMAELKAVSPALEEAERLAIAALDRALAEIPNLPLEDVPFGRDEN
HHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNPELRVVGEKPVFSFVPKEHFDIGEGLGLMDFEAAAKLSGARFVVNKGPLARLERALGQ
CCCCEEEEECCCCHHHCCCHHCCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHH
FMLDLHTGEHGYTEVNPPILARDDALFGTAQLPKLEEDMFAAHAGRVPQEAAGDLYWLIP
HHHHHCCCCCCCEECCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCEEEEEC
TSEVVLTNLVRETILDEKQLPLRFTACTPCFRAEAGSAGRDTRGMIRQHQFTKTELVSIT
CHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEE
TPEEALVEHERMLTCAEEVLKRLGLAYRVVTLCTGDMGFASQKTYDIEVWLPGQGRYREI
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCCCCCEEEEEEEECCCCCCEEC
SSCSVCGDFQARRMNARYRPEGGKTTRFVHTLNGSGVAVGRALVAVLENYQREDGGVNVP
CCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCH
RALLPYMGGITTITRG
HHHHHHHCCCEEECCC
>Mature Secondary Structure
MYDIKWIRDNSALFDQGRERRGLPKLSAELLALDDARRAAIAESQAAQERRNAASKEIGA
CCCEEEEECCCHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKAKDNARAEALKAEMAELKAVSPALEEAERLAIAALDRALAEIPNLPLEDVPFGRDEN
HHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNPELRVVGEKPVFSFVPKEHFDIGEGLGLMDFEAAAKLSGARFVVNKGPLARLERALGQ
CCCCEEEEECCCCHHHCCCHHCCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHH
FMLDLHTGEHGYTEVNPPILARDDALFGTAQLPKLEEDMFAAHAGRVPQEAAGDLYWLIP
HHHHHCCCCCCCEECCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCEEEEEC
TSEVVLTNLVRETILDEKQLPLRFTACTPCFRAEAGSAGRDTRGMIRQHQFTKTELVSIT
CHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEE
TPEEALVEHERMLTCAEEVLKRLGLAYRVVTLCTGDMGFASQKTYDIEVWLPGQGRYREI
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCCCCCEEEEEEEECCCCCCEEC
SSCSVCGDFQARRMNARYRPEGGKTTRFVHTLNGSGVAVGRALVAVLENYQREDGGVNVP
CCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCH
RALLPYMGGITTITRG
HHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA