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The map label for this gene is rkpK [H]

Identifier: 182679563

GI number: 182679563

Start: 3002507

End: 3003811

Strand: Reverse

Name: rkpK [H]

Synonym: Bind_2639

Alternate gene names: 182679563

Gene position: 3003811-3002507 (Counterclockwise)

Preceding gene: 182679564

Following gene: 182679562

Centisome position: 72.03

GC content: 59.16

Gene sequence:

>1305_bases
ATGCGTATAGCGGTGGTGGGTTCTGGATATGTCGGTCTTGTCTCTGGCGCGTGTTTCTCGGATTTTGGGCACATCGTGTC
CTGTGTCGATAATGATGCAAGCAAGATTGCTTCGCTCAATGCCGGCAAGATGCCGATCTACGAACCGGGCCTCGCGGAAC
TCGTCGCCAATAGTGTCCGCCAAAAGCGCCTGTTCTTTTCCACCGAATTGAAAACCGCCGTCCGCGAGGCGGAGGCCGTG
TTCATCGCGGTCGGTACACCCTCGCGGCGCGGCGATGGCCATGCCGATCTATCCTATGTCTATCAGGTGGCCCGTGACAT
TGCCGGGGCCCTTCAGGGCTTTACCGTCGTCGTCACCAAATCCACCGTGCCGGTCGGGACCGGTGACGAAGTCGAACGCA
TCATCAAAGAGGTGCGTCCCGATGCCGATATAGCGGTCGTCTCCAATCCGGAATTTTTGCGTGAAGGCGCAGCCATCGAG
GATTTCAAACGGCCCGATCGCATCGTTCTTGGCGTAGAGGACAAGCGCGCCGAGGCGGTGATGACTGAAATCTACCGGCC
GCTCTATCTCAATCAGGCGCCATTCGTCTTCACCAGCCGCCGCACGTCCGAACTCACCAAATATGCGGCCAATGCCTTTC
TCGCGACCAAGATCACCTTCATCAACGAGGTCGCTGATCTTTGCGAAAAAGTTGGCGCCAATGTCCAGGATGTCGCGCGC
GGCATCGGGCTCGACAAGCGCATCGGCGGAAAATTCCTCCATGCGGGGCCAGGGTATGGCGGCTCCTGCTTCCCCAAGGA
TACGCAAGCCCTGATCAAGACGGCCCAGGACTATGGCGCGCCGATCCGCATCGTGGAAACCGTCAGCGCCGTCAATGATC
AGCGTAAAAGGGCGATGGCGCGCAAGGTGCTCGCGGCCTGTGATGGCTCGGTGCGCGGCAAAACCATCGCCGTGCTGGGC
CTGACCTTTAAACCGAATACCGATGATATGCGGGATTCGCCCGCCATTTCCATCATCACGGCCTTGCAAGACCATGGCGC
ATTGATCAGGGCCTATGATCCGGAAGGCGAGGAGCAGGCCAAGCTCGTCCTCAACAATATCACCTATACGAAAGACCCCT
ATGAGTGCGGCACCGGCGCCGACGCTTTGGTGATCGTCACGGAATGGGACGAATTCCGCGCCCTCGACCTGCCACGCCTG
ACCGGTCTCCTGACCAAGCCCATCCTGATCGATCTGCGCAATATCTACGACCCCGCGGAAGTCAGGCGCCAGTCCTTCAC
CTATGCCAGCATCGGACGCTCCTGA

Upstream 100 bases:

>100_bases
GACGGAAAATCGCTGTATCTCTTATGGGGAAGATCGTGGCCCGATAGGTTTTCTAATGTTATAGACAATTCTTAATTTCA
GCTCGGCCTTGGGGACAAAC

Downstream 100 bases:

>100_bases
GACGAACTGAGAGAGGGCGTTCTGTTGCAAAGTCTGGCCTCAGGTTGCATGAGAACCATGCGGGTGGATCAGGCAGTTGG
ACGGTTCTATTAACCGTGTC

Product: nucleotide sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRIAVVGSGYVGLVSGACFSDFGHIVSCVDNDASKIASLNAGKMPIYEPGLAELVANSVRQKRLFFSTELKTAVREAEAV
FIAVGTPSRRGDGHADLSYVYQVARDIAGALQGFTVVVTKSTVPVGTGDEVERIIKEVRPDADIAVVSNPEFLREGAAIE
DFKRPDRIVLGVEDKRAEAVMTEIYRPLYLNQAPFVFTSRRTSELTKYAANAFLATKITFINEVADLCEKVGANVQDVAR
GIGLDKRIGGKFLHAGPGYGGSCFPKDTQALIKTAQDYGAPIRIVETVSAVNDQRKRAMARKVLAACDGSVRGKTIAVLG
LTFKPNTDDMRDSPAISIITALQDHGALIRAYDPEGEEQAKLVLNNITYTKDPYECGTGADALVIVTEWDEFRALDLPRL
TGLLTKPILIDLRNIYDPAEVRRQSFTYASIGRS

Sequences:

>Translated_434_residues
MRIAVVGSGYVGLVSGACFSDFGHIVSCVDNDASKIASLNAGKMPIYEPGLAELVANSVRQKRLFFSTELKTAVREAEAV
FIAVGTPSRRGDGHADLSYVYQVARDIAGALQGFTVVVTKSTVPVGTGDEVERIIKEVRPDADIAVVSNPEFLREGAAIE
DFKRPDRIVLGVEDKRAEAVMTEIYRPLYLNQAPFVFTSRRTSELTKYAANAFLATKITFINEVADLCEKVGANVQDVAR
GIGLDKRIGGKFLHAGPGYGGSCFPKDTQALIKTAQDYGAPIRIVETVSAVNDQRKRAMARKVLAACDGSVRGKTIAVLG
LTFKPNTDDMRDSPAISIITALQDHGALIRAYDPEGEEQAKLVLNNITYTKDPYECGTGADALVIVTEWDEFRALDLPRL
TGLLTKPILIDLRNIYDPAEVRRQSFTYASIGRS
>Mature_434_residues
MRIAVVGSGYVGLVSGACFSDFGHIVSCVDNDASKIASLNAGKMPIYEPGLAELVANSVRQKRLFFSTELKTAVREAEAV
FIAVGTPSRRGDGHADLSYVYQVARDIAGALQGFTVVVTKSTVPVGTGDEVERIIKEVRPDADIAVVSNPEFLREGAAIE
DFKRPDRIVLGVEDKRAEAVMTEIYRPLYLNQAPFVFTSRRTSELTKYAANAFLATKITFINEVADLCEKVGANVQDVAR
GIGLDKRIGGKFLHAGPGYGGSCFPKDTQALIKTAQDYGAPIRIVETVSAVNDQRKRAMARKVLAACDGSVRGKTIAVLG
LTFKPNTDDMRDSPAISIITALQDHGALIRAYDPEGEEQAKLVLNNITYTKDPYECGTGADALVIVTEWDEFRALDLPRL
TGLLTKPILIDLRNIYDPAEVRRQSFTYASIGRS

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=464, Percent_Identity=39.6551724137931, Blast_Score=301, Evalue=6e-82,
Organism=Homo sapiens, GI296040438, Length=362, Percent_Identity=38.9502762430939, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI296040443, Length=312, Percent_Identity=39.7435897435897, Blast_Score=209, Evalue=5e-54,
Organism=Escherichia coli, GI48994968, Length=412, Percent_Identity=31.0679611650485, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1788340, Length=362, Percent_Identity=29.5580110497238, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17560350, Length=464, Percent_Identity=38.1465517241379, Blast_Score=285, Evalue=2e-77,
Organism=Drosophila melanogaster, GI17136908, Length=463, Percent_Identity=38.0129589632829, Blast_Score=291, Evalue=5e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47114; Mature: 47114

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAVVGSGYVGLVSGACFSDFGHIVSCVDNDASKIASLNAGKMPIYEPGLAELVANSVR
CEEEEEECCCHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHH
QKRLFFSTELKTAVREAEAVFIAVGTPSRRGDGHADLSYVYQVARDIAGALQGFTVVVTK
HHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERIIKEVRPDADIAVVSNPEFLREGAAIEDFKRPDRIVLGVEDKRAEAV
CCCCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHCCCCHHHCCCCCEEEEECCCHHHHHH
MTEIYRPLYLNQAPFVFTSRRTSELTKYAANAFLATKITFINEVADLCEKVGANVQDVAR
HHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDKRIGGKFLHAGPGYGGSCFPKDTQALIKTAQDYGAPIRIVETVSAVNDQRKRAMA
HCCCCHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
RKVLAACDGSVRGKTIAVLGLTFKPNTDDMRDSPAISIITALQDHGALIRAYDPEGEEQA
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHEEHHHHCCCEEEEECCCCCHHH
KLVLNNITYTKDPYECGTGADALVIVTEWDEFRALDLPRLTGLLTKPILIDLRNIYDPAE
HHEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
VRRQSFTYASIGRS
HHHHCCCHHHCCCC
>Mature Secondary Structure
MRIAVVGSGYVGLVSGACFSDFGHIVSCVDNDASKIASLNAGKMPIYEPGLAELVANSVR
CEEEEEECCCHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHH
QKRLFFSTELKTAVREAEAVFIAVGTPSRRGDGHADLSYVYQVARDIAGALQGFTVVVTK
HHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERIIKEVRPDADIAVVSNPEFLREGAAIEDFKRPDRIVLGVEDKRAEAV
CCCCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHCCCCHHHCCCCCEEEEECCCHHHHHH
MTEIYRPLYLNQAPFVFTSRRTSELTKYAANAFLATKITFINEVADLCEKVGANVQDVAR
HHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDKRIGGKFLHAGPGYGGSCFPKDTQALIKTAQDYGAPIRIVETVSAVNDQRKRAMA
HCCCCHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
RKVLAACDGSVRGKTIAVLGLTFKPNTDDMRDSPAISIITALQDHGALIRAYDPEGEEQA
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHEEHHHHCCCEEEEECCCCCHHH
KLVLNNITYTKDPYECGTGADALVIVTEWDEFRALDLPRLTGLLTKPILIDLRNIYDPAE
HHEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
VRRQSFTYASIGRS
HHHHCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]