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The map label for this gene is mtlK [H]

Identifier: 182679411

GI number: 182679411

Start: 2806410

End: 2808179

Strand: Reverse

Name: mtlK [H]

Synonym: Bind_2459

Alternate gene names: 182679411

Gene position: 2808179-2806410 (Counterclockwise)

Preceding gene: 182679412

Following gene: 182679409

Centisome position: 67.34

GC content: 56.33

Gene sequence:

>1770_bases
ATGACCTGCAAGCTCTCGTTGACGACATTGAACGAGGCCACGGCACCGACGGCGGTTCCGACCTATGCGCGCCAAAGTCT
TTCCGCCGGCATTGTCCATTTCGGCATCGGAAATTTTCACCGCGCTCATCAGGCGGTCTATCTCGATGAATTGTTCAATG
CCGGTCAAGATCTTGACTGGGCCATCATCGGCGCGGGCGTCATGCCTTCCGACGCGTTGATCCGCGAAAAGCTGCTCGAT
CAGGATTGCCTGACGACGGTTGTCGAGCAGGACAATAACCGGGTTGCCGCCCGCATCACCGGCGCGATGATCGATATTTT
GCCGACCGGCAATGCGCCGGTCATCATCGAAAAGCTTGCCGAGCCGGCGATCCGCATCGTCTCCATGACCATCACGGAAG
GCGGTTATTTCCTCAACGCGAATGGCGCCTTCAATCTCGAACATCCGGCGATCATCGAGGATGGTCGTCACCCGGAATCA
CCGAAAACAATATTCGGGTTGATCGTCGCCGGCCTCAAAGCACGGAAGGAGAAGGGTATCGAGCCTTTTACTGTCGCTTC
CTGTGACAACATTCCCCATAATGGCAAGGTAACCTATAACGCTGTCACCGGGCTCGCGCGGCTCTCCGATCCAGATTTCG
CCAATTGGATCGCGGCCAATGTATCCTTTCCCAATTCCATGGTGGACCGTATCACGCCGGCGACGGGCCAGCGTGAGATT
GATATTGCCCGTGAAGATTTTGGCATTGAGGACAATTGGCCGGTCTTCTGCGAAGAATTTCGGCAATGGGTGATCGAGGA
TAAATTTCCTGCGGGGCGTCCGGCTTTGGAGAAAGTGGGCGTTCAATTCGTCCTCGATGTTTCGCCCTACGAACTCATGA
AGATCCGTATTCTCAACGGCGGCCATGCGGCTATCGCTTATCCTGCGGCTTTGCTTGACATTCATTTCGTTCACGAAGCG
ATGGAAGAGCCGCTCATCCGCTCCTTTCTCGCCAAGCTCGAACGCGAGGAAATCATTCCGGTCGTTCCACCCGTGCCGGA
TACCGATATCGATGCTTATTTCCAGTTGATCGAGCGGCGTTTCTCCAATTCGAAGATTGGCGATACGATCCCCCGGCTGG
CGCAGGATGGCTCTAATCGGCAGCCGAAATTCATTTTGCCGACGACGAAAGACCGGCTGGCGCGCGGCGACGATGTCATC
GGCCTCTCGCTGGTCTCGGCGCTCTGGTGTCGTTATTTCGCGGGAACATCGGACAGCGGCAAGGACATCGTCTTCAACGA
TGCGAGCGCCGAGCGGCTGCATGCGGCTGCGCTCGAAGCGAAAACAGACCCATCTGCCTTTCTTGCCCTCGATGATATTT
TCGGCACTATCGGCCATTCGGAACTGTTTGCCCGACGTTTCGCTCACGCGCTCAAGACATTGTGGGAGAAAGGAACGCGC
GAGACGCTGACGCTTTATCTGGAAAATCGCCTGATTCAAGAGGCTGAGGCGCAGACATATCCGCAGGAACATGAAATCCT
CGACATGATCCGAGGCCATCGTGGGGAAGACGCGCGGCCCATCGTGGCGGCTTGGCTGGCCGATCAGCGTGATCGCGGAA
CGATCGTTCTGGATGATGTTCAAAGCGGCGCCCGTATATTGATAGACATGATCTTCGGCGCGATCATTCCCAAACCGGAC
GACGAATGGCCTGATCGTGATGCCCGGCAGGCGCATATTCACCGGTGCATCGGCATCTTTCTCAATGGTGTGCTTCAGCG
CGCGCATTGA

Upstream 100 bases:

>100_bases
CGACGAGTCGTGCTTCAATGAAGGTGGATACTAGACAAACTCACAGCTCTCCATCCGGCCGGATGGTTCCAGATCGCTCT
TCCCTTTCGAGGATCGTAAT

Downstream 100 bases:

>100_bases
GTGCCGAGGTCGTGTATCTCCTTATCGCATGTGGCCGCGTCGACGCCGTCTCGGTTGTAGGGCCCATTTGTTGGGTCCAA
GCCTATTGGGTTGTCGCGGC

Product: mannitol dehydrogenase domain-containing protein

Products: NA

Alternate protein names: M2DH; MDH [H]

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MTCKLSLTTLNEATAPTAVPTYARQSLSAGIVHFGIGNFHRAHQAVYLDELFNAGQDLDWAIIGAGVMPSDALIREKLLD
QDCLTTVVEQDNNRVAARITGAMIDILPTGNAPVIIEKLAEPAIRIVSMTITEGGYFLNANGAFNLEHPAIIEDGRHPES
PKTIFGLIVAGLKARKEKGIEPFTVASCDNIPHNGKVTYNAVTGLARLSDPDFANWIAANVSFPNSMVDRITPATGQREI
DIAREDFGIEDNWPVFCEEFRQWVIEDKFPAGRPALEKVGVQFVLDVSPYELMKIRILNGGHAAIAYPAALLDIHFVHEA
MEEPLIRSFLAKLEREEIIPVVPPVPDTDIDAYFQLIERRFSNSKIGDTIPRLAQDGSNRQPKFILPTTKDRLARGDDVI
GLSLVSALWCRYFAGTSDSGKDIVFNDASAERLHAAALEAKTDPSAFLALDDIFGTIGHSELFARRFAHALKTLWEKGTR
ETLTLYLENRLIQEAEAQTYPQEHEILDMIRGHRGEDARPIVAAWLADQRDRGTIVLDDVQSGARILIDMIFGAIIPKPD
DEWPDRDARQAHIHRCIGIFLNGVLQRAH

Sequences:

>Translated_589_residues
MTCKLSLTTLNEATAPTAVPTYARQSLSAGIVHFGIGNFHRAHQAVYLDELFNAGQDLDWAIIGAGVMPSDALIREKLLD
QDCLTTVVEQDNNRVAARITGAMIDILPTGNAPVIIEKLAEPAIRIVSMTITEGGYFLNANGAFNLEHPAIIEDGRHPES
PKTIFGLIVAGLKARKEKGIEPFTVASCDNIPHNGKVTYNAVTGLARLSDPDFANWIAANVSFPNSMVDRITPATGQREI
DIAREDFGIEDNWPVFCEEFRQWVIEDKFPAGRPALEKVGVQFVLDVSPYELMKIRILNGGHAAIAYPAALLDIHFVHEA
MEEPLIRSFLAKLEREEIIPVVPPVPDTDIDAYFQLIERRFSNSKIGDTIPRLAQDGSNRQPKFILPTTKDRLARGDDVI
GLSLVSALWCRYFAGTSDSGKDIVFNDASAERLHAAALEAKTDPSAFLALDDIFGTIGHSELFARRFAHALKTLWEKGTR
ETLTLYLENRLIQEAEAQTYPQEHEILDMIRGHRGEDARPIVAAWLADQRDRGTIVLDDVQSGARILIDMIFGAIIPKPD
DEWPDRDARQAHIHRCIGIFLNGVLQRAH
>Mature_588_residues
TCKLSLTTLNEATAPTAVPTYARQSLSAGIVHFGIGNFHRAHQAVYLDELFNAGQDLDWAIIGAGVMPSDALIREKLLDQ
DCLTTVVEQDNNRVAARITGAMIDILPTGNAPVIIEKLAEPAIRIVSMTITEGGYFLNANGAFNLEHPAIIEDGRHPESP
KTIFGLIVAGLKARKEKGIEPFTVASCDNIPHNGKVTYNAVTGLARLSDPDFANWIAANVSFPNSMVDRITPATGQREID
IAREDFGIEDNWPVFCEEFRQWVIEDKFPAGRPALEKVGVQFVLDVSPYELMKIRILNGGHAAIAYPAALLDIHFVHEAM
EEPLIRSFLAKLEREEIIPVVPPVPDTDIDAYFQLIERRFSNSKIGDTIPRLAQDGSNRQPKFILPTTKDRLARGDDVIG
LSLVSALWCRYFAGTSDSGKDIVFNDASAERLHAAALEAKTDPSAFLALDDIFGTIGHSELFARRFAHALKTLWEKGTRE
TLTLYLENRLIQEAEAQTYPQEHEILDMIRGHRGEDARPIVAAWLADQRDRGTIVLDDVQSGARILIDMIFGAIIPKPDD
EWPDRDARQAHIHRCIGIFLNGVLQRAH

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=458, Percent_Identity=39.3013100436681, Blast_Score=301, Evalue=1e-82,
Organism=Escherichia coli, GI1790779, Length=485, Percent_Identity=36.9072164948454, Blast_Score=298, Evalue=8e-82,
Organism=Escherichia coli, GI1787823, Length=488, Percent_Identity=36.2704918032787, Blast_Score=279, Evalue=4e-76,
Organism=Escherichia coli, GI48994885, Length=368, Percent_Identity=27.9891304347826, Blast_Score=92, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324401, Length=479, Percent_Identity=39.6659707724426, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6320765, Length=479, Percent_Identity=39.6659707724426, Blast_Score=370, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.67 [H]

Molecular weight: Translated: 65241; Mature: 65110

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCKLSLTTLNEATAPTAVPTYARQSLSAGIVHFGIGNFHRAHQAVYLDELFNAGQDLDW
CEEEEEEEECCCCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCE
AIIGAGVMPSDALIREKLLDQDCLTTVVEQDNNRVAARITGAMIDILPTGNAPVIIEKLA
EEEECCCCCCHHHHHHHHHCHHHHHHHHHCCCCEEEEEEECEEEEEEECCCCCCHHHHHH
EPAIRIVSMTITEGGYFLNANGAFNLEHPAIIEDGRHPESPKTIFGLIVAGLKARKEKGI
CHHEEEEEEEEECCCEEEECCCEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
EPFTVASCDNIPHNGKVTYNAVTGLARLSDPDFANWIAANVSFPNSMVDRITPATGQREI
CCEEEECCCCCCCCCEEEEHHHHHHHHCCCCCHHHHEEECCCCCHHHHHHCCCCCCCCEE
DIAREDFGIEDNWPVFCEEFRQWVIEDKFPAGRPALEKVGVQFVLDVSPYELMKIRILNG
EEHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEEECCCCEEEEEEEECC
GHAAIAYPAALLDIHFVHEAMEEPLIRSFLAKLEREEIIPVVPPVPDTDIDAYFQLIERR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
FSNSKIGDTIPRLAQDGSNRQPKFILPTTKDRLARGDDVIGLSLVSALWCRYFAGTSDSG
HCCCCCCHHHHHHHHCCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
KDIVFNDASAERLHAAALEAKTDPSAFLALDDIFGTIGHSELFARRFAHALKTLWEKGTR
CEEEEECCCHHHHHHHHHHCCCCCHHEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCH
ETLTLYLENRLIQEAEAQTYPQEHEILDMIRGHRGEDARPIVAAWLADQRDRGTIVLDDV
HHEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCEEEECC
QSGARILIDMIFGAIIPKPDDEWPDRDARQAHIHRCIGIFLNGVLQRAH
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TCKLSLTTLNEATAPTAVPTYARQSLSAGIVHFGIGNFHRAHQAVYLDELFNAGQDLDW
EEEEEEEECCCCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCE
AIIGAGVMPSDALIREKLLDQDCLTTVVEQDNNRVAARITGAMIDILPTGNAPVIIEKLA
EEEECCCCCCHHHHHHHHHCHHHHHHHHHCCCCEEEEEEECEEEEEEECCCCCCHHHHHH
EPAIRIVSMTITEGGYFLNANGAFNLEHPAIIEDGRHPESPKTIFGLIVAGLKARKEKGI
CHHEEEEEEEEECCCEEEECCCEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
EPFTVASCDNIPHNGKVTYNAVTGLARLSDPDFANWIAANVSFPNSMVDRITPATGQREI
CCEEEECCCCCCCCCEEEEHHHHHHHHCCCCCHHHHEEECCCCCHHHHHHCCCCCCCCEE
DIAREDFGIEDNWPVFCEEFRQWVIEDKFPAGRPALEKVGVQFVLDVSPYELMKIRILNG
EEHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEEECCCCEEEEEEEECC
GHAAIAYPAALLDIHFVHEAMEEPLIRSFLAKLEREEIIPVVPPVPDTDIDAYFQLIERR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
FSNSKIGDTIPRLAQDGSNRQPKFILPTTKDRLARGDDVIGLSLVSALWCRYFAGTSDSG
HCCCCCCHHHHHHHHCCCCCCCEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
KDIVFNDASAERLHAAALEAKTDPSAFLALDDIFGTIGHSELFARRFAHALKTLWEKGTR
CEEEEECCCHHHHHHHHHHCCCCCHHEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCH
ETLTLYLENRLIQEAEAQTYPQEHEILDMIRGHRGEDARPIVAAWLADQRDRGTIVLDDV
HHEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCEEEECC
QSGARILIDMIFGAIIPKPDDEWPDRDARQAHIHRCIGIFLNGVLQRAH
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8254318 [H]