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The map label for this gene is aqpZ [H]

Identifier: 182679281

GI number: 182679281

Start: 2661030

End: 2661734

Strand: Reverse

Name: aqpZ [H]

Synonym: Bind_2325

Alternate gene names: 182679281

Gene position: 2661734-2661030 (Counterclockwise)

Preceding gene: 182679282

Following gene: 182679279

Centisome position: 63.83

GC content: 58.01

Gene sequence:

>705_bases
ATGGATTTTAGGAAATATTTGGCTGAATTAATCGGCACTTTTTGGTTGACCTTTGGTGGCTGCGGCGCCGCGGTCGTTTC
AGCGGCTTTTCCGCATGTCGGTATCGGCCTGCTTGGCGTCGCTTTCGCCTTTGGTTTGACCGTTCTCACCATGGCTTTTG
CAGTCGGACATATTTCCGGCGGGCATTTCAATCCAGCGGTTACTTTCGGCCTGACGGCTGGCGGACGCTTCCCAGCCAGC
CAGGTCATTCCTTATGTCATCGCGCAGGTGCTTGGCGCTATTGCGGCTTCGGCGCTTCTCTATTTCATCGCGAGTGGTGC
GCCTGGTTTTGACCTTGCCGGCGGCTTTGCTGCCAATGGTTATGACGCGCATTCGCCGGGGCATTACAATCTGGTCTCGG
CTTTTACCGCTGAAACCGTGCTCACCGCCGTCTTCCTCTTCGTTATCATGGGATCGACGCATCCAGATGCGGGGACGGGG
TTCGCTCCGATCGCCATTGGCCTCTGCCTGACGCTGATCCATTTGATCAGTATTCCGATCACCAATACGTCGGTCAATCC
GGCGCGCAGCACCGGCCCGGCCCTCATCGTCGGCGGATGGGCTTTGGAACAGCTCTGGCTGTTTTGGGCGGCGCCTCTGA
TCGGCGGCATTGTCGGTGCCATTCTCTATCGCATCGTTCGCCCAGCGCCGACGATCCGCATCTGA

Upstream 100 bases:

>100_bases
ATCAAGCCAGGCCGGGGTGTATGGCGGGCTAACGTCGGCGGTCGATATTTTTCAAGATGACCGCTTTTTGGGGTTTAGTC
AGATCGAGGGGTAATCTCCT

Downstream 100 bases:

>100_bases
GATCTTGTGCGTTTACGCGCTATAAGTATCGCACTTTCATTCGTGCCCATGTGAGATGCGATAAGCCTTTATAATCACAT
GAAGCTGACCCTAAAGGGGC

Product: MIP family channel protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MDFRKYLAELIGTFWLTFGGCGAAVVSAAFPHVGIGLLGVAFAFGLTVLTMAFAVGHISGGHFNPAVTFGLTAGGRFPAS
QVIPYVIAQVLGAIAASALLYFIASGAPGFDLAGGFAANGYDAHSPGHYNLVSAFTAETVLTAVFLFVIMGSTHPDAGTG
FAPIAIGLCLTLIHLISIPITNTSVNPARSTGPALIVGGWALEQLWLFWAAPLIGGIVGAILYRIVRPAPTIRI

Sequences:

>Translated_234_residues
MDFRKYLAELIGTFWLTFGGCGAAVVSAAFPHVGIGLLGVAFAFGLTVLTMAFAVGHISGGHFNPAVTFGLTAGGRFPAS
QVIPYVIAQVLGAIAASALLYFIASGAPGFDLAGGFAANGYDAHSPGHYNLVSAFTAETVLTAVFLFVIMGSTHPDAGTG
FAPIAIGLCLTLIHLISIPITNTSVNPARSTGPALIVGGWALEQLWLFWAAPLIGGIVGAILYRIVRPAPTIRI
>Mature_234_residues
MDFRKYLAELIGTFWLTFGGCGAAVVSAAFPHVGIGLLGVAFAFGLTVLTMAFAVGHISGGHFNPAVTFGLTAGGRFPAS
QVIPYVIAQVLGAIAASALLYFIASGAPGFDLAGGFAANGYDAHSPGHYNLVSAFTAETVLTAVFLFVIMGSTHPDAGTG
FAPIAIGLCLTLIHLISIPITNTSVNPARSTGPALIVGGWALEQLWLFWAAPLIGGIVGAILYRIVRPAPTIRI

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502179, Length=225, Percent_Identity=36.4444444444444, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI37694062, Length=190, Percent_Identity=36.8421052631579, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI6912506, Length=224, Percent_Identity=35.7142857142857, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI4502181, Length=195, Percent_Identity=34.3589743589744, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI4755125, Length=195, Percent_Identity=34.3589743589744, Blast_Score=103, Evalue=9e-23,
Organism=Homo sapiens, GI4502183, Length=223, Percent_Identity=34.0807174887892, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI86792455, Length=224, Percent_Identity=31.25, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI45446752, Length=204, Percent_Identity=30.3921568627451, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI157266307, Length=244, Percent_Identity=31.9672131147541, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4826645, Length=250, Percent_Identity=27.6, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4502187, Length=241, Percent_Identity=28.6307053941909, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI22538420, Length=246, Percent_Identity=28.0487804878049, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=71.6346153846154, Blast_Score=282, Evalue=1e-77,
Organism=Escherichia coli, GI1790362, Length=251, Percent_Identity=30.6772908366534, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71993722, Length=230, Percent_Identity=32.6086956521739, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17558372, Length=235, Percent_Identity=31.9148936170213, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71992966, Length=242, Percent_Identity=28.5123966942149, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531431, Length=238, Percent_Identity=31.5126050420168, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17531429, Length=238, Percent_Identity=31.5126050420168, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652747, Length=226, Percent_Identity=36.7256637168142, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45551084, Length=226, Percent_Identity=36.7256637168142, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI19922038, Length=235, Percent_Identity=32.3404255319149, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24652751, Length=233, Percent_Identity=32.618025751073, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17136672, Length=228, Percent_Identity=30.7017543859649, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45550503, Length=229, Percent_Identity=26.6375545851528, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24762344, Length=226, Percent_Identity=30.5309734513274, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24762346, Length=226, Percent_Identity=30.5309734513274, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24762348, Length=226, Percent_Identity=30.5309734513274, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130305, Length=226, Percent_Identity=30.5309734513274, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24762342, Length=230, Percent_Identity=29.1304347826087, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 24071; Mature: 24071

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFRKYLAELIGTFWLTFGGCGAAVVSAAFPHVGIGLLGVAFAFGLTVLTMAFAVGHISG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GHFNPAVTFGLTAGGRFPASQVIPYVIAQVLGAIAASALLYFIASGAPGFDLAGGFAANG
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
YDAHSPGHYNLVSAFTAETVLTAVFLFVIMGSTHPDAGTGFAPIAIGLCLTLIHLISIPI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TNTSVNPARSTGPALIVGGWALEQLWLFWAAPLIGGIVGAILYRIVRPAPTIRI
CCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDFRKYLAELIGTFWLTFGGCGAAVVSAAFPHVGIGLLGVAFAFGLTVLTMAFAVGHISG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GHFNPAVTFGLTAGGRFPASQVIPYVIAQVLGAIAASALLYFIASGAPGFDLAGGFAANG
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
YDAHSPGHYNLVSAFTAETVLTAVFLFVIMGSTHPDAGTGFAPIAIGLCLTLIHLISIPI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TNTSVNPARSTGPALIVGGWALEQLWLFWAAPLIGGIVGAILYRIVRPAPTIRI
CCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]