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The map label for this gene is bdhA [H]

Identifier: 182679178

GI number: 182679178

Start: 2541706

End: 2542779

Strand: Reverse

Name: bdhA [H]

Synonym: Bind_2217

Alternate gene names: 182679178

Gene position: 2542779-2541706 (Counterclockwise)

Preceding gene: 182679179

Following gene: 182679175

Centisome position: 60.98

GC content: 56.89

Gene sequence:

>1074_bases
ATGAAAGCGCTTCGCTTCCACGCTGCCAAGGATTTGCGTATCGAGGATATTCCGGCGCCGCCGCCGACGCCTGGGCCGGG
AGAGGTGCTGGTCAAGAACCGTTTCTGCGGTATTTGCGGGACCGATCTGCATGAATATGTGTCTGGTCCGATTTTCATTC
CGGTCGAACCGCATCCCTTTACCAAAGTGTCTGGTCCGCAGATCCTGGGGCATGAATTCGGCGGCGAGGTCGTGGCCGTG
GGGCCAGGGGTCACCTCGGCCAAGCCGGGCGATCGCGTCTCGATCCAGCCGCTTCTCATGCCGCGTTCCGGGGATTATTT
CTCTGATCGGGGTCTGTTCCATCTGAGCCCCGTACTCGCACTCGTCGGGTTGAGCTGGCAATGGGGCGGCATGGCGGAAT
ATGCTCTGGTGAACGACTACAACATCCATGTGATTCCGAACGAGATGACGGATGAAGAAGCGGCATTGGTCGAGCCGACA
GCCGTTGCCGTTTATGCTTGTGACCGTGGCGGTGTCACAGCCGGTTCAAGCGTGCTCGTCACGGGCGCAGGCCCAATTGG
CATGCTCACTTTGCTCGCAGCGAGGGCGGCTGGCGCGACACAACTCTTTCTGTCCGATCTCAACGAAACACGGCTACAGA
TTGCCAAATTCATTCTTCCTGATGTGATTACTCTCAACCCTAAAAAGGATAATGTCGGTGATCGTGTGCGTGAAGAGAGC
GAAGGCAAGGTTGGTTGCGATGTCGCGATCGAGTGCGTTGGCAATGAACATGCCTTGAAAGCCTGCGCGGATGCCGTGCG
TAAACAAGGTGTCGTCGTGCAGACCGGATTGCATCCCGGAGAAAACCCCCTCAACTGGTTCAATGTTACCTTCAAGGATA
TCGATATTCGGGGGTCCTGGGCCTATCCCACCCATTATTGGCCTCGCGTCAGCCGCTTGATCGCTTCCAAACAATTGCCG
GCCCAAAAGGTTGTCACCAAGCGCATTAAGCTGGATCAGGCGGTCAAAGAGGGCTTCGACGCGCTTCTCGACCCAGCCGG
TCAACAATTGAAGATCCTGATCGATCTCGCCTGA

Upstream 100 bases:

>100_bases
ATTTTCAATAAAATAACAATAATGTAGTTCCCGGCACGGCCCTTGCCCAAAGGTAGAACCGCCCACGAAAAATAATGGGG
CGGAATGCAGGAGGAAAAGG

Downstream 100 bases:

>100_bases
TAGGGGGATCTGTTGTCGGATTGCCACTAACTACGCGACTTGAGTGCTTTTTGAGGTGAAGCATTAACTTGAGACAAAAT
TTCCTATTTTGTCTCAAGTA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKALRFHAAKDLRIEDIPAPPPTPGPGEVLVKNRFCGICGTDLHEYVSGPIFIPVEPHPFTKVSGPQILGHEFGGEVVAV
GPGVTSAKPGDRVSIQPLLMPRSGDYFSDRGLFHLSPVLALVGLSWQWGGMAEYALVNDYNIHVIPNEMTDEEAALVEPT
AVAVYACDRGGVTAGSSVLVTGAGPIGMLTLLAARAAGATQLFLSDLNETRLQIAKFILPDVITLNPKKDNVGDRVREES
EGKVGCDVAIECVGNEHALKACADAVRKQGVVVQTGLHPGENPLNWFNVTFKDIDIRGSWAYPTHYWPRVSRLIASKQLP
AQKVVTKRIKLDQAVKEGFDALLDPAGQQLKILIDLA

Sequences:

>Translated_357_residues
MKALRFHAAKDLRIEDIPAPPPTPGPGEVLVKNRFCGICGTDLHEYVSGPIFIPVEPHPFTKVSGPQILGHEFGGEVVAV
GPGVTSAKPGDRVSIQPLLMPRSGDYFSDRGLFHLSPVLALVGLSWQWGGMAEYALVNDYNIHVIPNEMTDEEAALVEPT
AVAVYACDRGGVTAGSSVLVTGAGPIGMLTLLAARAAGATQLFLSDLNETRLQIAKFILPDVITLNPKKDNVGDRVREES
EGKVGCDVAIECVGNEHALKACADAVRKQGVVVQTGLHPGENPLNWFNVTFKDIDIRGSWAYPTHYWPRVSRLIASKQLP
AQKVVTKRIKLDQAVKEGFDALLDPAGQQLKILIDLA
>Mature_357_residues
MKALRFHAAKDLRIEDIPAPPPTPGPGEVLVKNRFCGICGTDLHEYVSGPIFIPVEPHPFTKVSGPQILGHEFGGEVVAV
GPGVTSAKPGDRVSIQPLLMPRSGDYFSDRGLFHLSPVLALVGLSWQWGGMAEYALVNDYNIHVIPNEMTDEEAALVEPT
AVAVYACDRGGVTAGSSVLVTGAGPIGMLTLLAARAAGATQLFLSDLNETRLQIAKFILPDVITLNPKKDNVGDRVREES
EGKVGCDVAIECVGNEHALKACADAVRKQGVVVQTGLHPGENPLNWFNVTFKDIDIRGSWAYPTHYWPRVSRLIASKQLP
AQKVVTKRIKLDQAVKEGFDALLDPAGQQLKILIDLA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=357, Percent_Identity=37.8151260504202, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1788073, Length=342, Percent_Identity=29.5321637426901, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1790045, Length=357, Percent_Identity=31.0924369747899, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI226510992, Length=310, Percent_Identity=30.6451612903226, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788075, Length=377, Percent_Identity=28.3819628647215, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787863, Length=196, Percent_Identity=35.7142857142857, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786825, Length=384, Percent_Identity=27.6041666666667, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790718, Length=287, Percent_Identity=27.1777003484321, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI87082125, Length=345, Percent_Identity=28.1159420289855, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1788407, Length=331, Percent_Identity=27.190332326284, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081918, Length=275, Percent_Identity=30.5454545454545, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=337, Percent_Identity=32.9376854599407, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=32.0359281437126, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71988145, Length=283, Percent_Identity=27.208480565371, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=403, Percent_Identity=24.5657568238213, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=374, Percent_Identity=30.7486631016043, Blast_Score=163, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319257, Length=376, Percent_Identity=28.4574468085106, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322619, Length=352, Percent_Identity=31.25, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6319955, Length=352, Percent_Identity=31.25, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323099, Length=337, Percent_Identity=28.7833827893175, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319621, Length=302, Percent_Identity=28.8079470198675, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=299, Percent_Identity=28.0936454849498, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=304, Percent_Identity=28.6184210526316, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=304, Percent_Identity=29.2763157894737, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17137530, Length=353, Percent_Identity=32.8611898016997, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI17737897, Length=354, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 38432; Mature: 38432

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALRFHAAKDLRIEDIPAPPPTPGPGEVLVKNRFCGICGTDLHEYVSGPIFIPVEPHPF
CCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHCCCEEEEECCCCC
TKVSGPQILGHEFGGEVVAVGPGVTSAKPGDRVSIQPLLMPRSGDYFSDRGLFHLSPVLA
CCCCCCEEECHHCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHH
LVGLSWQWGGMAEYALVNDYNIHVIPNEMTDEEAALVEPTAVAVYACDRGGVTAGSSVLV
HHCCCCCCCCEEEEEEEECCEEEECCCCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEE
TGAGPIGMLTLLAARAAGATQLFLSDLNETRLQIAKFILPDVITLNPKKDNVGDRVREES
ECCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHC
EGKVGCDVAIECVGNEHALKACADAVRKQGVVVQTGLHPGENPLNWFNVTFKDIDIRGSW
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEEEEECCC
AYPTHYWPRVSRLIASKQLPAQKVVTKRIKLDQAVKEGFDALLDPAGQQLKILIDLA
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
>Mature Secondary Structure
MKALRFHAAKDLRIEDIPAPPPTPGPGEVLVKNRFCGICGTDLHEYVSGPIFIPVEPHPF
CCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHCCCEEEEECCCCC
TKVSGPQILGHEFGGEVVAVGPGVTSAKPGDRVSIQPLLMPRSGDYFSDRGLFHLSPVLA
CCCCCCEEECHHCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHH
LVGLSWQWGGMAEYALVNDYNIHVIPNEMTDEEAALVEPTAVAVYACDRGGVTAGSSVLV
HHCCCCCCCCEEEEEEEECCEEEECCCCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEE
TGAGPIGMLTLLAARAAGATQLFLSDLNETRLQIAKFILPDVITLNPKKDNVGDRVREES
ECCCHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHC
EGKVGCDVAIECVGNEHALKACADAVRKQGVVVQTGLHPGENPLNWFNVTFKDIDIRGSW
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEEEEECCC
AYPTHYWPRVSRLIASKQLPAQKVVTKRIKLDQAVKEGFDALLDPAGQQLKILIDLA
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]