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The map label for this gene is pcoA [H]

Identifier: 182679149

GI number: 182679149

Start: 2499715

End: 2501241

Strand: Direct

Name: pcoA [H]

Synonym: Bind_2186

Alternate gene names: 182679149

Gene position: 2499715-2501241 (Clockwise)

Preceding gene: 182679144

Following gene: 182679150

Centisome position: 59.94

GC content: 60.58

Gene sequence:

>1527_bases
ATGCGGCAAGGCCTCCCCCTCACACGCCGCCATTTTCTCGGGCAGATATCGATCAGCCTCAGCCTGTTGCCGCACCTTTC
CCGAACCGCACAGGCCGCCACGGAGGATGGTTTCCAAATCCTCGAGGCCCGGCAAGGCAAGCTGCGCCTTTTGCCCGAGC
CACAGCCAGAGACGGATATTTGGGGTTTCGACGGCCTGGTGCCTGGCCCCCTTTTGCGCTTCAAAAAAGGCGACGAAATC
AAGATCCGGCTTTTGAACAAGCTCGATCAACCGCTGACTCTGCACTGGCACGGCATGCGCGGCCCCAACGCTATGGCCGG
TGTCGGCGGCCTCACGCAGCCGTCCGTGCCGCCCGGTGGCAGTTTTGACTATCGTTTCACGCCGCCCGACAGCGGTCTCT
TCTGGTATCATTCGCATGTGCTGCCCTTGACCGGCGAACAATTAGACCACGGTCTTTATGGCGGGATCATCGTGGATGAA
CCGGAGCCGCCGCAAGTCGATCGGGATCTGCTGCTGGTTCTGAGTGACTGGCGGCTCGATGGCACAGGCGCACTCGAAAA
GGATTATATCGATCGCCGGACTGCCATGGGTATTGGCCGCCTCGGCACACTTATCACCATCAATGACAAGCCGGTTCCCG
TAACCGAAACCCTGCGGCCACGCAGCCGGGTCCGTCTGCGCATCATCAGCGCGACGGACGCCCGCGTTATGTTCCTCGGC
TTTGAAGCGCTCCGGCCTTACATTATCGCGGTCGATGGCATGCCCTGCGACGCGCCTTTCGAACCGATCCGCCAAACGAT
CCCCGCCGGTCCTGGCGCTTGTTTCGACCTCTTGCTCGACCTCCCCGACGCAGCAGAGACGGAGGCCCGTCTCGTCCTGC
GCGGCGATGAGGGGCAGCCAGATCAGCCCCTCTTCATTTTCAAGACGGCAAAGGAATCGTCCGACAAGGAAACGCCGAAA
GAGGCCCCGCCTCCCATTCCCTCGCTCCCGCATAATCCACTGCTGCCCGTGGCGATCCCTTTGCAAGCGGCTTTCCGTCT
CGATCTCACGATCGATGGCGGCGACAAACAGGAGCCTGGGCCGGACAAAAGCATGGCGGGCGCGACGACCAGCAATGGGA
AAGGCTCGGACAACAAGGCCGGCACGCCACCAAACCCGCAACAAACCAGTCCCCAACCTGCGTCCCCACCGAATGGCCCT
GCTCTATTCTGGACCTTGAACGGAATCTCGCAGCAAGGATTTGGGCCAAAGCCTCTCTTTTCGGTCAAGCGAGGTTCCGC
TGTCACGCTTGGCTTCATCAATCGTTCCGCCTTCGTGCAGCAAATGCGCGTCCATGGCCATTGTTTCAGACTTTTGCATG
ATCTCGACGATGGCTGGGAACCCTATTGGCGCAATGCGGTACTGGTGCCGCCCGGCCGCACCAAACATATTGCCTTCATC
GCCGATAATCCCGGCAAATGGCCAATCGAAAGTCTGATGGCGAGCCGGCAGTCGACCGGGCTCGCGACGTGGTTCGAAGT
CACATAA

Upstream 100 bases:

>100_bases
CCTTTCGACGTTCCGATCGGACACGCGTTTAAAAGCAACTCGTCGGTCCAAACATCCGTTCCAAGGTCGACAAGCCAGGA
TCAACAATCAGGGACTATCC

Downstream 100 bases:

>100_bases
TCGATACGCAAAGCCAATTAGCCTTGCGTCATAAGGAGAGTTCATGCCCAACGTCCGCGAACCGCTTCTGCATCCCGTCG
AAATCGCGCTCCTGCGCCCC

Product: multicopper oxidase type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MRQGLPLTRRHFLGQISISLSLLPHLSRTAQAATEDGFQILEARQGKLRLLPEPQPETDIWGFDGLVPGPLLRFKKGDEI
KIRLLNKLDQPLTLHWHGMRGPNAMAGVGGLTQPSVPPGGSFDYRFTPPDSGLFWYHSHVLPLTGEQLDHGLYGGIIVDE
PEPPQVDRDLLLVLSDWRLDGTGALEKDYIDRRTAMGIGRLGTLITINDKPVPVTETLRPRSRVRLRIISATDARVMFLG
FEALRPYIIAVDGMPCDAPFEPIRQTIPAGPGACFDLLLDLPDAAETEARLVLRGDEGQPDQPLFIFKTAKESSDKETPK
EAPPPIPSLPHNPLLPVAIPLQAAFRLDLTIDGGDKQEPGPDKSMAGATTSNGKGSDNKAGTPPNPQQTSPQPASPPNGP
ALFWTLNGISQQGFGPKPLFSVKRGSAVTLGFINRSAFVQQMRVHGHCFRLLHDLDDGWEPYWRNAVLVPPGRTKHIAFI
ADNPGKWPIESLMASRQSTGLATWFEVT

Sequences:

>Translated_508_residues
MRQGLPLTRRHFLGQISISLSLLPHLSRTAQAATEDGFQILEARQGKLRLLPEPQPETDIWGFDGLVPGPLLRFKKGDEI
KIRLLNKLDQPLTLHWHGMRGPNAMAGVGGLTQPSVPPGGSFDYRFTPPDSGLFWYHSHVLPLTGEQLDHGLYGGIIVDE
PEPPQVDRDLLLVLSDWRLDGTGALEKDYIDRRTAMGIGRLGTLITINDKPVPVTETLRPRSRVRLRIISATDARVMFLG
FEALRPYIIAVDGMPCDAPFEPIRQTIPAGPGACFDLLLDLPDAAETEARLVLRGDEGQPDQPLFIFKTAKESSDKETPK
EAPPPIPSLPHNPLLPVAIPLQAAFRLDLTIDGGDKQEPGPDKSMAGATTSNGKGSDNKAGTPPNPQQTSPQPASPPNGP
ALFWTLNGISQQGFGPKPLFSVKRGSAVTLGFINRSAFVQQMRVHGHCFRLLHDLDDGWEPYWRNAVLVPPGRTKHIAFI
ADNPGKWPIESLMASRQSTGLATWFEVT
>Mature_508_residues
MRQGLPLTRRHFLGQISISLSLLPHLSRTAQAATEDGFQILEARQGKLRLLPEPQPETDIWGFDGLVPGPLLRFKKGDEI
KIRLLNKLDQPLTLHWHGMRGPNAMAGVGGLTQPSVPPGGSFDYRFTPPDSGLFWYHSHVLPLTGEQLDHGLYGGIIVDE
PEPPQVDRDLLLVLSDWRLDGTGALEKDYIDRRTAMGIGRLGTLITINDKPVPVTETLRPRSRVRLRIISATDARVMFLG
FEALRPYIIAVDGMPCDAPFEPIRQTIPAGPGACFDLLLDLPDAAETEARLVLRGDEGQPDQPLFIFKTAKESSDKETPK
EAPPPIPSLPHNPLLPVAIPLQAAFRLDLTIDGGDKQEPGPDKSMAGATTSNGKGSDNKAGTPPNPQQTSPQPASPPNGP
ALFWTLNGISQQGFGPKPLFSVKRGSAVTLGFINRSAFVQQMRVHGHCFRLLHDLDDGWEPYWRNAVLVPPGRTKHIAFI
ADNPGKWPIESLMASRQSTGLATWFEVT

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=237, Percent_Identity=29.1139240506329, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789394, Length=305, Percent_Identity=24.5901639344262, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323703, Length=199, Percent_Identity=28.643216080402, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321067, Length=219, Percent_Identity=26.9406392694064, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574104, Length=139, Percent_Identity=32.3741007194245, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 55652; Mature: 55652

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00079 MULTICOPPER_OXIDASE1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQGLPLTRRHFLGQISISLSLLPHLSRTAQAATEDGFQILEARQGKLRLLPEPQPETDI
CCCCCCCHHHHHHEEEEEEEEHHHHHHHHHHHHHHCCHHHHHCCCCCEEECCCCCCCCCC
WGFDGLVPGPLLRFKKGDEIKIRLLNKLDQPLTLHWHGMRGPNAMAGVGGLTQPSVPPGG
CCCCCCCCCCHHCCCCCCCEEEEEEHHCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCC
SFDYRFTPPDSGLFWYHSHVLPLTGEQLDHGLYGGIIVDEPEPPQVDRDLLLVLSDWRLD
CCCEEECCCCCCEEEEECEEECCCCHHHCCCCCCCEEECCCCCCCCCCEEEEEEECCEEC
GTGALEKDYIDRRTAMGIGRLGTLITINDKPVPVTETLRPRSRVRLRIISATDARVMFLG
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCCCEEEEEEEECCCCEEEEEE
FEALRPYIIAVDGMPCDAPFEPIRQTIPAGPGACFDLLLDLPDAAETEARLVLRGDEGQP
HHHHCCEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCC
DQPLFIFKTAKESSDKETPKEAPPPIPSLPHNPLLPVAIPLQAAFRLDLTIDGGDKQEPG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEEEEEECCCCCCCCC
PDKSMAGATTSNGKGSDNKAGTPPNPQQTSPQPASPPNGPALFWTLNGISQQGFGPKPLF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCE
SVKRGSAVTLGFINRSAFVQQMRVHGHCFRLLHDLDDGWEPYWRNAVLVPPGRTKHIAFI
EECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEECCCCCEEEEEE
ADNPGKWPIESLMASRQSTGLATWFEVT
ECCCCCCCHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MRQGLPLTRRHFLGQISISLSLLPHLSRTAQAATEDGFQILEARQGKLRLLPEPQPETDI
CCCCCCCHHHHHHEEEEEEEEHHHHHHHHHHHHHHCCHHHHHCCCCCEEECCCCCCCCCC
WGFDGLVPGPLLRFKKGDEIKIRLLNKLDQPLTLHWHGMRGPNAMAGVGGLTQPSVPPGG
CCCCCCCCCCHHCCCCCCCEEEEEEHHCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCC
SFDYRFTPPDSGLFWYHSHVLPLTGEQLDHGLYGGIIVDEPEPPQVDRDLLLVLSDWRLD
CCCEEECCCCCCEEEEECEEECCCCHHHCCCCCCCEEECCCCCCCCCCEEEEEEECCEEC
GTGALEKDYIDRRTAMGIGRLGTLITINDKPVPVTETLRPRSRVRLRIISATDARVMFLG
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHCCCCCCEEEEEEEECCCCEEEEEE
FEALRPYIIAVDGMPCDAPFEPIRQTIPAGPGACFDLLLDLPDAAETEARLVLRGDEGQP
HHHHCCEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCC
DQPLFIFKTAKESSDKETPKEAPPPIPSLPHNPLLPVAIPLQAAFRLDLTIDGGDKQEPG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEEEEEECCCCCCCCC
PDKSMAGATTSNGKGSDNKAGTPPNPQQTSPQPASPPNGPALFWTLNGISQQGFGPKPLF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCE
SVKRGSAVTLGFINRSAFVQQMRVHGHCFRLLHDLDDGWEPYWRNAVLVPPGRTKHIAFI
EECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEECCCCCEEEEEE
ADNPGKWPIESLMASRQSTGLATWFEVT
ECCCCCCCHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]