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The map label for this gene is lon [H]

Identifier: 182679145

GI number: 182679145

Start: 2491969

End: 2494383

Strand: Reverse

Name: lon [H]

Synonym: Bind_2182

Alternate gene names: 182679145

Gene position: 2494383-2491969 (Counterclockwise)

Preceding gene: 182679146

Following gene: 182679142

Centisome position: 59.82

GC content: 58.59

Gene sequence:

>2415_bases
ATGACCCAGAAGCGTGATCTTGTTCGCCCCGGCTCCATAGAGAGCTATCCTGTTCTCCCTCTGCGCGACATAGTCGTATT
TCCGCATATGATCGTGCCGCTGTTCGTCGGCCGCGAGAAGTCGATTCGCGCCCTCGAGGAAGTGATGAAGGCCGACAAGC
TCATCCTTCTCGCGACCCAAATGAATGCGGCGGATGACGATCCGGCAACGGACGCCATTTTCACCACGGGAACGCTCGCC
TCTGTTCTGCAGCTTTTGAAGCTCCCCGACGGGACCGTCAAAGTGCTGGTCGAGGGCCAGTGGCGCGCCAAGGTGCAGAA
TTATACCCGCACCGAAGATTATTATGAGGCCGACGCGGAAGCGATCGCCGACGATCCGATTGACAAGGTCGAGGTCGAGG
CCTTGGCGCGGTCCGTGGTCTCCGAATTCGAAGGCTATGTGAAGCTTAACAAGAAGATCTCGCCGGAAGTCGTCGCTGCG
GTGACGCAGATCGACGATTATGCGAAGCTCGCCGATACGATCGCCTCGCATCTTGCGGTGAAGATCGCCGATAAGCAGGC
GGTTCTTGAGACGACTTCGGTCACGAAGAGGCTCGAGAAATGTCTCGCTTTGATGGAGAGCGAGATTTCCGTTCTGCAGG
TCGAGAAGCGTATTCGCACCCGGGTCAAGCGCCAGATGGAGAAGACCCAGCGCGAATATTATCTCAACGAGCAGATGAAG
GCGATCCAAAAGGAACTTGGCGACGAAGACGGTAAGGACGATCTCGCCGAAATCGAGGAGCGGATCAAGAATACCAAGCT
CTCCAAGGAGGCACGCGACAAGGCGACTGCCGAATTGAAGAAGCTTCGGCAGATGTCGCCCATGTCGGCCGAGGCGACCG
TCGTGCGCAATTACCTCGACTGGCTGCTCGCCATTCCGTGGAACAAGCGCTCGAAGGTCAAGAAGGATCTGACGGTTGCC
GAAGAAGTGCTCGACAGCGAGCATTATGGTCTCGACAAGGTCAAGGAGCGTATCCTTGAATATCTTGCTGTGCAGACTCG
CGCCAATAAGTTGACTGGTCCGATTCTGTGCCTCGTTGGCCCGCCCGGCGTCGGTAAAACCTCGCTCGGCAAGTCGATCG
CCAAGGCCACGGGACGTGAATTCGTGCGCATGTCGCTCGGCGGCGTCCGGGACGAAGCGGAGATCAGAGGCCATCGCCGG
ACCTATATCGGCTCCATGCCGGGCAAGATCATTCAGTCGATGCGGAAGGCGAAAACCTCCAATCCGCTGCTCCTGCTCGA
CGAGATCGACAAAATGGGCATGGATTTCCGCGGGGATCCGTCTTCGGCTTTGCTTGAAGTGCTCGATCCGGAGCAGAACC
AGACCTTCTCGGATCATTATCTCGAAGTGGATTATGATCTCTCGAACGTCATGTTCGTGACGACGGCGAATACGCTGAAC
ATTCCGGCGCCCTTGATGGACCGCATGGAAATCATCCGTATCGCTGGCTATACCGAGGACGAGAAGATCGAGATCGCGCG
GCGCCATCTTATTCCGGCGGCGCTCAAGAAGCATGGTCTCGATCCGAAGGAATGGTCGATCGACGATAGCGGTCTCACCA
TGCTGGTGCGCCGTTATACGAGAGAGGCTGGTGTTCGTAACCTCGAGCGCGAGATCTCGAATCTGATCCGCAAGGCGGTC
AAGCAGATCCTGCTCAACAAGGTGACGAGCGTCGCTGTGACCGCTGACAATGTCGCCGATTTCCTCGGCGTGCCGCGTTA
TCGCTACGGTGAGGCGGAACTTGAGGATCAGGTCGGTGTCGTCACGGGGCTCGCCTGGACGGAAGTCGGCGGCGAGTTGC
TCACGATCGAAGGTGTCATGATGCCCGGCAAAGGCCGCATGACGGTGACGGGCAATTTGAAGGACGTCATGAAGGAATCG
ATTTCGGCGGCGGCTTCCTATGTCCGCTCCCGGGCCGTCGATTTCGGCATCGAGCCGCCTCTCTTCGATCGGCGCGACAT
CCACGTGCACGTGCCGGAAGGCGCGACGCCCAAGGATGGCCCTTCCGCCGGCGTCGCCATGGCGACAACGATCACTTCGG
TGATGACCGGTATTCCGATCCGCCGCGATATTGCCATGACGGGTGAAATCACCCTGCGCGGCCGTGTCCTGCCGATCGGC
GGTTTGAAGGAAAAGCTTCTGGCGGCCATGCGTGGTGGCTTGAAGAAGGTCCTCATTCCGGAAGAAAATGCCAAGGATCT
CGCGGATATTCCGGATTCCGTGAAGAATGCCTTGGAAATCGTGCCGGTCTCCCGGATGGACGAAGTGCTCCAGCACGCTC
TGGTCCGCCAGCCCGTGCCGATCGTCTGGGAAGAAGAGACGAAGCCGGTCGCGCTTGGCACCGAGGATGAAGCCTCCGGC
GCTGTCGCGCACTGA

Upstream 100 bases:

>100_bases
GCTTGCGTTTCCCGCATCGTTATCCCCCAAACGATGCCATGTCTTTCCTGCCACGCAAGCGTAAAAATAGTCCAAATGCG
TTTCGAGATAGGACGATAAA

Downstream 100 bases:

>100_bases
GAAAGTTCCTTGAACAAAAGGCGGCGTGGGCTCTGCTCACGCCGCCTTTTTTGTCATGACGAAAGAAATCCGCTGACCGT
GCGCCATTGACACGAGAATG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 804; Mature: 803

Protein sequence:

>804_residues
MTQKRDLVRPGSIESYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMKADKLILLATQMNAADDDPATDAIFTTGTLA
SVLQLLKLPDGTVKVLVEGQWRAKVQNYTRTEDYYEADAEAIADDPIDKVEVEALARSVVSEFEGYVKLNKKISPEVVAA
VTQIDDYAKLADTIASHLAVKIADKQAVLETTSVTKRLEKCLALMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQMK
AIQKELGDEDGKDDLAEIEERIKNTKLSKEARDKATAELKKLRQMSPMSAEATVVRNYLDWLLAIPWNKRSKVKKDLTVA
EEVLDSEHYGLDKVKERILEYLAVQTRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRMSLGGVRDEAEIRGHRR
TYIGSMPGKIIQSMRKAKTSNPLLLLDEIDKMGMDFRGDPSSALLEVLDPEQNQTFSDHYLEVDYDLSNVMFVTTANTLN
IPAPLMDRMEIIRIAGYTEDEKIEIARRHLIPAALKKHGLDPKEWSIDDSGLTMLVRRYTREAGVRNLEREISNLIRKAV
KQILLNKVTSVAVTADNVADFLGVPRYRYGEAELEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKDVMKES
ISAAASYVRSRAVDFGIEPPLFDRRDIHVHVPEGATPKDGPSAGVAMATTITSVMTGIPIRRDIAMTGEITLRGRVLPIG
GLKEKLLAAMRGGLKKVLIPEENAKDLADIPDSVKNALEIVPVSRMDEVLQHALVRQPVPIVWEEETKPVALGTEDEASG
AVAH

Sequences:

>Translated_804_residues
MTQKRDLVRPGSIESYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMKADKLILLATQMNAADDDPATDAIFTTGTLA
SVLQLLKLPDGTVKVLVEGQWRAKVQNYTRTEDYYEADAEAIADDPIDKVEVEALARSVVSEFEGYVKLNKKISPEVVAA
VTQIDDYAKLADTIASHLAVKIADKQAVLETTSVTKRLEKCLALMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQMK
AIQKELGDEDGKDDLAEIEERIKNTKLSKEARDKATAELKKLRQMSPMSAEATVVRNYLDWLLAIPWNKRSKVKKDLTVA
EEVLDSEHYGLDKVKERILEYLAVQTRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRMSLGGVRDEAEIRGHRR
TYIGSMPGKIIQSMRKAKTSNPLLLLDEIDKMGMDFRGDPSSALLEVLDPEQNQTFSDHYLEVDYDLSNVMFVTTANTLN
IPAPLMDRMEIIRIAGYTEDEKIEIARRHLIPAALKKHGLDPKEWSIDDSGLTMLVRRYTREAGVRNLEREISNLIRKAV
KQILLNKVTSVAVTADNVADFLGVPRYRYGEAELEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKDVMKES
ISAAASYVRSRAVDFGIEPPLFDRRDIHVHVPEGATPKDGPSAGVAMATTITSVMTGIPIRRDIAMTGEITLRGRVLPIG
GLKEKLLAAMRGGLKKVLIPEENAKDLADIPDSVKNALEIVPVSRMDEVLQHALVRQPVPIVWEEETKPVALGTEDEASG
AVAH
>Mature_803_residues
TQKRDLVRPGSIESYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMKADKLILLATQMNAADDDPATDAIFTTGTLAS
VLQLLKLPDGTVKVLVEGQWRAKVQNYTRTEDYYEADAEAIADDPIDKVEVEALARSVVSEFEGYVKLNKKISPEVVAAV
TQIDDYAKLADTIASHLAVKIADKQAVLETTSVTKRLEKCLALMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQMKA
IQKELGDEDGKDDLAEIEERIKNTKLSKEARDKATAELKKLRQMSPMSAEATVVRNYLDWLLAIPWNKRSKVKKDLTVAE
EVLDSEHYGLDKVKERILEYLAVQTRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRMSLGGVRDEAEIRGHRRT
YIGSMPGKIIQSMRKAKTSNPLLLLDEIDKMGMDFRGDPSSALLEVLDPEQNQTFSDHYLEVDYDLSNVMFVTTANTLNI
PAPLMDRMEIIRIAGYTEDEKIEIARRHLIPAALKKHGLDPKEWSIDDSGLTMLVRRYTREAGVRNLEREISNLIRKAVK
QILLNKVTSVAVTADNVADFLGVPRYRYGEAELEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKDVMKESI
SAAASYVRSRAVDFGIEPPLFDRRDIHVHVPEGATPKDGPSAGVAMATTITSVMTGIPIRRDIAMTGEITLRGRVLPIGG
LKEKLLAAMRGGLKKVLIPEENAKDLADIPDSVKNALEIVPVSRMDEVLQHALVRQPVPIVWEEETKPVALGTEDEASGA
VAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=828, Percent_Identity=38.4057971014493, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI31377667, Length=776, Percent_Identity=39.9484536082474, Blast_Score=521, Evalue=1e-148,
Organism=Escherichia coli, GI1786643, Length=764, Percent_Identity=64.7905759162304, Blast_Score=1021, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=705, Percent_Identity=41.1347517730496, Blast_Score=526, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17556486, Length=650, Percent_Identity=35.8461538461538, Blast_Score=426, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=725, Percent_Identity=40.1379310344828, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221513036, Length=664, Percent_Identity=42.7710843373494, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24666867, Length=664, Percent_Identity=42.7710843373494, Blast_Score=528, Evalue=1e-150,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89208; Mature: 89077

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKRDLVRPGSIESYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMKADKLILLATQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEE
MNAADDDPATDAIFTTGTLASVLQLLKLPDGTVKVLVEGQWRAKVQNYTRTEDYYEADAE
CCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCHHHHCCHH
AIADDPIDKVEVEALARSVVSEFEGYVKLNKKISPEVVAAVTQIDDYAKLADTIASHLAV
HHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEE
KIADKQAVLETTSVTKRLEKCLALMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQMK
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIQKELGDEDGKDDLAEIEERIKNTKLSKEARDKATAELKKLRQMSPMSAEATVVRNYLD
HHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
WLLAIPWNKRSKVKKDLTVAEEVLDSEHYGLDKVKERILEYLAVQTRANKLTGPILCLVG
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PPGVGKTSLGKSIAKATGREFVRMSLGGVRDEAEIRGHRRTYIGSMPGKIIQSMRKAKTS
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHCCC
NPLLLLDEIDKMGMDFRGDPSSALLEVLDPEQNQTFSDHYLEVDYDLSNVMFVTTANTLN
CCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCC
IPAPLMDRMEIIRIAGYTEDEKIEIARRHLIPAALKKHGLDPKEWSIDDSGLTMLVRRYT
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
REAGVRNLEREISNLIRKAVKQILLNKVTSVAVTADNVADFLGVPRYRYGEAELEDQVGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCCCCCCCCHHHHCHHH
VTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKDVMKESISAAASYVRSRAVDFGIEPP
HHCCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LFDRRDIHVHVPEGATPKDGPSAGVAMATTITSVMTGIPIRRDIAMTGEITLRGRVLPIG
CCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECEEEEEEEEEECC
GLKEKLLAAMRGGLKKVLIPEENAKDLADIPDSVKNALEIVPVSRMDEVLQHALVRQPVP
CHHHHHHHHHHCCCEEEECCCCCCCHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
IVWEEETKPVALGTEDEASGAVAH
EEECCCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure 
TQKRDLVRPGSIESYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMKADKLILLATQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEE
MNAADDDPATDAIFTTGTLASVLQLLKLPDGTVKVLVEGQWRAKVQNYTRTEDYYEADAE
CCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCHHHHCCHH
AIADDPIDKVEVEALARSVVSEFEGYVKLNKKISPEVVAAVTQIDDYAKLADTIASHLAV
HHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEE
KIADKQAVLETTSVTKRLEKCLALMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQMK
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIQKELGDEDGKDDLAEIEERIKNTKLSKEARDKATAELKKLRQMSPMSAEATVVRNYLD
HHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
WLLAIPWNKRSKVKKDLTVAEEVLDSEHYGLDKVKERILEYLAVQTRANKLTGPILCLVG
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PPGVGKTSLGKSIAKATGREFVRMSLGGVRDEAEIRGHRRTYIGSMPGKIIQSMRKAKTS
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHCCC
NPLLLLDEIDKMGMDFRGDPSSALLEVLDPEQNQTFSDHYLEVDYDLSNVMFVTTANTLN
CCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCC
IPAPLMDRMEIIRIAGYTEDEKIEIARRHLIPAALKKHGLDPKEWSIDDSGLTMLVRRYT
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
REAGVRNLEREISNLIRKAVKQILLNKVTSVAVTADNVADFLGVPRYRYGEAELEDQVGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCCCCCCCCHHHHCHHH
VTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKDVMKESISAAASYVRSRAVDFGIEPP
HHCCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LFDRRDIHVHVPEGATPKDGPSAGVAMATTITSVMTGIPIRRDIAMTGEITLRGRVLPIG
CCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECEEEEEEEEEECC
GLKEKLLAAMRGGLKKVLIPEENAKDLADIPDSVKNALEIVPVSRMDEVLQHALVRQPVP
CHHHHHHHHHHCCCEEEECCCCCCCHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
IVWEEETKPVALGTEDEASGAVAH
EEECCCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA