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The map label for this gene is gntR [H]

Identifier: 182679047

GI number: 182679047

Start: 2381550

End: 2382569

Strand: Reverse

Name: gntR [H]

Synonym: Bind_2083

Alternate gene names: 182679047

Gene position: 2382569-2381550 (Counterclockwise)

Preceding gene: 182679052

Following gene: 182679046

Centisome position: 57.13

GC content: 58.82

Gene sequence:

>1020_bases
GTGTCTGAAGACCGCTGGCTTGACAATCGTAGGATCGCTTCCAGCGTGACCTTGACGGATGTCGCGCGCGAGGCGGGCGT
GGGCGAGAGCACGGTCTCCCGTGTTTTGCGCAACCACGGTTCCTTTTCGGAAAAGACGCGCGAAAGGGTCCAGAGCGCGG
TCGATCGGCTGGGTTATGTCCCAAACAAAATCGCCGGCGCGCTAGCTTCCACGGGATCGAATCTCGTTGCGATCATCATT
CCCTCCCTTGCGAATATCGTGTTTCCTGATGTCTTGCGCGGCGCGCAAAACGCGTTGATGACGGCCGGTTTTCAATCGGT
TATCGGCATCACGGATTATGATCAGAATCAGGAAGAGACGCTCATTGAATCCATGTTTGCCTGGCGCCCCGCGGGCCTGT
TGATCGCCGGTCTGGAGCATAGCGAGCGCGCCGTGACGATGATGCGCGCAAGTGGCGTCCGCATTGCCGAACTTCTCGAT
ACCGACGGGACGGGGATCGATCATGTCGTCGGCTTTTCGAGTCGTGAAGCGGGCCGGGTCAGCGCGCGTTATCTGCTCGC
GAGAGGCTATCGCCGCATTGGCTATGTCGGCCATGATCTGAATCGTGACCGCCGCGCGGCGAAGCGGCTTGCGGGCTTTC
TTGAAATCCTGGCCGAGGCAGGCATTAAACTTTATGATCGGGAAATCATCGACGCGGCCTCTTCTATCGAGAAAGGTCGC
GCCGGCCTTGAGCGCTTGTTATCGCGCTGCCCCAAGCTCGATGCGGTTTATTTCTCCAATGACGACATGGCCATGGGCGG
CTATTTCCTGTGCCTTGGCCGGGGGATCGCGATACCGGATCGCTTGGCCCTCTTCGGCTACAATGGATTGGATGTGGGCC
AGTGCGCACCGCAACCGCTCACGACGATCAGAACACCGCGTGTTCTGATCGGTGAATGCGGCGCTAAACTCGTCTGCTCG
GATGGACCGTCGCAGCTTATTGATGTCGGATTTGAATTGATGCAAGGCGCGACGGCCTGA

Upstream 100 bases:

>100_bases
ACCATTTTCTCTATCACATTTTGGCAGCGCTGCCAAATAGGACTTGAGACTCACTGCATTTTTATGGGAAAAGAGGTAGA
AAGGGCCGGGAGGATTTTGC

Downstream 100 bases:

>100_bases
GTGAGGCTGGCATACGAAGAGGCGGAAAACACGATGAGCGAGACAAAATTGCGCGACGAAATCTGCCGTTTTGGTCGTTC
GCTCTTTGAACGTGGCCTGA

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Gluconate utilization system GNT-I transcriptional repressor [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSEDRWLDNRRIASSVTLTDVAREAGVGESTVSRVLRNHGSFSEKTRERVQSAVDRLGYVPNKIAGALASTGSNLVAIII
PSLANIVFPDVLRGAQNALMTAGFQSVIGITDYDQNQEETLIESMFAWRPAGLLIAGLEHSERAVTMMRASGVRIAELLD
TDGTGIDHVVGFSSREAGRVSARYLLARGYRRIGYVGHDLNRDRRAAKRLAGFLEILAEAGIKLYDREIIDAASSIEKGR
AGLERLLSRCPKLDAVYFSNDDMAMGGYFLCLGRGIAIPDRLALFGYNGLDVGQCAPQPLTTIRTPRVLIGECGAKLVCS
DGPSQLIDVGFELMQGATA

Sequences:

>Translated_339_residues
MSEDRWLDNRRIASSVTLTDVAREAGVGESTVSRVLRNHGSFSEKTRERVQSAVDRLGYVPNKIAGALASTGSNLVAIII
PSLANIVFPDVLRGAQNALMTAGFQSVIGITDYDQNQEETLIESMFAWRPAGLLIAGLEHSERAVTMMRASGVRIAELLD
TDGTGIDHVVGFSSREAGRVSARYLLARGYRRIGYVGHDLNRDRRAAKRLAGFLEILAEAGIKLYDREIIDAASSIEKGR
AGLERLLSRCPKLDAVYFSNDDMAMGGYFLCLGRGIAIPDRLALFGYNGLDVGQCAPQPLTTIRTPRVLIGECGAKLVCS
DGPSQLIDVGFELMQGATA
>Mature_338_residues
SEDRWLDNRRIASSVTLTDVAREAGVGESTVSRVLRNHGSFSEKTRERVQSAVDRLGYVPNKIAGALASTGSNLVAIIIP
SLANIVFPDVLRGAQNALMTAGFQSVIGITDYDQNQEETLIESMFAWRPAGLLIAGLEHSERAVTMMRASGVRIAELLDT
DGTGIDHVVGFSSREAGRVSARYLLARGYRRIGYVGHDLNRDRRAAKRLAGFLEILAEAGIKLYDREIIDAASSIEKGRA
GLERLLSRCPKLDAVYFSNDDMAMGGYFLCLGRGIAIPDRLALFGYNGLDVGQCAPQPLTTIRTPRVLIGECGAKLVCSD
GPSQLIDVGFELMQGATA

Specific function: Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI48994940, Length=326, Percent_Identity=33.4355828220859, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1790715, Length=329, Percent_Identity=30.0911854103343, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI1790369, Length=333, Percent_Identity=26.4264264264264, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787948, Length=305, Percent_Identity=26.5573770491803, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1788474, Length=307, Percent_Identity=30.2931596091205, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790194, Length=297, Percent_Identity=26.9360269360269, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789202, Length=301, Percent_Identity=29.5681063122924, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789068, Length=293, Percent_Identity=25.938566552901, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786540, Length=302, Percent_Identity=28.476821192053, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1787906, Length=272, Percent_Identity=28.3088235294118, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787580, Length=283, Percent_Identity=27.5618374558304, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790689, Length=268, Percent_Identity=23.8805970149254, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36665; Mature: 36534

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDRWLDNRRIASSVTLTDVAREAGVGESTVSRVLRNHGSFSEKTRERVQSAVDRLGYV
CCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
PNKIAGALASTGSNLVAIIIPSLANIVFPDVLRGAQNALMTAGFQSVIGITDYDQNQEET
CHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LIESMFAWRPAGLLIAGLEHSERAVTMMRASGVRIAELLDTDGTGIDHVVGFSSREAGRV
HHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCHHHHHHCCCCCCHHHHHCCCCCCCCHH
SARYLLARGYRRIGYVGHDLNRDRRAAKRLAGFLEILAEAGIKLYDREIIDAASSIEKGR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AGLERLLSRCPKLDAVYFSNDDMAMGGYFLCLGRGIAIPDRLALFGYNGLDVGQCAPQPL
HHHHHHHHHCCCCCEEEECCCCCCCCCEEEECCCCCCCCCHHHEECCCCCCCCCCCCCCH
TTIRTPRVLIGECGAKLVCSDGPSQLIDVGFELMQGATA
HHHCCCHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SEDRWLDNRRIASSVTLTDVAREAGVGESTVSRVLRNHGSFSEKTRERVQSAVDRLGYV
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
PNKIAGALASTGSNLVAIIIPSLANIVFPDVLRGAQNALMTAGFQSVIGITDYDQNQEET
CHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LIESMFAWRPAGLLIAGLEHSERAVTMMRASGVRIAELLDTDGTGIDHVVGFSSREAGRV
HHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCHHHHHHCCCCCCHHHHHCCCCCCCCHH
SARYLLARGYRRIGYVGHDLNRDRRAAKRLAGFLEILAEAGIKLYDREIIDAASSIEKGR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AGLERLLSRCPKLDAVYFSNDDMAMGGYFLCLGRGIAIPDRLALFGYNGLDVGQCAPQPL
HHHHHHHHHCCCCCEEEECCCCCCCCCEEEECCCCCCCCCHHHEECCCCCCCCCCCCCCH
TTIRTPRVLIGECGAKLVCSDGPSQLIDVGFELMQGATA
HHHCCCHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]