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The map label for this gene is parC [H]

Identifier: 182678910

GI number: 182678910

Start: 2212630

End: 2214888

Strand: Reverse

Name: parC [H]

Synonym: Bind_1944

Alternate gene names: 182678910

Gene position: 2214888-2212630 (Counterclockwise)

Preceding gene: 182678911

Following gene: 182678905

Centisome position: 53.11

GC content: 57.77

Gene sequence:

>2259_bases
ATGGCCAAAACTCCCGCCGCTCCCATTGCTCCGCCGCCAACAGGCGGCACCGATCTTGTCAATCTGCGCGAAGCGCTCGA
AGAGCGCTATCTCGCTTACGCGCTTTCGACCATCACCGGGCGCGCGCTACCTGACGCGCGCGACGGCTTGAAGCCTGTTC
ATCGCCGCATTCTTTACGGCATGCAGATCCTACGGCTCGATCCGGGCACGGCTTTCAAAAAATGCGCGAAAATCGTCGGT
GACGTGATGGGTTCCTTCCATCCGCATGGCGATCAGGCGATCTATGACGCCTTGGTGCGGCTCGCACAGGATTTCTCCTC
GCGTTATCCCCTTGTCGATGGCCAGGGTAACTTCGGCAATATCGATGGTGATTCGGCTGCCGCTTATCGCTATACCGAAG
CGCGCATGACGGAAATCGCTCGGCTTCTGCTCGAGGGGATCGACGAAGATGCGATCGATTTTCGCGAAAATTATTCGGGC
GATCAGAAAGAGCCGATCGTCTTGCCGGCCGCTCTCCCCAATCTCCTTGCCAATGGCGCGCAAGGCATTGCGGTCGGCAT
GGCGACCTCGATCCCGCCGCATAATCTCTCCGAGCTTTGCGACGCGGCGCTCTATCTCATTTCGCATAGAGACGCGACAA
GCGATCAATTGCTGACTTTCGTGCGCGGGCCGGATTTCCCGACCGGCGGCATATTGGTCGATTCGCCTGAATCGATCGCC
GAGACCTATCGCACCGGGCGCGGCGCCTTTCGCTTGCGCGCCCGCTGGGAGCGGGAGGAGGGCACACGCGGCACCTATGT
GATCGTCGTGACTGAAATCCCCTATATGGTGCAGAAGTCGCGGCTCATCGAAAAGCTGGCCGAACTGCTCAACGACAAGA
AATTGCCGCTCGTCGGTGACATACGCGATGAATCGGCCGAAGATGTCCGCATCGTTATTGAACCCAAAAGCCGGGCGGTC
GAGCCCGAGCTTTTGATGGAATCTCTGTTCAAGCTCACCGAGCTCGAAACGCGATTCCCTGTCAATATGAATGTGCTTGT
CGATGGTGTCGTGCCGCGCGTCGTCTCCTTGGACGAGGCTCTGCGGCAATGGCTCGATCATCGGCGCGAGGTTCTGTTAC
GCCGCTCGCGCCATCGCCTGGCCGAGATTGAACGCCGGCTTGAAGTCCTGGCTGGCATGCTGATCGTCTTCCTCAATCTC
GATGAAGTCATCCGCATCATCCGTGAGGAGGATGAACCCAAAGAGGTTTTGAAGGCCACGTTCACGCTGAGCGACATACA
GGCCAATTACATTCTCGACACGCGTCTGCGCAGCCTGCGCCGCTTGGAAGAAATGGAACTGCGGCGTGAATATGAAAATC
TAGAAAAGGAAAAGAGCGAGATCGAGGGTCTGCTGGCCAGCGAAAGCAAGCAGTGGAAAGAGATTTCCTCTCAAATCCGC
GACCTGAAGAAACGTTATGGCGAGGCCACGCCGCTTGGACGGCGGCGCACAACATTCGGAAACGTGCCGGATGTCGGCGC
AGTGGATGTCGCCACGGCCCTGATCGAGCGCGAGCCTGTCACCATTGTCGTTTCCGAAAAGGGATGGATACGCGCCCTCA
AAGGCCATGTTGCCGATCTTTCGACCCTTACATTCAAGGGCGATGATCAGCTTGCCTTTCAGTTCTTTGCCGAGACGACG
TCCAAAATCCTGTTGTTTGCGAGCGATGGCAAGGTTTTTACGCTGGAAGCTTCGAAACTGCCCGGTGGACGCGGACATGG
CGAGCCTTTGCGTCTGATGGTCGATCTTGGCGAGGGCGAGGAGGTGACCTCCATTATCCCCTATGAGACCGGCGCCAAAC
TGTTGCTGACCGCGTCCGATGGGCGTGGTTTCATCGTCGGCCAGGATGATCTGATCGGTACGACCCGCAAGGGCAAGCAG
GTCCTCAATTGTGACGCTCCGGCGAAACTGAGCCATATAGTGCCGGCAGCGGGCGATCATCTTGCGATTATCGGCGAGAA
CCGGAAATTACTGATTTTCCCGCTGGTACAAATAGCGGAAATGACGCGTGGCAAGGGTGTGCGCCTGCAGAAATACAAGG
ATGGCGGCGTGAGCGATGCCAAGGTCATTTTCATCGACGCTGGCCTTTCGTGGCAAGACGCCGCCGGCCGCAGTTTTCAT
CTTGCCAAAGCCGATTTGGCCGACTGGATCGGTCAGCGCGGTGAGGCCGGTCGCCTGCCACCGCGCGGTTTTCCAAAAAA
CAATCGATTTACAGGGTGA

Upstream 100 bases:

>100_bases
TGGGGGGATAGCCCATCAAGGCTTGTTTAGCATGGTCCAACGCTCAAAAAGAACAAAGTGAGAACTTGCCTTGCGTGCAT
CCCTCGGTTAGGCCTGCCGT

Downstream 100 bases:

>100_bases
AGGGACAGCGTTCAGGCTGAATGAGCCGAAGGATGACTATCCCTCGACGGTATTTCCCACCTCCCATTTGGGAGGTGGGA
GCAGATGATCCTTTTTTGAG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 752; Mature: 751

Protein sequence:

>752_residues
MAKTPAAPIAPPPTGGTDLVNLREALEERYLAYALSTITGRALPDARDGLKPVHRRILYGMQILRLDPGTAFKKCAKIVG
DVMGSFHPHGDQAIYDALVRLAQDFSSRYPLVDGQGNFGNIDGDSAAAYRYTEARMTEIARLLLEGIDEDAIDFRENYSG
DQKEPIVLPAALPNLLANGAQGIAVGMATSIPPHNLSELCDAALYLISHRDATSDQLLTFVRGPDFPTGGILVDSPESIA
ETYRTGRGAFRLRARWEREEGTRGTYVIVVTEIPYMVQKSRLIEKLAELLNDKKLPLVGDIRDESAEDVRIVIEPKSRAV
EPELLMESLFKLTELETRFPVNMNVLVDGVVPRVVSLDEALRQWLDHRREVLLRRSRHRLAEIERRLEVLAGMLIVFLNL
DEVIRIIREEDEPKEVLKATFTLSDIQANYILDTRLRSLRRLEEMELRREYENLEKEKSEIEGLLASESKQWKEISSQIR
DLKKRYGEATPLGRRRTTFGNVPDVGAVDVATALIEREPVTIVVSEKGWIRALKGHVADLSTLTFKGDDQLAFQFFAETT
SKILLFASDGKVFTLEASKLPGGRGHGEPLRLMVDLGEGEEVTSIIPYETGAKLLLTASDGRGFIVGQDDLIGTTRKGKQ
VLNCDAPAKLSHIVPAAGDHLAIIGENRKLLIFPLVQIAEMTRGKGVRLQKYKDGGVSDAKVIFIDAGLSWQDAAGRSFH
LAKADLADWIGQRGEAGRLPPRGFPKNNRFTG

Sequences:

>Translated_752_residues
MAKTPAAPIAPPPTGGTDLVNLREALEERYLAYALSTITGRALPDARDGLKPVHRRILYGMQILRLDPGTAFKKCAKIVG
DVMGSFHPHGDQAIYDALVRLAQDFSSRYPLVDGQGNFGNIDGDSAAAYRYTEARMTEIARLLLEGIDEDAIDFRENYSG
DQKEPIVLPAALPNLLANGAQGIAVGMATSIPPHNLSELCDAALYLISHRDATSDQLLTFVRGPDFPTGGILVDSPESIA
ETYRTGRGAFRLRARWEREEGTRGTYVIVVTEIPYMVQKSRLIEKLAELLNDKKLPLVGDIRDESAEDVRIVIEPKSRAV
EPELLMESLFKLTELETRFPVNMNVLVDGVVPRVVSLDEALRQWLDHRREVLLRRSRHRLAEIERRLEVLAGMLIVFLNL
DEVIRIIREEDEPKEVLKATFTLSDIQANYILDTRLRSLRRLEEMELRREYENLEKEKSEIEGLLASESKQWKEISSQIR
DLKKRYGEATPLGRRRTTFGNVPDVGAVDVATALIEREPVTIVVSEKGWIRALKGHVADLSTLTFKGDDQLAFQFFAETT
SKILLFASDGKVFTLEASKLPGGRGHGEPLRLMVDLGEGEEVTSIIPYETGAKLLLTASDGRGFIVGQDDLIGTTRKGKQ
VLNCDAPAKLSHIVPAAGDHLAIIGENRKLLIFPLVQIAEMTRGKGVRLQKYKDGGVSDAKVIFIDAGLSWQDAAGRSFH
LAKADLADWIGQRGEAGRLPPRGFPKNNRFTG
>Mature_751_residues
AKTPAAPIAPPPTGGTDLVNLREALEERYLAYALSTITGRALPDARDGLKPVHRRILYGMQILRLDPGTAFKKCAKIVGD
VMGSFHPHGDQAIYDALVRLAQDFSSRYPLVDGQGNFGNIDGDSAAAYRYTEARMTEIARLLLEGIDEDAIDFRENYSGD
QKEPIVLPAALPNLLANGAQGIAVGMATSIPPHNLSELCDAALYLISHRDATSDQLLTFVRGPDFPTGGILVDSPESIAE
TYRTGRGAFRLRARWEREEGTRGTYVIVVTEIPYMVQKSRLIEKLAELLNDKKLPLVGDIRDESAEDVRIVIEPKSRAVE
PELLMESLFKLTELETRFPVNMNVLVDGVVPRVVSLDEALRQWLDHRREVLLRRSRHRLAEIERRLEVLAGMLIVFLNLD
EVIRIIREEDEPKEVLKATFTLSDIQANYILDTRLRSLRRLEEMELRREYENLEKEKSEIEGLLASESKQWKEISSQIRD
LKKRYGEATPLGRRRTTFGNVPDVGAVDVATALIEREPVTIVVSEKGWIRALKGHVADLSTLTFKGDDQLAFQFFAETTS
KILLFASDGKVFTLEASKLPGGRGHGEPLRLMVDLGEGEEVTSIIPYETGAKLLLTASDGRGFIVGQDDLIGTTRKGKQV
LNCDAPAKLSHIVPAAGDHLAIIGENRKLLIFPLVQIAEMTRGKGVRLQKYKDGGVSDAKVIFIDAGLSWQDAAGRSFHL
AKADLADWIGQRGEAGRLPPRGFPKNNRFTG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=442, Percent_Identity=25.3393665158371, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI19913406, Length=349, Percent_Identity=25.7879656160458, Blast_Score=80, Evalue=1e-14,
Organism=Escherichia coli, GI1789396, Length=744, Percent_Identity=38.8440860215054, Blast_Score=503, Evalue=1e-143,
Organism=Escherichia coli, GI1788562, Length=658, Percent_Identity=38.7537993920973, Blast_Score=430, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI212645845, Length=464, Percent_Identity=26.2931034482759, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17535065, Length=430, Percent_Identity=25.1162790697674, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324241, Length=362, Percent_Identity=27.3480662983425, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136538, Length=172, Percent_Identity=30.2325581395349, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83450; Mature: 83319

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTPAAPIAPPPTGGTDLVNLREALEERYLAYALSTITGRALPDARDGLKPVHRRILYG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHC
MQILRLDPGTAFKKCAKIVGDVMGSFHPHGDQAIYDALVRLAQDFSSRYPLVDGQGNFGN
CEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCC
IDGDSAAAYRYTEARMTEIARLLLEGIDEDAIDFRENYSGDQKEPIVLPAALPNLLANGA
CCCCCCHHEEHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHCCC
QGIAVGMATSIPPHNLSELCDAALYLISHRDATSDQLLTFVRGPDFPTGGILVDSPESIA
CCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHH
ETYRTGRGAFRLRARWEREEGTRGTYVIVVTEIPYMVQKSRLIEKLAELLNDKKLPLVGD
HHHHCCCCEEEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEC
IRDESAEDVRIVIEPKSRAVEPELLMESLFKLTELETRFPVNMNVLVDGVVPRVVSLDEA
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHH
LRQWLDHRREVLLRRSRHRLAEIERRLEVLAGMLIVFLNLDEVIRIIREEDEPKEVLKAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHH
FTLSDIQANYILDTRLRSLRRLEEMELRREYENLEKEKSEIEGLLASESKQWKEISSQIR
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
DLKKRYGEATPLGRRRTTFGNVPDVGAVDVATALIEREPVTIVVSEKGWIRALKGHVADL
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCC
STLTFKGDDQLAFQFFAETTSKILLFASDGKVFTLEASKLPGGRGHGEPLRLMVDLGEGE
EEEEECCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCCCCCEEEEEECCCCC
EVTSIIPYETGAKLLLTASDGRGFIVGQDDLIGTTRKGKQVLNCDAPAKLSHIVPAAGDH
CEEEECCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHCCCCCCCE
LAIIGENRKLLIFPLVQIAEMTRGKGVRLQKYKDGGVSDAKVIFIDAGLSWQDAAGRSFH
EEEEECCCEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCEEE
LAKADLADWIGQRGEAGRLPPRGFPKNNRFTG
EHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKTPAAPIAPPPTGGTDLVNLREALEERYLAYALSTITGRALPDARDGLKPVHRRILYG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHC
MQILRLDPGTAFKKCAKIVGDVMGSFHPHGDQAIYDALVRLAQDFSSRYPLVDGQGNFGN
CEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCC
IDGDSAAAYRYTEARMTEIARLLLEGIDEDAIDFRENYSGDQKEPIVLPAALPNLLANGA
CCCCCCHHEEHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHCCC
QGIAVGMATSIPPHNLSELCDAALYLISHRDATSDQLLTFVRGPDFPTGGILVDSPESIA
CCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHH
ETYRTGRGAFRLRARWEREEGTRGTYVIVVTEIPYMVQKSRLIEKLAELLNDKKLPLVGD
HHHHCCCCEEEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEC
IRDESAEDVRIVIEPKSRAVEPELLMESLFKLTELETRFPVNMNVLVDGVVPRVVSLDEA
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHH
LRQWLDHRREVLLRRSRHRLAEIERRLEVLAGMLIVFLNLDEVIRIIREEDEPKEVLKAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHH
FTLSDIQANYILDTRLRSLRRLEEMELRREYENLEKEKSEIEGLLASESKQWKEISSQIR
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
DLKKRYGEATPLGRRRTTFGNVPDVGAVDVATALIEREPVTIVVSEKGWIRALKGHVADL
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCC
STLTFKGDDQLAFQFFAETTSKILLFASDGKVFTLEASKLPGGRGHGEPLRLMVDLGEGE
EEEEECCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCCCCCEEEEEECCCCC
EVTSIIPYETGAKLLLTASDGRGFIVGQDDLIGTTRKGKQVLNCDAPAKLSHIVPAAGDH
CEEEECCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHCCCCCCCE
LAIIGENRKLLIFPLVQIAEMTRGKGVRLQKYKDGGVSDAKVIFIDAGLSWQDAAGRSFH
EEEEECCCEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCEEE
LAKADLADWIGQRGEAGRLPPRGFPKNNRFTG
EHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]