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The map label for this gene is guaB [H]

Identifier: 182678890

GI number: 182678890

Start: 2192020

End: 2193510

Strand: Reverse

Name: guaB [H]

Synonym: Bind_1923

Alternate gene names: 182678890

Gene position: 2193510-2192020 (Counterclockwise)

Preceding gene: 182678893

Following gene: 182678889

Centisome position: 52.6

GC content: 59.56

Gene sequence:

>1491_bases
TTGGCCGCGATCAAGCCACATAATTTTAAGGAAGCCTTCACGTTTGATGATGTGCTTCTGCTGCCTGGCCATTCCCAGGT
CATGCCCAATTCCGCCGACCTGCGAACCCGCCTGACCTCACAGATCCAGCTCAATATTCCGATTCTTTCCGCCGCGATGG
ATACAGTGACGGAAGCGCGGCTCGCCATCGCTTTGGCGCAAGCTGGCGGCATTGGTGTCATCCATCGCAATTTACCGGCG
GAGGAACAGGCCGAGGAAGTCCGCAAGGTCAAGCGCTACGAGAGCGGCATGGTGGTCAATCCGATCACTATTTTTCCCGA
CGAGACCCTGGCAGATGCTTTGGCTCTCATGCGCCGCTATGGCATTTCCGGTATTCCGGTGGTCGAGCGCAGGTCTGGCG
GCAAGCCTGGCAAATTATGTGGCATCCTGACCAATCGCGATGTCCGATTCGCCGATAATCCTTTGCAGCCGATCTCGGAA
TTGATGACCAAGAGCCTGATCACGGTTCGTGAGGGCGTGAGCCAGGACGAAGCGCGCCGGCTCCTGCATCAGCATCGGCT
GGAAAAGCTGCTTGTGGTCGATGAGGATTTCCGCTGCGTTGGTCTCATCACCGTCAAGGACATGGAAAAGGCGACGCTTT
ATCCCCTGGCCTGCAAGGACGGCGAAGGACGGCTGCGCGTTGCTGCCGCCTCGACGGTTGGCGAGAAAGGCTATGATCGG
GCCTTGATGCTGATTGATGCTGGTGTTGATTGTCTGGTCGTCGATACGGCGCATGGCCATTCGCAATCCGTGCTCGATCA
GGTTGTGCGGTTGAAACGGGCCTCGAACAAGGTTGGGATCGTGGCCGGCAATGTGGCGACTGCTGATGGCGCCAAGGCCC
TGATTGACGCGGGCGCTGACGCCATCAAGGTCGGTATTGGTCCGGGCTCGATCTGCACCACCCGCATGGTGGCGGGTGTT
GGCGTGCCGCAATTGACCGCGATCATGGATTGTGCCGAGGTGGCTCATGCGGCCAATGTGCCGGTGATCGGCGACGGCGG
CATCAAATATTCGGGCGATCTCGCCAAGGCGGTCGCGGCTGGCGCCGATTGCGTCATGATCGGTTCATTGCTCGCCGGCA
CGGATGAAAGCCCCGGAGAGGTCTATCTCTATCAAGGCCGTTCGTTCAAATCCTACCGTGGCATGGGCTCGGTCGGTGCC
ATGAGCAATGGTTCGGCGGATCGCTATTTCCAGCAGGACATCAAGGACAGCCAGAAACTGGTGCCGGAAGGCATTGAGGG
TCAGGTGCCTTACCGTGGCCCGGCGGGCGCCATTCTGCATCAATTGGCGGGCGGTCTGCGGGCGGCCATGGGTTATGTCG
GCGCGGGGACGATTGCCGAATATCAGGCGCGCGCCGAATTCGTACGGATTTCCTCGGCAGGTCTGCGCGAAAGCCATGTG
CATGATGTGGCGATCACGCGGGAAAGCCCGAACTATCCGACGGGAATCTGA

Upstream 100 bases:

>100_bases
AAGAGCCCCCGGCAACTCTTGTCGACATATTGATCCCCTCGATCCGCCCGCACCCCAGAGGGAGCGCGGCGGCGTTAGAG
GTTTTCCTAGGAGTTGTCTT

Downstream 100 bases:

>100_bases
CGCGCCATGACCTTGCAAGCCGTTCTTCTGCCGGTTTTCGTGCAGTTCGGATTGATGACCTTTCTGCTTCTGTGGATGGT
CGCCGACCGGCAGAAATTGT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MAAIKPHNFKEAFTFDDVLLLPGHSQVMPNSADLRTRLTSQIQLNIPILSAAMDTVTEARLAIALAQAGGIGVIHRNLPA
EEQAEEVRKVKRYESGMVVNPITIFPDETLADALALMRRYGISGIPVVERRSGGKPGKLCGILTNRDVRFADNPLQPISE
LMTKSLITVREGVSQDEARRLLHQHRLEKLLVVDEDFRCVGLITVKDMEKATLYPLACKDGEGRLRVAAASTVGEKGYDR
ALMLIDAGVDCLVVDTAHGHSQSVLDQVVRLKRASNKVGIVAGNVATADGAKALIDAGADAIKVGIGPGSICTTRMVAGV
GVPQLTAIMDCAEVAHAANVPVIGDGGIKYSGDLAKAVAAGADCVMIGSLLAGTDESPGEVYLYQGRSFKSYRGMGSVGA
MSNGSADRYFQQDIKDSQKLVPEGIEGQVPYRGPAGAILHQLAGGLRAAMGYVGAGTIAEYQARAEFVRISSAGLRESHV
HDVAITRESPNYPTGI

Sequences:

>Translated_496_residues
MAAIKPHNFKEAFTFDDVLLLPGHSQVMPNSADLRTRLTSQIQLNIPILSAAMDTVTEARLAIALAQAGGIGVIHRNLPA
EEQAEEVRKVKRYESGMVVNPITIFPDETLADALALMRRYGISGIPVVERRSGGKPGKLCGILTNRDVRFADNPLQPISE
LMTKSLITVREGVSQDEARRLLHQHRLEKLLVVDEDFRCVGLITVKDMEKATLYPLACKDGEGRLRVAAASTVGEKGYDR
ALMLIDAGVDCLVVDTAHGHSQSVLDQVVRLKRASNKVGIVAGNVATADGAKALIDAGADAIKVGIGPGSICTTRMVAGV
GVPQLTAIMDCAEVAHAANVPVIGDGGIKYSGDLAKAVAAGADCVMIGSLLAGTDESPGEVYLYQGRSFKSYRGMGSVGA
MSNGSADRYFQQDIKDSQKLVPEGIEGQVPYRGPAGAILHQLAGGLRAAMGYVGAGTIAEYQARAEFVRISSAGLRESHV
HDVAITRESPNYPTGI
>Mature_495_residues
AAIKPHNFKEAFTFDDVLLLPGHSQVMPNSADLRTRLTSQIQLNIPILSAAMDTVTEARLAIALAQAGGIGVIHRNLPAE
EQAEEVRKVKRYESGMVVNPITIFPDETLADALALMRRYGISGIPVVERRSGGKPGKLCGILTNRDVRFADNPLQPISEL
MTKSLITVREGVSQDEARRLLHQHRLEKLLVVDEDFRCVGLITVKDMEKATLYPLACKDGEGRLRVAAASTVGEKGYDRA
LMLIDAGVDCLVVDTAHGHSQSVLDQVVRLKRASNKVGIVAGNVATADGAKALIDAGADAIKVGIGPGSICTTRMVAGVG
VPQLTAIMDCAEVAHAANVPVIGDGGIKYSGDLAKAVAAGADCVMIGSLLAGTDESPGEVYLYQGRSFKSYRGMGSVGAM
SNGSADRYFQQDIKDSQKLVPEGIEGQVPYRGPAGAILHQLAGGLRAAMGYVGAGTIAEYQARAEFVRISSAGLRESHVH
DVAITRESPNYPTGI

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=494, Percent_Identity=38.0566801619433, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI217035146, Length=482, Percent_Identity=38.5892116182573, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI34328928, Length=482, Percent_Identity=38.5892116182573, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI156616279, Length=482, Percent_Identity=38.5892116182573, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI34328930, Length=482, Percent_Identity=38.5892116182573, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI217035152, Length=476, Percent_Identity=38.8655462184874, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI217035148, Length=482, Percent_Identity=37.551867219917, Blast_Score=292, Evalue=4e-79,
Organism=Homo sapiens, GI217035150, Length=482, Percent_Identity=35.2697095435685, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI50541956, Length=250, Percent_Identity=38, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI50541954, Length=250, Percent_Identity=38, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541952, Length=250, Percent_Identity=38, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541948, Length=250, Percent_Identity=38, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI156104880, Length=248, Percent_Identity=37.5, Blast_Score=163, Evalue=4e-40,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=58.6065573770492, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1786293, Length=233, Percent_Identity=37.7682403433476, Blast_Score=159, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=505, Percent_Identity=35.8415841584158, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=38.8758782201405, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=244, Percent_Identity=40.9836065573771, Blast_Score=179, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=38.5567010309278, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6322012, Length=486, Percent_Identity=37.4485596707819, Blast_Score=313, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6323464, Length=485, Percent_Identity=38.5567010309278, Blast_Score=309, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6319352, Length=337, Percent_Identity=37.6854599406528, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=101, Percent_Identity=45.5445544554455, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=38.0165289256198, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=38.0165289256198, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=38.4615384615385, Blast_Score=283, Evalue=3e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52588; Mature: 52457

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIKPHNFKEAFTFDDVLLLPGHSQVMPNSADLRTRLTSQIQLNIPILSAAMDTVTEAR
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHHHHH
LAIALAQAGGIGVIHRNLPAEEQAEEVRKVKRYESGMVVNPITIFPDETLADALALMRRY
HHHEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEECCEEECCCHHHHHHHHHHHHC
GISGIPVVERRSGGKPGKLCGILTNRDVRFADNPLQPISELMTKSLITVREGVSQDEARR
CCCCCCEEECCCCCCCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
LLHQHRLEKLLVVDEDFRCVGLITVKDMEKATLYPLACKDGEGRLRVAAASTVGEKGYDR
HHHHHHHHEEEEECCCCEEEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCC
ALMLIDAGVDCLVVDTAHGHSQSVLDQVVRLKRASNKVGIVAGNVATADGAKALIDAGAD
EEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCEECCCCCHHHHHCCCC
AIKVGIGPGSICTTRMVAGVGVPQLTAIMDCAEVAHAANVPVIGDGGIKYSGDLAKAVAA
EEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCEECCHHHHHHHC
GADCVMIGSLLAGTDESPGEVYLYQGRSFKSYRGMGSVGAMSNGSADRYFQQDIKDSQKL
CCCCEEHHHHHHCCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VPEGIEGQVPYRGPAGAILHQLAGGLRAAMGYVGAGTIAEYQARAEFVRISSAGLRESHV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCC
HDVAITRESPNYPTGI
EEEEEEECCCCCCCCC
>Mature Secondary Structure 
AAIKPHNFKEAFTFDDVLLLPGHSQVMPNSADLRTRLTSQIQLNIPILSAAMDTVTEAR
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHHHHH
LAIALAQAGGIGVIHRNLPAEEQAEEVRKVKRYESGMVVNPITIFPDETLADALALMRRY
HHHEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEECCEEECCCHHHHHHHHHHHHC
GISGIPVVERRSGGKPGKLCGILTNRDVRFADNPLQPISELMTKSLITVREGVSQDEARR
CCCCCCEEECCCCCCCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
LLHQHRLEKLLVVDEDFRCVGLITVKDMEKATLYPLACKDGEGRLRVAAASTVGEKGYDR
HHHHHHHHEEEEECCCCEEEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCC
ALMLIDAGVDCLVVDTAHGHSQSVLDQVVRLKRASNKVGIVAGNVATADGAKALIDAGAD
EEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCEECCCCCHHHHHCCCC
AIKVGIGPGSICTTRMVAGVGVPQLTAIMDCAEVAHAANVPVIGDGGIKYSGDLAKAVAA
EEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCEECCHHHHHHHC
GADCVMIGSLLAGTDESPGEVYLYQGRSFKSYRGMGSVGAMSNGSADRYFQQDIKDSQKL
CCCCEEHHHHHHCCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VPEGIEGQVPYRGPAGAILHQLAGGLRAAMGYVGAGTIAEYQARAEFVRISSAGLRESHV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCC
HDVAITRESPNYPTGI
EEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA