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The map label for this gene is paaF [H]

Identifier: 182678721

GI number: 182678721

Start: 1979081

End: 1979863

Strand: Reverse

Name: paaF [H]

Synonym: Bind_1748

Alternate gene names: 182678721

Gene position: 1979863-1979081 (Counterclockwise)

Preceding gene: 182678722

Following gene: 182678720

Centisome position: 47.48

GC content: 52.75

Gene sequence:

>783_bases
ATGACAACAGAATCGCTCATATCAGTGGCTTCGGATAGAGAGAACACTGTTATCATAGACGACCGTGAAAACGGCATTCG
TCTTTTGACGATCTCCCGTGTGGCGCGTCGGAACGCGCTGGATAGGAAGACCCATCAAGCCCTCACCAGTGCCCTGATCG
CAGCAGATGCCGATGAATCCGTGCGTGTTGTTGTCCTGACAGGGGCAGGCAATGTCTTTACCAGTGGTAATGATCTTGCC
GATTTTCAGAATGCGGCCGGTGATGACGCCGCCCGCGCGGGGCTGGATTTTTTGAAAGCCCTTTGCGCCTTTGCAAAGCC
GCTTGTCGCAGCGGTGGAAGGTTATGCGATTGGCATTGGGACGACTTTGCTTCTTCATTGCGATTTCGCCTATGCCGGGC
GCGGGACTCAATTTCGTCTTCCTTTTACGGCGCTCGGCTTGTGTCCGGAGGGAGGCTCAAGCTATCTTTTGCCACGAATT
GCCGGAACCAAGCGCGCAGCAGATCTCTTAATGCTGGGGGAAACATTCACGGCTGAGAGAGCAGCTGATTCCGGTATTAT
TACCAGCATTACGGATGATGGTGGTTCTCTTCCATTGGCTCTAAACAAAGCTCATGTACTGGCGGGACTCTCTCCGCAAG
CACTTACAATGACAAAGCATTTGCTCAAACAAAGTTTTGCTAAGGATCTCGAGCACACGCTGCAATTGGAAGCGGAAAGT
TTCGACGCTTTGCGCCGAACCCCCTATGCGCAGGCAGTCTTTGCGGCTTTCTTTGCCAGTTGA

Upstream 100 bases:

>100_bases
TTCCATCCATGATATTCCTGCGACGGCTGATCTTTGTTTGAGATTGAAAGAGGAATATGCGCGGGCGTGTCATGCCTTAG
CATCGTGAGGAACGATCGTA

Downstream 100 bases:

>100_bases
ACCTATTGATAAGCAACAGATCGAAGTCATCTCATAATACACAAGAATAGCGATATAAAAAAGCTTTCATGATAAGCAAT
ATAGGGAGGAAATATGATGA

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTTESLISVASDRENTVIIDDRENGIRLLTISRVARRNALDRKTHQALTSALIAADADESVRVVVLTGAGNVFTSGNDLA
DFQNAAGDDAARAGLDFLKALCAFAKPLVAAVEGYAIGIGTTLLLHCDFAYAGRGTQFRLPFTALGLCPEGGSSYLLPRI
AGTKRAADLLMLGETFTAERAADSGIITSITDDGGSLPLALNKAHVLAGLSPQALTMTKHLLKQSFAKDLEHTLQLEAES
FDALRRTPYAQAVFAAFFAS

Sequences:

>Translated_260_residues
MTTESLISVASDRENTVIIDDRENGIRLLTISRVARRNALDRKTHQALTSALIAADADESVRVVVLTGAGNVFTSGNDLA
DFQNAAGDDAARAGLDFLKALCAFAKPLVAAVEGYAIGIGTTLLLHCDFAYAGRGTQFRLPFTALGLCPEGGSSYLLPRI
AGTKRAADLLMLGETFTAERAADSGIITSITDDGGSLPLALNKAHVLAGLSPQALTMTKHLLKQSFAKDLEHTLQLEAES
FDALRRTPYAQAVFAAFFAS
>Mature_259_residues
TTESLISVASDRENTVIIDDRENGIRLLTISRVARRNALDRKTHQALTSALIAADADESVRVVVLTGAGNVFTSGNDLAD
FQNAAGDDAARAGLDFLKALCAFAKPLVAAVEGYAIGIGTTLLLHCDFAYAGRGTQFRLPFTALGLCPEGGSSYLLPRIA
GTKRAADLLMLGETFTAERAADSGIITSITDDGGSLPLALNKAHVLAGLSPQALTMTKHLLKQSFAKDLEHTLQLEAESF
DALRRTPYAQAVFAAFFAS

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI260274832, Length=249, Percent_Identity=30.5220883534137, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI45643119, Length=249, Percent_Identity=30.5220883534137, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI260275230, Length=249, Percent_Identity=30.5220883534137, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI221136756, Length=234, Percent_Identity=28.2051282051282, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI221136753, Length=234, Percent_Identity=28.2051282051282, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI221307494, Length=234, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI25453481, Length=230, Percent_Identity=29.1304347826087, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI51538573, Length=230, Percent_Identity=29.1304347826087, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4757966, Length=230, Percent_Identity=29.1304347826087, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI51538581, Length=230, Percent_Identity=29.1304347826087, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4757968, Length=230, Percent_Identity=29.1304347826087, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI49355787, Length=230, Percent_Identity=29.1304347826087, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI116235487, Length=181, Percent_Identity=30.939226519337, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI194097323, Length=223, Percent_Identity=30.0448430493274, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI70995211, Length=180, Percent_Identity=26.6666666666667, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI31542718, Length=213, Percent_Identity=26.2910798122066, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI68989263, Length=171, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787659, Length=244, Percent_Identity=35.655737704918, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787660, Length=227, Percent_Identity=33.0396475770925, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI221142681, Length=217, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788597, Length=183, Percent_Identity=31.6939890710383, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=247, Percent_Identity=29.9595141700405, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17549921, Length=215, Percent_Identity=33.0232558139535, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17554946, Length=228, Percent_Identity=28.9473684210526, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25145438, Length=221, Percent_Identity=28.0542986425339, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=245, Percent_Identity=26.9387755102041, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560910, Length=229, Percent_Identity=26.6375545851528, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17534483, Length=224, Percent_Identity=26.3392857142857, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=179, Percent_Identity=28.4916201117318, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17558304, Length=160, Percent_Identity=29.375, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323314, Length=211, Percent_Identity=28.9099526066351, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24654903, Length=224, Percent_Identity=33.9285714285714, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI20129971, Length=221, Percent_Identity=26.6968325791855, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24653477, Length=221, Percent_Identity=26.6968325791855, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19920382, Length=224, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922422, Length=189, Percent_Identity=25.9259259259259, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357171, Length=206, Percent_Identity=28.6407766990291, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24653139, Length=231, Percent_Identity=25.974025974026, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27516; Mature: 27384

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTESLISVASDRENTVIIDDRENGIRLLTISRVARRNALDRKTHQALTSALIAADADES
CCHHHHHHHHCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VRVVVLTGAGNVFTSGNDLADFQNAAGDDAARAGLDFLKALCAFAKPLVAAVEGYAIGIG
EEEEEEECCCCEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
TTLLLHCDFAYAGRGTQFRLPFTALGLCPEGGSSYLLPRIAGTKRAADLLMLGETFTAER
EEEEEEECHHCCCCCCEEECCHHEEECCCCCCCCEEEECCCCCHHHHHEEEECCCHHHHH
AADSGIITSITDDGGSLPLALNKAHVLAGLSPQALTMTKHLLKQSFAKDLEHTLQLEAES
HCCCCCEEEEECCCCCCEEEECCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHH
FDALRRTPYAQAVFAAFFAS
HHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TTESLISVASDRENTVIIDDRENGIRLLTISRVARRNALDRKTHQALTSALIAADADES
CHHHHHHHHCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VRVVVLTGAGNVFTSGNDLADFQNAAGDDAARAGLDFLKALCAFAKPLVAAVEGYAIGIG
EEEEEEECCCCEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
TTLLLHCDFAYAGRGTQFRLPFTALGLCPEGGSSYLLPRIAGTKRAADLLMLGETFTAER
EEEEEEECHHCCCCCCEEECCHHEEECCCCCCCCEEEECCCCCHHHHHEEEECCCHHHHH
AADSGIITSITDDGGSLPLALNKAHVLAGLSPQALTMTKHLLKQSFAKDLEHTLQLEAES
HCCCCCEEEEECCCCCCEEEECCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHH
FDALRRTPYAQAVFAAFFAS
HHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]