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The map label for this gene is prs [H]

Identifier: 182678682

GI number: 182678682

Start: 1929200

End: 1930132

Strand: Reverse

Name: prs [H]

Synonym: Bind_1709

Alternate gene names: 182678682

Gene position: 1930132-1929200 (Counterclockwise)

Preceding gene: 182678683

Following gene: 182678681

Centisome position: 46.28

GC content: 56.59

Gene sequence:

>933_bases
ATGATCATCCTTGCCGGAAATTCCAATCGTCCTCTTAGCGAGGCTATTGCCGCCTATCTCAGTATTCCCCTGACGAGATG
TCAGGTTCGGCGCTTCGCCGATATGGAAGTCTTCGTCGAGATTCAGGAAAATGTGCGCGGCGAGGACGCATTCATCATTC
AGTCGACATCGTTTCCAACCAATGACCATTTGATGGAAGCGTTGATCATGACCGATGCCTTGCGTCGGGCCTCGGCCAGA
CGCATCACGACAGTGATTCCCTATTTCGGTTATGCACGGCAAGATCGCAAGTCAGGGTCGCGCACGCCGATTTCGGCGAA
GCTGGTCGCCAATCTCATCACCCGCGCGGGCGCCGACCGCGTGCTGACCGTCGATCTTCATGCTGGCCAGATTCAAGGCT
TTTTCGATATTCCGACCGATAATTTATTCGCGGCGCCCGTGATGGTCCGTGACATCAAGGAAAGGTTGGAATTGAGCAAT
GTCATGGTCGTCTCGCCGGATGTCGGCGGTGTGGTCCGCGCCCGCGCGCTGGCGAAACGCATCGACGCTCCCTTGTCGAT
CGTCGATAAGCGACGGGAACGGGCCGGCGAATCCGAAGTGATGAATATTATCGGCGATGTGTCTGGTAAGAGCTGCATTC
TCGTTGATGATATCGTCGATTCCGGCGGCACCCTCTGCAATGCTGCGGAAGCTCTCCTGAAGAATGGCGCCAAGGAAGTC
TATGCCTATATCACCCATGGCGTTCTGTCCGGAGGCGCTGTCGCGCGTATCGCGGCCTCGTCTCTCAAGGAACTGGTGGT
GACGGACACGATCCTGGCGACGGAGGCAGTGCGCGTCGCAAAAAATATCAGGGTTGTGTCCATTGCGCCCCTGATCGGCG
AAGCGATCGGCCGGACTTCCAAGGAAGAGAGCGTTTCGAGCCTTTTCGACTAA

Upstream 100 bases:

>100_bases
TGCGATCGATGGTCCTTTCTTAAAGGGAAAATCGAGGCCGTTTATGTTCAACTAGAGGCAAACCAGTCAGGTTTGCTTCG
GCGTCGGAATGTCGAATGCG

Downstream 100 bases:

>100_bases
CGCGGCCGTCCCCCATTTAACCGAAAATCCTGCGTCAAATTTCTCCCTGGAGAGACGTCTCCTTTTGGTTTGATGCTGTA
ACGCCGCTTCGTTTTTCAGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MIILAGNSNRPLSEAIAAYLSIPLTRCQVRRFADMEVFVEIQENVRGEDAFIIQSTSFPTNDHLMEALIMTDALRRASAR
RITTVIPYFGYARQDRKSGSRTPISAKLVANLITRAGADRVLTVDLHAGQIQGFFDIPTDNLFAAPVMVRDIKERLELSN
VMVVSPDVGGVVRARALAKRIDAPLSIVDKRRERAGESEVMNIIGDVSGKSCILVDDIVDSGGTLCNAAEALLKNGAKEV
YAYITHGVLSGGAVARIAASSLKELVVTDTILATEAVRVAKNIRVVSIAPLIGEAIGRTSKEESVSSLFD

Sequences:

>Translated_310_residues
MIILAGNSNRPLSEAIAAYLSIPLTRCQVRRFADMEVFVEIQENVRGEDAFIIQSTSFPTNDHLMEALIMTDALRRASAR
RITTVIPYFGYARQDRKSGSRTPISAKLVANLITRAGADRVLTVDLHAGQIQGFFDIPTDNLFAAPVMVRDIKERLELSN
VMVVSPDVGGVVRARALAKRIDAPLSIVDKRRERAGESEVMNIIGDVSGKSCILVDDIVDSGGTLCNAAEALLKNGAKEV
YAYITHGVLSGGAVARIAASSLKELVVTDTILATEAVRVAKNIRVVSIAPLIGEAIGRTSKEESVSSLFD
>Mature_310_residues
MIILAGNSNRPLSEAIAAYLSIPLTRCQVRRFADMEVFVEIQENVRGEDAFIIQSTSFPTNDHLMEALIMTDALRRASAR
RITTVIPYFGYARQDRKSGSRTPISAKLVANLITRAGADRVLTVDLHAGQIQGFFDIPTDNLFAAPVMVRDIKERLELSN
VMVVSPDVGGVVRARALAKRIDAPLSIVDKRRERAGESEVMNIIGDVSGKSCILVDDIVDSGGTLCNAAEALLKNGAKEV
YAYITHGVLSGGAVARIAASSLKELVVTDTILATEAVRVAKNIRVVSIAPLIGEAIGRTSKEESVSSLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=308, Percent_Identity=47.7272727272727, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI4506129, Length=310, Percent_Identity=46.7741935483871, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI28557709, Length=308, Percent_Identity=47.4025974025974, Blast_Score=295, Evalue=3e-80,
Organism=Homo sapiens, GI84875539, Length=313, Percent_Identity=46.3258785942492, Blast_Score=291, Evalue=4e-79,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=35.5491329479769, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI194018537, Length=331, Percent_Identity=35.3474320241692, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=32.4137931034483, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=32.4137931034483, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=32.4137931034483, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=32.4137931034483, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=55.1282051282051, Blast_Score=342, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=46.4285714285714, Blast_Score=289, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI25149168, Length=308, Percent_Identity=46.4285714285714, Blast_Score=289, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17554702, Length=308, Percent_Identity=46.4285714285714, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI71989924, Length=308, Percent_Identity=46.4285714285714, Blast_Score=287, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=32.6409495548961, Blast_Score=181, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6319403, Length=310, Percent_Identity=47.741935483871, Blast_Score=279, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6320946, Length=309, Percent_Identity=45.6310679611651, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321776, Length=308, Percent_Identity=47.7272727272727, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6322667, Length=194, Percent_Identity=40.7216494845361, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=110, Percent_Identity=41.8181818181818, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355239, Length=308, Percent_Identity=46.7532467532467, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI45551540, Length=331, Percent_Identity=43.5045317220544, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24651458, Length=353, Percent_Identity=33.1444759206799, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24651456, Length=353, Percent_Identity=33.1444759206799, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI281362873, Length=353, Percent_Identity=33.1444759206799, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24651454, Length=353, Percent_Identity=33.1444759206799, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24651462, Length=201, Percent_Identity=35.8208955223881, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24651464, Length=201, Percent_Identity=35.8208955223881, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI45552010, Length=201, Percent_Identity=35.8208955223881, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33437; Mature: 33437

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILAGNSNRPLSEAIAAYLSIPLTRCQVRRFADMEVFVEIQENVRGEDAFIIQSTSFPT
CEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHCCHHHEEEEHHCCCCCCEEEEEECCCCC
NDHLMEALIMTDALRRASARRITTVIPYFGYARQDRKSGSRTPISAKLVANLITRAGADR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
VLTVDLHAGQIQGFFDIPTDNLFAAPVMVRDIKERLELSNVMVVSPDVGGVVRARALAKR
EEEEEEECCCCCEEEECCCCCEEECHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHH
IDAPLSIVDKRRERAGESEVMNIIGDVSGKSCILVDDIVDSGGTLCNAAEALLKNGAKEV
HCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCHHHHHHHHHHCCHHHH
YAYITHGVLSGGAVARIAASSLKELVVTDTILATEAVRVAKNIRVVSIAPLIGEAIGRTS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHCCCC
KEESVSSLFD
HHHHHHHHCC
>Mature Secondary Structure
MIILAGNSNRPLSEAIAAYLSIPLTRCQVRRFADMEVFVEIQENVRGEDAFIIQSTSFPT
CEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHCCHHHEEEEHHCCCCCCEEEEEECCCCC
NDHLMEALIMTDALRRASARRITTVIPYFGYARQDRKSGSRTPISAKLVANLITRAGADR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
VLTVDLHAGQIQGFFDIPTDNLFAAPVMVRDIKERLELSNVMVVSPDVGGVVRARALAKR
EEEEEEECCCCCEEEECCCCCEEECHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHH
IDAPLSIVDKRRERAGESEVMNIIGDVSGKSCILVDDIVDSGGTLCNAAEALLKNGAKEV
HCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCHHHHHHHHHHCCHHHH
YAYITHGVLSGGAVARIAASSLKELVVTDTILATEAVRVAKNIRVVSIAPLIGEAIGRTS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHCCCC
KEESVSSLFD
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]