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The map label for this gene is trpC [H]

Identifier: 182678535

GI number: 182678535

Start: 1762323

End: 1763165

Strand: Reverse

Name: trpC [H]

Synonym: Bind_1560

Alternate gene names: 182678535

Gene position: 1763165-1762323 (Counterclockwise)

Preceding gene: 182678537

Following gene: 182678534

Centisome position: 42.28

GC content: 61.68

Gene sequence:

>843_bases
ATGACCGAAGCTGATGGAACCTCGATCGGACCGCGCCTCAAACCGCTGCTCGCGCAGCGACAGGACGATGTCGAGAAAGC
CAAGGCCAAACGCTCGATTGGCAGCTTGACCGGCGCCATCGGCGAGGCACAGATGACGCGCGGCTTTCTCGCGGCCCTCT
ACGAGTATTATGCGAAGCACGGCAAACCTGGCGTCATCGCCGATATACGCGGCAGTTCGCCCGTCTCGAAATCCACGCGC
TCGCGCCTCGATGTCATGGAAATGGCCGAGGATTATCGTGACGCCGGCGCGGCTTGTGTCTCCGCCTCGCCGGATCGGCG
CTTTTTCCGTGGCAGCATCGCCGACCTTGCAACGGCCAAAGCCTCCAACCTGCCGATCCTGGCCAATGATATCGTGGTCG
ATCTCTATCAGGTCTATGAGGCGCGCTATGCCGGTGCCGATGCGAGCCTGCTCATTGCCAGCATTCTCGGCAAACAGCTC
CAGGAATTCGTCGCCCGCGCCCAATCGATCGCCATCGATCCGCTGGTCGAAGTCCGCAATGAGGCCGAGCTTGAAATAGC
GCTCGATGCGGGCGCCAGCCTGATCGCCGTGAACAATCGTGATCTCGAAACACTCGAGGTCGATCCGACGGTCTGTGAAA
GGCTGTTGCCGAAAATCCCGCATGACCGGGTTTTCGCCATTGCGTCCGGCGGCATCAGAACGCCGGAGGATATCGAAAAA
ATGGCGTCGCTCGGCGCCAAGGCGGTGCGTGTCGCGAGCGTGCTCCTGGAGGCCAAGGACCCCTATCTTGCCCTTCACCA
GTTGCTGGGCACCACGCCGCCGGACGATGACGCGGCGGGTTAA

Upstream 100 bases:

>100_bases
TCAGGATGACAACCTTGCCGCATTTGATTCAGACGAATCTGGTTCTTTCCAGCCTCTCGAAAGCATTTGAAACCTGCCTC
CGTCTGAAAGGATCGCGCTC

Downstream 100 bases:

>100_bases
ACCCACAGCACCCGAAATCAGAAAATTTTAGATATTTTTAACACACCATCCCCAAAAGTTGCCGCTTCTGGGGATGGTGC
TTTGCGTCTTGCGGACGTGT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTEADGTSIGPRLKPLLAQRQDDVEKAKAKRSIGSLTGAIGEAQMTRGFLAALYEYYAKHGKPGVIADIRGSSPVSKSTR
SRLDVMEMAEDYRDAGAACVSASPDRRFFRGSIADLATAKASNLPILANDIVVDLYQVYEARYAGADASLLIASILGKQL
QEFVARAQSIAIDPLVEVRNEAELEIALDAGASLIAVNNRDLETLEVDPTVCERLLPKIPHDRVFAIASGGIRTPEDIEK
MASLGAKAVRVASVLLEAKDPYLALHQLLGTTPPDDDAAG

Sequences:

>Translated_280_residues
MTEADGTSIGPRLKPLLAQRQDDVEKAKAKRSIGSLTGAIGEAQMTRGFLAALYEYYAKHGKPGVIADIRGSSPVSKSTR
SRLDVMEMAEDYRDAGAACVSASPDRRFFRGSIADLATAKASNLPILANDIVVDLYQVYEARYAGADASLLIASILGKQL
QEFVARAQSIAIDPLVEVRNEAELEIALDAGASLIAVNNRDLETLEVDPTVCERLLPKIPHDRVFAIASGGIRTPEDIEK
MASLGAKAVRVASVLLEAKDPYLALHQLLGTTPPDDDAAG
>Mature_279_residues
TEADGTSIGPRLKPLLAQRQDDVEKAKAKRSIGSLTGAIGEAQMTRGFLAALYEYYAKHGKPGVIADIRGSSPVSKSTRS
RLDVMEMAEDYRDAGAACVSASPDRRFFRGSIADLATAKASNLPILANDIVVDLYQVYEARYAGADASLLIASILGKQLQ
EFVARAQSIAIDPLVEVRNEAELEIALDAGASLIAVNNRDLETLEVDPTVCERLLPKIPHDRVFAIASGGIRTPEDIEKM
ASLGAKAVRVASVLLEAKDPYLALHQLLGTTPPDDDAAG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=259, Percent_Identity=30.5019305019305, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322638, Length=267, Percent_Identity=30.3370786516854, Blast_Score=115, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29901; Mature: 29770

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEADGTSIGPRLKPLLAQRQDDVEKAKAKRSIGSLTGAIGEAQMTRGFLAALYEYYAKH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKPGVIADIRGSSPVSKSTRSRLDVMEMAEDYRDAGAACVSASPDRRFFRGSIADLATAK
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHC
ASNLPILANDIVVDLYQVYEARYAGADASLLIASILGKQLQEFVARAQSIAIDPLVEVRN
CCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
EAELEIALDAGASLIAVNNRDLETLEVDPTVCERLLPKIPHDRVFAIASGGIRTPEDIEK
CCCEEEEEECCCEEEEECCCCCEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
MASLGAKAVRVASVLLEAKDPYLALHQLLGTTPPDDDAAG
HHHHCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TEADGTSIGPRLKPLLAQRQDDVEKAKAKRSIGSLTGAIGEAQMTRGFLAALYEYYAKH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKPGVIADIRGSSPVSKSTRSRLDVMEMAEDYRDAGAACVSASPDRRFFRGSIADLATAK
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHC
ASNLPILANDIVVDLYQVYEARYAGADASLLIASILGKQLQEFVARAQSIAIDPLVEVRN
CCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
EAELEIALDAGASLIAVNNRDLETLEVDPTVCERLLPKIPHDRVFAIASGGIRTPEDIEK
CCCEEEEEECCCEEEEECCCCCEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
MASLGAKAVRVASVLLEAKDPYLALHQLLGTTPPDDDAAG
HHHHCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA