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The map label for this gene is ribE [H]

Identifier: 182678212

GI number: 182678212

Start: 1424573

End: 1425181

Strand: Direct

Name: ribE [H]

Synonym: Bind_1227

Alternate gene names: 182678212

Gene position: 1424573-1425181 (Clockwise)

Preceding gene: 182678211

Following gene: 182678213

Centisome position: 34.16

GC content: 59.11

Gene sequence:

>609_bases
ATGTTCACGGGGCTCATCAGCGATGTCGGTGAGGTTGGCGCGGTCGAGGAACGCGGACAATTGCGGCGCCTGCGGATTTT
CTGCTCCTATCCGGCGGAAAGCGTGGTGCTCGGCGCTTCGATTGCCTGCAATGGACCGTGCCTGACGGTGGTCGCCTTCG
ATCAGGAAAAGAGCAGCAACCGTATCTGGTTCGAAGTCGATGTCGGCGCGGAAACCTTGGCGCGCACGACGGCCGAACAT
TGGACGCCCGGCACGAAACTCAATCTCGAACGCTCGCTGAAAGTCGGCGATGAGCTCGGCGGCCATATTGTGACGGGCCA
TGTGGATGCGGTGGCGGAGATCACGGCCATTGATGATTTCGACGGGATGCGGCGTTTTTCCATCCGCGTGCCCGAGTCGC
TGGCGCGTTTCATCGCCGAAAAAGGCTCGGTCAGCCTTGATGGCACGTCACTGACTGTCAATAGTGTCGAGGGCAATGTA
TTTTCGGTGCTGTTGATCCCCCATACGCTGGCCGTGACCACCTGGGGTGGCAAACAAGTGGAAGATCGTGTCAATCTCGA
AGTCGATCTCATGGCTCGCTATGCCGCCCGCCTGACCGAAACATCGTAA

Upstream 100 bases:

>100_bases
GGGCGCGCGCCATTCTGGGTAACCTTACCCTTTATCGTCCTGCCGAGACACGGATGATCGAAGAGGACCGCCTCACCCGC
TATGAAAGGATTGATTGATC

Downstream 100 bases:

>100_bases
ATTTTTTAAGAAAATGGCGTTAAAGCGGGAGGGATAAGAAGAGAGGCGGCGCGTGGAAACGGTTGTCAGTATCCTGATTT
TTCTTGTGGCTGTTGTGGTC

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MFTGLISDVGEVGAVEERGQLRRLRIFCSYPAESVVLGASIACNGPCLTVVAFDQEKSSNRIWFEVDVGAETLARTTAEH
WTPGTKLNLERSLKVGDELGGHIVTGHVDAVAEITAIDDFDGMRRFSIRVPESLARFIAEKGSVSLDGTSLTVNSVEGNV
FSVLLIPHTLAVTTWGGKQVEDRVNLEVDLMARYAARLTETS

Sequences:

>Translated_202_residues
MFTGLISDVGEVGAVEERGQLRRLRIFCSYPAESVVLGASIACNGPCLTVVAFDQEKSSNRIWFEVDVGAETLARTTAEH
WTPGTKLNLERSLKVGDELGGHIVTGHVDAVAEITAIDDFDGMRRFSIRVPESLARFIAEKGSVSLDGTSLTVNSVEGNV
FSVLLIPHTLAVTTWGGKQVEDRVNLEVDLMARYAARLTETS
>Mature_202_residues
MFTGLISDVGEVGAVEERGQLRRLRIFCSYPAESVVLGASIACNGPCLTVVAFDQEKSSNRIWFEVDVGAETLARTTAEH
WTPGTKLNLERSLKVGDELGGHIVTGHVDAVAEITAIDDFDGMRRFSIRVPESLARFIAEKGSVSLDGTSLTVNSVEGNV
FSVLLIPHTLAVTTWGGKQVEDRVNLEVDLMARYAARLTETS

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=191, Percent_Identity=36.1256544502618, Blast_Score=107, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319733, Length=170, Percent_Identity=37.0588235294118, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 21896; Mature: 21896

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGLISDVGEVGAVEERGQLRRLRIFCSYPAESVVLGASIACNGPCLTVVAFDQEKSSN
CCCCHHHHHHHCCCCHHCCCEEEEEEEECCCCCCEEEECEEEECCCEEEEEEECCCCCCC
RIWFEVDVGAETLARTTAEHWTPGTKLNLERSLKVGDELGGHIVTGHVDAVAEITAIDDF
EEEEEEECCHHHHHHHHHHHCCCCCEEEHHHCCCCCHHCCCEEEECCCCCEEEEEEECCC
DGMRRFSIRVPESLARFIAEKGSVSLDGTSLTVNSVEGNVFSVLLIPHTLAVTTWGGKQV
CCCEEEEEECCHHHHHHHHHCCCEEECCCEEEEEECCCCEEEEEEECCEEEEEECCCCCC
EDRVNLEVDLMARYAARLTETS
HHHCCEEHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFTGLISDVGEVGAVEERGQLRRLRIFCSYPAESVVLGASIACNGPCLTVVAFDQEKSSN
CCCCHHHHHHHCCCCHHCCCEEEEEEEECCCCCCEEEECEEEECCCEEEEEEECCCCCCC
RIWFEVDVGAETLARTTAEHWTPGTKLNLERSLKVGDELGGHIVTGHVDAVAEITAIDDF
EEEEEEECCHHHHHHHHHHHCCCCCEEEHHHCCCCCHHCCCEEEECCCCCEEEEEEECCC
DGMRRFSIRVPESLARFIAEKGSVSLDGTSLTVNSVEGNVFSVLLIPHTLAVTTWGGKQV
CCCEEEEEECCHHHHHHHHHCCCEEECCCEEEEEECCCCEEEEEEECCEEEEEECCCCCC
EDRVNLEVDLMARYAARLTETS
HHHCCEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144477 [H]