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The map label for this gene is gyaR [H]

Identifier: 182678077

GI number: 182678077

Start: 1252168

End: 1253136

Strand: Direct

Name: gyaR [H]

Synonym: Bind_1092

Alternate gene names: 182678077

Gene position: 1252168-1253136 (Clockwise)

Preceding gene: 182678076

Following gene: 182678078

Centisome position: 30.03

GC content: 56.86

Gene sequence:

>969_bases
TTGCCCGATTTCGACATCCTTCTGCCCTCTCCCTTGCCGGCCAAAGTCGTGCAGGGGCTTGCCCATGTCTGCAAGGTCCA
TCCGCTTTGGGAAGCGGCTGATCCGCAGGCCTTGATCGGGCAAATCAAGGATAAGGTACAGGGATTGGCGACGTGCTACG
GCAAAGGGAAGATTGATGGCGACTTCATGAGCCAATTTCCCAATCTCAAGATCGTGTCCCATTATGGCGTCGGCTATGAC
ATCATTGATGCCGCTTGGGCCGGGGCGCATCATATCGTTGTGACAAATACGCCGGACGTTCTGAACGATGAAGTCGCCGA
TCTCGCCATCGGCCTGATGCTGGCGACGATCCGGCAGATTCCGCAAGCTGATACGTTTTTGCGCGCGGGGCACTGGCTCA
AGGGATCTTTTCCCCTGACGGCGACCTTACGGGAACGCCGTCTTGGCATTTTCGGTCTTGGCCGGATCGGCAAGGCGATT
GCGAAACGCGCGGCTGCTTTCGATATCGAGATCGCCTATTGCGGCCGAAAAAAACAGGACGACGTACCCTATCGCTTTTA
TCCGAGCCTGCTCGAACTGGCACGGGAAAGCGATATTTTGATGGTTATCGCCCCGGCGACACACGAGACGACAAACGCCG
TCAATGCGGAAGTATTGAGCGCGCTGGGGGCCAATGGCGTTCTCATCAATGTCGCGCGCGGGTCTCTCGTCGATGAAAAC
GCTTTGATCGAAGCCTTGAAGAACAAGACCATTCTTTCGGCTGGCCTCGATGTCTTTGCCGCTGAGCCGCAAGTGCCGCA
GGCGCTCATCGATATGGAGCAAGTCGTTCTGCTGCCACATGTCGGCTCGGCATCGCATTATACACGCGATGCCATGGGAC
AATTGGTGGTTGATAATCTGATCTCATTCGCGGAAGGGCGGGGACCCTTGACGCCCGTGGCGGAAACGCCCTGGCCGTTT
TCCGCTTGA

Upstream 100 bases:

>100_bases
CGGCCTCTTTTCGCGCATGGCGTGACAAGCTATGGAAGCGCTGCCAAAATTCGCGAACCCCTTTCACCCTTGCCATGTTT
TCCGCTGACAGGAGCCGACC

Downstream 100 bases:

>100_bases
TCGGCGCGGACAGCTTATACCCTGCGCTCGAGCAGACCTCTGAAGTGAAACACTTTTTGGGGATTATGCGCTGAAACGAA
CAGAGTGAGCATTGGAGACG

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MPDFDILLPSPLPAKVVQGLAHVCKVHPLWEAADPQALIGQIKDKVQGLATCYGKGKIDGDFMSQFPNLKIVSHYGVGYD
IIDAAWAGAHHIVVTNTPDVLNDEVADLAIGLMLATIRQIPQADTFLRAGHWLKGSFPLTATLRERRLGIFGLGRIGKAI
AKRAAAFDIEIAYCGRKKQDDVPYRFYPSLLELARESDILMVIAPATHETTNAVNAEVLSALGANGVLINVARGSLVDEN
ALIEALKNKTILSAGLDVFAAEPQVPQALIDMEQVVLLPHVGSASHYTRDAMGQLVVDNLISFAEGRGPLTPVAETPWPF
SA

Sequences:

>Translated_322_residues
MPDFDILLPSPLPAKVVQGLAHVCKVHPLWEAADPQALIGQIKDKVQGLATCYGKGKIDGDFMSQFPNLKIVSHYGVGYD
IIDAAWAGAHHIVVTNTPDVLNDEVADLAIGLMLATIRQIPQADTFLRAGHWLKGSFPLTATLRERRLGIFGLGRIGKAI
AKRAAAFDIEIAYCGRKKQDDVPYRFYPSLLELARESDILMVIAPATHETTNAVNAEVLSALGANGVLINVARGSLVDEN
ALIEALKNKTILSAGLDVFAAEPQVPQALIDMEQVVLLPHVGSASHYTRDAMGQLVVDNLISFAEGRGPLTPVAETPWPF
SA
>Mature_321_residues
PDFDILLPSPLPAKVVQGLAHVCKVHPLWEAADPQALIGQIKDKVQGLATCYGKGKIDGDFMSQFPNLKIVSHYGVGYDI
IDAAWAGAHHIVVTNTPDVLNDEVADLAIGLMLATIRQIPQADTFLRAGHWLKGSFPLTATLRERRLGIFGLGRIGKAIA
KRAAAFDIEIAYCGRKKQDDVPYRFYPSLLELARESDILMVIAPATHETTNAVNAEVLSALGANGVLINVARGSLVDENA
LIEALKNKTILSAGLDVFAAEPQVPQALIDMEQVVLLPHVGSASHYTRDAMGQLVVDNLISFAEGRGPLTPVAETPWPFS
A

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=246, Percent_Identity=35.7723577235772, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI23308577, Length=275, Percent_Identity=29.8181818181818, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI145580578, Length=262, Percent_Identity=29.3893129770992, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4557499, Length=262, Percent_Identity=29.3893129770992, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI145580575, Length=262, Percent_Identity=29.3893129770992, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI4557497, Length=261, Percent_Identity=29.5019157088123, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI61743967, Length=261, Percent_Identity=29.5019157088123, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI87082289, Length=309, Percent_Identity=34.6278317152104, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1789279, Length=264, Percent_Identity=27.6515151515151, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787645, Length=211, Percent_Identity=30.8056872037915, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87081824, Length=188, Percent_Identity=26.063829787234, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=241, Percent_Identity=32.3651452282158, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=255, Percent_Identity=27.4509803921569, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324055, Length=279, Percent_Identity=33.6917562724014, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6322116, Length=316, Percent_Identity=26.2658227848101, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=279, Percent_Identity=26.5232974910394, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321253, Length=284, Percent_Identity=24.6478873239437, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=148, Percent_Identity=30.4054054054054, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45552429, Length=254, Percent_Identity=34.6456692913386, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI28574284, Length=254, Percent_Identity=34.6456692913386, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24585514, Length=254, Percent_Identity=34.6456692913386, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI28574282, Length=254, Percent_Identity=34.6456692913386, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI45551003, Length=254, Percent_Identity=34.6456692913386, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24585516, Length=250, Percent_Identity=35.2, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28571528, Length=264, Percent_Identity=37.8787878787879, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574286, Length=322, Percent_Identity=30.7453416149068, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI19921140, Length=242, Percent_Identity=28.5123966942149, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI62472511, Length=231, Percent_Identity=32.034632034632, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24646446, Length=231, Percent_Identity=32.034632034632, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646448, Length=231, Percent_Identity=32.034632034632, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646452, Length=231, Percent_Identity=32.034632034632, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646450, Length=231, Percent_Identity=32.034632034632, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34667; Mature: 34536

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDFDILLPSPLPAKVVQGLAHVCKVHPLWEAADPQALIGQIKDKVQGLATCYGKGKIDG
CCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
DFMSQFPNLKIVSHYGVGYDIIDAAWAGAHHIVVTNTPDVLNDEVADLAIGLMLATIRQI
HHHHHCCCEEEEEECCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
PQADTFLRAGHWLKGSFPLTATLRERRLGIFGLGRIGKAIAKRAAAFDIEIAYCGRKKQD
CCHHHHHHCCCCCCCCCCEEHHHHHHCCCEEEHHHHHHHHHHHHHHEEEEEEECCCCCCC
DVPYRFYPSLLELARESDILMVIAPATHETTNAVNAEVLSALGANGVLINVARGSLVDEN
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCHH
ALIEALKNKTILSAGLDVFAAEPQVPQALIDMEQVVLLPHVGSASHYTRDAMGQLVVDNL
HHHHHHHCCHHHHHCCHHEECCCCCCHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHH
ISFAEGRGPLTPVAETPWPFSA
HHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PDFDILLPSPLPAKVVQGLAHVCKVHPLWEAADPQALIGQIKDKVQGLATCYGKGKIDG
CCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
DFMSQFPNLKIVSHYGVGYDIIDAAWAGAHHIVVTNTPDVLNDEVADLAIGLMLATIRQI
HHHHHCCCEEEEEECCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
PQADTFLRAGHWLKGSFPLTATLRERRLGIFGLGRIGKAIAKRAAAFDIEIAYCGRKKQD
CCHHHHHHCCCCCCCCCCEEHHHHHHCCCEEEHHHHHHHHHHHHHHEEEEEEECCCCCCC
DVPYRFYPSLLELARESDILMVIAPATHETTNAVNAEVLSALGANGVLINVARGSLVDEN
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCHH
ALIEALKNKTILSAGLDVFAAEPQVPQALIDMEQVVLLPHVGSASHYTRDAMGQLVVDNL
HHHHHHHCCHHHHHCCHHEECCCCCCHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHH
ISFAEGRGPLTPVAETPWPFSA
HHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA