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The map label for this gene is pyrD [H]

Identifier: 182678054

GI number: 182678054

Start: 1225574

End: 1226659

Strand: Direct

Name: pyrD [H]

Synonym: Bind_1068

Alternate gene names: 182678054

Gene position: 1225574-1226659 (Clockwise)

Preceding gene: 182678053

Following gene: 182678061

Centisome position: 29.39

GC content: 60.5

Gene sequence:

>1086_bases
ATGACGTTCTTGGCGCCGCATCGGCTGCTCTTCGGCCTCGATCCCGAGCGGGCGCATCGCCTGGCGATCTGGGCGCTCGC
GCATGTTCCCCTCCCGCCGCCTCCGGCCGTTGATCCCAGGCTGTCGGTCGAGGCTTTTGGCCTTGCCTTTGCCAATCCGC
TCGGCCTTGCCGCGGGCATGGACAAGAATGGCGAGGCGCCGGGCGCGCTTTTGCGGCTCGGTTTTGGTTTTGCCGAAATC
GGCACGGTGACACCGCTGCCGCAGCCGGGCAATCCGTTGCCGCGCCTGTTTCGCCTGACCAAGGATGAGGCGATCATCAA
TCGTTTTGGCTTCAACAGTGAAGGCCATGCGCGCGTACATGAGCGGCTTACGGCTTTCTTGGCAGGCGCGCGGCGGAAAG
GCGTGATCGGCATCAATATTGGCGCGAACAAAGACAGTCTCGATCGCGCCGAGGATTATGTGAAAGGCATTCATGCCTTT
GCCGATTGTGCGGATTATTTCACAATCAATATTTCCTCGCCCAATACGCCGGCTTTGCGCGATTTGCAGCAGCCCCTTGC
GCTTGATGATCTTGTGGTGCGCGCGCTGGCTGCGCGTGATGCCGAGGCGGAGCGCCATGGCCGCAAGCCGGTGCTGGTGA
AGATCGCACCCGATCTGACATTGTCCGAACTTGACGCGATCGTGAAAATCACCTGCGCACGAAAAGTCGATGGGCTGATC
GTCTCCAATACGACGCTCAGCCGGCCTTCAGATCTTCAGGATCCGCAAGCGCGTGAGGCGGGAGGTCTTTCGGGCAAGCC
GCTCTTTGATCTCTCGACACGCATGCTCGCTGAAACCTTTGTGCGCGTCGAGAACCAGTTTCCACTGATCGGCGTGGGCG
GGATCGACAGCGCGGAAACAGCACTCGCCAAGATCGAGGCAGGGGCTACTCTCGTGCAGCTTTATTCGGGCCTCGTTTTT
CAAGGCCCGGGGCTGGTCAGGAGGATTCTTGGCGAATTGCCGCGCTTGTTGACAGCGCGAAATTATCCACGGCTCGTGGA
TGCCGTGGGGGCTGCCGCGGTCGATCGGGTGAGTGAAAAAATCTGA

Upstream 100 bases:

>100_bases
CCTTGCCGCTCACGGCTGTGGTCTTTGCCAAGTCCCTGCCGCTCAAGCCAGACGGATTGCATGATTTCACCGGCCTTTTG
GACGAAACCCATTGACCGGG

Downstream 100 bases:

>100_bases
GCATAAAGTGTGCGATAACGCCAGGCGAGCGTGAGGCCACGGCTTGAGAGGAAGACCAGCAGAGCGAACCACAGGCCGCG
ATTGCCCAAATCCGGTCTCA

Product: dihydroorotate oxidase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTFLAPHRLLFGLDPERAHRLAIWALAHVPLPPPPAVDPRLSVEAFGLAFANPLGLAAGMDKNGEAPGALLRLGFGFAEI
GTVTPLPQPGNPLPRLFRLTKDEAIINRFGFNSEGHARVHERLTAFLAGARRKGVIGINIGANKDSLDRAEDYVKGIHAF
ADCADYFTINISSPNTPALRDLQQPLALDDLVVRALAARDAEAERHGRKPVLVKIAPDLTLSELDAIVKITCARKVDGLI
VSNTTLSRPSDLQDPQAREAGGLSGKPLFDLSTRMLAETFVRVENQFPLIGVGGIDSAETALAKIEAGATLVQLYSGLVF
QGPGLVRRILGELPRLLTARNYPRLVDAVGAAAVDRVSEKI

Sequences:

>Translated_361_residues
MTFLAPHRLLFGLDPERAHRLAIWALAHVPLPPPPAVDPRLSVEAFGLAFANPLGLAAGMDKNGEAPGALLRLGFGFAEI
GTVTPLPQPGNPLPRLFRLTKDEAIINRFGFNSEGHARVHERLTAFLAGARRKGVIGINIGANKDSLDRAEDYVKGIHAF
ADCADYFTINISSPNTPALRDLQQPLALDDLVVRALAARDAEAERHGRKPVLVKIAPDLTLSELDAIVKITCARKVDGLI
VSNTTLSRPSDLQDPQAREAGGLSGKPLFDLSTRMLAETFVRVENQFPLIGVGGIDSAETALAKIEAGATLVQLYSGLVF
QGPGLVRRILGELPRLLTARNYPRLVDAVGAAAVDRVSEKI
>Mature_360_residues
TFLAPHRLLFGLDPERAHRLAIWALAHVPLPPPPAVDPRLSVEAFGLAFANPLGLAAGMDKNGEAPGALLRLGFGFAEIG
TVTPLPQPGNPLPRLFRLTKDEAIINRFGFNSEGHARVHERLTAFLAGARRKGVIGINIGANKDSLDRAEDYVKGIHAFA
DCADYFTINISSPNTPALRDLQQPLALDDLVVRALAARDAEAERHGRKPVLVKIAPDLTLSELDAIVKITCARKVDGLIV
SNTTLSRPSDLQDPQAREAGGLSGKPLFDLSTRMLAETFVRVENQFPLIGVGGIDSAETALAKIEAGATLVQLYSGLVFQ
GPGLVRRILGELPRLLTARNYPRLVDAVGAAAVDRVSEKI

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=344, Percent_Identity=48.2558139534884, Blast_Score=296, Evalue=1e-80,
Organism=Escherichia coli, GI1787177, Length=340, Percent_Identity=44.4117647058823, Blast_Score=251, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17509475, Length=352, Percent_Identity=42.8977272727273, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI281361352, Length=355, Percent_Identity=44.2253521126761, Blast_Score=288, Evalue=3e-78,
Organism=Drosophila melanogaster, GI17137316, Length=355, Percent_Identity=44.2253521126761, Blast_Score=288, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 38732; Mature: 38601

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLAPHRLLFGLDPERAHRLAIWALAHVPLPPPPAVDPRLSVEAFGLAFANPLGLAAGM
CCCCCCCHHHCCCCHHHHHHEEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCHHHHCCC
DKNGEAPGALLRLGFGFAEIGTVTPLPQPGNPLPRLFRLTKDEAIINRFGFNSEGHARVH
CCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
ERLTAFLAGARRKGVIGINIGANKDSLDRAEDYVKGIHAFADCADYFTINISSPNTPALR
HHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHH
DLQQPLALDDLVVRALAARDAEAERHGRKPVLVKIAPDLTLSELDAIVKITCARKVDGLI
HHHCCHHHHHHHHHHHHHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
VSNTTLSRPSDLQDPQAREAGGLSGKPLFDLSTRMLAETFVRVENQFPLIGVGGIDSAET
EECCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ALAKIEAGATLVQLYSGLVFQGPGLVRRILGELPRLLTARNYPRLVDAVGAAAVDRVSEK
HHHHHHCCHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
I
C
>Mature Secondary Structure 
TFLAPHRLLFGLDPERAHRLAIWALAHVPLPPPPAVDPRLSVEAFGLAFANPLGLAAGM
CCCCCCHHHCCCCHHHHHHEEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCHHHHCCC
DKNGEAPGALLRLGFGFAEIGTVTPLPQPGNPLPRLFRLTKDEAIINRFGFNSEGHARVH
CCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
ERLTAFLAGARRKGVIGINIGANKDSLDRAEDYVKGIHAFADCADYFTINISSPNTPALR
HHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHH
DLQQPLALDDLVVRALAARDAEAERHGRKPVLVKIAPDLTLSELDAIVKITCARKVDGLI
HHHCCHHHHHHHHHHHHHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
VSNTTLSRPSDLQDPQAREAGGLSGKPLFDLSTRMLAETFVRVENQFPLIGVGGIDSAET
EECCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHH
ALAKIEAGATLVQLYSGLVFQGPGLVRRILGELPRLLTARNYPRLVDAVGAAAVDRVSEK
HHHHHHCCHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
I
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA