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The map label for this gene is lspA

Identifier: 182677993

GI number: 182677993

Start: 1155959

End: 1156462

Strand: Direct

Name: lspA

Synonym: Bind_1007

Alternate gene names: 182677993

Gene position: 1155959-1156462 (Clockwise)

Preceding gene: 182677992

Following gene: 182677994

Centisome position: 27.72

GC content: 60.32

Gene sequence:

>504_bases
GTGAGCCCGCGCGTGCTCGGCGGGCTCGCCGCTTTCCTATGCCTCGTGCTCGATCAGGCGAACAAGCTCTGGTTGATTCA
TGTGTTCGATATCGAGGCGCGCCGGCCCGTGCGGCTCGCGCCCTTTTTTGATATTATCTACGAGCGCAATCCGGGCATTT
CCTATTCCCTGTTCCGCGCGCAGAGTGCCATGGGGCGCTGGATTCTCGTCGCTCTGACGCTTTTTGCTATTCTCCTGCTC
TCGATTTGGCTTTGGCGTGCCACCAACCGGCTTGTGGCTCTGGCGCTCGGCTGCATTATCGGTGGCGCGCTCGGCAATGC
CATCGATCGGATCGCGGCCGGCGCAGTCGCCGATTTCTATTATTTTCACATCGGCTCCTTCTCCTGGTATGTCTTCAACC
TGGCCGATGCCGCGATCGTCGCCGGGGTGGCGCTTTTGATCCTTGATGCGTTCACGAGTGAAGAGGCGGGGGTGCCAGCG
CCCGACAGTGAGGGACATTCTTGA

Upstream 100 bases:

>100_bases
TATCCCGATGTGAGCCCGCGCGATGCCCAGGCCTTGCGGGAATTGAAGGCGGCCGGCCTGTGGACGGCGTGAGAATGGCC
CGCCTTTGCGGAATGGCTTC

Downstream 100 bases:

>100_bases
GCGAGCTAAACCCTTGCAAGTTTTCCTTAGTTTATGTTTTGATAAAGAGGATAAGCGGTCGCCAGACGCGACCCAGAGCA
TCAAACCTGAAAGTGGTCTC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MSPRVLGGLAAFLCLVLDQANKLWLIHVFDIEARRPVRLAPFFDIIYERNPGISYSLFRAQSAMGRWILVALTLFAILLL
SIWLWRATNRLVALALGCIIGGALGNAIDRIAAGAVADFYYFHIGSFSWYVFNLADAAIVAGVALLILDAFTSEEAGVPA
PDSEGHS

Sequences:

>Translated_167_residues
MSPRVLGGLAAFLCLVLDQANKLWLIHVFDIEARRPVRLAPFFDIIYERNPGISYSLFRAQSAMGRWILVALTLFAILLL
SIWLWRATNRLVALALGCIIGGALGNAIDRIAAGAVADFYYFHIGSFSWYVFNLADAAIVAGVALLILDAFTSEEAGVPA
PDSEGHS
>Mature_166_residues
SPRVLGGLAAFLCLVLDQANKLWLIHVFDIEARRPVRLAPFFDIIYERNPGISYSLFRAQSAMGRWILVALTLFAILLLS
IWLWRATNRLVALALGCIIGGALGNAIDRIAAGAVADFYYFHIGSFSWYVFNLADAAIVAGVALLILDAFTSEEAGVPAP
DSEGHS

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=146, Percent_Identity=32.8767123287671, Blast_Score=78, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_BEII9 (B2II67)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001832139.1
- MEROPS:   A08.001
- GeneID:   6200809
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_1007
- HOGENOM:   HBG724422
- OMA:   KLWLLYG
- ProtClustDB:   PRK14796
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18197; Mature: 18066

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 109-109 ACT_SITE 136-136

Signals:

None

Transmembrane regions:

HASH(0x155823cc)-; HASH(0x13990330)-; HASH(0x15be61f0)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPRVLGGLAAFLCLVLDQANKLWLIHVFDIEARRPVRLAPFFDIIYERNPGISYSLFRA
CCCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEECHHHHHHEECCCCCCHHHHHH
QSAMGRWILVALTLFAILLLSIWLWRATNRLVALALGCIIGGALGNAIDRIAAGAVADFY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFHIGSFSWYVFNLADAAIVAGVALLILDAFTSEEAGVPAPDSEGHS
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
SPRVLGGLAAFLCLVLDQANKLWLIHVFDIEARRPVRLAPFFDIIYERNPGISYSLFRA
CCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEECHHHHHHEECCCCCCHHHHHH
QSAMGRWILVALTLFAILLLSIWLWRATNRLVALALGCIIGGALGNAIDRIAAGAVADFY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFHIGSFSWYVFNLADAAIVAGVALLILDAFTSEEAGVPAPDSEGHS
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA