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The map label for this gene is moeA [H]

Identifier: 182677979

GI number: 182677979

Start: 1138323

End: 1139537

Strand: Direct

Name: moeA [H]

Synonym: Bind_0992

Alternate gene names: 182677979

Gene position: 1138323-1139537 (Clockwise)

Preceding gene: 182677978

Following gene: 182677980

Centisome position: 27.3

GC content: 55.72

Gene sequence:

>1215_bases
ATGACAACTTCGTGTTTTACAAATGCCGTATCTTTTCAGGAGGCCTTGCAACTCGTTCTGAGCCTCGCCGATCGCCGCGT
GCGGGCTGAAACGGTTCCGTTGGCGCAATGCGTTGGCCGGATCATCGAGACAGATATTGTCGCCACCGAACATCGGCCCG
CGATGAATCTCTCGGCGATGGATGGATATGCCGTTCGGCATAATGATCTCGCGCCCGGATGTGTCCTTCCCCTTGTCGGT
GAGAGTGCGGCTGGCGATCCGGCTGGCCTTTTGCGTGAGCACACTGTGTGTCGCATCCTGACCGGGGCTCCCTTGCCTGA
GGGAGCGGATACTGTCATTCCCCAGGAGGATGTCCTAATAGCTCCAGAAGGGATTATTATTCCCTCGTTGCCGCCCTTGG
GGGCACATATCAGGCGTATGGGTGAGGAATTCGCACGCGGCGACAGGCTGGTCGAGGCAGGATCGCGGCTCGACTGGCGT
CATGTCGCGATCCTTGCCAGTCAGGGGATCGCTTTGCCATCGGTGAGGCGAAAAATCCATATTTCCATTCTGGCCAATGG
CAAGGAACTGGTGGCACCTGACGCTGGCGCGCAGCCGCGCACCGGGCAGATTTTCGACTCCAATTCGCCAATGCTGGCGG
CGCTGCTCGAATCCCTCGGGGTGAATACGTCGACGCATATCGTGGCGACGGACACTCCAGACGTACTGAAATCGGTCTTG
CAACAGGCCTGCGCAATCTCCGACATTGTCGTGACGACCGGTGGCATTTCCGTCGGCGACACGGATCATGTCCATGCCAT
GCTGCGCGATCTGGGCGCGGATGTGCTTTTCCGTGGTGTGGCGATCAAGCCGGGCAAGCCTTTAACAGTCTCGACGTTGG
GAAAGACGATTATCTTTGGTTTGCCTGGCAATCCGACCGCTGCTGTCGTTGGTGTTTATATGCTGCTCCTTCCTTTGATC
AGACAATTATATGGTCAAAAGGAAATCTCGCGGTGCTCCGGCATTCTCGATTTCGAGCCAAGGATACGCCGGGATCTTAC
TCAGTTTATTTTTGTCGATATGGTACAGGACAGACATGAAATGCGGATCAGACCTGTAAAAAGTGTCGGCGCTGCGGATA
TTATGACATTGCTGCGTGCGAAAGGGTTGCTGCAATTGGATCCGGACAGTGCGAATGTAACATTGGGCCGAACGGCGGAA
GTCATTCTGTTTTGA

Upstream 100 bases:

>100_bases
AAGAGGCCAAGGCAGCGCTGGTCTCTGTGAGGCACGTTTCCTGGGCGGGGGAGACCGGCGGCGTGGCATCCGATATGAAC
GTCACGGGAGGGTAAAGCCC

Downstream 100 bases:

>100_bases
GTCTACAACCTGATGAATTGGTGAGATCATTGATCATACCAGAGAAGAAGACAGGACTATGGCCTCAATCGATCATCGCT
GTGGTGCCGTGATTTTAGCC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTTSCFTNAVSFQEALQLVLSLADRRVRAETVPLAQCVGRIIETDIVATEHRPAMNLSAMDGYAVRHNDLAPGCVLPLVG
ESAAGDPAGLLREHTVCRILTGAPLPEGADTVIPQEDVLIAPEGIIIPSLPPLGAHIRRMGEEFARGDRLVEAGSRLDWR
HVAILASQGIALPSVRRKIHISILANGKELVAPDAGAQPRTGQIFDSNSPMLAALLESLGVNTSTHIVATDTPDVLKSVL
QQACAISDIVVTTGGISVGDTDHVHAMLRDLGADVLFRGVAIKPGKPLTVSTLGKTIIFGLPGNPTAAVVGVYMLLLPLI
RQLYGQKEISRCSGILDFEPRIRRDLTQFIFVDMVQDRHEMRIRPVKSVGAADIMTLLRAKGLLQLDPDSANVTLGRTAE
VILF

Sequences:

>Translated_404_residues
MTTSCFTNAVSFQEALQLVLSLADRRVRAETVPLAQCVGRIIETDIVATEHRPAMNLSAMDGYAVRHNDLAPGCVLPLVG
ESAAGDPAGLLREHTVCRILTGAPLPEGADTVIPQEDVLIAPEGIIIPSLPPLGAHIRRMGEEFARGDRLVEAGSRLDWR
HVAILASQGIALPSVRRKIHISILANGKELVAPDAGAQPRTGQIFDSNSPMLAALLESLGVNTSTHIVATDTPDVLKSVL
QQACAISDIVVTTGGISVGDTDHVHAMLRDLGADVLFRGVAIKPGKPLTVSTLGKTIIFGLPGNPTAAVVGVYMLLLPLI
RQLYGQKEISRCSGILDFEPRIRRDLTQFIFVDMVQDRHEMRIRPVKSVGAADIMTLLRAKGLLQLDPDSANVTLGRTAE
VILF
>Mature_403_residues
TTSCFTNAVSFQEALQLVLSLADRRVRAETVPLAQCVGRIIETDIVATEHRPAMNLSAMDGYAVRHNDLAPGCVLPLVGE
SAAGDPAGLLREHTVCRILTGAPLPEGADTVIPQEDVLIAPEGIIIPSLPPLGAHIRRMGEEFARGDRLVEAGSRLDWRH
VAILASQGIALPSVRRKIHISILANGKELVAPDAGAQPRTGQIFDSNSPMLAALLESLGVNTSTHIVATDTPDVLKSVLQ
QACAISDIVVTTGGISVGDTDHVHAMLRDLGADVLFRGVAIKPGKPLTVSTLGKTIIFGLPGNPTAAVVGVYMLLLPLIR
QLYGQKEISRCSGILDFEPRIRRDLTQFIFVDMVQDRHEMRIRPVKSVGAADIMTLLRAKGLLQLDPDSANVTLGRTAEV
ILF

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=392, Percent_Identity=30.3571428571429, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI66932975, Length=392, Percent_Identity=30.3571428571429, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1787049, Length=322, Percent_Identity=38.1987577639752, Blast_Score=206, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI25147659, Length=383, Percent_Identity=30.5483028720627, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17562606, Length=320, Percent_Identity=27.5, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17136978, Length=298, Percent_Identity=34.8993288590604, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24638841, Length=298, Percent_Identity=34.8993288590604, Blast_Score=131, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43236; Mature: 43105

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSCFTNAVSFQEALQLVLSLADRRVRAETVPLAQCVGRIIETDIVATEHRPAMNLSAM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCCCCCCCCC
DGYAVRHNDLAPGCVLPLVGESAAGDPAGLLREHTVCRILTGAPLPEGADTVIPQEDVLI
CCEEEECCCCCCCCCCEECCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCEEE
APEGIIIPSLPPLGAHIRRMGEEFARGDRLVEAGSRLDWRHVAILASQGIALPSVRRKIH
CCCCEECCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHEEEECCCCCCCCCCCCEEE
ISILANGKELVAPDAGAQPRTGQIFDSNSPMLAALLESLGVNTSTHIVATDTPDVLKSVL
EEEEECCCEEECCCCCCCCCCCCEECCCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
QQACAISDIVVTTGGISVGDTDHVHAMLRDLGADVLFRGVAIKPGKPLTVSTLGKTIIFG
HHHHHHHHEEEEECCCCCCCHHHHHHHHHHHCHHHHHCCEEECCCCCEEHEECCCEEEEE
LPGNPTAAVVGVYMLLLPLIRQLYGQKEISRCSGILDFEPRIRRDLTQFIFVDMVQDRHE
CCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MRIRPVKSVGAADIMTLLRAKGLLQLDPDSANVTLGRTAEVILF
HEECCHHHCCHHHHHHHHHHCCCEEECCCCCCEEECCCEEEEEC
>Mature Secondary Structure 
TTSCFTNAVSFQEALQLVLSLADRRVRAETVPLAQCVGRIIETDIVATEHRPAMNLSAM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCCCCCCCCC
DGYAVRHNDLAPGCVLPLVGESAAGDPAGLLREHTVCRILTGAPLPEGADTVIPQEDVLI
CCEEEECCCCCCCCCCEECCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCEEE
APEGIIIPSLPPLGAHIRRMGEEFARGDRLVEAGSRLDWRHVAILASQGIALPSVRRKIH
CCCCEECCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCHHHEEEECCCCCCCCCCCCEEE
ISILANGKELVAPDAGAQPRTGQIFDSNSPMLAALLESLGVNTSTHIVATDTPDVLKSVL
EEEEECCCEEECCCCCCCCCCCCEECCCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHH
QQACAISDIVVTTGGISVGDTDHVHAMLRDLGADVLFRGVAIKPGKPLTVSTLGKTIIFG
HHHHHHHHEEEEECCCCCCCHHHHHHHHHHHCHHHHHCCEEECCCCCEEHEECCCEEEEE
LPGNPTAAVVGVYMLLLPLIRQLYGQKEISRCSGILDFEPRIRRDLTQFIFVDMVQDRHE
CCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MRIRPVKSVGAADIMTLLRAKGLLQLDPDSANVTLGRTAEVILF
HEECCHHHCCHHHHHHHHHHCCCEEECCCCCCEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]