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The map label for this gene is rsmA [H]

Identifier: 182677647

GI number: 182677647

Start: 736755

End: 737648

Strand: Direct

Name: rsmA [H]

Synonym: Bind_0654

Alternate gene names: 182677647

Gene position: 736755-737648 (Clockwise)

Preceding gene: 182677646

Following gene: 182677648

Centisome position: 17.67

GC content: 61.41

Gene sequence:

>894_bases
ATGTGCTTGTGCTGCATGAGTGCGACAAAGGATGATCTGCCGCCTTTGCGCGAGGTCGTGGCGACCTATGGTCTTGCCGC
CAAAAAGGCGCTTGGCCAGAATTTCCTCTTCGACCTTAATCTGACGGGCCGCATCGCTCGCGCTGCGGATCCTTCAAAGA
CGGCGCTGATCGTGGAAATCGGCCCGGGTCCTGGAGGTTTGACGCGCGCTCTCCTGGCCGAGGGAGCGCCCAAAGTCATC
GCCATCGAGCAGGATGAGCGTTGTCTGCCCGCCCTCGCTGAAATTGCCGCGCATTATCCGGGTCGGCTGGAGGTCGTCGC
CGGTGATGCCCTGACCACGGATCTCGGCTTATTGGTCGCTTCTTACCGGCCGGCCAGGATCTGCGCCAATCTGCCCTATA
ATATCGGCACGGCTCTGCTCACGCGCTGGATCGAGACCGAGCCCTGGCCGCCTTGGTTCGATCGCCTGGTGTTAATGTTT
CAGCGCGAGGTTGCCGAACGCATCGTGGCGACTCCTGCGCAACGGGCCGATTACGGCCGACTGGCGGTCCTGTGCAATTG
GCGTTGCGAGACCCGCATTCTTTTCGATGTCTCGCCTTCCGCTTTCACACCGCCCCCCAAGGTGACCTCGGCCGTTGTCG
AACTCGTGCCGCGTGCCGAGCCGCTGACTTGCGACCGGGAAAAGCTCTCCGCCGTGACCCAGGCCGCCTTTGGGCAGCGT
CGTAAAATGCTGCGGCAATCGCTCAAAAGTCTCTTGGGAGGGGGAACATCTGCCTTGATCGAGGCTGCTGGTCTTGCACC
GACCCTGCGAGCCGAAGAGGTTGATATAGCCGGATTTGTCGCACTGGCCCGGGGAGATTTCAGGCTGCCGGCTACAGAGC
ACGTGCTAAAATAG

Upstream 100 bases:

>100_bases
GTGCATTGGGCGCTTTTTCAAAGAGCCGTGCCCTCGGACGCAGCCTTGCCAATCCGGCGAGCCTGATCGCGGTGCTTGAA
CGCGTCTGTTGGCTCGCCGC

Downstream 100 bases:

>100_bases
CAAGAAAATTTGTGGGATTCGCACGGCCTTGTCTCTTCACGGAATCCTGACTACCGGACCTCGTGCTGATCATGCGATCC
TTCCACAAATGAAACAGGGA

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MCLCCMSATKDDLPPLREVVATYGLAAKKALGQNFLFDLNLTGRIARAADPSKTALIVEIGPGPGGLTRALLAEGAPKVI
AIEQDERCLPALAEIAAHYPGRLEVVAGDALTTDLGLLVASYRPARICANLPYNIGTALLTRWIETEPWPPWFDRLVLMF
QREVAERIVATPAQRADYGRLAVLCNWRCETRILFDVSPSAFTPPPKVTSAVVELVPRAEPLTCDREKLSAVTQAAFGQR
RKMLRQSLKSLLGGGTSALIEAAGLAPTLRAEEVDIAGFVALARGDFRLPATEHVLK

Sequences:

>Translated_297_residues
MCLCCMSATKDDLPPLREVVATYGLAAKKALGQNFLFDLNLTGRIARAADPSKTALIVEIGPGPGGLTRALLAEGAPKVI
AIEQDERCLPALAEIAAHYPGRLEVVAGDALTTDLGLLVASYRPARICANLPYNIGTALLTRWIETEPWPPWFDRLVLMF
QREVAERIVATPAQRADYGRLAVLCNWRCETRILFDVSPSAFTPPPKVTSAVVELVPRAEPLTCDREKLSAVTQAAFGQR
RKMLRQSLKSLLGGGTSALIEAAGLAPTLRAEEVDIAGFVALARGDFRLPATEHVLK
>Mature_297_residues
MCLCCMSATKDDLPPLREVVATYGLAAKKALGQNFLFDLNLTGRIARAADPSKTALIVEIGPGPGGLTRALLAEGAPKVI
AIEQDERCLPALAEIAAHYPGRLEVVAGDALTTDLGLLVASYRPARICANLPYNIGTALLTRWIETEPWPPWFDRLVLMF
QREVAERIVATPAQRADYGRLAVLCNWRCETRILFDVSPSAFTPPPKVTSAVVELVPRAEPLTCDREKLSAVTQAAFGQR
RKMLRQSLKSLLGGGTSALIEAAGLAPTLRAEEVDIAGFVALARGDFRLPATEHVLK

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI156415992, Length=290, Percent_Identity=34.1379310344828, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI7657198, Length=229, Percent_Identity=32.3144104803493, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786236, Length=265, Percent_Identity=37.7358490566038, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25141369, Length=298, Percent_Identity=32.2147651006711, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25146882, Length=216, Percent_Identity=31.4814814814815, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324989, Length=244, Percent_Identity=29.9180327868852, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357273, Length=289, Percent_Identity=31.8339100346021, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI21358017, Length=273, Percent_Identity=32.2344322344322, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 32081; Mature: 32081

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLCCMSATKDDLPPLREVVATYGLAAKKALGQNFLFDLNLTGRIARAADPSKTALIVEI
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEEEE
GPGPGGLTRALLAEGAPKVIAIEQDERCLPALAEIAAHYPGRLEVVAGDALTTDLGLLVA
CCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHH
SYRPARICANLPYNIGTALLTRWIETEPWPPWFDRLVLMFQREVAERIVATPAQRADYGR
CCCCHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
LAVLCNWRCETRILFDVSPSAFTPPPKVTSAVVELVPRAEPLTCDREKLSAVTQAAFGQR
EEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RKMLRQSLKSLLGGGTSALIEAAGLAPTLRAEEVDIAGFVALARGDFRLPATEHVLK
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHEEEEECCCCCCCHHHHHCC
>Mature Secondary Structure
MCLCCMSATKDDLPPLREVVATYGLAAKKALGQNFLFDLNLTGRIARAADPSKTALIVEI
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEEEE
GPGPGGLTRALLAEGAPKVIAIEQDERCLPALAEIAAHYPGRLEVVAGDALTTDLGLLVA
CCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHH
SYRPARICANLPYNIGTALLTRWIETEPWPPWFDRLVLMFQREVAERIVATPAQRADYGR
CCCCHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
LAVLCNWRCETRILFDVSPSAFTPPPKVTSAVVELVPRAEPLTCDREKLSAVTQAAFGQR
EEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RKMLRQSLKSLLGGGTSALIEAAGLAPTLRAEEVDIAGFVALARGDFRLPATEHVLK
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHEEEEECCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA