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The map label for this gene is 182677010

Identifier: 182677010

GI number: 182677010

Start: 6552

End: 7292

Strand: Direct

Name: 182677010

Synonym: Bind_0008

Alternate gene names: NA

Gene position: 6552-7292 (Clockwise)

Preceding gene: 182677009

Following gene: 182677011

Centisome position: 0.16

GC content: 61.54

Gene sequence:

>741_bases
GTGCTGGTTCTGATCACGAGGCCTTTCGAGGAAGCCCTGCGCAGCGCCGCCAAGCTCGAGGGAGCCGGCTATTCCGCGCT
CTTGTCGCCGGTCCTCACCATGCGCGCCACGGGAGCCTCCTGGCCCGAGGGCGTCGTTGATGGCGTGATCGCGACCAGCG
CCCAAGCTTTCGATCTTTTGGTTCTGCGGCCTGAATGGCCCTTGCCGGAAGCGCTTCGTCTGATGCCGCTATGGCTCGTC
GGAGATCGAACGGGCGATGCGGCGCACCGCAAGGGATTTGACGGTCCGGTACGATTAGCTCCCCATGCGAAACTCCTAGC
GCAGGAAATTACCGCCGCCCTTTCGCCGCCAGCGCGCCTCATCTATCTCGCAGGCCAGGATCGCAAGCCCGATCTCGAAA
AGAAATTGAGCAAGGCGGGTCTGACCGTTGAAGCCCAGGAAATCTACGCCGCGGAGGCGGTTGACCAATTGAGCGATATC
GCCCTTGAGTCCTTGAGGCGCAATGATGTTGGCGCGGCCATGCATTATTCACGGCGCAGCGCCGAGATTTTTCTTGGCCT
GATGCGGAAGGCCGAACTCGATCCGGCGACATTCGTGCATATCTGCATGTCGGAGGATGTGGCTGTGCCGCTGAAAGATG
CCGGTTGCGCGACGCAGGTAGCCGCAACCTCGAATGAAGAAGGCATGCTCGACGCGCTTAAGGCCATAGCCGCCGCGCGG
GAGTCTTCTCGGGAGTCTTGA

Upstream 100 bases:

>100_bases
GCGAAACCGCAGCGCGCGCTATTCTGGCGCGGTTGCCGGAAGGATTCTTCCAAGAGAGCGCCCAAGAAAATGCCCAAAAA
AACGCTAAGGAGTAGAGAGC

Downstream 100 bases:

>100_bases
TCCAATGCACGGCCATGGTCTCGATGATCGATGTCGCGGCGTTGCAATCGTCATCGGTGCACATGCCGATGCATCGTGAC
TCCGCGCTCGCGGTCGAGGC

Product: uroporphyrinogen III synthase HEM4

Products: uroporphyrinogen III; H2O

Alternate protein names: Uroporphyrinogen III Synthase

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLVLITRPFEEALRSAAKLEGAGYSALLSPVLTMRATGASWPEGVVDGVIATSAQAFDLLVLRPEWPLPEALRLMPLWLV
GDRTGDAAHRKGFDGPVRLAPHAKLLAQEITAALSPPARLIYLAGQDRKPDLEKKLSKAGLTVEAQEIYAAEAVDQLSDI
ALESLRRNDVGAAMHYSRRSAEIFLGLMRKAELDPATFVHICMSEDVAVPLKDAGCATQVAATSNEEGMLDALKAIAAAR
ESSRES

Sequences:

>Translated_246_residues
MLVLITRPFEEALRSAAKLEGAGYSALLSPVLTMRATGASWPEGVVDGVIATSAQAFDLLVLRPEWPLPEALRLMPLWLV
GDRTGDAAHRKGFDGPVRLAPHAKLLAQEITAALSPPARLIYLAGQDRKPDLEKKLSKAGLTVEAQEIYAAEAVDQLSDI
ALESLRRNDVGAAMHYSRRSAEIFLGLMRKAELDPATFVHICMSEDVAVPLKDAGCATQVAATSNEEGMLDALKAIAAAR
ESSRES
>Mature_246_residues
MLVLITRPFEEALRSAAKLEGAGYSALLSPVLTMRATGASWPEGVVDGVIATSAQAFDLLVLRPEWPLPEALRLMPLWLV
GDRTGDAAHRKGFDGPVRLAPHAKLLAQEITAALSPPARLIYLAGQDRKPDLEKKLSKAGLTVEAQEIYAAEAVDQLSDI
ALESLRRNDVGAAMHYSRRSAEIFLGLMRKAELDPATFVHICMSEDVAVPLKDAGCATQVAATSNEEGMLDALKAIAAAR
ESSRES

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 26411; Mature: 26411

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLITRPFEEALRSAAKLEGAGYSALLSPVLTMRATGASWPEGVVDGVIATSAQAFDLL
CEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEE
VLRPEWPLPEALRLMPLWLVGDRTGDAAHRKGFDGPVRLAPHAKLLAQEITAALSPPARL
EECCCCCCHHHHHHCCCEEEECCCCCHHHHCCCCCCEEECCHHHHHHHHHHHHHCCCEEE
IYLAGQDRKPDLEKKLSKAGLTVEAQEIYAAEAVDQLSDIALESLRRNDVGAAMHYSRRS
EEEECCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AEIFLGLMRKAELDPATFVHICMSEDVAVPLKDAGCATQVAATSNEEGMLDALKAIAAAR
HHHHHHHHHHCCCCHHHEEEEEECCCCEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
ESSRES
HHCCCC
>Mature Secondary Structure
MLVLITRPFEEALRSAAKLEGAGYSALLSPVLTMRATGASWPEGVVDGVIATSAQAFDLL
CEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEE
VLRPEWPLPEALRLMPLWLVGDRTGDAAHRKGFDGPVRLAPHAKLLAQEITAALSPPARL
EECCCCCCHHHHHHCCCEEEECCCCCHHHHCCCCCCEEECCHHHHHHHHHHHHHCCCEEE
IYLAGQDRKPDLEKKLSKAGLTVEAQEIYAAEAVDQLSDIALESLRRNDVGAAMHYSRRS
EEEECCCCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
AEIFLGLMRKAELDPATFVHICMSEDVAVPLKDAGCATQVAATSNEEGMLDALKAIAAAR
HHHHHHHHHHCCCCHHHEEEEEECCCCEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
ESSRES
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA