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The map label for this gene is pcaR [H]

Identifier: 17548128

GI number: 17548128

Start: 3687198

End: 3687986

Strand: Direct

Name: pcaR [H]

Synonym: RSc3411

Alternate gene names: 17548128

Gene position: 3687198-3687986 (Clockwise)

Preceding gene: 17548123

Following gene: 17548130

Centisome position: 99.21

GC content: 68.44

Gene sequence:

>789_bases
ATGATCCAACCCGACGACGCTCCCAACCTGCTGTTCAACCAGTCGCTGGAGAAAGGGCTGGCCGTGCTGGGCGCCTTCAA
CGCGCAGCGCCGCACCATGACGATTGCCGAGGTGGCCGCCGTCGCCGGCATCAACAAGAGTTCGGCCCAGCGCATGGTCT
ATACGCTGGAGCACCTCGGCTACCTGCGCAAGCACCCCAAGACCCGCCGCTATCAGCTGACGCCCGCGGCCATGAAGATC
GGCTTCAACTACCTGGCCGCCGACACCCTCATCGACGTGGCCAACCCCTTCCTGGCCGAGCTGACCAAGGTGACCACCGA
GACCTCCTGTCTCACCGAGCCCGACCAGCGCGAGATGGTCTACGTCGCCCGCTTCGTGAGCGCGCAGTTCGTGCCGGTGC
ACATGCCGATCGGCAGCCGTATCCCCATGTACTGCACCGCATCGGGTCGCGCCTACCTGTCCGCCCTGCCCGAGCCCGAG
GCGCGCGCCATCGTGGAGACGTCCGAGCGCGTCGCCCACACCATGCATACCCGCACCGAAGTCGCCGACATCCTCGCCAC
GCTGCGCGAGGCGCGCCAGCGCGGCTACGCCATCAATCGCGAAGAGCTGTTCCTCGGCGACATGACCGTCGCCGCGCCCA
TCGTCGGCGGCAACGGCCGGCCGCTGGGCGCCATCCACCTGGTGGCTCCGACGGGCCGGTGGACGGCGGAAGACATGGAA
GCCAAGCTGGGGCCGCCGCTGCTGCAGTGCGCACGGGCGATCAGCACATCGGTGCGGGCACTGGGGTAG

Upstream 100 bases:

>100_bases
GACATATAATCATGGAAAACCACTAATCGACGCATATGAATCGATATGCGATTCTACACGGGTCGATGTTCCGCGGATAA
GCCAAGCCGGCGCCACTTCC

Downstream 100 bases:

>100_bases
CCGGCGCGCGAGGCGCGTCGCCGGCGGGGGCCAAGCCGTATCAACCGCCCTTGCCCTTGAGTCGGGGCCGGACCAACGGC
GATCCCCCATCGTCGGGCGT

Product: transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MIQPDDAPNLLFNQSLEKGLAVLGAFNAQRRTMTIAEVAAVAGINKSSAQRMVYTLEHLGYLRKHPKTRRYQLTPAAMKI
GFNYLAADTLIDVANPFLAELTKVTTETSCLTEPDQREMVYVARFVSAQFVPVHMPIGSRIPMYCTASGRAYLSALPEPE
ARAIVETSERVAHTMHTRTEVADILATLREARQRGYAINREELFLGDMTVAAPIVGGNGRPLGAIHLVAPTGRWTAEDME
AKLGPPLLQCARAISTSVRALG

Sequences:

>Translated_262_residues
MIQPDDAPNLLFNQSLEKGLAVLGAFNAQRRTMTIAEVAAVAGINKSSAQRMVYTLEHLGYLRKHPKTRRYQLTPAAMKI
GFNYLAADTLIDVANPFLAELTKVTTETSCLTEPDQREMVYVARFVSAQFVPVHMPIGSRIPMYCTASGRAYLSALPEPE
ARAIVETSERVAHTMHTRTEVADILATLREARQRGYAINREELFLGDMTVAAPIVGGNGRPLGAIHLVAPTGRWTAEDME
AKLGPPLLQCARAISTSVRALG
>Mature_262_residues
MIQPDDAPNLLFNQSLEKGLAVLGAFNAQRRTMTIAEVAAVAGINKSSAQRMVYTLEHLGYLRKHPKTRRYQLTPAAMKI
GFNYLAADTLIDVANPFLAELTKVTTETSCLTEPDQREMVYVARFVSAQFVPVHMPIGSRIPMYCTASGRAYLSALPEPE
ARAIVETSERVAHTMHTRTEVADILATLREARQRGYAINREELFLGDMTVAAPIVGGNGRPLGAIHLVAPTGRWTAEDME
AKLGPPLLQCARAISTSVRALG

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=250, Percent_Identity=29.2, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI87082359, Length=244, Percent_Identity=25, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788131, Length=253, Percent_Identity=28.0632411067194, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1786715, Length=245, Percent_Identity=24.4897959183673, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789999, Length=250, Percent_Identity=27.2, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI145693096, Length=237, Percent_Identity=24.4725738396624, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28647; Mature: 28647

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQPDDAPNLLFNQSLEKGLAVLGAFNAQRRTMTIAEVAAVAGINKSSAQRMVYTLEHLG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YLRKHPKTRRYQLTPAAMKIGFNYLAADTLIDVANPFLAELTKVTTETSCLTEPDQREMV
HHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHCCCCCHHHHH
YVARFVSAQFVPVHMPIGSRIPMYCTASGRAYLSALPEPEARAIVETSERVAHTMHTRTE
HHHHHHHCCEEEEECCCCCCCCEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
VADILATLREARQRGYAINREELFLGDMTVAAPIVGGNGRPLGAIHLVAPTGRWTAEDME
HHHHHHHHHHHHHCCCCCCHHHEEECCCEEEEEEECCCCCCEEEEEEEECCCCCCHHHHH
AKLGPPLLQCARAISTSVRALG
HHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIQPDDAPNLLFNQSLEKGLAVLGAFNAQRRTMTIAEVAAVAGINKSSAQRMVYTLEHLG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YLRKHPKTRRYQLTPAAMKIGFNYLAADTLIDVANPFLAELTKVTTETSCLTEPDQREMV
HHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHCCCCCHHHHH
YVARFVSAQFVPVHMPIGSRIPMYCTASGRAYLSALPEPEARAIVETSERVAHTMHTRTE
HHHHHHHCCEEEEECCCCCCCCEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
VADILATLREARQRGYAINREELFLGDMTVAAPIVGGNGRPLGAIHLVAPTGRWTAEDME
HHHHHHHHHHHHHCCCCCCHHHEEECCCEEEEEEECCCCCCEEEEEEEECCCCCCHHHHH
AKLGPPLLQCARAISTSVRALG
HHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]