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The map label for this gene is hmp [H]

Identifier: 17548115

GI number: 17548115

Start: 3666630

End: 3667835

Strand: Direct

Name: hmp [H]

Synonym: RSc3398

Alternate gene names: 17548115

Gene position: 3666630-3667835 (Clockwise)

Preceding gene: 17548109

Following gene: 17548116

Centisome position: 98.66

GC content: 69.9

Gene sequence:

>1206_bases
ATGCTGTCGGAACAGTCCAAGCCCCTGATCGATGCGAGCGTGCCGGTGTTGCGCGAACACGGTCTGACCATCACCCAGAC
CTTCTACCGCAACATGTTCGCCAGCCACCCGGAGCTGACCAACCTGTTCAACATGGGCAACCAGGCCAACGGTTCGCAGC
AGCAGTCGCTGGCTTCGGCGGTGTTCGCCTATGCCGCCAACCACGGCAACAACGCCGCGCTGGCGCCGGTGGTCGGCCGC
ATCGTCCACAAGCATGCGGCGGTCGGCATCCGGCCGAGCCACTACCCGATCGTCGGGCGGCATCTGCTGGGCGCGATCGC
CGAGGTGCTGGGCGATGCTGCCACGCCTGAGCTGCTGGCGGCGTGGGACGAGGCGTACTGGCTGCTGGCCGCCGAGCTGA
TCGCCGCCGAAGCCCGCCTGTACGCGCACACGCAGAGCGGCCCGGACCACCGCCAGCCCGTGCGCATCATCGAGCGCCAC
GCGCAGGCCGAAGACGTGGTGTCGTTCACGCTGGAAGCCGTCGGCGGGGCCAAGCTGGCCGATTTCCTACCGGGTCAGTA
CATCTCGGTGCAGGTGGAACTGGCGCCGGGCGTGCTGCAGCAACGCCAGTACAGCCTGTCGGACGCGCCCAACGGCCGCA
CCTGGCGCATCTCCGTCAAGCGTGATGCCGGCGGCAGCGGCCGCCCGGCCGGCACCGTGTCGAACTGGCTGCACGACAAC
GCGCGCCCGGGCGAGGTCCTGCTGGTCAGCCAGCCCTACGGCGATTTCGTTCCGCAGCTCGCCACCGATAGCCCCATCGT
GCTGATGTCGGCCGGCGTCGGCATCACGCCGATGATCGCCACGCTCAACGCGCTGGCCCGGCGGAACACCGCGCGCAAGG
TGGTGTTCAGCCATGCCGGCCAAGCCGCTTCGCACGTCGCGCATGCCGACGACCTGGAGCGTGCCGCGCAGGTCCTGCCG
GATTTCGCGGCGCATGTGTTCCTGGAATCGGGCGAGGCCGCGGACTTCGCTGCGCGTCCGGCGCGTCCGGGGCGCATGAC
GGTCGAGACCTTCCTCGACGACGGGGTCGCCGATGCCGACTTCTACCTGTGCGGTCCGCTGCCGTTCATGCAGGCGCAGC
GCGCGGCGCTGCTCGCCGGCGGCGTGCCGGCGGGGCGCATCCACCGCGAGGTGTTCGGCCCCGATCTGCTGGACGACATC
CTCTGA

Upstream 100 bases:

>100_bases
ACACGATCCAGCGACGGATCGGCAGGGCGCGGTTTTCACCGCATGCCGGGTCGGTCCGCCGCATTTGTTGTGTTGAACAT
GCTGCTTTGTGGAGAAGAAC

Downstream 100 bases:

>100_bases
CCGCGAGTCCGCCATGCCCCGCCCGGCTCCGCTCCTGAACATCGGCCAGCCTGATCCGGCCAGCCGCGTACCGTACACCG
GCCTGCCGGTCTTTGCCCTC

Product: flavohemoprotein (hemoglobin-like) transmembrane

Products: NA

Alternate protein names: Flavohemoglobin; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MLSEQSKPLIDASVPVLREHGLTITQTFYRNMFASHPELTNLFNMGNQANGSQQQSLASAVFAYAANHGNNAALAPVVGR
IVHKHAAVGIRPSHYPIVGRHLLGAIAEVLGDAATPELLAAWDEAYWLLAAELIAAEARLYAHTQSGPDHRQPVRIIERH
AQAEDVVSFTLEAVGGAKLADFLPGQYISVQVELAPGVLQQRQYSLSDAPNGRTWRISVKRDAGGSGRPAGTVSNWLHDN
ARPGEVLLVSQPYGDFVPQLATDSPIVLMSAGVGITPMIATLNALARRNTARKVVFSHAGQAASHVAHADDLERAAQVLP
DFAAHVFLESGEAADFAARPARPGRMTVETFLDDGVADADFYLCGPLPFMQAQRAALLAGGVPAGRIHREVFGPDLLDDI
L

Sequences:

>Translated_401_residues
MLSEQSKPLIDASVPVLREHGLTITQTFYRNMFASHPELTNLFNMGNQANGSQQQSLASAVFAYAANHGNNAALAPVVGR
IVHKHAAVGIRPSHYPIVGRHLLGAIAEVLGDAATPELLAAWDEAYWLLAAELIAAEARLYAHTQSGPDHRQPVRIIERH
AQAEDVVSFTLEAVGGAKLADFLPGQYISVQVELAPGVLQQRQYSLSDAPNGRTWRISVKRDAGGSGRPAGTVSNWLHDN
ARPGEVLLVSQPYGDFVPQLATDSPIVLMSAGVGITPMIATLNALARRNTARKVVFSHAGQAASHVAHADDLERAAQVLP
DFAAHVFLESGEAADFAARPARPGRMTVETFLDDGVADADFYLCGPLPFMQAQRAALLAGGVPAGRIHREVFGPDLLDDI
L
>Mature_401_residues
MLSEQSKPLIDASVPVLREHGLTITQTFYRNMFASHPELTNLFNMGNQANGSQQQSLASAVFAYAANHGNNAALAPVVGR
IVHKHAAVGIRPSHYPIVGRHLLGAIAEVLGDAATPELLAAWDEAYWLLAAELIAAEARLYAHTQSGPDHRQPVRIIERH
AQAEDVVSFTLEAVGGAKLADFLPGQYISVQVELAPGVLQQRQYSLSDAPNGRTWRISVKRDAGGSGRPAGTVSNWLHDN
ARPGEVLLVSQPYGDFVPQLATDSPIVLMSAGVGITPMIATLNALARRNTARKVVFSHAGQAASHVAHADDLERAAQVLP
DFAAHVFLESGEAADFAARPARPGRMTVETFLDDGVADADFYLCGPLPFMQAQRAALLAGGVPAGRIHREVFGPDLLDDI
L

Specific function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a centra

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788903, Length=401, Percent_Identity=38.9027431421446, Blast_Score=262, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6321673, Length=410, Percent_Identity=36.0975609756098, Blast_Score=219, Evalue=4e-58,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017927
- InterPro:   IPR001709
- InterPro:   IPR012292
- InterPro:   IPR009050
- InterPro:   IPR000971
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00042 Globin; PF00175 NAD_binding_1 [H]

EC number: =1.14.12.17 [H]

Molecular weight: Translated: 42889; Mature: 42889

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS01033 GLOBIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSEQSKPLIDASVPVLREHGLTITQTFYRNMFASHPELTNLFNMGNQANGSQQQSLASA
CCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHH
VFAYAANHGNNAALAPVVGRIVHKHAAVGIRPSHYPIVGRHLLGAIAEVLGDAATPELLA
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
AWDEAYWLLAAELIAAEARLYAHTQSGPDHRQPVRIIERHAQAEDVVSFTLEAVGGAKLA
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
DFLPGQYISVQVELAPGVLQQRQYSLSDAPNGRTWRISVKRDAGGSGRPAGTVSNWLHDN
HHCCCCEEEEEEEECCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHCCC
ARPGEVLLVSQPYGDFVPQLATDSPIVLMSAGVGITPMIATLNALARRNTARKVVFSHAG
CCCCCEEEEECCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
QAASHVAHADDLERAAQVLPDFAAHVFLESGEAADFAARPARPGRMTVETFLDDGVADAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCC
FYLCGPLPFMQAQRAALLAGGVPAGRIHREVFGPDLLDDIL
EEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure
MLSEQSKPLIDASVPVLREHGLTITQTFYRNMFASHPELTNLFNMGNQANGSQQQSLASA
CCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHH
VFAYAANHGNNAALAPVVGRIVHKHAAVGIRPSHYPIVGRHLLGAIAEVLGDAATPELLA
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
AWDEAYWLLAAELIAAEARLYAHTQSGPDHRQPVRIIERHAQAEDVVSFTLEAVGGAKLA
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
DFLPGQYISVQVELAPGVLQQRQYSLSDAPNGRTWRISVKRDAGGSGRPAGTVSNWLHDN
HHCCCCEEEEEEEECCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHCCC
ARPGEVLLVSQPYGDFVPQLATDSPIVLMSAGVGITPMIATLNALARRNTARKVVFSHAG
CCCCCEEEEECCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
QAASHVAHADDLERAAQVLPDFAAHVFLESGEAADFAARPARPGRMTVETFLDDGVADAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCC
FYLCGPLPFMQAQRAALLAGGVPAGRIHREVFGPDLLDDIL
EEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14521231; 11481432 [H]