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The map label for this gene is phhA

Identifier: 17548072

GI number: 17548072

Start: 3615539

End: 3616480

Strand: Direct

Name: phhA

Synonym: RSc3355

Alternate gene names: 17548072

Gene position: 3615539-3616480 (Clockwise)

Preceding gene: 17548066

Following gene: 17548073

Centisome position: 97.29

GC content: 69.21

Gene sequence:

>942_bases
ATGGCCATCGCCACCCCCACCAGCGCAGCCCCCACCCCGGCCCCGGCCGGCTTCACCGGCACCCTGACCGACAAGCTCCG
CGAGCAGTTCGCCGAAGGCCTCGACGGCCAGACGCTGCGCCCGGACTTCACGATGGAACAGCCTGTCCACCGCTACACCG
CCGCCGACCACGCCACCTGGCGCACGCTGTACGACCGCCAGGAAGCCCTGCTCCCGGGACGCGCCTGCGATGAATTCCTG
CAAGGCCTGTCCACGCTGGGCATGAGCCGCGAAGGCGTGCCGTCGTTCGACCGGCTCAACGAAACGCTGATGCGCGCCAC
CGGCTGGCAGATCGTGGCCGTGCCCGGCCTGGTGCCGGACGAAGTCTTCTTCGAGCACCTCGCCAACCGCCGCTTCCCGG
CCAGCTGGTGGATGCGCCGTCCCGACCAGCTCGACTACCTGCAGGAGCCGGACGGCTTCCACGACATCTTTGGCCACGTG
CCGCTGCTGATCAACCCGGTCTTCGCCGACTACATGCAGGCCTATGGCCAGGGCGGCCTGAAGGCGGCGCGCCTGGGTGC
GCTCGACATGCTGGCGCGGCTGTACTGGTACACGGTGGAGTTCGGCCTGATCCGCACGCCGGCCGGCCTGCGCATCTACG
GCGCGGGCATCGTGTCGAGCAAGAGCGAGTCGGTCTACGCGCTGGATTCGGCCAGCCCCAACCGCATCGGCTTCGACGTG
CACCGCATCATGCGCACGCGCTACCGCATCGACACCTTCCAGAAGACCTACTTCGTGATCGACAGCTTCGAGCAGCTGTT
CGACGCCACCCGCCCGGACTTCACGCCGCTGTACGAGGCACTCGGCACGCTGCCGACCTTCGGCGCCGGCGACGTGGTGG
ACGGCGACGCCGTGCTCAACGCCGGCACCCGCGAGGGCTGGGCCGACACGGCGGATATCTGA

Upstream 100 bases:

>100_bases
TCTGCAAACAACGCGCGAATGGCGCCGGTTTTGCGGTCAATCCGCGCGGCCCCGCCCCTACACTGGCGAATTCCGATCGC
CCCCGACCAGGATATCCATC

Downstream 100 bases:

>100_bases
GCGCTGGCTATACTGCGCGCATTCCCATCCGCCATCGACCCGAGACCATGATGCCGACTCTCAATGACGAACAACGCAAG
GCCCTGTTTGCCGAACTGCC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MAIATPTSAAPTPAPAGFTGTLTDKLREQFAEGLDGQTLRPDFTMEQPVHRYTAADHATWRTLYDRQEALLPGRACDEFL
QGLSTLGMSREGVPSFDRLNETLMRATGWQIVAVPGLVPDEVFFEHLANRRFPASWWMRRPDQLDYLQEPDGFHDIFGHV
PLLINPVFADYMQAYGQGGLKAARLGALDMLARLYWYTVEFGLIRTPAGLRIYGAGIVSSKSESVYALDSASPNRIGFDV
HRIMRTRYRIDTFQKTYFVIDSFEQLFDATRPDFTPLYEALGTLPTFGAGDVVDGDAVLNAGTREGWADTADI

Sequences:

>Translated_313_residues
MAIATPTSAAPTPAPAGFTGTLTDKLREQFAEGLDGQTLRPDFTMEQPVHRYTAADHATWRTLYDRQEALLPGRACDEFL
QGLSTLGMSREGVPSFDRLNETLMRATGWQIVAVPGLVPDEVFFEHLANRRFPASWWMRRPDQLDYLQEPDGFHDIFGHV
PLLINPVFADYMQAYGQGGLKAARLGALDMLARLYWYTVEFGLIRTPAGLRIYGAGIVSSKSESVYALDSASPNRIGFDV
HRIMRTRYRIDTFQKTYFVIDSFEQLFDATRPDFTPLYEALGTLPTFGAGDVVDGDAVLNAGTREGWADTADI
>Mature_312_residues
AIATPTSAAPTPAPAGFTGTLTDKLREQFAEGLDGQTLRPDFTMEQPVHRYTAADHATWRTLYDRQEALLPGRACDEFLQ
GLSTLGMSREGVPSFDRLNETLMRATGWQIVAVPGLVPDEVFFEHLANRRFPASWWMRRPDQLDYLQEPDGFHDIFGHVP
LLINPVFADYMQAYGQGGLKAARLGALDMLARLYWYTVEFGLIRTPAGLRIYGAGIVSSKSESVYALDSASPNRIGFDVH
RIMRTRYRIDTFQKTYFVIDSFEQLFDATRPDFTPLYEALGTLPTFGAGDVVDGDAVLNAGTREGWADTADI

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family

Homologues:

Organism=Homo sapiens, GI4759248, Length=265, Percent_Identity=33.5849056603774, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI88900505, Length=228, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI88900501, Length=228, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI88900503, Length=228, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI31795563, Length=231, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI4557819, Length=261, Percent_Identity=29.5019157088123, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17531391, Length=222, Percent_Identity=35.5855855855856, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71980736, Length=234, Percent_Identity=30.3418803418803, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI115532103, Length=268, Percent_Identity=30.2238805970149, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI115533973, Length=268, Percent_Identity=30.2238805970149, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71980731, Length=167, Percent_Identity=28.1437125748503, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI62472054, Length=260, Percent_Identity=30.7692307692308, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24660393, Length=260, Percent_Identity=30.7692307692308, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24654994, Length=263, Percent_Identity=31.1787072243346, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17136776, Length=228, Percent_Identity=29.3859649122807, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17136774, Length=228, Percent_Identity=29.3859649122807, Blast_Score=114, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PH4H_RALSO (Q8XU39)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_521474.1
- ProteinModelPortal:   Q8XU39
- SMR:   Q8XU39
- GeneID:   1222219
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc3355
- NMPDR:   fig|267608.1.peg.3353
- HOGENOM:   HBG403840
- OMA:   FLARLYW
- ProtClustDB:   PRK11913
- BioCyc:   RSOL267608:RSC3355-MONOMER
- BRENDA:   1.14.16.1
- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960
- Gene3D:   G3DSA:1.10.800.10
- PANTHER:   PTHR11473
- PRINTS:   PR00372
- TIGRFAMs:   TIGR01267

Pfam domain/function: PF00351 Biopterin_H; SSF56534 Aaa_hydroxylase

EC number: =1.14.16.1

Molecular weight: Translated: 34902; Mature: 34771

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00367 BH4_AAA_HYDROXYL_1; PS51410 BH4_AAA_HYDROXYL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIATPTSAAPTPAPAGFTGTLTDKLREQFAEGLDGQTLRPDFTMEQPVHRYTAADHATW
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHH
RTLYDRQEALLPGRACDEFLQGLSTLGMSREGVPSFDRLNETLMRATGWQIVAVPGLVPD
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCH
EVFFEHLANRRFPASWWMRRPDQLDYLQEPDGFHDIFGHVPLLINPVFADYMQAYGQGGL
HHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCC
KAARLGALDMLARLYWYTVEFGLIRTPAGLRIYGAGIVSSKSESVYALDSASPNRIGFDV
HHHHHHHHHHHHHHHHHHHHHCEEECCCCCEEEECCEECCCCCCEEEECCCCCCCCHHHH
HRIMRTRYRIDTFQKTYFVIDSFEQLFDATRPDFTPLYEALGTLPTFGAGDVVDGDAVLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHCC
AGTREGWADTADI
CCCCCCCCCCCCC
>Mature Secondary Structure 
AIATPTSAAPTPAPAGFTGTLTDKLREQFAEGLDGQTLRPDFTMEQPVHRYTAADHATW
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHH
RTLYDRQEALLPGRACDEFLQGLSTLGMSREGVPSFDRLNETLMRATGWQIVAVPGLVPD
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCH
EVFFEHLANRRFPASWWMRRPDQLDYLQEPDGFHDIFGHVPLLINPVFADYMQAYGQGGL
HHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCC
KAARLGALDMLARLYWYTVEFGLIRTPAGLRIYGAGIVSSKSESVYALDSASPNRIGFDV
HHHHHHHHHHHHHHHHHHHHHCEEECCCCCEEEECCEECCCCCCEEEECCCCCCCCHHHH
HRIMRTRYRIDTFQKTYFVIDSFEQLFDATRPDFTPLYEALGTLPTFGAGDVVDGDAVLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHCC
AGTREGWADTADI
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852