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The map label for this gene is hemE [H]

Identifier: 17548020

GI number: 17548020

Start: 3565798

End: 3566892

Strand: Reverse

Name: hemE [H]

Synonym: RSc3303

Alternate gene names: 17548020

Gene position: 3566892-3565798 (Counterclockwise)

Preceding gene: 17548021

Following gene: 17548019

Centisome position: 95.98

GC content: 70.23

Gene sequence:

>1095_bases
ATGTCCGCACCGCTCGCCAACGACACCTTCCTGCGTGCCCTGCGCCGCCAGCCCACCGAATACACGCCGCTGTGGCTGAT
GCGCCAGGCGGGCCGCTACCTGCCCGAGTACAACGCCACGCGCGCGCGCGCCGGCAGCTTCCTGGGCCTGGCCAAGTCGC
CGGCCTATGCCACCGAGGTGACGCTGCAGCCGCTGGACCGCTATCCGCTGGATGCCGCCATCCTGTTCTCCGACATCCTG
ACCGTGCCCGATGCGATGGGCCTGGGGCTGTCGTTCGAGCAGGGCGAAGGTCCGCGCTTCGCGCGACCGGTGCGCTCCGA
GGCGGACGTGGCCGCGCTGTCGGTGCCCGACATGGCCTCGTTGCAATACGTCTTCGATGCGGTGTCGGAAATCCGCCGCG
CGCTGGTGCAGGACGGCCGCCAGCGCGTGCCGCTGATCGGCTTCTCGGGCAGCCCGTGGACGCTGGCCTGCTACATGGTC
GAAGGCGGCGGCTCGGACGACTTCCGCACCGTCAAGTCGATGCTCTACGCGCGCCCGGACCTGATGCACCGCATCCTGGA
AATCAACGCGGCCGCCGTGATCGACTACCTGAACGCGCAGATCGACGCTGGCGCCCAGGCCGTGATGGTGTTCGACACCT
GGGGCGGCGCGCTGGCCGACGGCATCTACCAGACGTTTTCGCTGGCCTATATGGCGCGCGTGGTGGAAGGCCTGCGCGCC
GGCGCGGACGGCCAGCGTGTGCCGGTGATCCTGTTCACCAAGGGCGGCGGGCTGTGGCTCGAATCGATGGCCCAGACCGG
CGCCGATGCGCTGGGCGTGGACTGGACGGTCAACCTGCAGCTGGCGCGCGTGCGCACCGGCGGCCGGGTGGCGCTGCAGG
GCAACCTCGACCCGACCGTGCTGTTCGCCGAGCCGGATGCCATCCGCGCGCAGGTGCGCCGGGTGCTGGAGGACTATGCC
GCCGGCGGCGACAGCGATGGCCATGTGTTCAACCTCGGTCACGGCATCTCGCAGTTCACGCCGCCGGAGTCGGTGGCGGT
GCTGGTGGACGAAGTGCACACCTTCAGTCGCGCGCTGCGGACCCGCTTGCCGTAG

Upstream 100 bases:

>100_bases
GCACTCCGGCGCGCAGCCGCGCGGCGCGGCGCGCGCGTGGCCGTCCGGCCGCCGATCCCCCATCCCGTACAATGGCGGCC
TTCGTTTCGATCCCGCCGCC

Downstream 100 bases:

>100_bases
CAACGGAATGTTGCGGTGCGATAGCGTTTGAATGGCCGGCCCTTGGTGCAGCGGGCCGATGCAACGGAGCGGCGGTTCGC
CACTCTGGTGCAGACGCGGT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSAPLANDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKSPAYATEVTLQPLDRYPLDAAILFSDIL
TVPDAMGLGLSFEQGEGPRFARPVRSEADVAALSVPDMASLQYVFDAVSEIRRALVQDGRQRVPLIGFSGSPWTLACYMV
EGGGSDDFRTVKSMLYARPDLMHRILEINAAAVIDYLNAQIDAGAQAVMVFDTWGGALADGIYQTFSLAYMARVVEGLRA
GADGQRVPVILFTKGGGLWLESMAQTGADALGVDWTVNLQLARVRTGGRVALQGNLDPTVLFAEPDAIRAQVRRVLEDYA
AGGDSDGHVFNLGHGISQFTPPESVAVLVDEVHTFSRALRTRLP

Sequences:

>Translated_364_residues
MSAPLANDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKSPAYATEVTLQPLDRYPLDAAILFSDIL
TVPDAMGLGLSFEQGEGPRFARPVRSEADVAALSVPDMASLQYVFDAVSEIRRALVQDGRQRVPLIGFSGSPWTLACYMV
EGGGSDDFRTVKSMLYARPDLMHRILEINAAAVIDYLNAQIDAGAQAVMVFDTWGGALADGIYQTFSLAYMARVVEGLRA
GADGQRVPVILFTKGGGLWLESMAQTGADALGVDWTVNLQLARVRTGGRVALQGNLDPTVLFAEPDAIRAQVRRVLEDYA
AGGDSDGHVFNLGHGISQFTPPESVAVLVDEVHTFSRALRTRLP
>Mature_363_residues
SAPLANDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKSPAYATEVTLQPLDRYPLDAAILFSDILT
VPDAMGLGLSFEQGEGPRFARPVRSEADVAALSVPDMASLQYVFDAVSEIRRALVQDGRQRVPLIGFSGSPWTLACYMVE
GGGSDDFRTVKSMLYARPDLMHRILEINAAAVIDYLNAQIDAGAQAVMVFDTWGGALADGIYQTFSLAYMARVVEGLRAG
ADGQRVPVILFTKGGGLWLESMAQTGADALGVDWTVNLQLARVRTGGRVALQGNLDPTVLFAEPDAIRAQVRRVLEDYAA
GGDSDGHVFNLGHGISQFTPPESVAVLVDEVHTFSRALRTRLP

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=361, Percent_Identity=45.4293628808864, Blast_Score=298, Evalue=4e-81,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=61.2994350282486, Blast_Score=427, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6320252, Length=357, Percent_Identity=37.2549019607843, Blast_Score=250, Evalue=3e-67,
Organism=Drosophila melanogaster, GI221330099, Length=354, Percent_Identity=38.9830508474576, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI19921920, Length=354, Percent_Identity=38.9830508474576, Blast_Score=253, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39525; Mature: 39393

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPLANDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKSPAYATEV
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCCCCEEEE
TLQPLDRYPLDAAILFSDILTVPDAMGLGLSFEQGEGPRFARPVRSEADVAALSVPDMAS
EECCCCCCCCHHHHHHHHHHHCCCHHCCCCEECCCCCCCCCCCCCCCCCEEEECCCCHHH
LQYVFDAVSEIRRALVQDGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMLYARPD
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHH
LMHRILEINAAAVIDYLNAQIDAGAQAVMVFDTWGGALADGIYQTFSLAYMARVVEGLRA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
GADGQRVPVILFTKGGGLWLESMAQTGADALGVDWTVNLQLARVRTGGRVALQGNLDPTV
CCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCEE
LFAEPDAIRAQVRRVLEDYAAGGDSDGHVFNLGHGISQFTPPESVAVLVDEVHTFSRALR
EEECCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TRLP
HCCC
>Mature Secondary Structure 
SAPLANDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKSPAYATEV
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCCCCEEEE
TLQPLDRYPLDAAILFSDILTVPDAMGLGLSFEQGEGPRFARPVRSEADVAALSVPDMAS
EECCCCCCCCHHHHHHHHHHHCCCHHCCCCEECCCCCCCCCCCCCCCCCEEEECCCCHHH
LQYVFDAVSEIRRALVQDGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMLYARPD
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHH
LMHRILEINAAAVIDYLNAQIDAGAQAVMVFDTWGGALADGIYQTFSLAYMARVVEGLRA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
GADGQRVPVILFTKGGGLWLESMAQTGADALGVDWTVNLQLARVRTGGRVALQGNLDPTV
CCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCEE
LFAEPDAIRAQVRRVLEDYAAGGDSDGHVFNLGHGISQFTPPESVAVLVDEVHTFSRALR
EEECCHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TRLP
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA