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The map label for this gene is hemN [H]

Identifier: 17548001

GI number: 17548001

Start: 3534913

End: 3536445

Strand: Reverse

Name: hemN [H]

Synonym: RSc3284

Alternate gene names: 17548001

Gene position: 3536445-3534913 (Counterclockwise)

Preceding gene: 17548003

Following gene: 17547997

Centisome position: 95.16

GC content: 69.02

Gene sequence:

>1533_bases
ATGCATGTCAACGCGACGCCCGGGCCCCGGACTTACGATGAACCATCCCCATCGCACCCCACGATCATGTTCCCCTTCGC
CCAGCCGGCCGCCGATGCCGCGGCCGCCAACGATGCGCCGTTCCGCTGGTCCGCGCCGCAGGTGCGCGCGCTGGCGCAGC
GCTTTGACACACACGGCCCGCGCTACACGTCGTACCCGACGGCAGACCGCTTCCACACGGGCTTCGGCACCGATACCTAC
CTGGACGCCCTGCATCGGCGCGCCGCCATCGCGCCCGCGCTGCATGCGCCGCTGTCGCTGTACGTGCACCTGCCGTTCTG
CGCCAACCTCTGCTACTACTGCGGCTGCAACAAGGTCGTGACCAAGGACCACACCCGCAGCGCGCGCTACATCGGCGCAC
TGGCGCGCGAGATGGCGATGGTCGCCCGGCACATCGGCCCGCTGCGCCAGGCGACCCAGCTGCACTGGGGCGGCGGCACG
CCCACCTTCCTGTCGCACGACGAGATGCGCGATGTGATGGCCGCCACGCGCGAGCACTTCGCCCTGACCTCCGATGCGGA
AGTTTCCGTCGAGCTCGATCCGCGCCACGCCAGCGACGCCACGCTGGAGGTGCTGGCCGGCCTGGGCTTCAATCGCGCGA
GCCTCGGCATCCAGGATTTCGACGCCGACGTGCAGCGCGCCATCCACCGCGTCCAGAGCGTGGAACAGACGCGCCGCGTG
GTCGATTCCGCGCGCCGGCTCGGCTTCGAGTCGATCAGCTTCGATCTGATCTACGGCCTGCCGCACCAGCACACCGCAAC
CTTCAACGCCACGCTGGACCGGGTGCTGGAGATGGCGCCCGACCGCCTGTCCGTCTACAGCTACGCGCACCTGCCGCACC
TGTTCAAGCCGCAGCGCCGCATCGACGCGCTCGCGCTGCCGAGCGCCGACGAGAAGCTCGACCTGCTGGCGATGACGGTG
GAGCGGCTGGTGGCCGCCGGCTACGTCTACATCGGCATGGACCACTTCGCGCGGCCCGACGACGCGCTCGCCATCGCGCA
GCGCGAAGGGCGGTTGCAGCGCAACTTCCAGGGCTATTCCACGCACGCCGATTGCGACCTGCTGGCCTTCGGCATGTCCG
CCATCAGCCGCGTCGGCGATGTCTATGCGCAGAACGAAAAAGAGCTCGATGCCTATTACGCGCGTATCGACGCGGGCGAG
CTGCCAGTGCTGCGCGGCCTGACCCTGACGCCGGACGACCATGTGCGCCGTGCCCTGATCGGCGAACTGATGTGCGGCTT
CGAGCTGGACATGCGCTTGTTCGGCACCCGCCACGGGCTGAACTTCCGGCAGAGCTTCGCCAGTGAGCTGACCGCGCTGG
CGCCGCTCGAAGATGCTGGCCTGGTGAAGGTGGGCGACGAGCGCATCGTCATCACGCCGCAGGGGCGGCTGCTGGTGCGG
CGCATCGCCATGGTGTTCGATGCGCACCTGCACGCGGTCCACGTGCAGGTGCCGACTGTGGGCGGCGTCCCGCGCTACTC
CAAGGTCGTCTGA

Upstream 100 bases:

>100_bases
GATGGTAGGGCCGCATCTGTGACATCGCCGTGACGCCGGACACCCACCGGCGTGGAGATCGGTTGGATCCGCGCGCCGCG
CCATGCATCGATCGACGTTG

Downstream 100 bases:

>100_bases
GCGCCCGGGCCGGAAGTCGCTGCCTCGGCCGCGCGGCTCAGGCGATCGCGTGGTTCGACATGATCTCGATCGCGCGGCAC
AGCGCCGAGTGATCCTGCTT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MHVNATPGPRTYDEPSPSHPTIMFPFAQPAADAAAANDAPFRWSAPQVRALAQRFDTHGPRYTSYPTADRFHTGFGTDTY
LDALHRRAAIAPALHAPLSLYVHLPFCANLCYYCGCNKVVTKDHTRSARYIGALAREMAMVARHIGPLRQATQLHWGGGT
PTFLSHDEMRDVMAATREHFALTSDAEVSVELDPRHASDATLEVLAGLGFNRASLGIQDFDADVQRAIHRVQSVEQTRRV
VDSARRLGFESISFDLIYGLPHQHTATFNATLDRVLEMAPDRLSVYSYAHLPHLFKPQRRIDALALPSADEKLDLLAMTV
ERLVAAGYVYIGMDHFARPDDALAIAQREGRLQRNFQGYSTHADCDLLAFGMSAISRVGDVYAQNEKELDAYYARIDAGE
LPVLRGLTLTPDDHVRRALIGELMCGFELDMRLFGTRHGLNFRQSFASELTALAPLEDAGLVKVGDERIVITPQGRLLVR
RIAMVFDAHLHAVHVQVPTVGGVPRYSKVV

Sequences:

>Translated_510_residues
MHVNATPGPRTYDEPSPSHPTIMFPFAQPAADAAAANDAPFRWSAPQVRALAQRFDTHGPRYTSYPTADRFHTGFGTDTY
LDALHRRAAIAPALHAPLSLYVHLPFCANLCYYCGCNKVVTKDHTRSARYIGALAREMAMVARHIGPLRQATQLHWGGGT
PTFLSHDEMRDVMAATREHFALTSDAEVSVELDPRHASDATLEVLAGLGFNRASLGIQDFDADVQRAIHRVQSVEQTRRV
VDSARRLGFESISFDLIYGLPHQHTATFNATLDRVLEMAPDRLSVYSYAHLPHLFKPQRRIDALALPSADEKLDLLAMTV
ERLVAAGYVYIGMDHFARPDDALAIAQREGRLQRNFQGYSTHADCDLLAFGMSAISRVGDVYAQNEKELDAYYARIDAGE
LPVLRGLTLTPDDHVRRALIGELMCGFELDMRLFGTRHGLNFRQSFASELTALAPLEDAGLVKVGDERIVITPQGRLLVR
RIAMVFDAHLHAVHVQVPTVGGVPRYSKVV
>Mature_510_residues
MHVNATPGPRTYDEPSPSHPTIMFPFAQPAADAAAANDAPFRWSAPQVRALAQRFDTHGPRYTSYPTADRFHTGFGTDTY
LDALHRRAAIAPALHAPLSLYVHLPFCANLCYYCGCNKVVTKDHTRSARYIGALAREMAMVARHIGPLRQATQLHWGGGT
PTFLSHDEMRDVMAATREHFALTSDAEVSVELDPRHASDATLEVLAGLGFNRASLGIQDFDADVQRAIHRVQSVEQTRRV
VDSARRLGFESISFDLIYGLPHQHTATFNATLDRVLEMAPDRLSVYSYAHLPHLFKPQRRIDALALPSADEKLDLLAMTV
ERLVAAGYVYIGMDHFARPDDALAIAQREGRLQRNFQGYSTHADCDLLAFGMSAISRVGDVYAQNEKELDAYYARIDAGE
LPVLRGLTLTPDDHVRRALIGELMCGFELDMRLFGTRHGLNFRQSFASELTALAPLEDAGLVKVGDERIVITPQGRLLVR
RIAMVFDAHLHAVHVQVPTVGGVPRYSKVV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=244, Percent_Identity=30.7377049180328, Blast_Score=97, Evalue=5e-20,
Organism=Escherichia coli, GI87082341, Length=444, Percent_Identity=49.0990990990991, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1789325, Length=244, Percent_Identity=29.5081967213115, Blast_Score=112, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 56540; Mature: 56540

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVNATPGPRTYDEPSPSHPTIMFPFAQPAADAAAANDAPFRWSAPQVRALAQRFDTHGP
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHCCCC
RYTSYPTADRFHTGFGTDTYLDALHRRAAIAPALHAPLSLYVHLPFCANLCYYCGCNKVV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCEE
TKDHTRSARYIGALAREMAMVARHIGPLRQATQLHWGGGTPTFLSHDEMRDVMAATREHF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHH
ALTSDAEVSVELDPRHASDATLEVLAGLGFNRASLGIQDFDADVQRAIHRVQSVEQTRRV
EECCCCEEEEEECCCCCCCHHHHHHHCCCCCHHHCCCHHCCHHHHHHHHHHHHHHHHHHH
VDSARRLGFESISFDLIYGLPHQHTATFNATLDRVLEMAPDRLSVYSYAHLPHLFKPQRR
HHHHHHCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHCCHHCCCHHH
IDALALPSADEKLDLLAMTVERLVAAGYVYIGMDHFARPDDALAIAQREGRLQRNFQGYS
HHEEECCCCCCHHHHHHHHHHHHHHCCEEEEECHHCCCCCHHHHHHHHHCHHHHCCCCCC
THADCDLLAFGMSAISRVGDVYAQNEKELDAYYARIDAGELPVLRGLTLTPDDHVRRALI
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHCCCEECCHHHHHHHHH
GELMCGFELDMRLFGTRHGLNFRQSFASELTALAPLEDAGLVKVGDERIVITPQGRLLVR
HHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCHHHHH
RIAMVFDAHLHAVHVQVPTVGGVPRYSKVV
HHHHHHHHCEEEEEEEECCCCCCCCHHCCC
>Mature Secondary Structure
MHVNATPGPRTYDEPSPSHPTIMFPFAQPAADAAAANDAPFRWSAPQVRALAQRFDTHGP
CCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHCCCC
RYTSYPTADRFHTGFGTDTYLDALHRRAAIAPALHAPLSLYVHLPFCANLCYYCGCNKVV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCEE
TKDHTRSARYIGALAREMAMVARHIGPLRQATQLHWGGGTPTFLSHDEMRDVMAATREHF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHH
ALTSDAEVSVELDPRHASDATLEVLAGLGFNRASLGIQDFDADVQRAIHRVQSVEQTRRV
EECCCCEEEEEECCCCCCCHHHHHHHCCCCCHHHCCCHHCCHHHHHHHHHHHHHHHHHHH
VDSARRLGFESISFDLIYGLPHQHTATFNATLDRVLEMAPDRLSVYSYAHLPHLFKPQRR
HHHHHHCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHCCHHCCCHHH
IDALALPSADEKLDLLAMTVERLVAAGYVYIGMDHFARPDDALAIAQREGRLQRNFQGYS
HHEEECCCCCCHHHHHHHHHHHHHHCCEEEEECHHCCCCCHHHHHHHHHCHHHHCCCCCC
THADCDLLAFGMSAISRVGDVYAQNEKELDAYYARIDAGELPVLRGLTLTPDDHVRRALI
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHCCCEECCHHHHHHHHH
GELMCGFELDMRLFGTRHGLNFRQSFASELTALAPLEDAGLVKVGDERIVITPQGRLLVR
HHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCHHHHH
RIAMVFDAHLHAVHVQVPTVGGVPRYSKVV
HHHHHHHHCEEEEEEEECCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]