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The map label for this gene is argE [H]

Identifier: 17547990

GI number: 17547990

Start: 3523086

End: 3524360

Strand: Reverse

Name: argE [H]

Synonym: RSc3273

Alternate gene names: 17547990

Gene position: 3524360-3523086 (Counterclockwise)

Preceding gene: 17547991

Following gene: 17547988

Centisome position: 94.83

GC content: 72.16

Gene sequence:

>1275_bases
ATGACTCAGGCCGACATCGCCGCCAGCGGGATCGACGCGGACATCCGCGCATTCGTCGAGGCCGCGCACGCGCAGCAGGT
CGTCTTCCTGCGCGAACTGGTGAAGGTGCCGTCGGACAATCCGTCCGGCGACTGCGCCCCGCATGCCGCGCGCGCCAGGG
CGCTGCTCGAGGCGCTCGGCCTCGCGGTCGAGGCGCATCCCGTGCCCGAGGCTGAAGTGCTTGCTGCCGGCATGGTCAGC
GCCACCAACCTGATCGTGCGGCACACCTTCGGCCGGGGCGGGCCGACCATCGCCCTGAACGCGCACGGCGACGTGGTGCC
GCCGGGCCTGGGCTGGACGCACGACCCGTACGGCGGCGAGATCGTCGAGACCGAGCACGGCCCGACCATGTTCGGCCGCG
GCGTGGCGGTTTCCAAGTCGGATTTCGCCACCTACACGTGGGCGCTGCTGGCGCTGATCGAAGCCGAGCGGCGCGGCGCC
CGGCTCAACGGCACCGTCGAGCTGCACTTCACCTACGACGAAGAAACGGGCGGCCACATCGGCCCGAAATGGCTGCTGGA
CCACGGACTGACCCGGCCCGACTACGCCATCTCGGCGGGGTTTGCCCATGGCATCACCTCGGCGCACAACGGCTGTCTGC
ACGCGGCGGTCACGGTGCGCGGCCGGCAGGCGCATGCCGCCATGCCGCACACCGGCCTCGATGCCATCGAGGCCGCCACG
CACATCCTGCAGGCCGTGTACGCCTACCGCGCCGAACTGGCGACGCGGACGTCCGCCGTGCCGGGCATCGACCATGCGAC
GCTCAATGTCGGCCTGATCCAGGGCGGCATCAACACCAACGTCGTGCCGGATCGGGTCACGTTCCGTGTCGACCGGCGGA
TGATTCCGGAAGAGGCCGGGCGCGATGCCGAAGGCGAGCTGCGCGCCGTGATCGAACGCGCGGCGCGCGAGCGGCCGGGG
ATCGCGGTGTCGGTCGAGCGCATCCTGCTCGCCGAGCCGCTGGCCGAGCTGCCGGGCGTGCAGACGCTGATCGCGGCCCT
ACGGCAGCAGGCGCTGGCGGTGTTCGGCGGCGACGTGCCGGTGCACGGCGTGCCGCTGTACACCGATGCGCGCCACTACA
CGGCGCACGGCGTGCCCACCGTGCTGTACGGCGCCGGCCCCCGCACCCTGATGGAAGCCCGCGGCCACAACACTGACGAG
AACCTCCGGCTGAGCGACCTGCGCGGCGCGACCGTGGTCGTGGGCTGCGCGGTCGGGGCGCTGCTGGGCGGCTGA

Upstream 100 bases:

>100_bases
GGCCCCAACTGCGACGAGCAGGATCTGCCCGAGCCGGTGTGGCTGACCGAAGCGGCCCTGCGCGCCGCACAACCGCAATG
ACAGCAACGGGAACCCGGAC

Downstream 100 bases:

>100_bases
GCGCTCAGGCCGGCCGCGTCGTTGTGCCGGCGTCCGCCGCGGTCGTGCGCGACGCATACTGCTCCACGACGACAGCCACG
GTGCCGGTGGTGCCCCCATC

Product: hypothetical protein

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTQADIAASGIDADIRAFVEAAHAQQVVFLRELVKVPSDNPSGDCAPHAARARALLEALGLAVEAHPVPEAEVLAAGMVS
ATNLIVRHTFGRGGPTIALNAHGDVVPPGLGWTHDPYGGEIVETEHGPTMFGRGVAVSKSDFATYTWALLALIEAERRGA
RLNGTVELHFTYDEETGGHIGPKWLLDHGLTRPDYAISAGFAHGITSAHNGCLHAAVTVRGRQAHAAMPHTGLDAIEAAT
HILQAVYAYRAELATRTSAVPGIDHATLNVGLIQGGINTNVVPDRVTFRVDRRMIPEEAGRDAEGELRAVIERAARERPG
IAVSVERILLAEPLAELPGVQTLIAALRQQALAVFGGDVPVHGVPLYTDARHYTAHGVPTVLYGAGPRTLMEARGHNTDE
NLRLSDLRGATVVVGCAVGALLGG

Sequences:

>Translated_424_residues
MTQADIAASGIDADIRAFVEAAHAQQVVFLRELVKVPSDNPSGDCAPHAARARALLEALGLAVEAHPVPEAEVLAAGMVS
ATNLIVRHTFGRGGPTIALNAHGDVVPPGLGWTHDPYGGEIVETEHGPTMFGRGVAVSKSDFATYTWALLALIEAERRGA
RLNGTVELHFTYDEETGGHIGPKWLLDHGLTRPDYAISAGFAHGITSAHNGCLHAAVTVRGRQAHAAMPHTGLDAIEAAT
HILQAVYAYRAELATRTSAVPGIDHATLNVGLIQGGINTNVVPDRVTFRVDRRMIPEEAGRDAEGELRAVIERAARERPG
IAVSVERILLAEPLAELPGVQTLIAALRQQALAVFGGDVPVHGVPLYTDARHYTAHGVPTVLYGAGPRTLMEARGHNTDE
NLRLSDLRGATVVVGCAVGALLGG
>Mature_423_residues
TQADIAASGIDADIRAFVEAAHAQQVVFLRELVKVPSDNPSGDCAPHAARARALLEALGLAVEAHPVPEAEVLAAGMVSA
TNLIVRHTFGRGGPTIALNAHGDVVPPGLGWTHDPYGGEIVETEHGPTMFGRGVAVSKSDFATYTWALLALIEAERRGAR
LNGTVELHFTYDEETGGHIGPKWLLDHGLTRPDYAISAGFAHGITSAHNGCLHAAVTVRGRQAHAAMPHTGLDAIEAATH
ILQAVYAYRAELATRTSAVPGIDHATLNVGLIQGGINTNVVPDRVTFRVDRRMIPEEAGRDAEGELRAVIERAARERPGI
AVSVERILLAEPLAELPGVQTLIAALRQQALAVFGGDVPVHGVPLYTDARHYTAHGVPTVLYGAGPRTLMEARGHNTDEN
LRLSDLRGATVVVGCAVGALLGG

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=398, Percent_Identity=24.3718592964824, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790395, Length=300, Percent_Identity=27.6666666666667, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17538642, Length=336, Percent_Identity=25.5952380952381, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356353, Length=419, Percent_Identity=23.8663484486874, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24649202, Length=409, Percent_Identity=26.161369193154, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24649204, Length=409, Percent_Identity=26.161369193154, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24649206, Length=310, Percent_Identity=25.4838709677419, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 44679; Mature: 44548

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQADIAASGIDADIRAFVEAAHAQQVVFLRELVKVPSDNPSGDCAPHAARARALLEALG
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHC
LAVEAHPVPEAEVLAAGMVSATNLIVRHTFGRGGPTIALNAHGDVVPPGLGWTHDPYGGE
CEEECCCCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCE
IVETEHGPTMFGRGVAVSKSDFATYTWALLALIEAERRGARLNGTVELHFTYDEETGGHI
EEECCCCCCEECCCEEECCCCHHHHHHHHHHHHHHHHCCCEECCEEEEEEEECCCCCCCC
GPKWLLDHGLTRPDYAISAGFAHGITSAHNGCLHAAVTVRGRQAHAAMPHTGLDAIEAAT
CHHHHHHCCCCCCCCEEECCHHHCCHHHCCCEEEEEEEEECCHHCCCCCCCCHHHHHHHH
HILQAVYAYRAELATRTSAVPGIDHATLNVGLIQGGINTNVVPDRVTFRVDRRMIPEEAG
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEHHHCCHHHHC
RDAEGELRAVIERAARERPGIAVSVERILLAEPLAELPGVQTLIAALRQQALAVFGGDVP
CCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
VHGVPLYTDARHYTAHGVPTVLYGAGPRTLMEARGHNTDENLRLSDLRGATVVVGCAVGA
CCCEEEEECCCCEECCCCCEEEECCCCHHHHHHCCCCCCCCEEEECCCCCEEEHHHHHHH
LLGG
HHCC
>Mature Secondary Structure 
TQADIAASGIDADIRAFVEAAHAQQVVFLRELVKVPSDNPSGDCAPHAARARALLEALG
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHC
LAVEAHPVPEAEVLAAGMVSATNLIVRHTFGRGGPTIALNAHGDVVPPGLGWTHDPYGGE
CEEECCCCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCE
IVETEHGPTMFGRGVAVSKSDFATYTWALLALIEAERRGARLNGTVELHFTYDEETGGHI
EEECCCCCCEECCCEEECCCCHHHHHHHHHHHHHHHHCCCEECCEEEEEEEECCCCCCCC
GPKWLLDHGLTRPDYAISAGFAHGITSAHNGCLHAAVTVRGRQAHAAMPHTGLDAIEAAT
CHHHHHHCCCCCCCCEEECCHHHCCHHHCCCEEEEEEEEECCHHCCCCCCCCHHHHHHHH
HILQAVYAYRAELATRTSAVPGIDHATLNVGLIQGGINTNVVPDRVTFRVDRRMIPEEAG
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEHHHCCHHHHC
RDAEGELRAVIERAARERPGIAVSVERILLAEPLAELPGVQTLIAALRQQALAVFGGDVP
CCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
VHGVPLYTDARHYTAHGVPTVLYGAGPRTLMEARGHNTDENLRLSDLRGATVVVGCAVGA
CCCEEEEECCCCEECCCCCEEEECCCCHHHHHHCCCCCCCCEEEECCCCCEEEHHHHHHH
LLGG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9829957 [H]