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The map label for this gene is hpd [H]

Identifier: 17547822

GI number: 17547822

Start: 3341193

End: 3342296

Strand: Direct

Name: hpd [H]

Synonym: RSc3103

Alternate gene names: 17547822

Gene position: 3341193-3342296 (Clockwise)

Preceding gene: 17547819

Following gene: 17547825

Centisome position: 89.9

GC content: 63.59

Gene sequence:

>1104_bases
ATGTCATTCACGCCTTGGGAAAACCCGATGGGCACCGCCGGCTTCGAGTTCATCGAATACGCCGCGCCGGACCCCGTCGC
CATGGGCAAGCTGTTCGAGAAGATGGGCTTCAGCGCCATCGCGAAGCACCGCCACAAGAACGTGACGCTGTACCGCCAGG
GCGGCATCAACTTCATCATCAACGCTGAAGCCGATTCGTTCGCGCAGCGCTTCGCGCGCCTGCACGGGCCGTCCATCTGC
GCCATCGCCTTCCGCGTGCAGGACGCGGCCCTCGCCTACCAGCGCGCGCTGGAACTGGGCGCGTGGGGCTTCGACACCCA
CAGCGGCCCGATGGAGCTGAACATCCCGGCGATCAAGGGCATCGGCGATTCGCTGATCTACCTGGTGGACCGCTGGACCG
GCAAGAACGGCGCCAAAGACGTCGACATCGGCAACATCAGTATCTACGACGTCGACTTCGTGCCCATTCCCGGCGCCAAC
CCGAACCCCATCGGGCACGGCCTGACCTACATCGACCACCTGACGCACAACGTCTACCGTGGTCGCATGAAGGAGTGGGC
CGAGTTCTACGAACGCTTCTTCAACTTCCGCGAGATCCGCTATTTCGATATCGAGGGCCAGGTCACCGGCGTGAAGAGCA
AGGCCATGACGAGCCCGTGCGGCAACATCCGCATTCCCATCAACGAGGAAGGGACGGAGAAGGCCGGCCAGATCCAGGAA
TACCTGGACATGTACCACGGCGAGGGCATCCAGCACATCGCGCTGGGCTCGACCGACCTGCACCGGACGGTGGACGCGCT
GCGCGGCAACGGCATCAAGCTGCTGGACACCATCGACACGTACTACGAGCTGGTCGACAAGCGGATCCCCGGCCATGGCG
AGAACGTGGCGGAGCTGAAGAAGCGCAAGATCCTGATCGACGGCGCGCCGGGCGACCTGCTGCTGCAGATCTTCTCGGAA
AACCAGCTGGGCCCGATCTTCTTCGAGTTCATCCAGCGCAAGGGCAACCAGGGCTTCGGCGAGGGCAACTTCAAGGCGCT
GTTCGAGTCGATCGAGCTCGACCAGATGCGCCGCGGCGTGCTGAAGGCGGATCAGCCGGCCTGA

Upstream 100 bases:

>100_bases
CAACTTCGCAATTTTTGCGTGCGTGGACACTTCTACACTGCGTGGATCGTCCAAATCCTGAGCGCTGACCCCAGCGCCGC
ACCCCGCAGGAGGCTCCGCC

Downstream 100 bases:

>100_bases
GGCCCGATCGCACCAGGCCCCGGCACACTCCCATGAAAAACGCGACCCTCGGGTCGCGTTTTTTGTTGCGGGCGCCGGCC
GATGCCGCGCTCATTCGCCC

Product: 4-hydroxyphenylpyruvate dioxygenase oxidoreductase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSFTPWENPMGTAGFEFIEYAAPDPVAMGKLFEKMGFSAIAKHRHKNVTLYRQGGINFIINAEADSFAQRFARLHGPSIC
AIAFRVQDAALAYQRALELGAWGFDTHSGPMELNIPAIKGIGDSLIYLVDRWTGKNGAKDVDIGNISIYDVDFVPIPGAN
PNPIGHGLTYIDHLTHNVYRGRMKEWAEFYERFFNFREIRYFDIEGQVTGVKSKAMTSPCGNIRIPINEEGTEKAGQIQE
YLDMYHGEGIQHIALGSTDLHRTVDALRGNGIKLLDTIDTYYELVDKRIPGHGENVAELKKRKILIDGAPGDLLLQIFSE
NQLGPIFFEFIQRKGNQGFGEGNFKALFESIELDQMRRGVLKADQPA

Sequences:

>Translated_367_residues
MSFTPWENPMGTAGFEFIEYAAPDPVAMGKLFEKMGFSAIAKHRHKNVTLYRQGGINFIINAEADSFAQRFARLHGPSIC
AIAFRVQDAALAYQRALELGAWGFDTHSGPMELNIPAIKGIGDSLIYLVDRWTGKNGAKDVDIGNISIYDVDFVPIPGAN
PNPIGHGLTYIDHLTHNVYRGRMKEWAEFYERFFNFREIRYFDIEGQVTGVKSKAMTSPCGNIRIPINEEGTEKAGQIQE
YLDMYHGEGIQHIALGSTDLHRTVDALRGNGIKLLDTIDTYYELVDKRIPGHGENVAELKKRKILIDGAPGDLLLQIFSE
NQLGPIFFEFIQRKGNQGFGEGNFKALFESIELDQMRRGVLKADQPA
>Mature_366_residues
SFTPWENPMGTAGFEFIEYAAPDPVAMGKLFEKMGFSAIAKHRHKNVTLYRQGGINFIINAEADSFAQRFARLHGPSICA
IAFRVQDAALAYQRALELGAWGFDTHSGPMELNIPAIKGIGDSLIYLVDRWTGKNGAKDVDIGNISIYDVDFVPIPGANP
NPIGHGLTYIDHLTHNVYRGRMKEWAEFYERFFNFREIRYFDIEGQVTGVKSKAMTSPCGNIRIPINEEGTEKAGQIQEY
LDMYHGEGIQHIALGSTDLHRTVDALRGNGIKLLDTIDTYYELVDKRIPGHGENVAELKKRKILIDGAPGDLLLQIFSEN
QLGPIFFEFIQRKGNQGFGEGNFKALFESIELDQMRRGVLKADQPA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=360, Percent_Identity=28.0555555555556, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI285002264, Length=357, Percent_Identity=27.4509803921569, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI14249394, Length=334, Percent_Identity=24.251497005988, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17555220, Length=231, Percent_Identity=38.0952380952381, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17550752, Length=204, Percent_Identity=29.9019607843137, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356105, Length=309, Percent_Identity=32.6860841423948, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24667510, Length=309, Percent_Identity=32.6860841423948, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41091; Mature: 40960

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTPWENPMGTAGFEFIEYAAPDPVAMGKLFEKMGFSAIAKHRHKNVTLYRQGGINFII
CCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEADSFAQRFARLHGPSICAIAFRVQDAALAYQRALELGAWGFDTHSGPMELNIPAIKG
ECCHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHCC
IGDSLIYLVDRWTGKNGAKDVDIGNISIYDVDFVPIPGANPNPIGHGLTYIDHLTHNVYR
CCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
GRMKEWAEFYERFFNFREIRYFDIEGQVTGVKSKAMTSPCGNIRIPINEEGTEKAGQIQE
HHHHHHHHHHHHHCCCCEEEEEEECCEEECCCHHHHCCCCCCEEEECCCCCCHHHHHHHH
YLDMYHGEGIQHIALGSTDLHRTVDALRGNGIKLLDTIDTYYELVDKRIPGHGENVAELK
HHHHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHH
KRKILIDGAPGDLLLQIFSENQLGPIFFEFIQRKGNQGFGEGNFKALFESIELDQMRRGV
HCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
LKADQPA
CCCCCCC
>Mature Secondary Structure 
SFTPWENPMGTAGFEFIEYAAPDPVAMGKLFEKMGFSAIAKHRHKNVTLYRQGGINFII
CCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEADSFAQRFARLHGPSICAIAFRVQDAALAYQRALELGAWGFDTHSGPMELNIPAIKG
ECCHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHCC
IGDSLIYLVDRWTGKNGAKDVDIGNISIYDVDFVPIPGANPNPIGHGLTYIDHLTHNVYR
CCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
GRMKEWAEFYERFFNFREIRYFDIEGQVTGVKSKAMTSPCGNIRIPINEEGTEKAGQIQE
HHHHHHHHHHHHHCCCCEEEEEEECCEEECCCHHHHCCCCCCEEEECCCCCCHHHHHHHH
YLDMYHGEGIQHIALGSTDLHRTVDALRGNGIKLLDTIDTYYELVDKRIPGHGENVAELK
HHHHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHH
KRKILIDGAPGDLLLQIFSENQLGPIFFEFIQRKGNQGFGEGNFKALFESIELDQMRRGV
HCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
LKADQPA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]