Click here to switch to the map view.

The map label for this gene is kefC [H]

Identifier: 17547815

GI number: 17547815

Start: 3333347

End: 3335245

Strand: Reverse

Name: kefC [H]

Synonym: RSc3096

Alternate gene names: 17547815

Gene position: 3335245-3333347 (Counterclockwise)

Preceding gene: 17547816

Following gene: 17547812

Centisome position: 89.74

GC content: 69.25

Gene sequence:

>1899_bases
ATGCAATCGCACGATCTGCTCGCCAATTTCGTCATCTACCTGGCTGCGGCGGTGGCCGTCGTACCCCTGGCGCGCCGACT
GGGACTGGGTTCGGTGCTCGGCTACCTGTTGGCCGGGGTGATCGTCGGGCCGTGGGGTCTGCGGCTGATCACCAATGTGC
AGTCGATCCTGGATTTCTCCGAATTCGGCGTCGTGCTGATGATGTTCGTGATCGGGCTGGAGCTCGAGCCCGCGCGTCTG
TGGTCGCTGCGGCGCAGCATCTTCGGCTACGGCGGGCTGCAGCTGGTGGTCTGCGCCCTGGCGGTCGGGCTGGCGGTGAT
GGCCGTCGACCACCCATGGCGCGCGGCCGTGGTGGCGGGGCTCGGGCTGGCGCTGTCGTCCACGGCCATCGCGCTGGCCA
CGCTCGCCGAGCGCAACCTGATGCGCACGCCGGCCGGCACGGCGAGCTTCGGCATCCTGCTGTTCCAGGACATCGCCGCC
ATCCCGATGATTGCGCTGCTGCCGCTGCTCGCGCCCGACACCGGCGACACCGCGGGCGGTCACCACTGGCTGGCGGCGGC
CAAGGCGGTGGGTGTGGTGGCGGCGGTCATCTTCGGCGGGCGGACCGTGCTGCGGCCGGTGCTGCGCGCGATCGCCCGCA
CCAACATGCGCGAGATGTTCACCTCGTTCTCGCTGCTGCTGGTGGTAGGCATTGCGCTGCTGATGCACAGCGTGGGCCTG
TCGATGGCGCTGGGCGCCTTCATCGCCGGCGTGCTGCTGGCCGATTCCGAATACCGCCACGCGCTGGAGACCGATATCGA
GCCCTTCAAGGGGCTGCTGCTCGGGCTGTTCTTCCTCGCGGTCGGCATGTCGATCGACTTCGGTGTGCTGATGCGCCAGC
CGCTGGCGGTGGTGCTGCTTGTGGCGGTGTTCCTGGTGGTGAAGATCGGCGCGCTGCGCGTGCTGGCGATGCGCTTCGGC
ATCGCGCGGGGACAGGCATGGCTGTTTGCCTTTCTGCTGTCGCAGGGCGGCGAGTTCGCCTTCGTGATGTTCGGCCCCGG
CGTGGCGGGCGACGTGCTGGGCGCGGAGACGGCGGCCACGCTGAACCTGGTGGTGGCCCTGTCGATGGCGGCCACGCCGT
TGCTGCTGCTGTTCCACGACAAGATCCTGGCGCCGCGCCTGATGGCCGGCAAGACGCGCGCGCCGGACGCCATCGGCCCC
CAGGGCAACGAGGTCATCATCGCCGGCTTCGGCCGCTTCGGGCAGATCGTCGGCCGCCTGCTGTACAGCCAGGGCTATAC
CGCCACCGTGCTCGACCACGATCCCGACCAGGTCGACATGGTGCGGCGCTTCGGCTTCAAGGTGTTCTACGGCGATGCCA
CGCGCATGGACCTGCTGGAAACAGCCGGCGCCGATACTGCCCGCATCATGGTGGTCGCCATCGACGACATGGAGACCAGC
CTGGAAGTGGTCGACCGCGTGCGCGAGCGCTTTCCGCGCCTGAAGCTCTACGTGCGCGCACGCAACGTGTCGCACGTGTA
CCAGCTGCGCGACCGTGGGGTCGAGGGGATCGAGCGGGAGATGTTCGAGGGTTCGCTGACACTGGCCCGGCACGTGCTGG
AGGGCCTGGGCAAAGAGCCTTACGAGGCACTGCGCGTGGCGCAGACCTTCCGGCGCCATGCGTTGAATTCGATGGACCAG
CTCTACCCGGTCTACCGAGACCAGAAGAAGCTGGTGCCGCTCGCCCAGCAGGGCCGCGAGGAACTGGCCGAGATGTTCCG
GCGCGACCGGCTCCAGCGCAAGCGCCTGCGCGAGAGCGGCATGCCCTGGGGCGAAGGCGGCCCGCACACCGCCGGAGCGG
ATGCGCAGGATGCCGGCGACGGCGACGCCGCCGGGACACCGGCGGCGCACGAGGGCTGA

Upstream 100 bases:

>100_bases
GCTCGACGCCCATCTCGAGCAGGTACGCGCCAGCCTGCAGCCATGGCTGGCGGCTGTACCCGCCTGATTTCGGCCTGACC
CTTCTTCTCGATTCCGCTCC

Downstream 100 bases:

>100_bases
CCCCGTGCGCCTGCCCGCGCGTCAGCCGTAGACGCTGATGTTGCTGCCCACCGCCATCGACGAGGCCGACTGACCGGCCA
CGCTCTGCGCCAGCTTTTCC

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MQSHDLLANFVIYLAAAVAVVPLARRLGLGSVLGYLLAGVIVGPWGLRLITNVQSILDFSEFGVVLMMFVIGLELEPARL
WSLRRSIFGYGGLQLVVCALAVGLAVMAVDHPWRAAVVAGLGLALSSTAIALATLAERNLMRTPAGTASFGILLFQDIAA
IPMIALLPLLAPDTGDTAGGHHWLAAAKAVGVVAAVIFGGRTVLRPVLRAIARTNMREMFTSFSLLLVVGIALLMHSVGL
SMALGAFIAGVLLADSEYRHALETDIEPFKGLLLGLFFLAVGMSIDFGVLMRQPLAVVLLVAVFLVVKIGALRVLAMRFG
IARGQAWLFAFLLSQGGEFAFVMFGPGVAGDVLGAETAATLNLVVALSMAATPLLLLFHDKILAPRLMAGKTRAPDAIGP
QGNEVIIAGFGRFGQIVGRLLYSQGYTATVLDHDPDQVDMVRRFGFKVFYGDATRMDLLETAGADTARIMVVAIDDMETS
LEVVDRVRERFPRLKLYVRARNVSHVYQLRDRGVEGIEREMFEGSLTLARHVLEGLGKEPYEALRVAQTFRRHALNSMDQ
LYPVYRDQKKLVPLAQQGREELAEMFRRDRLQRKRLRESGMPWGEGGPHTAGADAQDAGDGDAAGTPAAHEG

Sequences:

>Translated_632_residues
MQSHDLLANFVIYLAAAVAVVPLARRLGLGSVLGYLLAGVIVGPWGLRLITNVQSILDFSEFGVVLMMFVIGLELEPARL
WSLRRSIFGYGGLQLVVCALAVGLAVMAVDHPWRAAVVAGLGLALSSTAIALATLAERNLMRTPAGTASFGILLFQDIAA
IPMIALLPLLAPDTGDTAGGHHWLAAAKAVGVVAAVIFGGRTVLRPVLRAIARTNMREMFTSFSLLLVVGIALLMHSVGL
SMALGAFIAGVLLADSEYRHALETDIEPFKGLLLGLFFLAVGMSIDFGVLMRQPLAVVLLVAVFLVVKIGALRVLAMRFG
IARGQAWLFAFLLSQGGEFAFVMFGPGVAGDVLGAETAATLNLVVALSMAATPLLLLFHDKILAPRLMAGKTRAPDAIGP
QGNEVIIAGFGRFGQIVGRLLYSQGYTATVLDHDPDQVDMVRRFGFKVFYGDATRMDLLETAGADTARIMVVAIDDMETS
LEVVDRVRERFPRLKLYVRARNVSHVYQLRDRGVEGIEREMFEGSLTLARHVLEGLGKEPYEALRVAQTFRRHALNSMDQ
LYPVYRDQKKLVPLAQQGREELAEMFRRDRLQRKRLRESGMPWGEGGPHTAGADAQDAGDGDAAGTPAAHEG
>Mature_632_residues
MQSHDLLANFVIYLAAAVAVVPLARRLGLGSVLGYLLAGVIVGPWGLRLITNVQSILDFSEFGVVLMMFVIGLELEPARL
WSLRRSIFGYGGLQLVVCALAVGLAVMAVDHPWRAAVVAGLGLALSSTAIALATLAERNLMRTPAGTASFGILLFQDIAA
IPMIALLPLLAPDTGDTAGGHHWLAAAKAVGVVAAVIFGGRTVLRPVLRAIARTNMREMFTSFSLLLVVGIALLMHSVGL
SMALGAFIAGVLLADSEYRHALETDIEPFKGLLLGLFFLAVGMSIDFGVLMRQPLAVVLLVAVFLVVKIGALRVLAMRFG
IARGQAWLFAFLLSQGGEFAFVMFGPGVAGDVLGAETAATLNLVVALSMAATPLLLLFHDKILAPRLMAGKTRAPDAIGP
QGNEVIIAGFGRFGQIVGRLLYSQGYTATVLDHDPDQVDMVRRFGFKVFYGDATRMDLLETAGADTARIMVVAIDDMETS
LEVVDRVRERFPRLKLYVRARNVSHVYQLRDRGVEGIEREMFEGSLTLARHVLEGLGKEPYEALRVAQTFRRHALNSMDQ
LYPVYRDQKKLVPLAQQGREELAEMFRRDRLQRKRLRESGMPWGEGGPHTAGADAQDAGDGDAAGTPAAHEG

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=352, Percent_Identity=25.2840909090909, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1786232, Length=610, Percent_Identity=51.4754098360656, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1789749, Length=597, Percent_Identity=46.0636515912898, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1786685, Length=536, Percent_Identity=29.4776119402985, Blast_Score=176, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 68143; Mature: 68143

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSHDLLANFVIYLAAAVAVVPLARRLGLGSVLGYLLAGVIVGPWGLRLITNVQSILDFS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EFGVVLMMFVIGLELEPARLWSLRRSIFGYGGLQLVVCALAVGLAVMAVDHPWRAAVVAG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LGLALSSTAIALATLAERNLMRTPAGTASFGILLFQDIAAIPMIALLPLLAPDTGDTAGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
HHWLAAAKAVGVVAAVIFGGRTVLRPVLRAIARTNMREMFTSFSLLLVVGIALLMHSVGL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMALGAFIAGVLLADSEYRHALETDIEPFKGLLLGLFFLAVGMSIDFGVLMRQPLAVVLL
HHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAVFLVVKIGALRVLAMRFGIARGQAWLFAFLLSQGGEFAFVMFGPGVAGDVLGAETAAT
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHH
LNLVVALSMAATPLLLLFHDKILAPRLMAGKTRAPDAIGPQGNEVIIAGFGRFGQIVGRL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHH
LYSQGYTATVLDHDPDQVDMVRRFGFKVFYGDATRMDLLETAGADTARIMVVAIDDMETS
HHHCCCEEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEEECCHHHH
LEVVDRVRERFPRLKLYVRARNVSHVYQLRDRGVEGIEREMFEGSLTLARHVLEGLGKEP
HHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
YEALRVAQTFRRHALNSMDQLYPVYRDQKKLVPLAQQGREELAEMFRRDRLQRKRLRESG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MPWGEGGPHTAGADAQDAGDGDAAGTPAAHEG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQSHDLLANFVIYLAAAVAVVPLARRLGLGSVLGYLLAGVIVGPWGLRLITNVQSILDFS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EFGVVLMMFVIGLELEPARLWSLRRSIFGYGGLQLVVCALAVGLAVMAVDHPWRAAVVAG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LGLALSSTAIALATLAERNLMRTPAGTASFGILLFQDIAAIPMIALLPLLAPDTGDTAGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
HHWLAAAKAVGVVAAVIFGGRTVLRPVLRAIARTNMREMFTSFSLLLVVGIALLMHSVGL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMALGAFIAGVLLADSEYRHALETDIEPFKGLLLGLFFLAVGMSIDFGVLMRQPLAVVLL
HHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAVFLVVKIGALRVLAMRFGIARGQAWLFAFLLSQGGEFAFVMFGPGVAGDVLGAETAAT
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHH
LNLVVALSMAATPLLLLFHDKILAPRLMAGKTRAPDAIGPQGNEVIIAGFGRFGQIVGRL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHH
LYSQGYTATVLDHDPDQVDMVRRFGFKVFYGDATRMDLLETAGADTARIMVVAIDDMETS
HHHCCCEEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEEECCHHHH
LEVVDRVRERFPRLKLYVRARNVSHVYQLRDRGVEGIEREMFEGSLTLARHVLEGLGKEP
HHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
YEALRVAQTFRRHALNSMDQLYPVYRDQKKLVPLAQQGREELAEMFRRDRLQRKRLRESG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MPWGEGGPHTAGADAQDAGDGDAAGTPAAHEG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA