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The map label for this gene is glpK [H]

Identifier: 17547771

GI number: 17547771

Start: 3289517

End: 3291013

Strand: Direct

Name: glpK [H]

Synonym: RSc3052

Alternate gene names: 17547771

Gene position: 3289517-3291013 (Clockwise)

Preceding gene: 17547770

Following gene: 17547773

Centisome position: 88.51

GC content: 71.01

Gene sequence:

>1497_bases
ATGGAATACCTCCTCGCGCTCGACCAGGGCACGTCCAGTTCGCGTGCCATCGTGTTCAACCGCGCCGGCCAGATCGTCGC
CAGCGCCCAGCAGGAGTTTCCGCAGCATTTTCCGCAGCCCGGCTGGGTCGAGCACGATCCGCTCGACATCTGGAGCAGCC
AGCTCGCCACCTGCCGCGCCGCGCTCGAACAAGCCAGGCTGGGCGCCGCCGACATGGCCGCGCTCGGCATCACCAACCAG
CGCGAGACCACCGTGGTGTGGGAACGCGCCACCGGCCGCCCCATCTTCAATGCCATCGTCTGGCAGGACCGCCGCACCGA
GGCGATCTGCGAGCGGCTGCGCGCCGAGGGCCTGGAGGACGAGGTGCGCAAGCGCACCGGGCTGGTGATCGATCCGTATT
TCTCGGGCACCAAGCTGCGCTGGATCCTCGACCACGTGGACGGTGCCCGCGAACGCGCCGCGCGCGGCGAGCTCGCCTTC
GGCACCATCGACAGCTGGCTGGTGTGGCAACTCACGCGCGGCCGCCTGCACGTGACCGACGTATCCAACGCCTCGCGCAC
CCTGCTGTGGAACATCCACACCGGCCAGTGGGATGCCGACCTGATGCGCGCGCTCGACATCCACCCGAGCCTGCTGCCGG
AGGTGCACCCGTCGGCCCATCGCTTCGGGCAGACCGATGCCGACTGGCTGGGCGCGCCGCTCACCATCGGCGGCATCGCC
GGCGACCAGCAGTCGGCGCTGTTCGGCCAGGCCTGCTTCAAGCCTGGCATGGCCAAGAACACCTACGGCACCGGCTGCTT
CATGCTGCTCAACACCGGCGAGCGCGCGGTCGAATCGCGCAATGGGCTGATCAGCACGGCGGCCTGCCAGAGCGGCAGCC
GGCGCAGCTACGCGCTGGAAGGCAGCGTGTTCGTCGGCGGCGCGGTGGTGCAGTGGCTGCGCGACGGGCTGCGCGCGATC
CAGCGCTCGGCCGACGTGGAGGGGCTCGCCGCCTCGGTGCCGGATTCGGGCGGCGTGGTGTTCGTGCCCTCGTTCACCGG
ACTGGGGGCGCCGTACTGGGACCCGACCGCGCAGGGCGCGATCGTCGGGCTGTCGCGCGGCACGACCATCGGCCATATCG
CGCGGGCGGCGCTGGAGTCGATCGCGTTCCAGAGCACCGCGCTGCTGCAGGCGATGACGCGCGACGCGGTCTCGGCCATC
ACGGAGCTGCGCGTGGACGGCGGCGCCTCAGCCAACAACCTGCTGCTGCAGTTCCAGGCCGACCTGCTCGGCATCCCGGT
GGTGCGCCCGGAGATCATCGAAACCACGGCGCTGGGCGCGGCCTACCTGGCCGGCATCGCCACCGGCTTCTACCGGAGCG
AGGACGAGGTCGCCCGGCAATGGCGCGCCTCGCGCACGTTCCACCCGGTCATCAGCCGCGACGAAGCGCAGCACCGCATG
GCGCAATGGGAGATGGCGGTGGCGCAGGTGCGGCTGCCGACCACGCACGGCCACTGA

Upstream 100 bases:

>100_bases
CCGCCGCCGGCGGGCTATGCTTTCGCATCACCGCATCAAACCCAGCCGGAGCGGATCGGTCAGGACCGGCTCGCCCCCGG
CGCATCGAAGCCACTGCCTT

Downstream 100 bases:

>100_bases
CGACACGCGTCGGTGAAAAAAAGCGACCCGCAGGTCGCCTTTTTTGGGCGGAACGCACCTCTACTCGCCACCACTACCCG
TCGTTGGCGCCGGCCCGCCT

Product: ATP:glycerol 3-phosphotransferase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MEYLLALDQGTSSSRAIVFNRAGQIVASAQQEFPQHFPQPGWVEHDPLDIWSSQLATCRAALEQARLGAADMAALGITNQ
RETTVVWERATGRPIFNAIVWQDRRTEAICERLRAEGLEDEVRKRTGLVIDPYFSGTKLRWILDHVDGARERAARGELAF
GTIDSWLVWQLTRGRLHVTDVSNASRTLLWNIHTGQWDADLMRALDIHPSLLPEVHPSAHRFGQTDADWLGAPLTIGGIA
GDQQSALFGQACFKPGMAKNTYGTGCFMLLNTGERAVESRNGLISTAACQSGSRRSYALEGSVFVGGAVVQWLRDGLRAI
QRSADVEGLAASVPDSGGVVFVPSFTGLGAPYWDPTAQGAIVGLSRGTTIGHIARAALESIAFQSTALLQAMTRDAVSAI
TELRVDGGASANNLLLQFQADLLGIPVVRPEIIETTALGAAYLAGIATGFYRSEDEVARQWRASRTFHPVISRDEAQHRM
AQWEMAVAQVRLPTTHGH

Sequences:

>Translated_498_residues
MEYLLALDQGTSSSRAIVFNRAGQIVASAQQEFPQHFPQPGWVEHDPLDIWSSQLATCRAALEQARLGAADMAALGITNQ
RETTVVWERATGRPIFNAIVWQDRRTEAICERLRAEGLEDEVRKRTGLVIDPYFSGTKLRWILDHVDGARERAARGELAF
GTIDSWLVWQLTRGRLHVTDVSNASRTLLWNIHTGQWDADLMRALDIHPSLLPEVHPSAHRFGQTDADWLGAPLTIGGIA
GDQQSALFGQACFKPGMAKNTYGTGCFMLLNTGERAVESRNGLISTAACQSGSRRSYALEGSVFVGGAVVQWLRDGLRAI
QRSADVEGLAASVPDSGGVVFVPSFTGLGAPYWDPTAQGAIVGLSRGTTIGHIARAALESIAFQSTALLQAMTRDAVSAI
TELRVDGGASANNLLLQFQADLLGIPVVRPEIIETTALGAAYLAGIATGFYRSEDEVARQWRASRTFHPVISRDEAQHRM
AQWEMAVAQVRLPTTHGH
>Mature_498_residues
MEYLLALDQGTSSSRAIVFNRAGQIVASAQQEFPQHFPQPGWVEHDPLDIWSSQLATCRAALEQARLGAADMAALGITNQ
RETTVVWERATGRPIFNAIVWQDRRTEAICERLRAEGLEDEVRKRTGLVIDPYFSGTKLRWILDHVDGARERAARGELAF
GTIDSWLVWQLTRGRLHVTDVSNASRTLLWNIHTGQWDADLMRALDIHPSLLPEVHPSAHRFGQTDADWLGAPLTIGGIA
GDQQSALFGQACFKPGMAKNTYGTGCFMLLNTGERAVESRNGLISTAACQSGSRRSYALEGSVFVGGAVVQWLRDGLRAI
QRSADVEGLAASVPDSGGVVFVPSFTGLGAPYWDPTAQGAIVGLSRGTTIGHIARAALESIAFQSTALLQAMTRDAVSAI
TELRVDGGASANNLLLQFQADLLGIPVVRPEIIETTALGAAYLAGIATGFYRSEDEVARQWRASRTFHPVISRDEAQHRM
AQWEMAVAQVRLPTTHGH

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=499, Percent_Identity=45.2905811623246, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI4504007, Length=499, Percent_Identity=45.2905811623246, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI41393575, Length=499, Percent_Identity=44.0881763527054, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI42794763, Length=505, Percent_Identity=44.7524752475248, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI88196792, Length=503, Percent_Identity=33.0019880715706, Blast_Score=293, Evalue=3e-79,
Organism=Escherichia coli, GI1790361, Length=489, Percent_Identity=57.0552147239264, Blast_Score=593, Evalue=1e-171,
Organism=Escherichia coli, GI1790005, Length=509, Percent_Identity=26.1296660117878, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787789, Length=518, Percent_Identity=26.8339768339768, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789168, Length=482, Percent_Identity=24.2738589211618, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789987, Length=489, Percent_Identity=25.1533742331288, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=501, Percent_Identity=42.9141716566866, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71986140, Length=479, Percent_Identity=24.8434237995825, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71986147, Length=231, Percent_Identity=32.4675324675325, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321755, Length=479, Percent_Identity=40.7098121085595, Blast_Score=321, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24655555, Length=495, Percent_Identity=40.8080808080808, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24655560, Length=495, Percent_Identity=40.8080808080808, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24655570, Length=495, Percent_Identity=40.8080808080808, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24655574, Length=495, Percent_Identity=40.8080808080808, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24655565, Length=495, Percent_Identity=40.8080808080808, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI17864214, Length=502, Percent_Identity=42.8286852589641, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24654573, Length=429, Percent_Identity=44.5221445221445, Blast_Score=354, Evalue=8e-98,
Organism=Drosophila melanogaster, GI19922058, Length=523, Percent_Identity=32.3135755258126, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI24652871, Length=490, Percent_Identity=33.265306122449, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24656367, Length=510, Percent_Identity=29.4117647058824, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI21357867, Length=525, Percent_Identity=28.952380952381, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24656372, Length=357, Percent_Identity=31.6526610644258, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI45552909, Length=302, Percent_Identity=29.1390728476821, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 54171; Mature: 54171

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYLLALDQGTSSSRAIVFNRAGQIVASAQQEFPQHFPQPGWVEHDPLDIWSSQLATCRA
CCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ALEQARLGAADMAALGITNQRETTVVWERATGRPIFNAIVWQDRRTEAICERLRAEGLED
HHHHHHCCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHCCCHH
EVRKRTGLVIDPYFSGTKLRWILDHVDGARERAARGELAFGTIDSWLVWQLTRGRLHVTD
HHHHHCCCEEECCCCCCEEEEHHHHCCCHHHHHHCCCEEEECCCHHHEEEEECCEEEEEE
VSNASRTLLWNIHTGQWDADLMRALDIHPSLLPEVHPSAHRFGQTDADWLGAPLTIGGIA
CCCCCEEEEEEEECCCCCHHHHHHHCCCHHHCCCCCCCHHHCCCCCHHHCCCCEEEECCC
GDQQSALFGQACFKPGMAKNTYGTGCFMLLNTGERAVESRNGLISTAACQSGSRRSYALE
CCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHCCCCEEEHHHCCCCCCEEEEC
GSVFVGGAVVQWLRDGLRAIQRSADVEGLAASVPDSGGVVFVPSFTGLGAPYWDPTAQGA
CCEEEHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCCCCCE
IVGLSRGTTIGHIARAALESIAFQSTALLQAMTRDAVSAITELRVDGGASANNLLLQFQA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEH
DLLGIPVVRPEIIETTALGAAYLAGIATGFYRSEDEVARQWRASRTFHPVISRDEAQHRM
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCHHHHHH
AQWEMAVAQVRLPTTHGH
HHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MEYLLALDQGTSSSRAIVFNRAGQIVASAQQEFPQHFPQPGWVEHDPLDIWSSQLATCRA
CCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ALEQARLGAADMAALGITNQRETTVVWERATGRPIFNAIVWQDRRTEAICERLRAEGLED
HHHHHHCCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHCCCHH
EVRKRTGLVIDPYFSGTKLRWILDHVDGARERAARGELAFGTIDSWLVWQLTRGRLHVTD
HHHHHCCCEEECCCCCCEEEEHHHHCCCHHHHHHCCCEEEECCCHHHEEEEECCEEEEEE
VSNASRTLLWNIHTGQWDADLMRALDIHPSLLPEVHPSAHRFGQTDADWLGAPLTIGGIA
CCCCCEEEEEEEECCCCCHHHHHHHCCCHHHCCCCCCCHHHCCCCCHHHCCCCEEEECCC
GDQQSALFGQACFKPGMAKNTYGTGCFMLLNTGERAVESRNGLISTAACQSGSRRSYALE
CCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHCCCCEEEHHHCCCCCCEEEEC
GSVFVGGAVVQWLRDGLRAIQRSADVEGLAASVPDSGGVVFVPSFTGLGAPYWDPTAQGA
CCEEEHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCCCCCE
IVGLSRGTTIGHIARAALESIAFQSTALLQAMTRDAVSAITELRVDGGASANNLLLQFQA
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEH
DLLGIPVVRPEIIETTALGAAYLAGIATGFYRSEDEVARQWRASRTFHPVISRDEAQHRM
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCHHHHHH
AQWEMAVAQVRLPTTHGH
HHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA