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The map label for this gene is dsbD

Identifier: 17547709

GI number: 17547709

Start: 3223189

End: 3225015

Strand: Reverse

Name: dsbD

Synonym: RSc2990

Alternate gene names: 17547709

Gene position: 3225015-3223189 (Counterclockwise)

Preceding gene: 17547710

Following gene: 17547706

Centisome position: 86.78

GC content: 69.62

Gene sequence:

>1827_bases
ATGACGCTGTCTGCATTCCTGCCCCTGCGCCGCTTGCTGCAACTGGGGCTGTTGCTGGTCGCCATGGCGACCCTCGCCCT
GCCTGCCCGCGCCGCGGATGATTTTCTGCCGCCCGAACAGGCGTTCCGCTTTTCGGCGGTGCAGATCGACGGGCAGACCG
TGGAGGTGAAATTCGCGATTGCCGATGGCTACTACATGTACCGTGAGCGGCTCGCTGTCGCGGCGGATCCCGCCACCGTC
ACGTTCGCGCCGCTGGAACTGCCTCCGGGCAAAGTCAAATTCGACGATACCTTCAACAAGGATGTCGAGACGTATCGCCA
TGCGCTCGTGTTTCGCGTGAAGGCGCGGGAGGCGGCCAGCCCGTTCTCGCTGATCGTCACTTCGCAGGGCTGCGCGGATC
AGGGCGTGTGCTACCCGCCGATGAAGAGCCGCTTCCGGGTCGAACCGGCGGCAGCGTCCCCGGCACCGCCGGCGGCGCCG
CTTGAGGCCGCCGGATCGAGCGACGCGCTGGGCGGCCGCATCGCAAGCACGCTCGGCGGCGGCAATCTGGGGGCGATTGC
CGTACTGTTCTTGGGGCTCGGTCTGTTGCTGACCTTTACGCCGTGCGTGCTGCCGATGCTGCCGATCCTGTCGGCCATCG
TGGTTGGCGAGCATGCGACGCGGATGCGCGCGGCGGCGGTGTCGGTAGCCTATGTGCTGGGGATGGCGGTGGTGTATACG
GCGGTCGGCGTGGCGGCCGGCCTGGCGGGGCAGGGCCTGCAGGCGGCTCTGCAGAACGCCTGGGTGCTGGGGGCATTTGC
GGCGCTGATGGTGGTGCTGTCGCTGGCGATGTTCGGACTGTACGAGCTGCAGCTGCCGGCTGCTTGGCGCCACCGCCTGA
CGCAGGCTTCCAACCGGTTGAGCGGGGGGCAGGTGGCCGGGGCGGCTGTCATGGGGGCGCTGTCGGCGCTGATTGTCTCG
CCGTGCGTGACGCCGGCGCTGGCGGGGGCGCTGGCCTATATCGCGCAGACGGGCAACGCGATGGTGGGCGGCGCGGCGCT
GTTCTCCATGTCCATCGGGATGGGGGTGCCGCTGGTGCTCGTCGGCGTGGGCGCGGGCAATCTGCTGCCGCGCGCCGGCT
ATTGGCTGGTGGTCACCAAGGCCATCTTCGGGTTCATTCTGCTGGGCGTGGCCTTGTGGATCGTGCAGCCGGTGCTGCCG
GCCTGGCTGGCGATGGTTGCCTGGGCCGTGCTGCTGATTGCGGCGGCCGTGTTTCTGCGCACCTTCGATTCCCTGCCCGC
CGATGCCGGGCCGCTGCCGCGCCTGGGCAAGGTGGTTGGCGTGGTGCTGGCTCTGGCGGGGGCCGTGCAACTGGTGGGCG
TGGCAGCGGGCGGGCGCGATCCGCTGCAGCCGCTGGCGGGGGTGATGCGCGCATCGGCGGGCGCTCAGCCGGATGCCCGC
GGCGTGGTGTTCCAGCGCGTGAAAAGCGTATCGGAAGTCGATGAGGCGGTTCGTGCCGCCACCGCAACCGGCCGCCCGGT
GATGCTCGATTTCTACGCGGACTGGTGCGTCAGCTGCAAGGAGATGGAGCGCCTGACCTTCACGGACGCGCGGGTCCGTG
CCGCGCTTGCCGATGTCGTGCTCCTGCAAGCCGACGTGACGGCCGATGGTGCCGATGATCGCGCGCTGCTCAAGCGCTTC
AGCCTGTTTGGTCCGCCCGCCACGATCTTCTTCGACGCGCAGGGCAACCAGGCGCCGGTGCGCGTGGTCGGCTTCGAGCG
CGCCGAGACCTTCCTGGCCAGCCTGCGCCGCGCGCTGGGCACGGCGCAGGCCAAGCCCTCGACCTGA

Upstream 100 bases:

>100_bases
GATCATTGCCGTGCCGGTCGCAGCCGGGTTGCCTGCCTATCTGGCGTGGGTGGCCGGGGAGACCGGCCGGTCTACTGTTT
GATGTCTGATTGCCGCTGAT

Downstream 100 bases:

>100_bases
GCCGGGTCAGCCGCGCAGCAGGCGCGCGGCGTCCAGCGCGAAGTAGGTCAGGATGCCGTTGGCACCGGCGCGCTTGAAGG
CCAGCAGCGACTCCAGCACG

Product: thiol:disulfide interchange transmembrane protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MTLSAFLPLRRLLQLGLLLVAMATLALPARAADDFLPPEQAFRFSAVQIDGQTVEVKFAIADGYYMYRERLAVAADPATV
TFAPLELPPGKVKFDDTFNKDVETYRHALVFRVKAREAASPFSLIVTSQGCADQGVCYPPMKSRFRVEPAAASPAPPAAP
LEAAGSSDALGGRIASTLGGGNLGAIAVLFLGLGLLLTFTPCVLPMLPILSAIVVGEHATRMRAAAVSVAYVLGMAVVYT
AVGVAAGLAGQGLQAALQNAWVLGAFAALMVVLSLAMFGLYELQLPAAWRHRLTQASNRLSGGQVAGAAVMGALSALIVS
PCVTPALAGALAYIAQTGNAMVGGAALFSMSIGMGVPLVLVGVGAGNLLPRAGYWLVVTKAIFGFILLGVALWIVQPVLP
AWLAMVAWAVLLIAAAVFLRTFDSLPADAGPLPRLGKVVGVVLALAGAVQLVGVAAGGRDPLQPLAGVMRASAGAQPDAR
GVVFQRVKSVSEVDEAVRAATATGRPVMLDFYADWCVSCKEMERLTFTDARVRAALADVVLLQADVTADGADDRALLKRF
SLFGPPATIFFDAQGNQAPVRVVGFERAETFLASLRRALGTAQAKPST

Sequences:

>Translated_608_residues
MTLSAFLPLRRLLQLGLLLVAMATLALPARAADDFLPPEQAFRFSAVQIDGQTVEVKFAIADGYYMYRERLAVAADPATV
TFAPLELPPGKVKFDDTFNKDVETYRHALVFRVKAREAASPFSLIVTSQGCADQGVCYPPMKSRFRVEPAAASPAPPAAP
LEAAGSSDALGGRIASTLGGGNLGAIAVLFLGLGLLLTFTPCVLPMLPILSAIVVGEHATRMRAAAVSVAYVLGMAVVYT
AVGVAAGLAGQGLQAALQNAWVLGAFAALMVVLSLAMFGLYELQLPAAWRHRLTQASNRLSGGQVAGAAVMGALSALIVS
PCVTPALAGALAYIAQTGNAMVGGAALFSMSIGMGVPLVLVGVGAGNLLPRAGYWLVVTKAIFGFILLGVALWIVQPVLP
AWLAMVAWAVLLIAAAVFLRTFDSLPADAGPLPRLGKVVGVVLALAGAVQLVGVAAGGRDPLQPLAGVMRASAGAQPDAR
GVVFQRVKSVSEVDEAVRAATATGRPVMLDFYADWCVSCKEMERLTFTDARVRAALADVVLLQADVTADGADDRALLKRF
SLFGPPATIFFDAQGNQAPVRVVGFERAETFLASLRRALGTAQAKPST
>Mature_607_residues
TLSAFLPLRRLLQLGLLLVAMATLALPARAADDFLPPEQAFRFSAVQIDGQTVEVKFAIADGYYMYRERLAVAADPATVT
FAPLELPPGKVKFDDTFNKDVETYRHALVFRVKAREAASPFSLIVTSQGCADQGVCYPPMKSRFRVEPAAASPAPPAAPL
EAAGSSDALGGRIASTLGGGNLGAIAVLFLGLGLLLTFTPCVLPMLPILSAIVVGEHATRMRAAAVSVAYVLGMAVVYTA
VGVAAGLAGQGLQAALQNAWVLGAFAALMVVLSLAMFGLYELQLPAAWRHRLTQASNRLSGGQVAGAAVMGALSALIVSP
CVTPALAGALAYIAQTGNAMVGGAALFSMSIGMGVPLVLVGVGAGNLLPRAGYWLVVTKAIFGFILLGVALWIVQPVLPA
WLAMVAWAVLLIAAAVFLRTFDSLPADAGPLPRLGKVVGVVLALAGAVQLVGVAAGGRDPLQPLAGVMRASAGAQPDARG
VVFQRVKSVSEVDEAVRAATATGRPVMLDFYADWCVSCKEMERLTFTDARVRAALADVVLLQADVTADGADDRALLKRFS
LFGPPATIFFDAQGNQAPVRVVGFERAETFLASLRRALGTAQAKPST

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Escherichia coli, GI1790578, Length=596, Percent_Identity=38.758389261745, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DSBD_RALSO (Q8XV41)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_521111.1
- ProteinModelPortal:   Q8XV41
- GeneID:   1221844
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2990
- NMPDR:   fig|267608.1.peg.2990
- HOGENOM:   HBG640883
- OMA:   HTDEYFG
- ProtClustDB:   CLSK2302757
- BioCyc:   RSOL267608:RSC2990-MONOMER
- BRENDA:   1.8.1.8
- GO:   GO:0006810
- HAMAP:   MF_00399
- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: =1.8.1.8

Molecular weight: Translated: 63190; Mature: 63059

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf668334)-; HASH(0xf7a5848)-; HASH(0xf6fa308)-; HASH(0xf63d674)-; HASH(0xf7d4564)-; HASH(0xf7d3958)-; HASH(0xf742644)-; HASH(0xf573abc)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSAFLPLRRLLQLGLLLVAMATLALPARAADDFLPPEQAFRFSAVQIDGQTVEVKFAI
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHEEEEEEECCEEEEEEEEE
ADGYYMYRERLAVAADPATVTFAPLELPPGKVKFDDTFNKDVETYRHALVFRVKAREAAS
ECCHHHHHHHHHHEECCCEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHEEEHHHCCCC
PFSLIVTSQGCADQGVCYPPMKSRFRVEPAAASPAPPAAPLEAAGSSDALGGRIASTLGG
CEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCC
GNLGAIAVLFLGLGLLLTFTPCVLPMLPILSAIVVGEHATRMRAAAVSVAYVLGMAVVYT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AVGVAAGLAGQGLQAALQNAWVLGAFAALMVVLSLAMFGLYELQLPAAWRHRLTQASNRL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCC
SGGQVAGAAVMGALSALIVSPCVTPALAGALAYIAQTGNAMVGGAALFSMSIGMGVPLVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEE
VGVGAGNLLPRAGYWLVVTKAIFGFILLGVALWIVQPVLPAWLAMVAWAVLLIAAAVFLR
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFDSLPADAGPLPRLGKVVGVVLALAGAVQLVGVAAGGRDPLQPLAGVMRASAGAQPDAR
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCCCC
GVVFQRVKSVSEVDEAVRAATATGRPVMLDFYADWCVSCKEMERLTFTDARVRAALADVV
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
LLQADVTADGADDRALLKRFSLFGPPATIFFDAQGNQAPVRVVGFERAETFLASLRRALG
HHEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHC
TAQAKPST
CCCCCCCH
>Mature Secondary Structure 
TLSAFLPLRRLLQLGLLLVAMATLALPARAADDFLPPEQAFRFSAVQIDGQTVEVKFAI
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHEEEEEEECCEEEEEEEEE
ADGYYMYRERLAVAADPATVTFAPLELPPGKVKFDDTFNKDVETYRHALVFRVKAREAAS
ECCHHHHHHHHHHEECCCEEEEEECCCCCCCEEECCCCCHHHHHHHHHHHEEEHHHCCCC
PFSLIVTSQGCADQGVCYPPMKSRFRVEPAAASPAPPAAPLEAAGSSDALGGRIASTLGG
CEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCC
GNLGAIAVLFLGLGLLLTFTPCVLPMLPILSAIVVGEHATRMRAAAVSVAYVLGMAVVYT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AVGVAAGLAGQGLQAALQNAWVLGAFAALMVVLSLAMFGLYELQLPAAWRHRLTQASNRL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCC
SGGQVAGAAVMGALSALIVSPCVTPALAGALAYIAQTGNAMVGGAALFSMSIGMGVPLVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEE
VGVGAGNLLPRAGYWLVVTKAIFGFILLGVALWIVQPVLPAWLAMVAWAVLLIAAAVFLR
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFDSLPADAGPLPRLGKVVGVVLALAGAVQLVGVAAGGRDPLQPLAGVMRASAGAQPDAR
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCCCCCCC
GVVFQRVKSVSEVDEAVRAATATGRPVMLDFYADWCVSCKEMERLTFTDARVRAALADVV
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
LLQADVTADGADDRALLKRFSLFGPPATIFFDAQGNQAPVRVVGFERAETFLASLRRALG
HHEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHC
TAQAKPST
CCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852