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The map label for this gene is ung

Identifier: 17547606

GI number: 17547606

Start: 3114046

End: 3114846

Strand: Direct

Name: ung

Synonym: RSc2887

Alternate gene names: 17547606

Gene position: 3114046-3114846 (Clockwise)

Preceding gene: 17547605

Following gene: 17547607

Centisome position: 83.79

GC content: 71.91

Gene sequence:

>801_bases
ATGACGCGCCGCGCTGACCCGGCCCAGGCCACGCTCTTCGACGATGACGAACCCGCCGGTGCGCCGACGGCCACGGGTGG
CTTCGTTCCGCTGGCCGACCAGTTCGATGCGTTGCCCGCCGACTGGAAAGCGCTGCTCGGGCCCTGCCTGGCGCGGACCG
ACTGGCCGGCCTTGTGCGCCTTCGTCGACGGCGAACGCGCGGCCGGCAAGCCGATCTTCCCGACCGAGGTCTTCCACGCC
CTGCACCTGACGCCGGTCGACGCGGTGCGCGTGATCATCCTCGGCCAGGATCCGTACCACGGCACCGGCACGGTCGATGG
CCGCGAAGTGCCGCAGGCGCACGGGCTGGCGTTCTCGGTGCCCGCCGGCGTGCGCGTGCCGCCGAGCCTGCGCAACATCT
ACAAGGAAATCGAGGCGGAATACGGCCGCAAGCTGTCCGCCGGCTCCGGCAACCTGGAGGGCTGGGCGCAACAGGGCGTG
CTGCTGCTCAACACAGTGCTGACCGTCGAGCAGGGCCAAGCCGCGAGCCACGCCCGGCGCGGCTGGGAGCGCATCACGGA
TTGCCTGCTGGAGCACCTGGCGCGCGTCGGCCACGCTCGCGTGTTCATGCTGTGGGGCAGCCACGCCCAGGCCAAGCGCG
CCTTGCTGCCGGAAGGGCATCTGGTGCTCGAGGCGCCGCATCCGTCGCCGCTGTCGGCGCATCGCGGCTTCCTGGGGTGC
GGGCATTTCCGGGCCGCCAACGACTGGCTGGCGGCGCAGGGGCAGTCGACGATCGATTGGCTCCGGCCCCAGGCGGACTG
A

Upstream 100 bases:

>100_bases
CGCAAACCCTGCGCACGGCCGTGCCGGGCCTCGCGCCGCTCGACGCCAGCAAGGCCCTGCGCGGCTACCGGCTGCATGCG
ACGGCGACCGGAGCCCTGGC

Downstream 100 bases:

>100_bases
CGCAGCGGACAAGCAACCTGACGGAAAGCGGTTCCCGACATTCCTAGCATGTAAGCGACACTTCTCTTTCACCATCGGAG
CGAAGGGCTTACATGATCGA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MTRRADPAQATLFDDDEPAGAPTATGGFVPLADQFDALPADWKALLGPCLARTDWPALCAFVDGERAAGKPIFPTEVFHA
LHLTPVDAVRVIILGQDPYHGTGTVDGREVPQAHGLAFSVPAGVRVPPSLRNIYKEIEAEYGRKLSAGSGNLEGWAQQGV
LLLNTVLTVEQGQAASHARRGWERITDCLLEHLARVGHARVFMLWGSHAQAKRALLPEGHLVLEAPHPSPLSAHRGFLGC
GHFRAANDWLAAQGQSTIDWLRPQAD

Sequences:

>Translated_266_residues
MTRRADPAQATLFDDDEPAGAPTATGGFVPLADQFDALPADWKALLGPCLARTDWPALCAFVDGERAAGKPIFPTEVFHA
LHLTPVDAVRVIILGQDPYHGTGTVDGREVPQAHGLAFSVPAGVRVPPSLRNIYKEIEAEYGRKLSAGSGNLEGWAQQGV
LLLNTVLTVEQGQAASHARRGWERITDCLLEHLARVGHARVFMLWGSHAQAKRALLPEGHLVLEAPHPSPLSAHRGFLGC
GHFRAANDWLAAQGQSTIDWLRPQAD
>Mature_265_residues
TRRADPAQATLFDDDEPAGAPTATGGFVPLADQFDALPADWKALLGPCLARTDWPALCAFVDGERAAGKPIFPTEVFHAL
HLTPVDAVRVIILGQDPYHGTGTVDGREVPQAHGLAFSVPAGVRVPPSLRNIYKEIEAEYGRKLSAGSGNLEGWAQQGVL
LLNTVLTVEQGQAASHARRGWERITDCLLEHLARVGHARVFMLWGSHAQAKRALLPEGHLVLEAPHPSPLSAHRGFLGCG
HFRAANDWLAAQGQSTIDWLRPQAD

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=223, Percent_Identity=44.8430493273543, Blast_Score=177, Evalue=7e-45,
Organism=Homo sapiens, GI6224979, Length=223, Percent_Identity=44.8430493273543, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1788934, Length=203, Percent_Identity=53.2019704433498, Blast_Score=203, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17556304, Length=223, Percent_Identity=40.3587443946188, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6323620, Length=249, Percent_Identity=38.5542168674699, Blast_Score=160, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_RALSO (Q8XVE4)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_521008.1
- ProteinModelPortal:   Q8XVE4
- SMR:   Q8XVE4
- GeneID:   1221740
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2887
- NMPDR:   fig|267608.1.peg.2887
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   RSOL267608:RSC2887-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 28667; Mature: 28536

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 97-97

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRADPAQATLFDDDEPAGAPTATGGFVPLADQFDALPADWKALLGPCLARTDWPALCA
CCCCCCCCCEEECCCCCCCCCCCCCCCCEECCHHCCCCCCHHHHHHHHHHHCCCCHHEEE
FVDGERAAGKPIFPTEVFHALHLTPVDAVRVIILGQDPYHGTGTVDGREVPQAHGLAFSV
EECCCCCCCCCCCHHHHHHHHCCCCHHHEEEEEECCCCCCCCCCCCCCCCHHHCCEEEEC
PAGVRVPPSLRNIYKEIEAEYGRKLSAGSGNLEGWAQQGVLLLNTVLTVEQGQAASHARR
CCCCCCCHHHHHHHHHHHHHHCCEECCCCCCCCHHHHCCEEEEHHHHHHCCCCHHHHHHH
GWERITDCLLEHLARVGHARVFMLWGSHAQAKRALLPEGHLVLEAPHPSPLSAHRGFLGC
HHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCCCCCEEEECCCCCCHHHHCCCEEC
GHFRAANDWLAAQGQSTIDWLRPQAD
CCCCCCCCHHHCCCCCHHHHCCCCCC
>Mature Secondary Structure 
TRRADPAQATLFDDDEPAGAPTATGGFVPLADQFDALPADWKALLGPCLARTDWPALCA
CCCCCCCCEEECCCCCCCCCCCCCCCCEECCHHCCCCCCHHHHHHHHHHHCCCCHHEEE
FVDGERAAGKPIFPTEVFHALHLTPVDAVRVIILGQDPYHGTGTVDGREVPQAHGLAFSV
EECCCCCCCCCCCHHHHHHHHCCCCHHHEEEEEECCCCCCCCCCCCCCCCHHHCCEEEEC
PAGVRVPPSLRNIYKEIEAEYGRKLSAGSGNLEGWAQQGVLLLNTVLTVEQGQAASHARR
CCCCCCCHHHHHHHHHHHHHHCCEECCCCCCCCHHHHCCEEEEHHHHHHCCCCHHHHHHH
GWERITDCLLEHLARVGHARVFMLWGSHAQAKRALLPEGHLVLEAPHPSPLSAHRGFLGC
HHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCCCCCEEEECCCCCCHHHHCCCEEC
GHFRAANDWLAAQGQSTIDWLRPQAD
CCCCCCCCHHHCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852