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The map label for this gene is mltA [H]

Identifier: 17547595

GI number: 17547595

Start: 3105124

End: 3106266

Strand: Reverse

Name: mltA [H]

Synonym: RSc2876

Alternate gene names: 17547595

Gene position: 3106266-3105124 (Counterclockwise)

Preceding gene: 17547597

Following gene: 17547591

Centisome position: 83.58

GC content: 71.13

Gene sequence:

>1143_bases
ATGACAGCAACAACCTTGGACGCCTCGACTCGAGCGCACACCGTCCACCGGCGCGGATGGGCCGGCCTGTCCGCCGCACT
GGTCGCCGTCCTGCTGGCGGCCTGCACCAGCGGCCCGCCGCCACGCCTGGAAGCGCCGCAGGCGCCGACCGCCACGCTGG
GCGGCGGCCTGCAGCCCGCCACCTGGGCCGACGTGGCCGGCTGGACCACCGACGATCTCGCCTCCGCTTGGCCCGCGCTG
CAATCGAACTGCCTGGCGATGAAGCGTCGCGCCGACTGGGCACGCGTCTGCGCCGCCGGCCTGATGGTCGATGCCGGCGA
TCCGATCGCCATGCGCACCTTCTTCGAAGACAACTTCACGCCCTACCGCGTGGTCAAGGACGACGGTACCGACAGCGGCC
TGATCACCGGCTACTACGAGCCATTGCTGCGCGGCTCGCGCACGCGTCACGGCGTGTACCAGACCCCGCTGTACCGCATG
CCCGCCGCCTGGCGCGGCAAGACCCTGCCGGCGCGCGTCCAGCTGATCCGCAGCCCCGCGCTGGCGGGCAACGAGGTCGT
CTGGGTGGACGATCCCGTCGAAGCGGCCTTCCTGCAGATCCAGGGCTCAGGCCAGGTCCAGCTGGAAGAGGGCGGCATCA
TGCGCCTGGGCGTGGGCGGCACCAACAACCAGCCGTTCCGCTCGTTCGCGCGCTGGCTGCTCGACCAGGGCGAAATCACC
CCGGTGCAGGCCACCATGCAGGGCATCAAGGCATGGGCACGCGCCAACCCCGGCCGCGTCGACGAGATGCTCAACATCAA
CCCGCGCTACGTGTTCTTCAACGAGAACCCGGGCAACAGCGACGGTCCGATCGGCAAGCTGGGCGTGCCGCTCACGGCCG
AGCGCTCGATCGCGGTGGACCCGGGCTACATCCCGCTCGGCGCGCCGGTGTTCCTGTCGACCACCAAACCGCTGTCGACC
GAGCCCATCCAGAAGCTGGTCTTCGCGCAGGACGTGGGCTCGGCCATCCGTGGCGCCGTGCGCGCCGACTACTACTTCGG
CCACGGCGACGCGGCAGGCGACCTGGCCGGCCGCATGAAGCAGGCCGGCCGGCTGTGGGTGCTGGTGCCGAAGGGCAGCC
CCGTCGGCGTGGCCTCGCGCTAG

Upstream 100 bases:

>100_bases
TCGGATGGTTTTCGAAGAATTGGCTCATGATCGACGGCGGAAAGCGCGGTGCAGGCATTGTAGCCAAGCGCACCGGCCGG
CCGCAGGGGATGGAACACGC

Downstream 100 bases:

>100_bases
CGGCTACGGCTGGCCGCGCCGCAGATCCACCACGCGGCGCGCCTTCCCGACCGAGCGCTCGACCCCGCCGACGGCCAGCA
GCTCGATCGCCGCAGTCACG

Product: membrane-bound lytic murein transglycosylase A transmembrane protein

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTATTLDASTRAHTVHRRGWAGLSAALVAVLLAACTSGPPPRLEAPQAPTATLGGGLQPATWADVAGWTTDDLASAWPAL
QSNCLAMKRRADWARVCAAGLMVDAGDPIAMRTFFEDNFTPYRVVKDDGTDSGLITGYYEPLLRGSRTRHGVYQTPLYRM
PAAWRGKTLPARVQLIRSPALAGNEVVWVDDPVEAAFLQIQGSGQVQLEEGGIMRLGVGGTNNQPFRSFARWLLDQGEIT
PVQATMQGIKAWARANPGRVDEMLNINPRYVFFNENPGNSDGPIGKLGVPLTAERSIAVDPGYIPLGAPVFLSTTKPLST
EPIQKLVFAQDVGSAIRGAVRADYYFGHGDAAGDLAGRMKQAGRLWVLVPKGSPVGVASR

Sequences:

>Translated_380_residues
MTATTLDASTRAHTVHRRGWAGLSAALVAVLLAACTSGPPPRLEAPQAPTATLGGGLQPATWADVAGWTTDDLASAWPAL
QSNCLAMKRRADWARVCAAGLMVDAGDPIAMRTFFEDNFTPYRVVKDDGTDSGLITGYYEPLLRGSRTRHGVYQTPLYRM
PAAWRGKTLPARVQLIRSPALAGNEVVWVDDPVEAAFLQIQGSGQVQLEEGGIMRLGVGGTNNQPFRSFARWLLDQGEIT
PVQATMQGIKAWARANPGRVDEMLNINPRYVFFNENPGNSDGPIGKLGVPLTAERSIAVDPGYIPLGAPVFLSTTKPLST
EPIQKLVFAQDVGSAIRGAVRADYYFGHGDAAGDLAGRMKQAGRLWVLVPKGSPVGVASR
>Mature_379_residues
TATTLDASTRAHTVHRRGWAGLSAALVAVLLAACTSGPPPRLEAPQAPTATLGGGLQPATWADVAGWTTDDLASAWPALQ
SNCLAMKRRADWARVCAAGLMVDAGDPIAMRTFFEDNFTPYRVVKDDGTDSGLITGYYEPLLRGSRTRHGVYQTPLYRMP
AAWRGKTLPARVQLIRSPALAGNEVVWVDDPVEAAFLQIQGSGQVQLEEGGIMRLGVGGTNNQPFRSFARWLLDQGEITP
VQATMQGIKAWARANPGRVDEMLNINPRYVFFNENPGNSDGPIGKLGVPLTAERSIAVDPGYIPLGAPVFLSTTKPLSTE
PIQKLVFAQDVGSAIRGAVRADYYFGHGDAAGDLAGRMKQAGRLWVLVPKGSPVGVASR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=361, Percent_Identity=30.1939058171745, Blast_Score=118, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40645; Mature: 40514

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATTLDASTRAHTVHRRGWAGLSAALVAVLLAACTSGPPPRLEAPQAPTATLGGGLQPA
CCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCC
TWADVAGWTTDDLASAWPALQSNCLAMKRRADWARVCAAGLMVDAGDPIAMRTFFEDNFT
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEEEECCCCEEEEEECCCCCC
PYRVVKDDGTDSGLITGYYEPLLRGSRTRHGVYQTPLYRMPAAWRGKTLPARVQLIRSPA
EEEEEECCCCCCCEEEHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHCCC
LAGNEVVWVDDPVEAAFLQIQGSGQVQLEEGGIMRLGVGGTNNQPFRSFARWLLDQGEIT
CCCCEEEEECCCCCEEEEEEECCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCC
PVQATMQGIKAWARANPGRVDEMLNINPRYVFFNENPGNSDGPIGKLGVPLTAERSIAVD
HHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEECCCEEEEC
PGYIPLGAPVFLSTTKPLSTEPIQKLVFAQDVGSAIRGAVRADYYFGHGDAAGDLAGRMK
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHH
QAGRLWVLVPKGSPVGVASR
HCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TATTLDASTRAHTVHRRGWAGLSAALVAVLLAACTSGPPPRLEAPQAPTATLGGGLQPA
CCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCC
TWADVAGWTTDDLASAWPALQSNCLAMKRRADWARVCAAGLMVDAGDPIAMRTFFEDNFT
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEEEECCCCEEEEEECCCCCC
PYRVVKDDGTDSGLITGYYEPLLRGSRTRHGVYQTPLYRMPAAWRGKTLPARVQLIRSPA
EEEEEECCCCCCCEEEHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHCCC
LAGNEVVWVDDPVEAAFLQIQGSGQVQLEEGGIMRLGVGGTNNQPFRSFARWLLDQGEIT
CCCCEEEEECCCCCEEEEEEECCCEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCC
PVQATMQGIKAWARANPGRVDEMLNINPRYVFFNENPGNSDGPIGKLGVPLTAERSIAVD
HHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEECCCEEEEC
PGYIPLGAPVFLSTTKPLSTEPIQKLVFAQDVGSAIRGAVRADYYFGHGDAAGDLAGRMK
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHH
QAGRLWVLVPKGSPVGVASR
HCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]